The network for 'negative regulation of coagulation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of coagulation

Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation.

NameDescriptionProbabilityFunc Analog Organism
VEGFAvascular endothelial growth factor A0.998
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.995
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.994
C1QAcomplement component 1, q subcomponent, A chain0.993
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.971
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.967
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.950
NRP1neuropilin 10.943
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.756
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.756
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.606
C1QCcomplement component 1, q subcomponent, C chain0.575
SYKspleen tyrosine kinase0.555
S100A10S100 calcium binding protein A100.505
PLAUplasminogen activator, urokinase0.498
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.450
PLATplasminogen activator, tissue0.421
FGAfibrinogen alpha chain0.400
EGFRepidermal growth factor receptor0.380
PGFplacental growth factor0.290
PDGFCplatelet derived growth factor C0.277
PLAURplasminogen activator, urokinase receptor0.276
APOC1apolipoprotein C-I0.261
PLCG1phospholipase C, gamma 10.249
KNG1kininogen 10.216
C1QBcomplement component 1, q subcomponent, B chain0.195
PDGFAplatelet-derived growth factor alpha polypeptide0.181
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.108
C1Scomplement component 1, s subcomponent0.104
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.101
FN1fibronectin 10.100
CDCP1CUB domain containing protein 10.098
ACTBactin, beta0.093
PTPRBprotein tyrosine phosphatase, receptor type, B0.086
F11coagulation factor XI0.078
LATlinker for activation of T cells0.074
SPINT1serine peptidase inhibitor, Kunitz type 10.071
APOA2apolipoprotein A-II0.069
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.068
C1Rcomplement component 1, r subcomponent0.064
METmet proto-oncogene (hepatocyte growth factor receptor)0.064
APOC3apolipoprotein C-III0.063
CDH5cadherin 5, type 2 (vascular endothelium)0.062
AXLAXL receptor tyrosine kinase0.062
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.061
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.061
PTPRJprotein tyrosine phosphatase, receptor type, J0.058
KITLGKIT ligand0.055
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.055
GAB1GRB2-associated binding protein 10.049
NCF1neutrophil cytosolic factor 10.048
FLT4fms-related tyrosine kinase 40.046
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.042
CAV1caveolin 1, caveolae protein, 22kDa0.041
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.041
MASP2mannan-binding lectin serine peptidase 20.038
APOBapolipoprotein B (including Ag(x) antigen)0.038
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.037
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.035
C8Acomplement component 8, alpha polypeptide0.035
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.032
APOHapolipoprotein H (beta-2-glycoprotein I)0.032
SERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 50.031
LPAlipoprotein, Lp(a)0.031
HRGhistidine-rich glycoprotein0.030
C8Bcomplement component 8, beta polypeptide0.029
GAB2GRB2-associated binding protein 20.029
ARRDC3arrestin domain containing 30.029
ANGPTL2angiopoietin-like 20.029
SLC38A3solute carrier family 38, member 30.029
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.029
SHC2SHC (Src homology 2 domain containing) transforming protein 20.028
COL4A1collagen, type IV, alpha 10.027
LDLRlow density lipoprotein receptor0.027
SERPINF2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.026
ANXA1annexin A10.025
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.025
SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.024
LCATlecithin-cholesterol acyltransferase0.024
STAB1stabilin 10.024
F3coagulation factor III (thromboplastin, tissue factor)0.023
FGFR1fibroblast growth factor receptor 10.023
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.022
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.022
C6complement component 60.021
PLTPphospholipid transfer protein0.020
ORM1orosomucoid 10.018
TGFBItransforming growth factor, beta-induced, 68kDa0.018
SOS1son of sevenless homolog 1 (Drosophila)0.018
SHC1SHC (Src homology 2 domain containing) transforming protein 10.018
F10coagulation factor X0.017
CYBAcytochrome b-245, alpha polypeptide0.017
MARCOmacrophage receptor with collagenous structure0.017
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.017
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.017
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
anxa1aannexin A1a0.011
brpf1bromodomain and PHD finger containing, 10.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.900
Apoa1apolipoprotein A-I0.630
Itih1inter-alpha trypsin inhibitor, heavy chain 10.521
Fggfibrinogen gamma chain0.427
F2coagulation factor II0.423
Ceacam2carcinoembryonic antigen-related cell adhesion molecule 20.336
Cficomplement component factor i0.298
F7coagulation factor VII0.291
Itgb3integrin beta 30.287
Asgr2asialoglycoprotein receptor 20.256
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.238
Saa4serum amyloid A 40.215
ND6NADH dehydrogenase subunit 60.184
Pzppregnancy zone protein0.176
Procprotein C0.169
Plauplasminogen activator, urokinase0.165
Ambpalpha 1 microglobulin/bikunin0.162
Itih4inter alpha-trypsin inhibitor, heavy chain 40.161
Kng1kininogen 10.160
1300017J02RikRIKEN cDNA 1300017J02 gene0.156
C9complement component 90.144
Fgbfibrinogen beta chain0.143
Gcgroup specific component0.142
Lgals3lectin, galactose binding, soluble 30.141
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.138
F9coagulation factor IX0.136
Gcgrglucagon receptor0.129
Igfbp1insulin-like growth factor binding protein 10.121
Apoa5apolipoprotein A-V0.116
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.106
Fgafibrinogen alpha chain0.105
Ptgs2prostaglandin-endoperoxide synthase 20.102
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.095
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.093
F10coagulation factor X0.092
F12coagulation factor XII (Hageman factor)0.090
Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 10.086
Hgdhomogentisate 1, 2-dioxygenase0.080
Nos1nitric oxide synthase 1, neuronal0.077
Trfr2transferrin receptor 20.076
S100a10S100 calcium binding protein A10 (calpactin)0.075
Itgb1integrin beta 1 (fibronectin receptor beta)0.073
Platplasminogen activator, tissue0.066
F11coagulation factor XI0.064
Hnf4ahepatic nuclear factor 4, alpha0.060
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.059
Apomapolipoprotein M0.058
Spna1spectrin alpha 10.058
Prodh2proline dehydrogenase (oxidase) 20.057
Hchemolytic complement0.056
Hbb-b1hemoglobin, beta adult major chain0.055
Apoa4apolipoprotein A-IV0.055
Lipclipase, hepatic0.053
Serpinb6aserine (or cysteine) peptidase inhibitor, clade B, member 6a0.052
Foxa3forkhead box A30.049
Hgfachepatocyte growth factor activator0.046
Vhlvon Hippel-Lindau tumor suppressor0.044
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.043
Mmp9matrix metallopeptidase 90.041
Abcc6ATP-binding cassette, sub-family C (CFTR/MRP), member 60.038
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.037
Hamphepcidin antimicrobial peptide0.037
Agxtalanine-glyoxylate aminotransferase0.036
Psg21pregnancy-specific glycoprotein 210.035
Apobapolipoprotein B0.034
Halhistidine ammonia lyase0.033
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.033
Tnctenascin C0.032
Mat1amethionine adenosyltransferase I, alpha0.031
Cpn1carboxypeptidase N, polypeptide 10.031
Ldb3LIM domain binding 30.030
Amdhd1amidohydrolase domain containing 10.030
Loxlysyl oxidase0.029
Apoc4apolipoprotein C-IV0.029
P2rx1purinergic receptor P2X, ligand-gated ion channel, 10.029
Mplmyeloproliferative leukemia virus oncogene0.028
Egfrepidermal growth factor receptor0.027
Ces1ccarboxylesterase 1C0.026
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.026
S100a11S100 calcium binding protein A11 (calgizzarin)0.025
Timd2T-cell immunoglobulin and mucin domain containing 20.025
Nr0b2nuclear receptor subfamily 0, group B, member 20.025
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.024
Pea15aphosphoprotein enriched in astrocytes 15A0.022
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.022
Tnfrsf11btumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)0.022
Apofapolipoprotein F0.022
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.022
Mup3major urinary protein 30.021
Cd9CD9 antigen0.021
Mmp2matrix metallopeptidase 20.020
Cyr61cysteine rich protein 610.020
Gp9glycoprotein 9 (platelet)0.020
Aadataminoadipate aminotransferase0.020
Prkceprotein kinase C, epsilon0.020
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Anxa5annexin A50.401
S100a6S100 calcium binding protein A60.359
Pzppregnancy-zone protein0.326
Ctsbcathepsin B0.125
Plauplasminogen activator, urokinase0.084
Cma1chymase 1, mast cell0.079
Agtr1aangiotensin II receptor, type 1a0.059
Gja1gap junction protein, alpha 10.044
Ifitm3interferon induced transmembrane protein 30.042
Cnn3calponin 3, acidic0.039
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.034
Cpb2carboxypeptidase B2 (plasma)0.017
Serpinf2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.016
Haao3-hydroxyanthranilate 3,4-dioxygenase0.015
Rnase4ribonuclease, RNase A family 40.015
Itgb1integrin, beta 10.015
Mbl2mannose-binding lectin (protein C) 20.015
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.014
Myadmmyeloid-associated differentiation marker0.014
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.013
Gcgroup specific component0.013
Anxa4annexin A40.012
C1scomplement component 1, s subcomponent0.012
Pgcpplasma glutamate carboxypeptidase0.012
Pnliprp1pancreatic lipase-related protein 10.012
Mcpt1mast cell protease 10.012
Pnliprp2pancreatic lipase-related protein 20.011
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.011
Fabp1fatty acid binding protein 1, liver0.010
Lmnalamin A0.010
Olr1078olfactory receptor 10780.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism