The network for 'cardiac muscle tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle tissue development

The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.

NameDescriptionProbabilityFunc Analog Organism
TRIM63tripartite motif containing 631.000
YAP1Yes-associated protein 10.998
FN1fibronectin 10.997
CREBBPCREB binding protein0.997
FLNAfilamin A, alpha0.997
SMAD7SMAD family member 70.995
RARAretinoic acid receptor, alpha0.994
FGFR2fibroblast growth factor receptor 20.993
SRFserum response factor (c-fos serum response element-binding transcription factor)0.993
ESR1estrogen receptor 10.990
NOTCH1notch 10.989
FKBP1AFK506 binding protein 1A, 12kDa0.987
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.986
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.983
MYOD1myogenic differentiation 10.969
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.965
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.955
BMPR1Abone morphogenetic protein receptor, type IA0.952
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.951
TNNC1troponin C type 1 (slow)0.949
TNNI1troponin I type 1 (skeletal, slow)0.949
TPM1tropomyosin 1 (alpha)0.925
SMAD1SMAD family member 10.915
ACTN1actinin, alpha 10.911
COL4A2collagen, type IV, alpha 20.899
EP300E1A binding protein p3000.896
FGFR1fibroblast growth factor receptor 10.891
COL4A1collagen, type IV, alpha 10.878
FGF1fibroblast growth factor 1 (acidic)0.853
TBX5T-box 50.852
ACTA1actin, alpha 1, skeletal muscle0.837
NRP1neuropilin 10.821
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.820
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.812
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.802
FSTL1follistatin-like 10.801
MYOZ1myozenin 10.799
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.770
LRP6low density lipoprotein receptor-related protein 60.770
BMP2bone morphogenetic protein 20.744
TGFBR1transforming growth factor, beta receptor 10.725
MYH9myosin, heavy chain 9, non-muscle0.706
SMYD1SET and MYND domain containing 10.703
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.674
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.667
GATA4GATA binding protein 40.665
JAG1jagged 10.665
FLNCfilamin C, gamma0.661
PSEN1presenilin 10.661
TPM2tropomyosin 2 (beta)0.629
PDLIM7PDZ and LIM domain 7 (enigma)0.622
TNNT3troponin T type 3 (skeletal, fast)0.613
HDAC4histone deacetylase 40.612
TCAPtitin-cap (telethonin)0.606
MED25mediator complex subunit 250.603
NCOA1nuclear receptor coactivator 10.576
TNNI2troponin I type 2 (skeletal, fast)0.563
RXRAretinoid X receptor, alpha0.557
CKMcreatine kinase, muscle0.542
FGF10fibroblast growth factor 100.532
INADLInaD-like (Drosophila)0.497
TCF4transcription factor 40.494
FLNBfilamin B, beta0.490
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.482
EPAS1endothelial PAS domain protein 10.473
ARID1BAT rich interactive domain 1B (SWI1-like)0.463
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.423
MYH7myosin, heavy chain 7, cardiac muscle, beta0.423
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.411
MYOGmyogenin (myogenic factor 4)0.411
TGFB1transforming growth factor, beta 10.409
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.400
ACVR1Bactivin A receptor, type IB0.385
PTPN14protein tyrosine phosphatase, non-receptor type 140.382
MYL9myosin, light chain 9, regulatory0.378
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.376
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.362
MYL2myosin, light chain 2, regulatory, cardiac, slow0.353
NCOA3nuclear receptor coactivator 30.348
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.340
PMLpromyelocytic leukemia0.325
THBS1thrombospondin 10.324
JUPjunction plakoglobin0.323
SMAD6SMAD family member 60.322
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.314
CALD1caldesmon 10.313
TNNT2troponin T type 2 (cardiac)0.305
TGFB3transforming growth factor, beta 30.291
PDGFAplatelet-derived growth factor alpha polypeptide0.290
TSC2tuberous sclerosis 20.287
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.284
COL4A6collagen, type IV, alpha 60.280
ACTN2actinin, alpha 20.279
MYBPC2myosin binding protein C, fast type0.266
ARandrogen receptor0.253
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hey2hairy/enhancer-of-split related with YRPW motif 20.994
tbx1T-box 10.989
ttnatitin a0.982
smyd1bSET and MYND domain containing 1b0.968
fgf8afibroblast growth factor 8 a0.966
tbx20T-box 200.964
tnni1btroponin I, skeletal, slow b0.962
bmp4bone morphogenetic protein 40.959
tbx5aT-box 5a0.958
tnnc1btroponin C type 1b (slow)0.957
myod1myogenic differentiation 10.948
aldh1a2aldehyde dehydrogenase 1 family, member A20.943
mef2cbmyocyte enhancer factor 2cb0.936
nkx2.5NK2 transcription factor related 50.916
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.880
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.873
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.851
pcdh8protocadherin 80.841
pax2apaired box gene 2a0.743
her7hairy and enhancer of split related-70.742
smyhc1slow myosin heavy chain 10.733
wnt11rwingless-type MMTV integration site family, member 11, related0.722
synpo2lbsynaptopodin 2-like b0.711
hspb1heat shock protein, alpha-crystallin-related, 10.710
kdrlkinase insert domain receptor like0.694
foxd3forkhead box D30.687
myl1myosin, light chain 1, alkali; skeletal, fast0.687
tbx2bT-box 2b0.680
bmp2bbone morphogenetic protein 2b0.676
rbm24aRNA binding motif protein 24a0.657
wt1awilms tumor 1a0.628
crabp2acellular retinoic acid binding protein 2, a0.609
vmhcventricular myosin heavy chain0.600
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.597
hnf1baHNF1 homeobox Ba0.578
osr1odd-skipped related 1 (Drosophila)0.571
klf4Kruppel-like factor 40.546
eng2aengrailed 2a0.522
tbx18T-box 180.522
fn1fibronectin 10.520
itgb1b.2integrin, beta 1b.20.514
pax8paired box gene 80.511
tmem88atransmembrane protein 88 a0.509
mibmind bomb0.495
cdh2cadherin 2, neuronal0.486
gja3gap junction protein, alpha 30.476
myl7myosin, light polypeptide 7, regulatory0.459
notch1bnotch homolog 1b0.455
her9hairy-related 90.451
irx1airoquois homeobox protein 1, a0.416
atp1b2bATPase, Na+/K+ transporting, beta 2b polypeptide0.410
ttnbtitin b0.397
cyt1type I cytokeratin, enveloping layer0.368
tal1T-cell acute lymphocytic leukemia 10.366
myf6myogenic factor 60.365
eya4eyes absent homolog 4 (Drosophila)0.351
etv2ets variant gene 20.347
pdlim7PDZ and LIM domain 70.343
gata6GATA-binding protein 60.339
tbx5bT-box 5b0.322
desmadesmin a0.322
tnnc1atroponin C type 1a (slow)0.312
hsp90a.1heat shock protein 90-alpha 10.312
foxa3forkhead box A30.310
fgf17fibroblast growth factor 170.302
fgfr1afibroblast growth factor receptor 1a0.298
tp63tumor protein p630.292
adrb2aadrenergic receptor, beta 2a0.286
nkx2.2aNK2 transcription factor related 2a0.286
tnni1altroponin I, skeletal, slow like0.283
mespamesoderm posterior a0.276
tnni2a.4troponin I, skeletal, fast 2a.40.270
nog2noggin 20.268
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.268
six4bsine oculis homeobox homolog 4b0.262
hhexhematopoietically expressed homeobox0.260
plcg1phospholipase C, gamma 10.258
aplnrbapelin receptor b0.256
foxi1forkhead box I10.248
wnt8bwingless-type MMTV integration site family, member 8b0.242
pitx2paired-like homeodomain transcription factor 20.223
tbx2aT-box gene 2a0.222
has2hyaluronan synthase 20.222
lhx1aLIM homeobox 1a0.213
lrrc10leucine rich repeat containing 100.209
wt1bwilms tumor 1b0.204
tcf21transcription factor 210.203
cmlc1cardiac myosin light chain-10.203
fzd8bfrizzled homolog 8b0.202
efnb2aephrin B2a0.197
ncs1aneuronal calcium sensor 1a0.197
lmx1b.2LIM homeobox transcription factor 1, beta 20.193
fzd10frizzled homolog 100.187
bmp7bbone morphogenetic protein 7b0.187
actc1aactin, alpha, cardiac muscle 1a0.186
robo2roundabout homolog 20.184
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.835
Rac1CG2248 gene product from transcript CG2248-RA0.588
snssticks and stones0.442
MhcMyosin heavy chain0.337
LanB2Laminin B20.224
EgfrEpidermal growth factor receptor0.187
LanALaminin A0.156
cicubitus interruptus0.144
numbCG3779 gene product from transcript CG3779-RB0.140
wupAwings up A0.129
l(2)gllethal (2) giant larvae0.102
Tm2Tropomyosin 20.087
Zasp52Z band alternatively spliced PDZ-motif protein 520.081
stumpsCG31317 gene product from transcript CG31317-RC0.080
rolsrolling pebbles0.075
Mef2Myocyte enhancer factor 20.072
S6kRPS6-p70-protein kinase0.065
Actnalpha actinin0.060
EcREcdysone receptor0.059
sqhspaghetti squash0.058
Act88FActin 88F0.057
HLH54FCG5005 gene product from transcript CG5005-RA0.056
Ras85DRas oncogene at 85D0.053
PtenCG5671 gene product from transcript CG5671-RB0.047
Akt1CG4006 gene product from transcript CG4006-RA0.045
wbwing blister0.043
stanstarry night0.043
Pi3K92ECG4141 gene product from transcript CG4141-RB0.042
emcextra macrochaetae0.041
Rab11Rab-protein 110.038
Mlc2Myosin light chain 20.026
grhgrainy head0.024
Pabp2CG2163 gene product from transcript CG2163-RA0.022
MrtfMyocardin-related transcription factor0.022
Zasp66Z band alternatively spliced PDZ-motif protein 660.021
ThorCG8846 gene product from transcript CG8846-RA0.021
aopanterior open0.020
Stat92ESignal-transducer and activator of transcription protein at 92E0.018
CG12558CG12558 gene product from transcript CG12558-RA0.018
CG31226CG31226 gene product from transcript CG31226-RB0.018
fasfaint sausage0.017
HandCG18144 gene product from transcript CG18144-RA0.016
Tsc1CG6147 gene product from transcript CG6147-RA0.016
kirrekin of irre0.015
Su(H)Suppressor of Hairless0.014
PvrPDGF- and VEGF-receptor related0.014
HopHsp70/Hsp90 organizing protein homolog0.014
mbcmyoblast city0.014
RASSF8CG5053 gene product from transcript CG5053-RA0.013
InRInsulin-like receptor0.013
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Shhsonic hedgehog1.000
Gata4GATA binding protein 41.000
Pitx2paired-like homeodomain transcription factor 21.000
Foxc2forkhead box C20.999
Tbx3T-box 30.999
Foxc1forkhead box C10.999
Ctnnb1catenin (cadherin associated protein), beta 10.999
Gli3GLI-Kruppel family member GLI30.999
Bmp4bone morphogenetic protein 40.999
Hand2heart and neural crest derivatives expressed transcript 20.998
Pax3paired box gene 30.998
Ptpn11protein tyrosine phosphatase, non-receptor type 110.998
Fgf8fibroblast growth factor 80.998
Vegfavascular endothelial growth factor A0.996
Otx2orthodenticle homolog 2 (Drosophila)0.995
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.992
Gata6GATA binding protein 60.990
Tgfb2transforming growth factor, beta 20.990
Smad6MAD homolog 6 (Drosophila)0.988
Tbx1T-box 10.986
Fgfr2fibroblast growth factor receptor 20.986
Meox2mesenchyme homeobox 20.986
Sox9SRY-box containing gene 90.986
Nos3nitric oxide synthase 3, endothelial cell0.985
Pax2paired box gene 20.983
Hoxa13homeobox A130.981
Nr5a1nuclear receptor subfamily 5, group A, member 10.976
Hand1heart and neural crest derivatives expressed transcript 10.976
Ror2receptor tyrosine kinase-like orphan receptor 20.975
Gli2GLI-Kruppel family member GLI20.971
Rxraretinoid X receptor alpha0.971
Smad3MAD homolog 3 (Drosophila)0.970
Fgfr1fibroblast growth factor receptor 10.968
Tgfbr2transforming growth factor, beta receptor II0.956
Ptenphosphatase and tensin homolog0.953
Wnt11wingless-related MMTV integration site 110.948
Mesp1mesoderm posterior 10.948
Msx1homeobox, msh-like 10.944
Foxh1forkhead box H10.937
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.937
Acvr1activin A receptor, type 10.927
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.925
Egfrepidermal growth factor receptor0.922
Actc1actin, alpha, cardiac muscle 10.921
Chd7chromodomain helicase DNA binding protein 70.917
Notch1Notch gene homolog 1 (Drosophila)0.917
Rargretinoic acid receptor, gamma0.916
Ldb3LIM domain binding 30.914
Ntf3neurotrophin 30.911
Hspg2perlecan (heparan sulfate proteoglycan 2)0.911
Gscgoosecoid homeobox0.908
Isl1ISL1 transcription factor, LIM/homeodomain0.908
Zic3zinc finger protein of the cerebellum 30.902
Foxf1aforkhead box F1a0.897
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.885
Tcfap2atranscription factor AP-2, alpha0.884
Tbx5T-box 50.883
Prrx1paired related homeobox 10.880
Axin1axin 10.871
Gja1gap junction protein, alpha 10.870
Efnb2ephrin B20.869
Cnn1calponin 10.867
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.858
Notch2Notch gene homolog 2 (Drosophila)0.856
Wt1Wilms tumor 1 homolog0.856
Hoxd13homeobox D130.841
Esr1estrogen receptor 1 (alpha)0.839
Flt4FMS-like tyrosine kinase 40.836
Actn2actinin alpha 20.834
Tbx20T-box 200.831
Bmpr1abone morphogenetic protein receptor, type 1A0.831
Lhx1LIM homeobox protein 10.831
Scn5asodium channel, voltage-gated, type V, alpha0.828
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.825
Lhx3LIM homeobox protein 30.823
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.823
Pax8paired box gene 80.820
Epas1endothelial PAS domain protein 10.818
Vangl2vang-like 2 (van gogh, Drosophila)0.817
Wnt7awingless-related MMTV integration site 7A0.811
Twist2twist homolog 2 (Drosophila)0.805
Acvrl1activin A receptor, type II-like 10.796
Pcdh12protocadherin 120.793
Jag1jagged 10.793
Psen1presenilin 10.791
Apcadenomatosis polyposis coli0.787
Foxg1forkhead box G10.785
Wnt2bwingless related MMTV integration site 2b0.784
Yap1yes-associated protein 10.783
Hif3ahypoxia inducible factor 3, alpha subunit0.781
Fgfr3fibroblast growth factor receptor 30.781
Gja3gap junction protein, alpha 30.780
Bmp7bone morphogenetic protein 70.779
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Casq2calsequestrin 2 (cardiac muscle)0.093
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.080
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.068
LOC100362824caveolin 2-like0.061
Gja3gap junction protein, alpha 30.052
Scn5asodium channel, voltage-gated, type V, alpha subunit0.046
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.043
Syt8synaptotagmin VIII0.038
Emp1epithelial membrane protein 10.037
Anxa5annexin A50.037
Kcng2potassium voltage-gated channel, subfamily G, member 20.035
Foxd3forkhead box D30.034
Etfaelectron-transfer-flavoprotein, alpha polypeptide0.031
Gata6GATA binding protein 60.030
Tnni1troponin I type 1 (skeletal, slow)0.030
Gja5gap junction protein, alpha 50.028
Tnni3troponin I type 3 (cardiac)0.027
Myh7myosin, heavy chain 7, cardiac muscle, beta0.027
Myh9myosin, heavy chain 9, non-muscle0.026
Top2atopoisomerase (DNA) II alpha0.025
Csrp3cysteine and glycine-rich protein 30.025
Prrx1paired related homeobox 10.025
Slc10a2solute carrier family 10 (sodium/bile acid cotransporter family), member 20.025
Cdkn3cyclin-dependent kinase inhibitor 30.023
Fgf7fibroblast growth factor 70.023
Eif5aeukaryotic translation initiation factor 5A0.023
Nexnnexilin (F actin binding protein)0.023
Wt1Wilms tumor 10.022
Smad3SMAD family member 30.022
Bmp6bone morphogenetic protein 60.022
Foxi2forkhead box I20.021
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.021
Ptgfrprostaglandin F receptor0.021
Lifleukemia inhibitory factor0.020
Cdk1cyclin-dependent kinase 10.020
Fgf16fibroblast growth factor 160.020
Pdha2pyruvate dehydrogenase (lipoamide) alpha 20.020
Ube2cubiquitin-conjugating enzyme E2C0.020
Neurog1neurogenin 10.020
Hspb2heat shock protein beta 20.020
Cav1caveolin 1, caveolae protein0.019
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.019
Actc1actin, alpha, cardiac muscle 10.019
Pzppregnancy-zone protein0.019
Alx1ALX homeobox 10.019
Myl3myosin, light chain 3, alkali; ventricular, skeletal, slow0.019
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.018
Msmbmicroseminoprotein, beta0.018
Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta0.018
Tacr2tachykinin receptor 20.018
Hand2heart and neural crest derivatives expressed 20.018
Crygbcrystallin, gamma B0.018
Dnah2dynein, axonemal, heavy chain 20.018
Cav3caveolin 30.017
Il7interleukin 70.017
Fam70bfamily with sequence similarity 70, member B0.017
Sert1Sertoli cell protein 10.017
Hsp90b1heat shock protein 90, beta, member 10.017
P2rx5purinergic receptor P2X, ligand-gated ion channel, 50.017
Esr2estrogen receptor 2 (ER beta)0.016
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.016
Nos3nitric oxide synthase 3, endothelial cell0.016
Rararetinoic acid receptor, alpha0.016
Opn1swopsin 1 (cone pigments), short-wave-sensitive0.016
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.016
Mbl1mannose-binding lectin (protein A) 10.016
Tpothyroid peroxidase0.016
Acadlacyl-Coenzyme A dehydrogenase, long-chain0.016
Cdh16cadherin 160.016
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.015
Hnmthistamine N-methyltransferase0.015
Traf4af1TRAF4 associated factor 10.015
KitlgKIT ligand0.015
RT1-DOaRT1 class II, locus DOa0.015
Dmgdhdimethylglycine dehydrogenase0.015
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.015
Fgafibrinogen alpha chain0.015
Cfl1cofilin 1, non-muscle0.015
Ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.015
Dmrt1doublesex and mab-3 related transcription factor 10.014
Prl8a2prolactin family 8, subfamily a, member 20.014
Ifitm3interferon induced transmembrane protein 30.014
Cyp2b12cytochrome P450, family 2, subfamily b, polypeptide 120.014
CebpeCCAAT/enhancer binding protein (C/EBP), epsilon0.014
Cks2CDC28 protein kinase regulatory subunit 20.014
Bmp7bone morphogenetic protein 70.014
Pfn1profilin 10.014
Cald1caldesmon 10.014
Rrm2ribonucleotide reductase M20.014
Oprd1opioid receptor, delta 10.014
Notch2Notch homolog 2 (Drosophila)0.014
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism