The network for 'transdifferentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms


The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.

NameDescriptionProbabilityFunc Analog Organism
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.816
SMAD2SMAD family member 20.778
WDR5WD repeat domain 50.741
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.668
RBBP5retinoblastoma binding protein 50.483
CXXC1CXXC finger protein 10.442
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.416
SETD1ASET domain containing 1A0.338
PAX3paired box 30.198
MEN1multiple endocrine neoplasia I0.171
MLL2myeloid/lymphoid or mixed-lineage leukemia 20.167
CHD8chromodomain helicase DNA binding protein 80.130
S100BS100 calcium binding protein B0.076
MYST1MYST histone acetyltransferase 10.045
HCFC1host cell factor C1 (VP16-accessory protein)0.036
WDR82WD repeat domain 820.035
C16orf53chromosome 16 open reading frame 530.033
SP1Sp1 transcription factor0.032
SOX10SRY (sex determining region Y)-box 100.032
NCOA6nuclear receptor coactivator 60.031
MLL3myeloid/lymphoid or mixed-lineage leukemia 30.026
PAXIP1PAX interacting (with transcription-activation domain) protein 10.019
TBX5T-box 50.018
GATA4GATA binding protein 40.017
EGLN3egl nine homolog 3 (C. elegans)0.015
WHSC2Wolf-Hirschhorn syndrome candidate 20.015
CTBP1C-terminal binding protein 10.014
RB1retinoblastoma 10.014
KHSRPKH-type splicing regulatory protein0.014
CHD4chromodomain helicase DNA binding protein 40.013
GATAD2AGATA zinc finger domain containing 2A0.012
HIST1H3Bhistone cluster 1, H3b0.012
POU3F3POU class 3 homeobox 30.012
SOX1SRY (sex determining region Y)-box 10.011
MLL4myeloid/lymphoid or mixed-lineage leukemia 40.011
SETD1BSET domain containing 1B0.010
MBD3methyl-CpG binding domain protein 30.010
NOVA2neuro-oncological ventral antigen 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pou5f1POU domain, class 5, transcription factor 11.000
Sall4sal-like 4 (Drosophila)1.000
Neurod1neurogenic differentiation 11.000
NanogNanog homeobox1.000
Ascl1achaete-scute complex homolog 1 (Drosophila)0.999
Sox2SRY-box containing gene 20.999
Otx2orthodenticle homolog 2 (Drosophila)0.998
Esrrbestrogen related receptor, beta0.997
Sall3sal-like 3 (Drosophila)0.997
Rbbp5retinoblastoma binding protein 50.987
Sall1sal-like 1 (Drosophila)0.986
Neurog2neurogenin 20.982
Pax6paired box gene 60.971
Wdr5WD repeat domain 50.961
Pdx1pancreatic and duodenal homeobox 10.961
Mta1metastasis associated 10.958
Neurod4neurogenic differentiation 40.957
Nr0b1nuclear receptor subfamily 0, group B, member 10.955
Isl1ISL1 transcription factor, LIM/homeodomain0.943
Onecut1one cut domain, family member 10.938
Rnf2ring finger protein 20.916
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.911
Shhsonic hedgehog0.902
Tcfcp2l1transcription factor CP2-like 10.895
Robo3roundabout homolog 3 (Drosophila)0.885
Mta2metastasis-associated gene family, member 20.851
Lhx5LIM homeobox protein 50.836
Fgf8fibroblast growth factor 80.815
Insm1insulinoma-associated 10.797
Lhx3LIM homeobox protein 30.784
Nkx6-1NK6 homeobox 10.778
Neurog3neurogenin 30.770
Gata1GATA binding protein 10.752
Alx3aristaless-like homeobox 30.735
Sox1SRY-box containing gene 10.722
Hand1heart and neural crest derivatives expressed transcript 10.719
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.711
Ptf1apancreas specific transcription factor, 1a0.695
Zic2zinc finger protein of the cerebellum 20.692
Fgf17fibroblast growth factor 170.688
Mbd3methyl-CpG binding domain protein 30.676
Kiss1KiSS-1 metastasis-suppressor0.671
Smad4MAD homolog 4 (Drosophila)0.666
Sox3SRY-box containing gene 30.659
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.652
Neurog1neurogenin 10.642
Pou3f2POU domain, class 3, transcription factor 20.628
Hmx1H6 homeobox 10.620
Fgf15fibroblast growth factor 150.615
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.612
Tlx3T-cell leukemia, homeobox 30.589
Hes5hairy and enhancer of split 5 (Drosophila)0.589
Efna2ephrin A20.587
Nr5a1nuclear receptor subfamily 5, group A, member 10.581
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.579
Chd4chromodomain helicase DNA binding protein 40.578
En1engrailed 10.577
Foxd2forkhead box D20.574
Hdac1histone deacetylase 10.572
Arxaristaless related homeobox0.572
Ash2lash2 (absent, small, or homeotic)-like (Drosophila)0.544
Dlx1distal-less homeobox 10.541
Lhx9LIM homeobox protein 90.525
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.521
Hand2heart and neural crest derivatives expressed transcript 20.521
Zic1zinc finger protein of the cerebellum 10.484
Hoxd13homeobox D130.473
Emx1empty spiracles homolog 1 (Drosophila)0.454
Tbr1T-box brain gene 10.449
Nacc1nucleus accumbens associated 1, BEN and BTB (POZ) domain containing0.445
Dlx2distal-less homeobox 20.443
Pou3f3POU domain, class 3, transcription factor 30.429
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.427
UncxUNC homeobox0.425
Tal1T-cell acute lymphocytic leukemia 10.424
Igfbpl1insulin-like growth factor binding protein-like 10.423
Hoxd3homeobox D30.408
Fgf4fibroblast growth factor 40.406
Col22a1collagen, type XXII, alpha 10.401
MecomMDS1 and EVI1 complex locus0.381
Atoh7atonal homolog 7 (Drosophila)0.353
Snai1snail homolog 1 (Drosophila)0.352
Gdnfglial cell line derived neurotrophic factor0.351
Pou4f2POU domain, class 4, transcription factor 20.350
Gpr50G-protein-coupled receptor 500.346
Hmx3H6 homeobox 30.344
Hoxc5homeobox C50.322
Srrm4serine/arginine repetitive matrix 40.320
Hoxd1homeobox D10.308
Nhlh1nescient helix loop helix 10.307
Wnt6wingless-related MMTV integration site 60.304
Gata4GATA binding protein 40.304
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.294
Foxd3forkhead box D30.294
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.287
Tcfap2ctranscription factor AP-2, gamma0.280
Prph2peripherin 20.277
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism