The network for 'circadian sleep wake cycle process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

circadian sleep wake cycle process

A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.

NameDescriptionProbabilityFunc Analog Organism
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 11.000
DLG4discs, large homolog 4 (Drosophila)0.995
ADORA2Aadenosine A2a receptor0.994
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.990
ACTN2actinin, alpha 20.986
NLRC4NLR family, CARD domain containing 40.980
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.928
CLOCKclock homolog (mouse)0.914
DRD2dopamine receptor D20.885
IGF1Rinsulin-like growth factor 1 receptor0.765
INSRinsulin receptor0.714
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.660
IRS1insulin receptor substrate 10.643
HSPH1heat shock 105kDa/110kDa protein 10.606
GRB10growth factor receptor-bound protein 100.598
AKAP11A kinase (PRKA) anchor protein 110.481
IRS2insulin receptor substrate 20.440
CYFIP2cytoplasmic FMR1 interacting protein 20.418
CYFIP1cytoplasmic FMR1 interacting protein 10.377
AP1M1adaptor-related protein complex 1, mu 1 subunit0.229
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.227
STIP1stress-induced-phosphoprotein 10.211
CHORDC1cysteine and histidine-rich domain (CHORD) containing 10.211
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.198
MYOZ1myozenin 10.193
ADORA1adenosine A1 receptor0.183
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.183
FKBP4FK506 binding protein 4, 59kDa0.167
PRKAR2Bprotein kinase, cAMP-dependent, regulatory, type II, beta0.165
NECAB2N-terminal EF-hand calcium binding protein 20.158
CASP4caspase 4, apoptosis-related cysteine peptidase0.151
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.117
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.101
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.100
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.098
WASF2WAS protein family, member 20.093
RIPK2receptor-interacting serine-threonine kinase 20.092
CALM1calmodulin 1 (phosphorylase kinase, delta)0.086
PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 20.082
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.080
SETD7SET domain containing (lysine methyltransferase) 70.076
DLGAP1discs, large (Drosophila) homolog-associated protein 10.074
GSK3Bglycogen synthase kinase 3 beta0.073
METmet proto-oncogene (hepatocyte growth factor receptor)0.070
BTN3A2butyrophilin, subfamily 3, member A20.069
AHRaryl hydrocarbon receptor0.067
VAPBVAMP (vesicle-associated membrane protein)-associated protein B and C0.063
CSNK1Ecasein kinase 1, epsilon0.059
BBS10Bardet-Biedl syndrome 100.057
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.056
HSPA1Aheat shock 70kDa protein 1A0.055
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.054
NAMPTnicotinamide phosphoribosyltransferase0.052
KCNA2potassium voltage-gated channel, shaker-related subfamily, member 20.051
STAU1staufen, RNA binding protein, homolog 1 (Drosophila)0.050
CD81CD81 molecule0.049
PPP5Cprotein phosphatase 5, catalytic subunit0.049
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.048
KCTD4potassium channel tetramerisation domain containing 40.046
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.046
SMAD2SMAD family member 20.046
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.045
DVL2dishevelled, dsh homolog 2 (Drosophila)0.045
CFDcomplement factor D (adipsin)0.045
PPIDpeptidylprolyl isomerase D0.045
PTPN11protein tyrosine phosphatase, non-receptor type 110.044
CDK5RAP2CDK5 regulatory subunit associated protein 20.043
NSFN-ethylmaleimide-sensitive factor0.041
CASP8caspase 8, apoptosis-related cysteine peptidase0.040
NEK6NIMA (never in mitosis gene a)-related kinase 60.039
CARD16caspase recruitment domain family, member 160.039
AKAP10A kinase (PRKA) anchor protein 100.038
KCNA3potassium voltage-gated channel, shaker-related subfamily, member 30.037
NELL2NEL-like 2 (chicken)0.037
ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 10.037
HES1hairy and enhancer of split 1, (Drosophila)0.036
LIMK1LIM domain kinase 10.036
NLGN1neuroligin 10.036
FCGRTFc fragment of IgG, receptor, transporter, alpha0.035
MTNR1Amelatonin receptor 1A0.034
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.033
SNCAsynuclein, alpha (non A4 component of amyloid precursor)0.032
IL18interleukin 18 (interferon-gamma-inducing factor)0.032
LUC7L2LUC7-like 2 (S. cerevisiae)0.032
HSPA8heat shock 70kDa protein 80.031
ACACAacetyl-CoA carboxylase alpha0.030
LDOC1leucine zipper, down-regulated in cancer 10.030
APPamyloid beta (A4) precursor protein0.030
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha0.029
NOD1nucleotide-binding oligomerization domain containing 10.029
NAP1L1nucleosome assembly protein 1-like 10.028
MADDMAP-kinase activating death domain0.028
GABARAPL1GABA(A) receptor-associated protein like 10.028
C19orf50chromosome 19 open reading frame 500.028
GHRgrowth hormone receptor0.027
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.027
PRKAR1Bprotein kinase, cAMP-dependent, regulatory, type I, beta0.027
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
drd2adopamine receptor D2a0.968
siah2lseven in absentia homolog 2 (Drosophila)-like0.836
mxi1max interacting protein0.763
npy8arneuropeptide Y receptor Y8a0.756
drd2bdopamine receptor D2b0.725
dbhdopamine beta hydroxylase0.655
ntf7neurotrophin 70.649
drd2ldopamine receptor D2 like0.645
mtnr1bamelatonin receptor type 1B a0.606
insrbinsulin receptor b0.599
arntl1baryl hydrocarbon receptor nuclear translocator-like 1b0.557
ncam2neural cell adhesion molecule 20.532
dab1adisabled homolog 1a (Drosophila)0.515
hcrthypocretin (orexin) neuropeptide precursor0.491
vdravitamin D receptor a0.462
unc45bunc-45 homolog B (C. elegans)0.451
srfserum response factor0.450
cry2bcryptochrome 2b0.442
nlgn1neuroligin 10.434
insrainsulin receptor a0.434
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.423
htr1bd5-hydroxytryptamine (serotonin) receptor 1bd0.393
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.389
cebp1CCAAT/enhancer binding protein (C/EBP) 10.380
chatcholine acetyltransferase0.378
mchr1amelanin-concentrating hormone receptor 1a0.378
vephventricular zone expressed PH domain protein0.364
esr1estrogen receptor 10.363
thtyrosine hydroxylase0.360
mc4rmelanocortin 4 receptor0.340
tlr21toll-like receptor 210.333
cldnkclaudin k0.276
syce2synaptonemal complex central element protein 20.271
gabbr1agamma-aminobutyric acid (GABA) B receptor, 1a0.271
esr2bestrogen receptor 2b0.266
pth2parathyroid hormone 20.258
sox8SRY-box containing gene 80.248
ndr1nodal-related 10.247
tbx20T-box 200.243
trim13tripartite motif-containing 130.242
slc8a4bsolute carrier family 8 (sodium/calcium exchanger), member 4b0.241
gfra1bgdnf family receptor alpha 1b0.239
maomonoamine oxidase0.234
gh1growth hormone 10.231
cx55.5connexin 55.50.228
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.223
pomcaproopiomelanocortin a0.199
scn1asodium channel, voltage-gated, type I, alpha0.196
mpp6bmembrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)0.193
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.189
rxrbbretinoid x receptor, beta b0.187
cx39.9connexin 39.90.186
mmp13amatrix metalloproteinase 13a0.185
pou1f1POU domain, class 1, transcription factor 10.179
ptgdsprostaglandin D2 synthase0.177
tshbthyroid stimulating hormone, beta subunit0.173
clock3clock homolog 3 (mouse)0.169
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.169
adra2aadrenergic, alpha-2A-, receptor0.165
cry1acryptochrome 1a0.165
tp53bp2tumor protein p53 binding protein, 20.157
adra2badrenergic, alpha-2B-, receptor0.147
crhcorticotropin releasing hormone0.146
npas2neuronal PAS domain protein 20.146
bsk146brain specific kinase 1460.146
smyd1bSET and MYND domain containing 1b0.146
LOC799612prolactin 20.140
vipr2vasoactive intestinal peptide receptor 20.140
ttnatitin a0.139
ryr2aryanodine receptor 2a (cardiac)0.138
per2period homolog 2 (Drosophila)0.137
mchr1bmelanin-concentrating hormone receptor 1b0.131
gdnfglial cell derived neurotrophic factor0.128
gnrh2gonadotropin-releasing hormone 20.122
eif3s10eukaryotic translation initiation factor 3, subunit 10 (theta)0.119
hspb1heat shock protein, alpha-crystallin-related, 10.119
adra2dbadrenergic, alpha-2D-, receptor b0.118
roraaRAR-related orphan receptor A, paralog a0.117
nedd4lneural precursor cell expressed, developmentally down-regulated 4-like0.117
fevFEV (ETS oncogene family)0.115
pyyapeptide YYa0.113
valopbvertebrate ancient long opsin b0.111
cx35connexin 350.111
nadl1.2neural adhesion molecule L1.20.108
cry5cryptochrome 50.105
npy4rneuropeptide Y receptor Y40.105
kcnn1potassium intermediate/small conductance calcium-activated channel, subfamily N, member 10.104
efna5bephrin A5b0.100
abcb3l1ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 10.098
pde10aphosphodiesterase 10A0.096
pou4f2POU domain, class 4, transcription factor 20.093
aanat2arylalkylamine N-acetyltransferase0.092
barhl1.2BarH-like 1.20.087
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Octbeta2RCG33976 gene product from transcript CG33976-RA0.972
DatDopamine N acetyltransferase0.972
CG42629CG42629 gene product from transcript CG42629-RB0.881
CG32810CG32810 gene product from transcript CG32810-RB0.847
TbhTyramine beta hydroxylase0.619
imdimmune deficiency0.616
CanA1Calcineurin A10.384
nAcRalpha-7Enicotinic Acetylcholine Receptor alpha 7E0.352
CanA-14FCalcineurin A at 14F0.322
Cyp316a1CG8540 gene product from transcript CG8540-RA0.311
CG13253CG13253 gene product from transcript CG13253-RB0.301
EcREcdysone receptor0.282
IhI[[h]] channel0.262
AcerAngiotensin-converting enzyme-related0.251
nAcRalpha-80Bnicotinic Acetylcholine Receptor alpha 80B0.249
dnr1defense repressor 10.234
CrebB-17ACyclic-AMP response element binding protein B at 17A0.225
ShawShaker cognate w0.199
CG16778CG16778 gene product from transcript CG16778-RA0.186
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.177
CanBCalcineurin B0.154
jebjelly belly0.154
CG34400CG34400 gene product from transcript CG34400-RD0.144
l(3)82FdCG32464 gene product from transcript CG32464-RR0.143
CG6954CG6954 gene product from transcript CG6954-RB0.133
CG4857CG4857 gene product from transcript CG4857-RD0.116
CG5741CG5741 gene product from transcript CG5741-RC0.110
nordCG30418 gene product from transcript CG30418-RA0.108
foxoforkhead box, sub-group O0.108
Fmr1CG6203 gene product from transcript CG6203-RC0.106
Mob2CG11711 gene product from transcript CG11711-RC0.101
OambOctopamine receptor in mushroom bodies0.094
BG4CG12297 gene product from transcript CG12297-RA0.093
AdoRAdenosine receptor0.092
alphaTub84Balpha-Tubulin at 84B0.085
Roc1bCG16988 gene product from transcript CG16988-RA0.078
NPFR1neuropeptide F receptor0.074
PdfPigment-dispersing factor0.067
CG9184CG9184 gene product from transcript CG9184-RB0.067
CG34139CG34139 gene product from transcript CG34139-RD0.066
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.065
beta4GalNAcTACG8536 gene product from transcript CG8536-RA0.060
SNF4AgammaSNF4/AMP-activated protein kinase gamma subunit0.055
Pkd2Polycystic kidney disease gene-20.055
picoCG11940 gene product from transcript CG11940-RA0.054
Nmdar1NMDA receptor 10.054
Ef1alpha48DElongation factor 1alpha48D0.051
oa2octopamine receptor 20.051
CG31140CG31140 gene product from transcript CG31140-RF0.051
OdsHOds-site homeobox0.049
eagether a go-go0.047
highikaru genki0.046
CG5890CG5890 gene product from transcript CG5890-RB0.043
TimpTissue inhibitor of metalloproteases0.043
pdfrPDF receptor0.042
Socs36ESuppressor of cytokine signaling at 36E0.041
bondjames bond0.039
Fer2LCHFerritin 2 light chain homologue0.039
CG18594CG18594 gene product from transcript CG18594-RA0.037
CG4563CG4563 gene product from transcript CG4563-RA0.037
CG43073CG43073 gene product from transcript CG43073-RF0.036
TM9SF4CG7364 gene product from transcript CG7364-RA0.035
CG17244CG17244 gene product from transcript CG17244-RA0.034
TequilaCG4821 gene product from transcript CG4821-RE0.033
upd2unpaired 20.032
DdcDopa decarboxylase0.032
cbscentrosomin's beautiful sister0.031
Nf1Neurofibromin 10.030
dikarCG42799 gene product from transcript CG42799-RC0.030
unc79CG5237 gene product from transcript CG5237-RB0.030
fd85Eforkhead domain 85E0.030
nanarrow abdomen0.029
Ilp5Insulin-like peptide 50.028
E23Early gene at 230.025
GABA-B-R2metabotropic GABA-B receptor subtype 20.025
Obp56dOdorant-binding protein 56d0.024
CG18437CG18437 gene product from transcript CG18437-RB0.024
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Mapk9mitogen-activated protein kinase 90.090
LOC286987hemiferrin, transferrin-like protein0.070
Magmyelin-associated glycoprotein0.060
Il13interleukin 130.057
Unc45bunc-45 homolog B (C. elegans)0.055
Hist1h2aahistone cluster 1, H2aa0.053
Gabregamma-aminobutyric acid (GABA) A receptor, epsilon0.049
Aldobaldolase B, fructose-bisphosphate0.046
Tmsb4xthymosin beta 4, X-linked0.046
Kcng2potassium voltage-gated channel, subfamily G, member 20.044
Syt6synaptotagmin VI0.044
Il1binterleukin 1 beta0.043
Stk3serine/threonine kinase 3 (STE20 homolog, yeast)0.042
Olr416olfactory receptor 4160.040
Trhr2thyrotropin releasing hormone receptor 20.038
Rgs9regulator of G-protein signaling 90.038
Uoxurate oxidase0.038
Reg3aregenerating islet-derived 3 alpha0.035
Accn3amiloride-sensitive cation channel 30.035
Cpb2carboxypeptidase B2 (plasma)0.034
Galgalanin prepropeptide0.034
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.033
Casp8caspase 80.032
Gipgastric inhibitory polypeptide0.032
Adora1adenosine A1 receptor0.032
Krt34keratin 340.031
Fgf2fibroblast growth factor 20.030
Fgafibrinogen alpha chain0.029
Znf689zinc finger protein 6890.029
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.029
Drd1adopamine receptor D1A0.029
Adam10ADAM metallopeptidase domain 100.029
Insrrinsulin receptor-related receptor0.028
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.028
Calcrlcalcitonin receptor-like0.028
Tacr3tachykinin receptor 30.027
Crtac1cartilage acidic protein 10.027
Apohapolipoprotein H (beta-2-glycoprotein I)0.027
Prkciprotein kinase C, iota0.026
Hcrtr2hypocretin (orexin) receptor 20.026
Lim2lens intrinsic membrane protein 20.025
Ptch1patched homolog 1 (Drosophila)0.025
Vipr2vasoactive intestinal peptide receptor 20.025
Ripk3receptor-interacting serine-threonine kinase 30.024
Prp15proline-rich protein 150.024
Agxtalanine-glyoxylate aminotransferase0.024
Ednraendothelin receptor type A0.024
Reg3gregenerating islet-derived 3 gamma0.023
Ctsjcathepsin J0.023
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive0.023
Tlr4toll-like receptor 40.023
Spp2secreted phosphoprotein 20.022
Calcacalcitonin-related polypeptide alpha0.022
Glp1rglucagon-like peptide 1 receptor0.022
Adaradenosine deaminase, RNA-specific0.021
Olr1078olfactory receptor 10780.021
Casp2caspase 20.020
Chrm4cholinergic receptor, muscarinic 40.020
Hcrtr1hypocretin (orexin) receptor 10.020
Uhmk1U2AF homology motif (UHM) kinase 10.020
Apoeapolipoprotein E0.020
Pgfplacental growth factor0.020
Gpr6G protein-coupled receptor 60.020
Cdk2cyclin dependent kinase 20.019
RT1-N3RT1 class Ib, locus N30.019
Pdzd2PDZ domain containing 20.019
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.019
Ambpalpha-1-microglobulin/bikunin precursor0.019
Lims1LIM and senescent cell antigen-like domains 10.019
Adra2badrenergic, alpha-2B-, receptor0.019
Nrasneuroblastoma ras oncogene0.019
Lig3ligase III, DNA, ATP-dependent0.019
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.018
Smgbneonatal submandibular gland protein B0.018
Prl3b1Prolactin family 3, subfamily b, member 10.018
Olr226olfactory receptor 2260.018
Slc7a10solute carrier family 7, (neutral amino acid transporter, y+ system) member 100.018
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.017
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.017
Lin7clin-7 homolog C (C. elegans)0.017
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.017
Col2a1collagen, type II, alpha 10.016
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.016
Slc36a1solute carrier family 36 (proton/amino acid symporter), member 10.016
Nrapnebulin-related anchoring protein0.016
Andproandrogen regulated protein0.016
Lbrlamin B receptor0.016
Akr1d1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)0.016
DbpD site of albumin promoter (albumin D-box) binding protein0.016
Tnftumor necrosis factor (TNF superfamily, member 2)0.016
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.016
Chrna7cholinergic receptor, nicotinic, alpha 70.016
Atxn1ataxin 10.016
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism