The network for 'cytokine mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cytokine mediated signaling pathway

A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
FYNFYN oncogene related to SRC, FGR, YES1.000
IRAK1interleukin-1 receptor-associated kinase 11.000
TRAF1TNF receptor-associated factor 11.000
EGFRepidermal growth factor receptor0.999
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.999
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.999
SOCS3suppressor of cytokine signaling 30.999
GRB2growth factor receptor-bound protein 20.998
IL1Binterleukin 1, beta0.997
PTPN1protein tyrosine phosphatase, non-receptor type 10.997
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.997
TRAF6TNF receptor-associated factor 60.996
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.994
IRAK2interleukin-1 receptor-associated kinase 20.993
TNFAIP3tumor necrosis factor, alpha-induced protein 30.993
CCL4chemokine (C-C motif) ligand 40.992
CASP8caspase 8, apoptosis-related cysteine peptidase0.992
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.989
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.989
CCR7chemokine (C-C motif) receptor 70.989
CAV1caveolin 1, caveolae protein, 22kDa0.987
FASLGFas ligand (TNF superfamily, member 6)0.985
JAK2Janus kinase 20.985
IL2RBinterleukin 2 receptor, beta0.985
STAT1signal transducer and activator of transcription 1, 91kDa0.982
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.981
TRAF2TNF receptor-associated factor 20.979
FASFas (TNF receptor superfamily, member 6)0.975
BIRC3baculoviral IAP repeat containing 30.975
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.973
ZNF43zinc finger protein 430.973
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.972
CCL5chemokine (C-C motif) ligand 50.966
BCAR1breast cancer anti-estrogen resistance 10.966
CXCL9chemokine (C-X-C motif) ligand 90.965
CCR5chemokine (C-C motif) receptor 50.957
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.949
IL1R1interleukin 1 receptor, type I0.948
TNFtumor necrosis factor0.945
CD40CD40 molecule, TNF receptor superfamily member 50.943
MYD88myeloid differentiation primary response gene (88)0.942
MAP3K7mitogen-activated protein kinase kinase kinase 70.939
TRADDTNFRSF1A-associated via death domain0.936
IL8interleukin 80.936
ICAM1intercellular adhesion molecule 10.931
TRAF5TNF receptor-associated factor 50.931
CXCL10chemokine (C-X-C motif) ligand 100.927
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.926
IFNGinterferon, gamma0.921
CCL22chemokine (C-C motif) ligand 220.918
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.894
RIPK2receptor-interacting serine-threonine kinase 20.885
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.884
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.882
LATlinker for activation of T cells0.882
ZNF273zinc finger protein 2730.864
CXCL3chemokine (C-X-C motif) ligand 30.862
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.856
TNFRSF9tumor necrosis factor receptor superfamily, member 90.855
CREBBPCREB binding protein0.853
IL4Rinterleukin 4 receptor0.849
INADLInaD-like (Drosophila)0.846
SOCS1suppressor of cytokine signaling 10.845
EP300E1A binding protein p3000.837
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.834
IFITM3interferon induced transmembrane protein 3 (1-8U)0.834
IL6interleukin 6 (interferon, beta 2)0.819
PTPN11protein tyrosine phosphatase, non-receptor type 110.816
ZNF675zinc finger protein 6750.812
PTPRJprotein tyrosine phosphatase, receptor type, J0.801
STAT4signal transducer and activator of transcription 40.799
MAP3K14mitogen-activated protein kinase kinase kinase 140.788
NCOA1nuclear receptor coactivator 10.786
JAK1Janus kinase 10.785
CCL2chemokine (C-C motif) ligand 20.779
CFLARCASP8 and FADD-like apoptosis regulator0.775
PMLpromyelocytic leukemia0.771
TMEM173transmembrane protein 1730.767
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.736
ZNF746zinc finger protein 7460.733
TRAF3TNF receptor-associated factor 30.732
LCKlymphocyte-specific protein tyrosine kinase0.729
CASP10caspase 10, apoptosis-related cysteine peptidase0.723
STAT5Asignal transducer and activator of transcription 5A0.716
IRF9interferon regulatory factor 90.689
ZNF253zinc finger protein 2530.686
SHC2SHC (Src homology 2 domain containing) transforming protein 20.686
IFITM1interferon induced transmembrane protein 1 (9-27)0.672
METmet proto-oncogene (hepatocyte growth factor receptor)0.670
C1QAcomplement component 1, q subcomponent, A chain0.660
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.648
NR4A1nuclear receptor subfamily 4, group A, member 10.644
PTPRBprotein tyrosine phosphatase, receptor type, B0.640
IRF4interferon regulatory factor 40.634
GHRgrowth hormone receptor0.633
CXCL2chemokine (C-X-C motif) ligand 20.623
CCL8chemokine (C-C motif) ligand 80.616
IL1R2interleukin 1 receptor, type II0.612
PLCG1phospholipase C, gamma 10.612
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
il6stinterleukin 6 signal transducer0.369
il6rinterleukin 6 receptor0.283
mmp9matrix metalloproteinase 90.237
stc1lstanniocalcin 1, like0.181
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.176
fgfr3fibroblast growth factor receptor 30.157
anxa1aannexin A1a0.141
ghragrowth hormone receptor a0.138
il7rinterleukin 7 receptor0.111
pcsk5aproprotein convertase subtilisin/kexin type 5a0.105
tlr3toll-like receptor 30.092
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.087
smad1MAD homolog 1 (Drosophila)0.082
cav1caveolin 10.076
stat1bsignal transducer and activator of transcription 1b0.075
il8interleukin 80.073
bcl2l1bcl2-like 10.072
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.070
tlr21toll-like receptor 210.070
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.068
igfbp1ainsulin-like growth factor binding protein 1a0.068
spry4sprouty (Drosophila) homolog 40.066
adipor1badiponectin receptor 1b0.065
mef2amyocyte enhancer factor 2a0.064
cishcytokine inducible SH2-containing protein0.058
tnfatumor necrosis factor a (TNF superfamily, member 2)0.056
tyrtyrosinase0.050
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.050
socs3asuppressor of cytokine signaling 3a0.049
castcalpastatin0.048
LOC100000934hypothetical protein LOC1000009340.047
pabpc1bpoly A binding protein, cytoplasmic 1 b0.047
fabp2fatty acid binding protein 2, intestinal0.041
rargaretinoic acid receptor gamma a0.040
rbm22RNA binding motif protein 220.040
cmybtranscription factor cmyb0.039
nrp2bneuropilin 2b0.039
mpxmyeloid-specific peroxidase0.036
tnfsf10l2tumor necrosis factor (ligand) superfamily, member 10 like 20.033
tagln2transgelin 20.032
cntn2contactin 20.031
sh3gl1bSH3-domain GRB2-like 1b0.031
zgc:64051zgc:640510.030
adipor2adiponectin receptor 20.029
tgfbr2transforming growth factor, beta receptor II0.029
furinbfurin (paired basic amino acid cleaving enzyme) b0.029
cdh23cadherin-like 230.028
dnm2dynamin 20.028
mcl1amyeloid cell leukemia sequence 1a0.028
igf2binsulin-like growth factor 2b0.026
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.026
ca2carbonic anhydrase II0.026
si:dkey-261h17.1si:dkey-261h17.10.026
alcamaactivated leukocyte cell adhesion molecule a0.025
fgf10afibroblast growth factor 10a0.025
cxcr4bchemokine (C-X-C motif), receptor 4b0.025
adipor1aadiponectin receptor 1a0.025
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.024
epas1bendothelial PAS domain protein 1b0.024
atp2b4ATPase, Ca++ transporting, plasma membrane 40.023
eporerythropoietin receptor0.023
pax2bpaired box gene 2b0.022
igfbp1binsulin-like growth factor binding protein 1b0.022
slc25a14solute carrier family 25 (mitochondrial carrier, brain), member 140.022
nebnebulin0.022
slc2a13solute carrier family 2 (facilitated glucose transporter), member 130.022
xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.021
ptk2.1protein tyrosine kinase 2a0.021
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.021
abcg2cATP-binding cassette, sub-family G (WHITE), member 2c0.020
anxa2aannexin A2a0.020
egr2aearly growth response 2a0.020
zgc:171553zgc:1715530.020
anxa1bannexin A1b0.020
kitakit receptor a0.019
mbtps1membrane-bound transcription factor protease, site 10.019
s1pr3sphingosine-1-phosphate receptor 30.019
pcsk2proprotein convertase subtilisin/kexin type 20.018
ccr12.2chemokine (C-C motif) receptor 12.20.018
atf3activating transcription factor 30.018
hmx2H6 family homeobox 20.018
acta1bactin, alpha 1b, skeletal muscle0.018
stat3signal transduction and activation of transcription 30.018
jak1Janus kinase 10.018
krt4keratin 40.017
ugt1b1UDP glucuronosyltransferase 1 family, polypeptide B10.017
pcsk1proprotein convertase subtilisin/kexin type 10.016
junbjun B proto-oncogene0.016
angpt2angiopoietin 20.016
caspbcaspase b and caspase b-like0.016
cdc42cell division cycle 420.016
bcl2B-cell leukemia/lymphoma 20.016
csf3rcolony stimulating factor 3 receptor (granulocyte)0.015
casp8caspase 8, apoptosis-related cysteine peptidase0.015
zgc:56005zgc:560050.015
pcsk7proprotein convertase subtilisin/kexin type 70.015
il1binterleukin 1, beta and interleukin 1, beta0.015
lyzlysozyme0.015
il22interleukin 220.014
adrb2aadrenergic receptor, beta 2a0.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Stat3signal transducer and activator of transcription 31.000
Myd88myeloid differentiation primary response gene 881.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1001.000
Il1r1interleukin 1 receptor, type I1.000
Tlr4toll-like receptor 40.999
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.999
Lyz2lysozyme 20.999
Tnftumor necrosis factor0.998
Csf1colony stimulating factor 1 (macrophage)0.997
Ptpn11protein tyrosine phosphatase, non-receptor type 110.995
Jak2Janus kinase 20.994
Cd44CD44 antigen0.994
Ifnginterferon gamma0.993
Ikzf1IKAROS family zinc finger 10.993
Leprleptin receptor0.993
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.989
Il10interleukin 100.984
Ltalymphotoxin A0.975
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.974
Ccr2chemokine (C-C motif) receptor 20.973
Ccl2chemokine (C-C motif) ligand 20.957
Map3k8mitogen-activated protein kinase kinase kinase 80.956
Gzmbgranzyme B0.950
CblCasitas B-lineage lymphoma0.948
Traf6TNF receptor-associated factor 60.939
Il1binterleukin 1 beta0.919
FasFas (TNF receptor superfamily member 6)0.914
Batfbasic leucine zipper transcription factor, ATF-like0.900
Egfrepidermal growth factor receptor0.878
FynFyn proto-oncogene0.874
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.872
Apoeapolipoprotein E0.870
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.867
Krt17keratin 170.865
Lrp1low density lipoprotein receptor-related protein 10.862
Tgfb1transforming growth factor, beta 10.851
Tnfaip3tumor necrosis factor, alpha-induced protein 30.841
Trp63transformation related protein 630.835
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.834
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.823
Bbs4Bardet-Biedl syndrome 4 (human)0.814
Stat5asignal transducer and activator of transcription 5A0.802
Map3k14mitogen-activated protein kinase kinase kinase 140.800
FaslFas ligand (TNF superfamily, member 6)0.798
Ccr1chemokine (C-C motif) receptor 10.792
Stat6signal transducer and activator of transcription 60.780
Stat1signal transducer and activator of transcription 10.775
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.772
Il18rapinterleukin 18 receptor accessory protein0.747
Plcg1phospholipase C, gamma 10.746
Ptgs2prostaglandin-endoperoxide synthase 20.745
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.739
Ptenphosphatase and tensin homolog0.730
Il4interleukin 40.729
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.723
Prf1perforin 1 (pore forming protein)0.718
Selpselectin, platelet0.712
Cxcl12chemokine (C-X-C motif) ligand 120.711
Tlr2toll-like receptor 20.701
Robo1roundabout homolog 1 (Drosophila)0.693
Il2rginterleukin 2 receptor, gamma chain0.686
Inpp5dinositol polyphosphate-5-phosphatase D0.682
Casp4caspase 4, apoptosis-related cysteine peptidase0.676
Foxp3forkhead box P30.672
Klrk1killer cell lectin-like receptor subfamily K, member 10.670
Ltblymphotoxin B0.669
Irf9interferon regulatory factor 90.668
Trp53transformation related protein 530.663
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.655
Ifnar1interferon (alpha and beta) receptor 10.652
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.645
Ghrgrowth hormone receptor0.642
Pdcd1programmed cell death 10.621
Xcl1chemokine (C motif) ligand 10.620
Kdrkinase insert domain protein receptor0.615
Arandrogen receptor0.615
Icosinducible T-cell co-stimulator0.610
Icam1intercellular adhesion molecule 10.608
Cxcr2chemokine (C-X-C motif) receptor 20.607
Mavsmitochondrial antiviral signaling protein0.591
Calm4calmodulin 40.582
Fgf7fibroblast growth factor 70.581
Krt8keratin 80.576
Stat5bsignal transducer and activator of transcription 5B0.562
Rbpjlrecombination signal binding protein for immunoglobulin kappa J region-like0.561
Ahraryl-hydrocarbon receptor0.560
Runx2runt related transcription factor 20.559
Mmp9matrix metallopeptidase 90.559
Mc5rmelanocortin 5 receptor0.558
Cxcr5chemokine (C-X-C motif) receptor 50.554
Ttc7tetratricopeptide repeat domain 70.554
Cd40CD40 antigen0.551
Irf1interferon regulatory factor 10.551
Casp8caspase 80.546
Il1rninterleukin 1 receptor antagonist0.537
Itgalintegrin alpha L0.535
Esr1estrogen receptor 1 (alpha)0.527
Wnt10awingless related MMTV integration site 10a0.525
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.517
Gpr132G protein-coupled receptor 1320.516
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Junbjun B proto-oncogene0.857
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.855
Cxcl10chemokine (C-X-C motif) ligand 100.851
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.713
Il1r1interleukin 1 receptor, type I0.668
LOC100363783rCG53773-like0.652
Sellselectin L0.537
FosFBJ osteosarcoma oncogene0.535
Il1binterleukin 1 beta0.535
Il6interleukin 60.525
Itgb7integrin, beta 70.519
Cxcl2chemokine (C-X-C motif) ligand 20.471
Socs3suppressor of cytokine signaling 30.455
Icam1intercellular adhesion molecule 10.448
Krt18keratin 180.423
Il1ainterleukin 1 alpha0.406
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.403
Ier3immediate early response 30.375
Ccl20chemokine (C-C motif) ligand 200.360
Jak2Janus kinase 20.354
Il2rainterleukin 2 receptor, alpha0.348
RGD1561143similar to cell surface receptor FDFACT0.329
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.323
Hckhemopoietic cell kinase0.321
Cd2Cd2 molecule0.296
Cd5Cd5 molecule0.261
Cd53Cd53 molecule0.259
Tnftumor necrosis factor (TNF superfamily, member 2)0.253
Dnase1l3deoxyribonuclease 1-like 30.233
Stat3signal transducer and activator of transcription 30.222
Gdnfglial cell derived neurotrophic factor0.217
RT1-Db1RT1 class II, locus Db10.212
Tgfbr3transforming growth factor, beta receptor III0.208
Egr2early growth response 20.199
Ctla4cytotoxic T-lymphocyte-associated protein 40.197
Ccr5chemokine (C-C motif) receptor 50.195
Igsf6immunoglobulin superfamily, member 60.194
Map3k8mitogen-activated protein kinase kinase kinase 80.188
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.186
Cd4Cd4 molecule0.186
Btg2BTG family, member 20.183
Myd88myeloid differentiation primary response gene 880.181
Il2rbinterleukin 2 receptor, beta0.179
Igh-6immunoglobulin heavy chain 60.178
Cishcytokine inducible SH2-containing protein0.174
Il8rbinterleukin 8 receptor, beta0.163
Zfp36zinc finger protein 360.162
Csf1colony stimulating factor 1 (macrophage)0.161
Il1r2interleukin 1 receptor, type II0.160
FaslgFas ligand (TNF superfamily, member 6)0.153
Smad1SMAD family member 10.153
Ccl3chemokine (C-C motif) ligand 30.151
F2rl1coagulation factor II (thrombin) receptor-like 10.151
Cd14CD14 molecule0.146
Batf3basic leucine zipper transcription factor, ATF-like 30.146
Selpselectin P0.145
Mapk3mitogen activated protein kinase 30.143
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.142
Cd86CD86 molecule0.140
Runx1runt-related transcription factor 10.140
Trim47tripartite motif-containing 470.140
Vcam1vascular cell adhesion molecule 10.139
Pecam1platelet/endothelial cell adhesion molecule 10.138
Ptger4prostaglandin E receptor 4 (subtype EP4)0.137
Il4rainterleukin 4 receptor, alpha0.136
Mvpmajor vault protein0.134
Cyr61cysteine-rich, angiogenic inducer, 610.133
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.122
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.122
Gzmkgranzyme K0.120
Nr4a3nuclear receptor subfamily 4, group A, member 30.119
LOC100365106rCG32755-like0.118
Ptprcprotein tyrosine phosphatase, receptor type, C0.118
RGD1305793similar to hypothetical protein FLJ201540.116
Nkg7natural killer cell group 7 sequence0.116
Ptp4a2protein tyrosine phosphatase 4a20.115
Fosl1fos-like antigen 10.115
Bcl3B-cell CLL/lymphoma 30.114
RnmtRNA (guanine-7-) methyltransferase0.111
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.106
Itgamintegrin, alpha M0.106
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.106
Cxcl3chemokine (C-X-C motif) ligand 30.106
Reg3gregenerating islet-derived 3 gamma0.103
Mca32mast cell antigen 320.103
Klf4Kruppel-like factor 4 (gut)0.101
LOC24906RoBo-10.100
Stat5asignal transducer and activator of transcription 5A0.098
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.095
Svs3aseminal vesicle secretory protein 3A0.095
S1pr2sphingosine-1-phosphate receptor 20.094
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.093
Ier2immediate early response 20.092
Seleselectin E0.092
LOC286960preprotrypsinogen IV0.091
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.090
CebpeCCAAT/enhancer binding protein (C/EBP), epsilon0.087
Pdynprodynorphin0.086
Fcnbficolin B0.086
Prph2peripherin 20.084
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism