The network for 'transforming growth factor beta receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

transforming growth factor beta receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
SMAD4SMAD family member 41.000
SMAD2SMAD family member 21.000
SMURF2SMAD specific E3 ubiquitin protein ligase 21.000
SMAD7SMAD family member 71.000
FHL2four and a half LIM domains 21.000
SMAD3SMAD family member 31.000
FN1fibronectin 11.000
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.998
JUNjun proto-oncogene0.998
TP53tumor protein p530.997
FLNAfilamin A, alpha0.997
SMAD1SMAD family member 10.996
SKILSKI-like oncogene0.990
FOSFBJ murine osteosarcoma viral oncogene homolog0.990
SMAD5SMAD family member 50.984
TGFB1transforming growth factor, beta 10.983
ENGendoglin0.978
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.969
FYNFYN oncogene related to SRC, FGR, YES0.963
TGFBR1transforming growth factor, beta receptor 10.953
EP300E1A binding protein p3000.949
CREBBPCREB binding protein0.948
HIPK2homeodomain interacting protein kinase 20.932
COL1A1collagen, type I, alpha 10.928
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.900
FBLN1fibulin 10.870
PXNpaxillin0.862
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.858
WWP2WW domain containing E3 ubiquitin protein ligase 20.851
COL3A1collagen, type III, alpha 10.850
ATF3activating transcription factor 30.850
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.834
SMURF1SMAD specific E3 ubiquitin protein ligase 10.826
VCLvinculin0.785
PDIA3protein disulfide isomerase family A, member 30.781
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.759
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.754
MAP2K4mitogen-activated protein kinase kinase 40.750
JUNBjun B proto-oncogene0.749
SNX9sorting nexin 90.748
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.731
COL6A1collagen, type VI, alpha 10.709
CAV1caveolin 1, caveolae protein, 22kDa0.704
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.696
BMP2bone morphogenetic protein 20.693
ELNelastin0.689
COL1A2collagen, type I, alpha 20.684
BCAR1breast cancer anti-estrogen resistance 10.666
TRIM33tripartite motif containing 330.662
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.661
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.648
HIPK3homeodomain interacting protein kinase 30.637
RANBP9RAN binding protein 90.635
COL5A1collagen, type V, alpha 10.631
LCKlymphocyte-specific protein tyrosine kinase0.616
ATF2activating transcription factor 20.604
PTK2PTK2 protein tyrosine kinase 20.593
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.592
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.581
SNX6sorting nexin 60.562
SMN1survival of motor neuron 1, telomeric0.553
MAGEF1melanoma antigen family F, 10.546
MMP14matrix metallopeptidase 14 (membrane-inserted)0.545
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.541
MDM2Mdm2 p53 binding protein homolog (mouse)0.540
TGFB3transforming growth factor, beta 30.537
FLNBfilamin B, beta0.534
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.531
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.519
CTBP1C-terminal binding protein 10.512
SNX33sorting nexin 330.511
ARandrogen receptor0.505
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.503
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.500
MAPK8mitogen-activated protein kinase 80.487
TBX5T-box 50.486
COL4A1collagen, type IV, alpha 10.476
PLECplectin0.459
VCAM1vascular cell adhesion molecule 10.445
ESR1estrogen receptor 10.432
PDCD6IPprogrammed cell death 6 interacting protein0.430
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.427
SYKspleen tyrosine kinase0.421
COL6A2collagen, type VI, alpha 20.416
CXXC5CXXC finger protein 50.409
SOCS3suppressor of cytokine signaling 30.402
PTPN12protein tyrosine phosphatase, non-receptor type 120.386
FHL3four and a half LIM domains 30.383
LMNAlamin A/C0.377
FKBP1AFK506 binding protein 1A, 12kDa0.373
SIRT1sirtuin 10.361
ABI2abl-interactor 20.357
POU3F2POU class 3 homeobox 20.350
TCF4transcription factor 40.341
SNX1sorting nexin 10.334
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.331
TGFB1I1transforming growth factor beta 1 induced transcript 10.315
ITGA6integrin, alpha 60.311
PTENphosphatase and tensin homolog0.302
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
daf-11Protein DAF-110.396
daf-1Protein DAF-10.151
osm-3Protein OSM-30.069
vab-3Protein VAB-30.068
unc-9Protein UNC-90.063
cat-1Protein CAT-10.061
pqn-62Protein PQN-620.039
lin-25Protein LIN-250.036
pkg-1Protein PKG-10.035
lin-1Protein LIN-10.034
egl-18Protein EGL-180.032
egl-8Protein EGL-80.031
sma-6Protein SMA-60.029
vab-8Protein VAB-80.028
tag-320Protein TAG-3200.028
tax-4Protein TAX-40.025
hlh-30Protein HLH-300.025
nhr-97Protein NHR-970.023
F13H6.1Protein F13H6.10.022
olrn-1Protein OLRN-10.021
mab-31Protein MAB-310.019
osm-5Protein OSM-50.018
daf-12Protein DAF-120.018
pat-3Protein PAT-30.017
odr-3Protein ODR-30.016
daf-4Protein DAF-40.015
osm-6Protein OSM-60.015
dlk-1Protein DLK-10.015
nlp-8Protein NLP-80.014
abl-1Protein ABL-10.014
daf-14Protein DAF-140.014
lin-59Protein LIN-590.013
unc-112Protein UNC-1120.013
daf-2Protein DAF-20.013
unc-104Protein UNC-1040.012
inx-4Protein INX-40.012
vab-19Protein VAB-190.011
inx-2Protein INX-20.011
pry-1Protein PRY-10.011
unc-73Protein UNC-730.011
C14B9.2Protein C14B9.20.011
tax-6Protein TAX-60.011
sor-3Protein SOR-30.011
daf-7Protein DAF-70.011
unc-7Protein UNC-70.010
cat-4Protein CAT-40.010
zyg-8Protein ZYG-80.010
daf-10Protein DAF-100.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wnt11rwingless-type MMTV integration site family, member 11, related0.025
bmpr1aabone morphogenetic protein receptor, type 1aa0.023
ephb4beph receptor B4b0.023
matn4matrilin 40.022
tgfb2transforming growth factor, beta 20.022
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.022
tcf12transcription factor 120.021
si:dkeyp-50f5.1si:dkeyp-50f5.10.021
plcg1phospholipase C, gamma 10.019
twist3twist30.019
cdoncell adhesion molecule-related/down-regulated by oncogenes0.018
hs6st2heparan sulfate 6-O-sulfotransferase 20.018
ctgfconnective tissue growth factor0.016
ahr2aryl hydrocarbon receptor 20.016
plp1aproteolipid protein 1a0.015
gli2aGLI-Kruppel family member GLI2a0.013
robo1roundabout homolog 10.013
si:ch211-173o4.2si:ch211-173o4.20.013
bglapbone gamma-carboxyglutamate (gla) protein0.013
oepone-eyed pinhead0.013
sulf1sulfatase 10.012
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.012
wnt11wingless-type MMTV integration site family, member 110.012
bmp2abone morphogenetic protein 2a0.012
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.012
szlsizzled0.012
tp53tumor protein p530.011
sox17SRY-box containing gene 170.011
vgll4lvestigial like 4 like0.011
sdc2syndecan 20.011
zgc:112211zgc:1122110.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.998
kaykayak0.957
shnschnurri0.949
cicubitus interruptus0.814
babobaboon0.686
DadDaughters against dpp0.570
tkvthickveins0.532
krzkurtz0.257
rlrolled0.243
CG11347CG11347 gene product from transcript CG11347-RE0.202
Akt1CG4006 gene product from transcript CG4006-RA0.191
Stat92ESignal-transducer and activator of transcription protein at 92E0.188
uspultraspiracle0.186
sogshort gastrulation0.177
Nrx-IVNeurexin IV0.162
mysmyospheroid0.156
Pi3K92ECG4141 gene product from transcript CG4141-RB0.154
SaraSmad anchor for receptor activation0.149
grogroucho0.120
pucpuckered0.101
EgfrEpidermal growth factor receptor0.099
gbbglass bottom boat0.096
Plc21CPhospholipase C at 21C0.093
Eip93FCG18389 gene product from transcript CG18389-RB0.086
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.082
exexpanded0.081
putpunt0.070
panpangolin0.063
zipzipper0.062
neuroliginCG13772 gene product from transcript CG13772-RA0.061
hipkhomeodomain interacting protein kinase0.056
Rho1CG8416 gene product from transcript CG8416-RB0.055
CG31224CG31224 gene product from transcript CG31224-RA0.054
icsicarus0.052
ababrupt0.052
scbscab0.052
hhairy0.049
p53CG33336 gene product from transcript CG33336-RB0.048
coroCG9446 gene product from transcript CG9446-RC0.048
l(2)gllethal (2) giant larvae0.047
cactcactus0.046
LanALaminin A0.045
nejnejire0.045
cdicenter divider0.043
TlToll0.043
CG13792CG13792 gene product from transcript CG13792-RA0.041
Rac2CG8556 gene product from transcript CG8556-RA0.040
hephemipterous0.039
RelRelish0.035
wunwunen0.035
Rab5Rab-protein 50.032
htlheartless0.032
Cdc42CG12530 gene product from transcript CG12530-RA0.031
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.031
StimStromal interaction molecule0.031
GpdhGlycerol 3 phosphate dehydrogenase0.030
SmoxSmad on X0.029
PvrPDGF- and VEGF-receptor related0.029
ash1absent, small, or homeotic discs 10.028
dawdawdle0.027
AdarAdenosine deaminase acting on RNA0.027
CG2116CG2116 gene product from transcript CG2116-RA0.026
Mkk4MAP kinase kinase 40.026
kek5kekkon50.026
SdcSyndecan0.025
WnkCG7177 gene product from transcript CG7177-RA0.025
Ras85DRas oncogene at 85D0.024
PakPAK-kinase0.024
LamCLamin C0.024
iavinactive0.023
mewmultiple edematous wings0.023
trbltribbles0.023
Sir2CG5216 gene product from transcript CG5216-RA0.023
ash2absent, small, or homeotic discs 20.022
MAPk-Ak2MAP kinase activated protein-kinase-20.022
MaxCG9648 gene product from transcript CG9648-RA0.022
eIF-4BEukaryotic initiation factor 4B0.022
HcfHost cell factor0.022
fwdfour wheel drive0.021
mbcmyoblast city0.021
FsFollistatin0.021
PknProtein kinase related to protein kinase N0.019
Gnf1Germ line transcription factor 10.019
Gyc76CGuanylyl cyclase at 76C0.019
chicoCG5686 gene product from transcript CG5686-RB0.018
ensensconsin0.018
fkhfork head0.018
MedMedea0.018
Rac1CG2248 gene product from transcript CG2248-RA0.018
tefutelomere fusion0.018
S6kRPS6-p70-protein kinase0.018
saxsaxophone0.017
rokRho-kinase0.017
pllpelle0.017
PoxnPox neuro0.017
G-oalpha47AG protein oalpha 47A0.017
cwoclockwork orange0.016
MTF-1Metal response element-binding Transcription Factor-10.016
ftz-f1ftz transcription factor 10.016
par-1CG8201 gene product from transcript CG8201-RA0.016
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tgfbr2transforming growth factor, beta receptor II1.000
Nodalnodal0.995
Smad6MAD homolog 6 (Drosophila)0.984
Smad4MAD homolog 4 (Drosophila)0.980
Loxlysyl oxidase0.977
Smad3MAD homolog 3 (Drosophila)0.977
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.974
Smad7MAD homolog 7 (Drosophila)0.961
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.927
Tgfbr1transforming growth factor, beta receptor I0.898
Gpc3glypican 30.862
Tgfb2transforming growth factor, beta 20.855
Map3k7mitogen-activated protein kinase kinase kinase 70.851
SkilSKI-like0.841
Thbs1thrombospondin 10.839
Bmp1bone morphogenetic protein 10.828
Bgnbiglycan0.805
Mstnmyostatin0.801
Apcadenomatosis polyposis coli0.783
Lumlumican0.778
Acvr1activin A receptor, type 10.774
Axin1axin 10.767
Nr3c1nuclear receptor subfamily 3, group C, member 10.764
Col1a1collagen, type I, alpha 10.748
Tgfb1transforming growth factor, beta 10.735
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.735
Csf1colony stimulating factor 1 (macrophage)0.733
Bmpr1abone morphogenetic protein receptor, type 1A0.726
Lepleptin0.711
Pkd2polycystic kidney disease 20.698
Mmp2matrix metallopeptidase 20.689
Trp53transformation related protein 530.637
Bmp4bone morphogenetic protein 40.607
Fgfr2fibroblast growth factor receptor 20.561
Itgb3integrin beta 30.553
JunJun oncogene0.538
Fgfr1fibroblast growth factor receptor 10.529
Smosmoothened homolog (Drosophila)0.529
Fstfollistatin0.527
Fgf8fibroblast growth factor 80.504
Ctnnb1catenin (cadherin associated protein), beta 10.481
Col5a1collagen, type V, alpha 10.466
Pgrprogesterone receptor0.466
Nf1neurofibromatosis 10.433
Rargretinoic acid receptor, gamma0.428
Wnt4wingless-related MMTV integration site 40.423
Emp2epithelial membrane protein 20.422
Mdm2transformed mouse 3T3 cell double minute 20.418
Zfp651zinc finger protein 6510.406
Mmp9matrix metallopeptidase 90.397
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.396
Bmp7bone morphogenetic protein 70.392
Gas1growth arrest specific 10.383
Smad1MAD homolog 1 (Drosophila)0.381
Apoeapolipoprotein E0.379
Scara3scavenger receptor class A, member 30.364
Ltbp1latent transforming growth factor beta binding protein 10.364
Atf2activating transcription factor 20.360
Aebp1AE binding protein 10.358
Tbx1T-box 10.358
Trp63transformation related protein 630.356
Cyr61cysteine rich protein 610.356
Sulf2sulfatase 20.347
Fbln2fibulin 20.347
Timp2tissue inhibitor of metalloproteinase 20.345
Col12a1collagen, type XII, alpha 10.343
Dlg1discs, large homolog 1 (Drosophila)0.343
Foxc1forkhead box C10.341
Cul3cullin 30.338
Vclvinculin0.334
Smad2MAD homolog 2 (Drosophila)0.325
Ptenphosphatase and tensin homolog0.316
Col1a2collagen, type I, alpha 20.314
Foxf2forkhead box F20.312
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.312
Sox4SRY-box containing gene 40.309
Vegfavascular endothelial growth factor A0.308
Fgf5fibroblast growth factor 50.300
Lhx1LIM homeobox protein 10.298
Inhbainhibin beta-A0.296
Prrx2paired related homeobox 20.289
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.287
Islrimmunoglobulin superfamily containing leucine-rich repeat0.284
C1qtnf1C1q and tumor necrosis factor related protein 10.282
Efna4ephrin A40.280
Rarbretinoic acid receptor, beta0.280
Spnb2spectrin beta 20.277
Fgf10fibroblast growth factor 100.274
Gsk3bglycogen synthase kinase 3 beta0.273
Itgb1integrin beta 1 (fibronectin receptor beta)0.270
Fzd2frizzled homolog 2 (Drosophila)0.270
Pax2paired box gene 20.270
Cx3cr1chemokine (C-X3-C) receptor 10.268
Flnafilamin, alpha0.267
Loxl1lysyl oxidase-like 10.264
Atp7aATPase, Cu++ transporting, alpha polypeptide0.263
Plin1perilipin 10.263
Fzd1frizzled homolog 1 (Drosophila)0.257
Ephb2Eph receptor B20.255
Cdkn2acyclin-dependent kinase inhibitor 2A0.249
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.781
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.568
Atf3activating transcription factor 30.462
Bgnbiglycan0.451
Loxlysyl oxidase0.429
Col3a1collagen, type III, alpha 10.408
Dusp1dual specificity phosphatase 10.385
Smad7SMAD family member 70.362
Egr1early growth response 10.259
Btg2BTG family, member 20.233
Col1a2collagen, type I, alpha 20.202
Lamc1laminin, gamma 10.189
Loxl1lysyl oxidase-like 10.178
Klf4Kruppel-like factor 4 (gut)0.174
Lumlumican0.171
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.144
Tgfbr2transforming growth factor, beta receptor II0.138
Jak2Janus kinase 20.129
Pmepa1prostate transmembrane protein, androgen induced 10.123
Nr4a1nuclear receptor subfamily 4, group A, member 10.118
Adam17ADAM metallopeptidase domain 170.115
Arntaryl hydrocarbon receptor nuclear translocator0.110
Col5a2collagen, type V, alpha 20.102
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.098
Icam1intercellular adhesion molecule 10.098
Runx1runt-related transcription factor 10.096
Metmet proto-oncogene0.090
JunJun oncogene0.088
Cishcytokine inducible SH2-containing protein0.082
FosFBJ osteosarcoma oncogene0.081
Ier2immediate early response 20.081
Stat6signal transducer and activator of transcription 60.080
Slco2a1solute carrier organic anion transporter family, member 2a10.079
Cpsf2cleavage and polyadenylation specific factor 20.076
Elnelastin0.074
Rararetinoic acid receptor, alpha0.073
Junbjun B proto-oncogene0.069
Acta2smooth muscle alpha-actin0.069
Pecam1platelet/endothelial cell adhesion molecule 10.066
Gja4gap junction protein, alpha 40.060
Psen1presenilin 10.056
Aebp1AE binding protein 10.054
Ntn1netrin 10.050
Elk3ELK3, ETS-domain protein0.048
Tgfb1transforming growth factor, beta 10.047
Postnperiostin, osteoblast specific factor0.047
Cyr61cysteine-rich, angiogenic inducer, 610.047
Col6a2collagen, type VI, alpha 20.044
Smad1SMAD family member 10.044
Agtr1aangiotensin II receptor, type 1a0.043
Ggt5gamma-glutamyltransferase 50.043
Ncanneurocan0.042
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.042
S1pr2sphingosine-1-phosphate receptor 20.040
Tgfbr1transforming growth factor, beta receptor 10.040
Mfap5microfibrillar associated protein 50.038
Klf6Kruppel-like factor 60.037
Emp1epithelial membrane protein 10.036
Col12a1collagen, type XII, alpha 10.036
Jak1Janus kinase 10.035
Fgd4FYVE, RhoGEF and PH domain containing 40.035
Socs2suppressor of cytokine signaling 20.035
Myh9myosin, heavy chain 9, non-muscle0.035
Dcndecorin0.035
Tgfb3transforming growth factor, beta 30.034
Ecm1extracellular matrix protein 10.033
Usf2upstream transcription factor 2, c-fos interacting0.032
Cdh5cadherin 50.031
Sh2b1SH2B adaptor protein 10.031
Ctskcathepsin K0.031
Nlnneurolysin (metallopeptidase M3 family)0.030
Nr4a3nuclear receptor subfamily 4, group A, member 30.030
Igf2rinsulin-like growth factor 2 receptor0.030
Zfp36zinc finger protein 360.029
Casp3caspase 30.029
Bcar1breast cancer anti-estrogen resistance 10.028
Mark2MAP/microtubule affinity-regulating kinase 20.028
Col4a1collagen, type IV, alpha 10.028
Smad3SMAD family member 30.027
Rgs19regulator of G-protein signaling 190.027
Plaurplasminogen activator, urokinase receptor0.027
Map3k7ip2mitogen-activated protein kinase kinase kinase 7 interacting protein 20.026
Raf1v-raf-leukemia viral oncogene 10.026
Nck1NCK adaptor protein 10.024
Ucp2uncoupling protein 2 (mitochondrial, proton carrier)0.024
Fam38afamily with sequence similarity 38, member A0.024
Gsk3bglycogen synthase kinase 3 beta0.024
Hspa13heat shock protein 130.023
Egr2early growth response 20.023
Hspa1aheat shock 70kD protein 1A0.023
Coq10bcoenzyme Q10 homolog B (S. cerevisiae)0.023
Casp7caspase 70.022
Sox17SRY (sex determining region Y)-box 170.022
Mdm2Mdm2 p53 binding protein homolog (mouse)0.022
Trim47tripartite motif-containing 470.022
Pdia4protein disulfide isomerase family A, member 40.022
Castcalpastatin0.022
Itgb1integrin, beta 10.022
Mafbv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)0.022
Il1rapinterleukin 1 receptor accessory protein0.022
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism