The network for 'histone acetylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

histone acetylation

The modification of a histone by the addition of an acetyl group.

NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p531.000
C20orf20chromosome 20 open reading frame 201.000
TRRAPtransformation/transcription domain-associated protein1.000
KAT2BK(lysine) acetyltransferase 2B1.000
WDR5WD repeat domain 51.000
BRCA1breast cancer 1, early onset1.000
CREBBPCREB binding protein1.000
TAF4TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa0.999
KAT2AK(lysine) acetyltransferase 2A0.999
SIRT1sirtuin 10.997
USP22ubiquitin specific peptidase 220.995
TBPTATA box binding protein0.995
RUVBL1RuvB-like 1 (E. coli)0.987
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.985
JUNjun proto-oncogene0.980
ACTL6Aactin-like 6A0.976
VPS72vacuolar protein sorting 72 homolog (S. cerevisiae)0.969
TADA3transcriptional adaptor 30.958
SIN3ASIN3 homolog A, transcription regulator (yeast)0.954
RB1retinoblastoma 10.952
CFL1cofilin 1 (non-muscle)0.951
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.940
TAF10TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa0.937
EP300E1A binding protein p3000.928
ARID1AAT rich interactive domain 1A (SWI-like)0.926
MYST3MYST histone acetyltransferase (monocytic leukemia) 30.916
RUNX1runt-related transcription factor 10.901
SMN1survival of motor neuron 1, telomeric0.900
NCOA3nuclear receptor coactivator 30.893
NCOR1nuclear receptor corepressor 10.889
YY1YY1 transcription factor0.888
MAPK14mitogen-activated protein kinase 140.883
NCOA1nuclear receptor coactivator 10.879
TAL1T-cell acute lymphocytic leukemia 10.873
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.861
ESR1estrogen receptor 10.850
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.847
NCOA2nuclear receptor coactivator 20.832
RBBP5retinoblastoma binding protein 50.831
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.824
IKBKAPinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein0.824
HTThuntingtin0.823
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.820
ARandrogen receptor0.820
ING3inhibitor of growth family, member 30.819
SMAD3SMAD family member 30.799
CREB1cAMP responsive element binding protein 10.799
MBIPMAP3K12 binding inhibitory protein 10.797
GSK3Bglycogen synthase kinase 3 beta0.797
DAXXdeath-domain associated protein0.778
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.766
HIST1H3Bhistone cluster 1, H3b0.759
NCOA6nuclear receptor coactivator 60.706
HCFC1host cell factor C1 (VP16-accessory protein)0.699
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.693
EPC2enhancer of polycomb homolog 2 (Drosophila)0.686
ATXN7ataxin 70.662
RBBP7retinoblastoma binding protein 70.660
FOSFBJ murine osteosarcoma viral oncogene homolog0.657
HIST2H3Chistone cluster 2, H3c0.646
MLLT1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10.631
UBE3Aubiquitin protein ligase E3A0.630
HDAC1histone deacetylase 10.628
WRNWerner syndrome, RecQ helicase-like0.623
RBBP4retinoblastoma binding protein 40.620
TAF9TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa0.615
TAF6TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa0.609
MRFAP1Morf4 family associated protein 10.606
CCDC101coiled-coil domain containing 1010.571
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.551
SETD8SET domain containing (lysine methyltransferase) 80.539
MTA1metastasis associated 10.538
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.538
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.513
SMURF1SMAD specific E3 ubiquitin protein ligase 10.508
MORF4L2mortality factor 4 like 20.503
INO80INO80 homolog (S. cerevisiae)0.498
DUSP1dual specificity phosphatase 10.496
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.489
ZNF148zinc finger protein 1480.487
ZNF512Bzinc finger protein 512B0.467
INO80EINO80 complex subunit E0.466
TAF2TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa0.442
MECP2methyl CpG binding protein 2 (Rett syndrome)0.431
POLE3polymerase (DNA directed), epsilon 3 (p17 subunit)0.428
SKIv-ski sarcoma viral oncogene homolog (avian)0.420
ZNF496zinc finger protein 4960.412
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.412
ATF3activating transcription factor 30.403
CSNK1Ecasein kinase 1, epsilon0.395
MAP3K5mitogen-activated protein kinase kinase kinase 50.385
KAT5K(lysine) acetyltransferase 50.380
TAF1CTATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa0.371
EPC1enhancer of polycomb homolog 1 (Drosophila)0.367
GATAD2BGATA zinc finger domain containing 2B0.360
CBX5chromobox homolog 50.357
ELP2elongation protein 2 homolog (S. cerevisiae)0.349
DRAP1DR1-associated protein 1 (negative cofactor 2 alpha)0.347
MDM2Mdm2 p53 binding protein homolog (mouse)0.344
EP400E1A binding protein p4000.342
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
F33H1.4Protein F33H1.40.012
hda-2Protein HDA-20.011
apr-1Protein APR-10.011
F59G1.8Protein F59G1.80.010
attf-2Protein ATTF-20.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG10414CG10414 gene product from transcript CG10414-RA0.993
PcafCG4107 gene product from transcript CG4107-RA0.992
HcfHost cell factor0.990
dikdiskette0.968
D12CG13400 gene product from transcript CG13400-RA0.968
Sir2CG5216 gene product from transcript CG5216-RA0.928
Atac1ATAC component 10.909
Mocs2Molybdopterin synthase 20.909
Snr1Snf5-related 10.867
Saf6SAGA factor-like TAF60.848
His2AvHistone H2A variant0.841
Chrac-14CG13399 gene product from transcript CG13399-RA0.807
Bap55Brahma associated protein 55kD0.803
Sgf29CG30390 gene product from transcript CG30390-RA0.782
mod(mdg4)modifier of mdg40.755
eggeggless0.736
wdswill die slowly0.685
SuURSuppressor of Under-Replication0.572
Nipped-ACG33554 gene product from transcript CG33554-RE0.569
msl-3male-specific lethal 30.549
Nf-YBNuclear factor Y-box B0.478
RgaRegena0.415
waplwings apart-like0.408
Ino80CG31212 gene product from transcript CG31212-RA0.407
ash1absent, small, or homeotic discs 10.398
MRG15CG6363 gene product from transcript CG6363-RA0.396
e(y)3enhancer of yellow 30.396
B52CG10851 gene product from transcript CG10851-RB0.389
defldeflated0.365
Rpd3CG7471 gene product from transcript CG7471-RA0.351
SmD3Small ribonucleoprotein particle protein SmD30.333
pr-set7CG3307 gene product from transcript CG3307-RC0.324
panpangolin0.316
cgcombgap0.302
lwrlesswright0.296
Su(var)3-3Suppressor of variegation 3-30.289
MED16Mediator complex subunit 160.233
dbedribble0.229
Tao-1CG14217 gene product from transcript CG14217-RF0.228
ScmSex comb on midleg0.222
ph-dpolyhomeotic distal0.222
Hel25EHelicase at 25E0.194
O-fut1O-fucosyltransferase 10.184
Trn-SRTransportin-Serine/Arginine rich0.177
Rpb4CG33520 gene product from transcript CG33520-RF0.176
brmbrahma0.176
noinoisette0.173
gloglorund0.171
Cul-4Cullin-40.162
l(3)mbtlethal (3) malignant brain tumor0.156
dcodiscs overgrown0.155
msl-1male-specific lethal 10.151
MadMothers against dpp0.151
CG3995CG3995 gene product from transcript CG3995-RA0.150
dalaoCG7055 gene product from transcript CG7055-RA0.148
pzgputzig0.147
Su(H)Suppressor of Hairless0.141
hpohippo0.141
Aut1CG6877 gene product from transcript CG6877-RA0.140
Su(var)3-7Suppressor of variegation 3-70.140
SRm160CG11274 gene product from transcript CG11274-RA0.137
BRWD3CG31132 gene product from transcript CG31132-RA0.132
GmdGDP-mannose 4,6-dehydratase0.131
cyccycle0.129
OteOtefin0.124
CG3363CG3363 gene product from transcript CG3363-RB0.124
PcPolycomb0.117
NC2betaCG4185 gene product from transcript CG4185-RA0.112
picpiccolo0.112
keykenny0.103
Akt1CG4006 gene product from transcript CG4006-RA0.102
ksrkinase suppressor of ras0.101
Taf5TBP-associated factor 50.101
wdnwings down0.100
CTCFCG8591 gene product from transcript CG8591-RA0.097
Taf6TBP-associated factor 60.097
notnon-stop0.096
CG32343CG32343 gene product from transcript CG32343-RB0.094
Su(var)205Suppressor of variegation 2050.093
KrKruppel0.086
Traf6TNF-receptor-associated factor 60.084
SnapSoluble NSF attachment protein0.084
IswiImitation SWI0.082
CSN6COP9 complex homolog subunit 60.081
mofmales absent on the first0.080
kniknirps0.079
bonbonus0.077
CSN5COP9 complex homolog subunit 50.077
tsutsunagi0.075
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.074
Es2CG1474 gene product from transcript CG1474-RA0.073
CG10107CG10107 gene product from transcript CG10107-RA0.073
ChroChromator0.073
ltlight0.066
Taf1TBP-associated factor 10.066
CG32418CG32418 gene product from transcript CG32418-RA0.066
bynbrachyenteron0.064
Su(var)2-10Suppressor of variegation 2-100.064
Top2Topoisomerase 20.063
CG11242CG11242 gene product from transcript CG11242-RA0.063
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Kat2aK(lysine) acetyltransferase 2A1.000
Trraptransformation/transcription domain-associated protein0.999
Rnf2ring finger protein 20.999
RybpRING1 and YY1 binding protein0.996
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.995
Per2period homolog 2 (Drosophila)0.994
Arntlaryl hydrocarbon receptor nuclear translocator-like0.993
Arid1aAT rich interactive domain 1A (SWI-like)0.991
Otx2orthodenticle homolog 2 (Drosophila)0.985
Tal1T-cell acute lymphocytic leukemia 10.979
Wdr5WD repeat domain 50.978
Cry2cryptochrome 2 (photolyase-like)0.974
Clockcircadian locomotor output cycles kaput0.964
Ep300E1A binding protein p3000.963
Pax3paired box gene 30.957
Ezh2enhancer of zeste homolog 2 (Drosophila)0.954
Pou5f1POU domain, class 5, transcription factor 10.947
Brca1breast cancer 10.937
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.905
Dmap1DNA methyltransferase 1-associated protein 10.903
Suz12suppressor of zeste 12 homolog (Drosophila)0.894
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.890
Sin3atranscriptional regulator, SIN3A (yeast)0.883
Pitx2paired-like homeodomain transcription factor 20.861
Tbx1T-box 10.851
Tcfcp2l1transcription factor CP2-like 10.840
Kat5K(lysine) acetyltransferase 50.831
Neurod1neurogenic differentiation 10.828
Ep400E1A binding protein p4000.824
Tcf3transcription factor 30.822
Gata4GATA binding protein 40.814
Runx1runt related transcription factor 10.795
Rbbp7retinoblastoma binding protein 70.784
Foxc1forkhead box C10.763
Gli2GLI-Kruppel family member GLI20.743
Trp53transformation related protein 530.726
Cry1cryptochrome 1 (photolyase-like)0.724
CrebbpCREB binding protein0.723
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.676
Isl1ISL1 transcription factor, LIM/homeodomain0.647
Zeb1zinc finger E-box binding homeobox 10.631
Ptf1apancreas specific transcription factor, 1a0.566
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.562
Ascl1achaete-scute complex homolog 1 (Drosophila)0.557
Pax7paired box gene 70.505
Esr1estrogen receptor 1 (alpha)0.503
Pax9paired box gene 90.495
Nos2nitric oxide synthase 2, inducible0.480
Lepleptin0.475
Brd2bromodomain containing 20.460
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.460
MecomMDS1 and EVI1 complex locus0.456
Arid1bAT rich interactive domain 1B (SWI-like)0.439
Hdac2histone deacetylase 20.433
MgaMAX gene associated0.424
Prrx1paired related homeobox 10.424
Smarcc2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.417
Hoxd13homeobox D130.412
Hoxa1homeobox A10.410
Chd4chromodomain helicase DNA binding protein 40.407
Vegfavascular endothelial growth factor A0.406
Mecp2methyl CpG binding protein 20.402
Atg12autophagy-related 12 (yeast)0.399
Myogmyogenin0.378
Kdm2blysine (K)-specific demethylase 2B0.374
Dlx2distal-less homeobox 20.374
Myf5myogenic factor 50.368
Zfpm2zinc finger protein, multitype 20.365
Rxraretinoid X receptor alpha0.361
Eya1eyes absent 1 homolog (Drosophila)0.353
Tada3transcriptional adaptor 30.353
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.352
Rararetinoic acid receptor, alpha0.338
Gata6GATA binding protein 60.338
Hand2heart and neural crest derivatives expressed transcript 20.337
Kdm5blysine (K)-specific demethylase 5B0.335
Irs2insulin receptor substrate 20.329
Ciccapicua homolog (Drosophila)0.329
Smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.319
Ssbp2single-stranded DNA binding protein 20.318
Morf4l1mortality factor 4 like 10.307
Arid2AT rich interactive domain 2 (ARID, RFX-like)0.299
H2afzH2A histone family, member Z0.295
Map3k3mitogen-activated protein kinase kinase kinase 30.287
Kiss1KiSS-1 metastasis-suppressor0.283
Hdac1histone deacetylase 10.277
Bap1Brca1 associated protein 10.275
Neurog2neurogenin 20.273
Neurog3neurogenin 30.268
Ldb1LIM domain binding 10.264
Msx1homeobox, msh-like 10.258
Gscgoosecoid homeobox0.253
Stat1signal transducer and activator of transcription 10.246
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.243
Mta1metastasis associated 10.243
Gnb2guanine nucleotide binding protein (G protein), beta 20.241
Myod1myogenic differentiation 10.237
Atxn7l3ataxin 7-like 30.235
Mapk1mitogen-activated protein kinase 10.233
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.230
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.094
Tuba1ctubulin, alpha 1C0.029
Actbactin, beta0.029
Casp2caspase 20.019
Actg1actin, gamma 10.015
Hspa8heat shock protein 80.011
Ash1lash1 (absent, small, or homeotic)-like (Drosophila)0.011
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
TRA1Tra1p1.000
NGG1Ngg1p0.997
TAF6Taf6p0.991
GCN5Gcn5p0.991
ADA2Ada2p0.987
SPT8Spt8p0.977
HHT1Hht1p0.973
EPL1Epl1p0.933
TAF12Taf12p0.925
ARP4Arp4p0.911
SGF29Sgf29p0.909
HFI1Hfi1p0.907
TAF5Taf5p0.897
SPT7Spt7p0.868
SPT20Spt20p0.855
BDF1Bdf1p0.849
EAF1Eaf1p0.842
EAF3Eaf3p0.828
TAF10Taf10p0.821
EAF6Eaf6p0.814
EAF5Eaf5p0.805
YAF9Yaf9p0.782
ASF1Asf1p0.767
YNG1Yng1p0.662
ESA1Esa1p0.582
SWC4Swc4p0.512
HAT2Hat2p0.493
YNG2Yng2p0.484
RCO1Rco1p0.389
SGF73Sgf73p0.375
SDC1Sdc1p0.369
SPT15Spt15p0.360
UBP8Ubp8p0.298
SPT3Spt3p0.259
TAF9Taf9p0.234
RSC4Rsc4p0.232
SGF11Sgf11p0.224
HIF1Hif1p0.213
ISW1Isw1p0.211
SUS1Sus1p0.210
EAF7Eaf7p0.181
HAT1Hat1p0.179
ELP6Elp6p0.178
CAC2Cac2p0.165
TEC1Tec1p0.158
YTA7Yta7p0.157
RTT106Rtt106p0.153
FUS3Fus3p0.144
SWI1Swi1p0.144
TAF3Taf3p0.140
SAS3Sas3p0.140
NAT1Nat1p0.137
RSC1Rsc1p0.120
SNF5Snf5p0.117
SAS5Sas5p0.104
NTO1Nto1p0.093
PSH1Psh1p0.090
IKI1Iki1p0.089
MDM20Mdm20p0.083
VPS75Vps75p0.082
HIR1Hir1p0.078
HHO1Hho1p0.076
SET2Set2p0.073
CKB1Ckb1p0.071
SAP185Sap185p0.070
ORC4Orc4p0.068
NSA1Nsa1p0.067
HIR2Hir2p0.064
HMO1Hmo1p0.061
ELP4Elp4p0.061
RSC8Rsc8p0.061
SWD3Swd3p0.056
POL2Pol2p0.056
DPB3Dpb3p0.056
RSC30Rsc30p0.054
TAF14Taf14p0.051
SIN3Sin3p0.051
RPD3Rpd3p0.049
DLS1Dls1p0.046
HDA2Hda2p0.045
HOS2Hos2p0.044
ESF1Esf1p0.042
NOP10Nop10p0.040
SAM2Sam2p0.040
LEO1Leo1p0.039
NRG2Nrg2p0.038
RLF2Rlf2p0.038
SWR1Swr1p0.037
NPL6Npl6p0.036
IES2Ies2p0.036
GCN20Gcn20p0.036
SEN1Sen1p0.035
SPT10Spt10p0.035
SPP1Spp1p0.034
HPC2Hpc2p0.034
RSC6Rsc6p0.033
VMA7Vma7p0.032
YHB1Yhb1p0.032
SRD1Srd1p0.031
HST3Hst3p0.031