The network for 'pancreas development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pancreas development

The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.

NameDescriptionProbabilityFunc Analog Organism
HNF4Ahepatocyte nuclear factor 4, alpha0.963
NOTCH3notch 30.939
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.929
POU5F1POU class 5 homeobox 10.760
BMPR1Abone morphogenetic protein receptor, type IA0.681
BMPR1Bbone morphogenetic protein receptor, type IB0.345
FOXA2forkhead box A20.302
SETD8SET domain containing (lysine methyltransferase) 80.270
CDX2caudal type homeobox 20.255
RUNX1runt-related transcription factor 10.235
SOX1SRY (sex determining region Y)-box 10.197
EGFRepidermal growth factor receptor0.175
FOXF2forkhead box F20.161
SMAD3SMAD family member 30.157
IGF1Rinsulin-like growth factor 1 receptor0.152
ONECUT1one cut homeobox 10.147
BAXBCL2-associated X protein0.143
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.139
FGF10fibroblast growth factor 100.132
TAL1T-cell acute lymphocytic leukemia 10.131
INSRinsulin receptor0.122
HNF1BHNF1 homeobox B0.114
CD177CD177 molecule0.108
NOTCH2notch 20.079
MYOD1myogenic differentiation 10.075
GATA2GATA binding protein 20.075
MNX1motor neuron and pancreas homeobox 10.074
CCND1cyclin D10.068
FGF1fibroblast growth factor 1 (acidic)0.067
PTCH1patched 10.066
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.064
CDK6cyclin-dependent kinase 60.058
RBPMSRNA binding protein with multiple splicing0.056
NKX6-1NK6 homeobox 10.055
IL6Rinterleukin 6 receptor0.054
PITX2paired-like homeodomain 20.054
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.054
COL2A1collagen, type II, alpha 10.053
IGF2Rinsulin-like growth factor 2 receptor0.052
EEF2eukaryotic translation elongation factor 20.051
ITGB1BP3integrin beta 1 binding protein 30.051
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.051
FOXF1forkhead box F10.050
MDM2Mdm2 p53 binding protein homolog (mouse)0.050
PTF1Apancreas specific transcription factor, 1a0.048
HOXD12homeobox D120.047
HNF1AHNF1 homeobox A0.046
NKX2-2NK2 homeobox 20.046
CREBBPCREB binding protein0.045
LHX5LIM homeobox 50.045
CDT1chromatin licensing and DNA replication factor 10.043
FEVFEV (ETS oncogene family)0.043
SIM2single-minded homolog 2 (Drosophila)0.042
PDX1pancreatic and duodenal homeobox 10.041
B9D2B9 protein domain 20.040
CARD11caspase recruitment domain family, member 110.040
PROX1prospero homeobox 10.040
HDAC2histone deacetylase 20.038
GATA4GATA binding protein 40.037
SOX2SRY (sex determining region Y)-box 20.036
IL6interleukin 6 (interferon, beta 2)0.036
HOXD11homeobox D110.036
FOXL1forkhead box L10.036
BOP1block of proliferation 10.035
NR0B2nuclear receptor subfamily 0, group B, member 20.033
ZFYVE9zinc finger, FYVE domain containing 90.033
RPL8ribosomal protein L80.032
FGF3fibroblast growth factor 30.031
HIC1hypermethylated in cancer 10.030
NR5A2nuclear receptor subfamily 5, group A, member 20.030
NKX3-2NK3 homeobox 20.030
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.030
GFI1Bgrowth factor independent 1B transcription repressor0.030
NR4A1nuclear receptor subfamily 4, group A, member 10.029
FZD10frizzled homolog 10 (Drosophila)0.029
GJD2gap junction protein, delta 2, 36kDa0.029
EN2engrailed homeobox 20.028
HOXB9homeobox B90.028
POU4F2POU class 4 homeobox 20.028
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.028
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.027
KLF4Kruppel-like factor 4 (gut)0.027
MYT1myelin transcription factor 10.027
FOXB1forkhead box B10.026
HOXD13homeobox D130.026
SMAD6SMAD family member 60.026
HGFhepatocyte growth factor (hepapoietin A; scatter factor)0.026
AHRaryl hydrocarbon receptor0.026
EN1engrailed homeobox 10.026
PYYpeptide YY0.025
MARCKSL1MARCKS-like 10.025
PCNAproliferating cell nuclear antigen0.025
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.024
NOTCH1notch 10.024
DLX4distal-less homeobox 40.023
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.022
KDM1Alysine (K)-specific demethylase 1A0.022
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.022
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fgf8afibroblast growth factor 8 a0.994
hnf1baHNF1 homeobox Ba0.993
tbx1T-box 10.987
hoxb8ahomeo box B8a0.983
mibmind bomb0.968
pax2apaired box gene 2a0.959
jag2jagged 20.955
hoxa4ahomeo box A4a0.955
pax8paired box gene 80.950
shhasonic hedgehog a0.942
hoxb5bhomeo box B5b0.913
hoxc8ahomeo box C8a0.905
pax6bpaired box gene 6b0.905
hand2heart and neural crest derivatives expressed transcript 20.904
foxa3forkhead box A30.885
lhx1aLIM homeobox 1a0.876
ptf1apancreas specific transcription factor, 1a0.856
tp53tumor protein p530.851
hoxc4ahomeo box C4a0.840
fgfr2fibroblast growth factor receptor 20.836
gdf6agrowth differentiation factor 6a0.834
hoxb5ahomeo box B5a0.797
wnt4awingless-type MMTV integration site family, member 4a0.786
foxa1forkhead box A10.779
hhexhematopoietically expressed homeobox0.778
hoxb6bhomeo box B6b0.774
sox9bSRY-box containing gene 9b0.749
nkx2.2aNK2 transcription factor related 2a0.729
hoxb3ahomeo box B3a0.705
sox1aSRY-box containing gene 1a0.699
nkx6.2NK6 transcription factor related, locus 20.699
mnx1motor neuron and pancreas homeobox 10.693
pdx1pancreatic and duodenal homeobox 10.686
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.685
sfrp1asecreted frizzled-related protein 1a0.685
flhfloating head0.669
tbx16T-box gene 160.660
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.659
her5hairy-related 50.651
eya1eyes absent homolog 10.628
ahctf1AT hook containing transcription factor 10.623
dbx1adeveloping brain homeobox 1a0.622
hoxb1bhomeo box B1b0.613
sox2SRY-box containing gene 20.613
hoxd4ahomeo box D4a0.612
gbx2gastrulation brain homeo box 20.573
wif1wnt inhibitory factor 10.552
neurodneurogenic differentiation0.552
cdx4caudal type homeo box transcription factor 40.552
aldh1a2aldehyde dehydrogenase 1 family, member A20.526
gbx1gastrulation brain homeobox 10.524
shhbsonic hedgehog b0.522
notch2notch homolog 20.520
mab21l2mab-21-like 20.516
wnt11rwingless-type MMTV integration site family, member 11, related0.514
six3bsine oculis homeobox homolog 3b0.501
gro1groucho 10.496
wnt2wingless-type MMTV integration site family member 20.481
evx1even-skipped homeobox 10.472
raraaretinoic acid receptor, alpha a0.462
neurod4neurogenic differentiation 40.452
tal1T-cell acute lymphocytic leukemia 10.449
hlxb9lahomeo box HB9 like a0.443
foxa2forkhead box A20.442
eng2aengrailed 2a0.439
meis2.1myeloid ecotropic viral integration site 2.10.426
atoh1batonal homolog 1b0.415
rarabretinoic acid receptor, alpha b0.392
hmx3homeo box (H6 family) 30.391
fezf2FEZ family zinc finger 20.384
prox1prospero-related homeobox gene 10.378
alcamaactivated leukocyte cell adhesion molecule a0.371
fgfr1afibroblast growth factor receptor 1a0.370
notch3notch homolog 30.361
oepone-eyed pinhead0.348
atoh1aatonal homolog 1a0.346
otpborthopedia homolog b0.339
osr1odd-skipped related 1 (Drosophila)0.333
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.332
fgf4fibroblast growth factor 40.323
pax4paired box 40.316
olfm2olfactomedin 20.310
eng2bengrailed 2b0.307
hoxc6ahomeo box C6a0.299
gcgaglucagon a and glucagon a-like0.284
lef1lymphocyte enhancer binding factor 10.282
nanos3nanos homolog 30.276
spry2sprouty homolog 20.272
fgf3fibroblast growth factor 30.270
fgfr4fibroblast growth factor receptor 40.270
metrnmeteorin, glial cell differentiation regulator0.270
tfap2atranscription factor AP-2 alpha0.269
nkx2.3NK2 transcription factor related 30.267
sec13SEC13 homolog (S. cerevisiae)0.267
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.997
Fgfr2fibroblast growth factor receptor 20.996
Otx2orthodenticle homolog 2 (Drosophila)0.993
Pax3paired box gene 30.992
Gli3GLI-Kruppel family member GLI30.990
Pitx2paired-like homeodomain transcription factor 20.988
Pax6paired box gene 60.983
Pax2paired box gene 20.975
Neurod1neurogenic differentiation 10.968
Onecut1one cut domain, family member 10.963
Hes1hairy and enhancer of split 1 (Drosophila)0.950
Ptf1apancreas specific transcription factor, 1a0.948
Emx2empty spiracles homolog 2 (Drosophila)0.943
Ascl1achaete-scute complex homolog 1 (Drosophila)0.943
Fgf8fibroblast growth factor 80.926
Fgf10fibroblast growth factor 100.915
Foxc1forkhead box C10.913
Pdx1pancreatic and duodenal homeobox 10.913
Ptenphosphatase and tensin homolog0.912
Bmp4bone morphogenetic protein 40.900
Hand2heart and neural crest derivatives expressed transcript 20.889
Isl1ISL1 transcription factor, LIM/homeodomain0.885
Bglapbone gamma carboxyglutamate protein0.866
Gata4GATA binding protein 40.828
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.819
Foxg1forkhead box G10.816
Fgfr1fibroblast growth factor receptor 10.812
Leprleptin receptor0.799
Hand1heart and neural crest derivatives expressed transcript 10.788
Pax8paired box gene 80.786
Sox9SRY-box containing gene 90.777
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.774
Lmx1aLIM homeobox transcription factor 1 alpha0.767
Gli2GLI-Kruppel family member GLI20.764
Nkx2-1NK2 homeobox 10.757
Gscgoosecoid homeobox0.708
Lhx3LIM homeobox protein 30.677
Gbx2gastrulation brain homeobox 20.667
Lhx1LIM homeobox protein 10.660
Twist2twist homolog 2 (Drosophila)0.648
Sox4SRY-box containing gene 40.605
En1engrailed 10.572
Insm1insulinoma-associated 10.556
Eya1eyes absent 1 homolog (Drosophila)0.537
Emx1empty spiracles homolog 1 (Drosophila)0.535
Tcfap2atranscription factor AP-2, alpha0.530
Smad6MAD homolog 6 (Drosophila)0.513
Sox2SRY-box containing gene 20.510
Tbx1T-box 10.500
Grb10growth factor receptor bound protein 100.485
Foxa2forkhead box A20.465
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.449
Notch1Notch gene homolog 1 (Drosophila)0.444
Sim1single-minded homolog 1 (Drosophila)0.437
Sox3SRY-box containing gene 30.416
Hes5hairy and enhancer of split 5 (Drosophila)0.416
Fgf15fibroblast growth factor 150.411
Hoxd11homeobox D110.396
Neurog3neurogenin 30.395
Mesp1mesoderm posterior 10.386
Hmx3H6 homeobox 30.381
UncxUNC homeobox0.366
Foxf1aforkhead box F1a0.361
Zeb1zinc finger E-box binding homeobox 10.356
2210010C04RikRIKEN cDNA 2210010C04 gene0.353
Dll1delta-like 1 (Drosophila)0.351
Tbx3T-box 30.347
Pitx1paired-like homeodomain transcription factor 10.344
Meox2mesenchyme homeobox 20.311
Pou3f4POU domain, class 3, transcription factor 40.306
Ror2receptor tyrosine kinase-like orphan receptor 20.305
Otporthopedia homolog (Drosophila)0.302
Smad3MAD homolog 3 (Drosophila)0.291
Kiss1KiSS-1 metastasis-suppressor0.284
Lmx1bLIM homeobox transcription factor 1 beta0.281
Pou3f3POU domain, class 3, transcription factor 30.281
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.268
Sox17SRY-box containing gene 170.268
Hoxa11homeobox A110.257
Sox7SRY-box containing gene 70.247
Col1a1collagen, type I, alpha 10.247
Bmp7bone morphogenetic protein 70.242
Pitx3paired-like homeodomain transcription factor 30.242
Foxd3forkhead box D30.242
Neurog2neurogenin 20.239
Zfpm2zinc finger protein, multitype 20.238
Nr5a1nuclear receptor subfamily 5, group A, member 10.237
Npas2neuronal PAS domain protein 20.237
Wnt3awingless-related MMTV integration site 3A0.235
Foxd2forkhead box D20.235
Nkx6-1NK6 homeobox 10.227
Sox11SRY-box containing gene 110.225
Pthlhparathyroid hormone-like peptide0.225
Lhx5LIM homeobox protein 50.221
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Lgals3lectin, galactoside-binding, soluble, 30.035
Foxa3forkhead box A30.028
Cd36CD36 molecule (thrombospondin receptor)0.027
Anxa5annexin A50.026
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.024
S100a11S100 calcium binding protein A11 (calizzarin)0.023
Fgfr2fibroblast growth factor receptor 20.021
Arhgap23Rho GTPase activating protein 230.021
Chiachitinase, acidic0.020
Glra1glycine receptor, alpha 10.019
S100a10S100 calcium binding protein A100.018
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.017
Arpc1bactin related protein 2/3 complex, subunit 1B0.017
Hes5hairy and enhancer of split 5 (Drosophila)0.016
Stc1stanniocalcin 10.016
Uoxurate oxidase0.016
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.015
Galr1galanin receptor 10.014
Capn8calpain 80.014
Anxa2annexin A20.013
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.013
Cuzd1CUB and zona pellucida-like domains 10.013
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.013
Azgp1alpha-2-glycoprotein 1, zinc-binding0.013
Nfyanuclear transcription factor-Y alpha0.013
Asgr1asialoglycoprotein receptor 10.012
A1bgalpha-1-B glycoprotein0.012
Mc5rmelanocortin 5 receptor0.011
RGD1562618similar to RIKEN cDNA 6030419C18 gene0.011
Gata6GATA binding protein 60.011
Pnliprp2pancreatic lipase-related protein 20.011
Insrrinsulin receptor-related receptor0.011
Tcfe2atranscription factor E2a0.011
Clcn5chloride channel 50.011
Clpscolipase, pancreatic0.011
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism