The network for 'cardiac muscle contraction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle contraction

Muscle contraction of cardiac muscle tissue.

NameDescriptionProbabilityFunc Analog Organism
ACTN2actinin, alpha 20.999
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.996
MYOZ1myozenin 10.991
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.985
TNNI1troponin I type 1 (skeletal, slow)0.983
DTNAdystrobrevin, alpha0.982
TNNC1troponin C type 1 (slow)0.981
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.981
KCNE1potassium voltage-gated channel, Isk-related family, member 10.968
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 10.955
TRIM63tripartite motif containing 630.946
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.939
JUPjunction plakoglobin0.899
DLG4discs, large homolog 4 (Drosophila)0.891
SCN5Asodium channel, voltage-gated, type V, alpha subunit0.890
RIN3Ras and Rab interactor 30.871
LDB3LIM domain binding 30.851
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.850
TNNT2troponin T type 2 (cardiac)0.841
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.819
KCNIP2Kv channel interacting protein 20.804
SNTG2syntrophin, gamma 20.801
PSEN1presenilin 10.798
TNNT3troponin T type 3 (skeletal, fast)0.766
MAPK12mitogen-activated protein kinase 120.754
LIN7Blin-7 homolog B (C. elegans)0.754
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.723
HDAC6histone deacetylase 60.717
EHD1EH-domain containing 10.713
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.700
MYL2myosin, light chain 2, regulatory, cardiac, slow0.689
SPTBspectrin, beta, erythrocytic0.680
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.652
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.652
ACTA1actin, alpha 1, skeletal muscle0.651
TPM1tropomyosin 1 (alpha)0.644
CTNND1catenin (cadherin-associated protein), delta 10.632
PKP3plakophilin 30.611
TNNI2troponin I type 2 (skeletal, fast)0.607
CLCN3chloride channel 30.591
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.590
CKMcreatine kinase, muscle0.585
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.537
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.526
TNNC2troponin C type 2 (fast)0.518
CFL1cofilin 1 (non-muscle)0.487
MYH7myosin, heavy chain 7, cardiac muscle, beta0.486
CAV3caveolin 30.477
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.467
MYBPC2myosin binding protein C, fast type0.458
PKP2plakophilin 20.448
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.424
KRT14keratin 140.404
PKD1polycystic kidney disease 1 (autosomal dominant)0.402
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.371
LRRK2leucine-rich repeat kinase 20.324
BMPR1Bbone morphogenetic protein receptor, type IB0.313
ACTN3actinin, alpha 30.302
DSC2desmocollin 20.300
MYH6myosin, heavy chain 6, cardiac muscle, alpha0.288
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.279
PYGMphosphorylase, glycogen, muscle0.275
FLNBfilamin B, beta0.268
CYR61cysteine-rich, angiogenic inducer, 610.262
CASQ2calsequestrin 2 (cardiac muscle)0.261
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.257
FHL2four and a half LIM domains 20.253
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.248
SMAD1SMAD family member 10.238
ACTC1actin, alpha, cardiac muscle 10.237
MYH2myosin, heavy chain 2, skeletal muscle, adult0.230
DSG2desmoglein 20.226
SGCAsarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)0.221
SKILSKI-like oncogene0.215
ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)0.213
SRPK3SRSF protein kinase 30.212
MYOZ2myozenin 20.211
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.209
KRT8keratin 80.205
MEF2Cmyocyte enhancer factor 2C0.199
MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow0.197
RYR2ryanodine receptor 2 (cardiac)0.193
CORO1Ccoronin, actin binding protein, 1C0.191
CAV1caveolin 1, caveolae protein, 22kDa0.188
CIB1calcium and integrin binding 1 (calmyrin)0.188
PGAM2phosphoglycerate mutase 2 (muscle)0.187
TBX5T-box 50.185
CTNNBIP1catenin, beta interacting protein 10.180
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.179
SLC2A4solute carrier family 2 (facilitated glucose transporter), member 40.168
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
actc1aactin, alpha, cardiac muscle 1a0.322
tnnc1btroponin C type 1b (slow)0.175
mybpc3myosin binding protein C, cardiac0.108
myhz2myosin, heavy polypeptide 2, fast muscle specific0.090
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.072
eya4eyes absent homolog 4 (Drosophila)0.069
tnnt2atroponin T2a, cardiac0.056
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.052
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.050
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.045
vmhcventricular myosin heavy chain0.042
mylz2myosin, light polypeptide 2, skeletal muscle0.039
myl1myosin, light chain 1, alkali; skeletal, fast0.039
ttnatitin a0.038
actc1bactin, alpha, cardiac muscle 1b0.038
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.035
tpm2tropomyosin 2 (beta)0.033
smyd1bSET and MYND domain containing 1b0.033
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.032
mef2camyocyte enhancer factor 2ca0.031
hspb1heat shock protein, alpha-crystallin-related, 10.030
smyhc1slow myosin heavy chain 10.030
acta1aactin, alpha 1a, skeletal muscle0.029
tnnc1atroponin C type 1a (slow)0.029
flot1bflotillin 1b0.028
me2malic enzyme 2, NAD(+)-dependent, mitochondrial0.027
tnnt3btroponin T3b, skeletal, fast0.026
ckmacreatine kinase, muscle a0.026
unc45bunc-45 homolog B (C. elegans)0.026
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.025
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.025
tnni1btroponin I, skeletal, slow b0.025
cmlc1cardiac myosin light chain-10.023
scn12absodium channel, voltage gated, type XII, alpha b0.022
tp53tumor protein p530.022
cav3caveolin 30.022
tmem38atransmembrane protein 38A0.020
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.020
scn2bsodium channel, voltage-gated, type II, beta0.020
scn4basodium channel, voltage-gated, type IV, beta a0.019
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.019
tpm3tropomyosin 30.018
fhlafour and a half LIM domains a0.018
xirp1xin actin-binding repeat containing 10.018
aldoabaldolase a, fructose-bisphosphate, b0.017
rbm24aRNA binding motif protein 24a0.016
actn2actinin, alpha 20.016
alcambactivated leukocyte cell adhesion molecule b0.015
sumo2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.014
pvalb2parvalbumin 20.014
casq2calsequestrin 20.014
mitfbmicrophthalmia-associated transcription factor b0.014
trpv6transient receptor potential cation channel, subfamily V, member 60.013
tnni2a.4troponin I, skeletal, fast 2a.40.013
tnnt1troponin T1, skeletal, slow0.013
adrb2aadrenergic receptor, beta 2a0.013
tnnc2troponin C type 2 (fast)0.013
hsp90a.2heat shock protein 90-alpha 20.012
scn12aasodium channel, voltage gated, type XII, alpha a0.012
calm1acalmodulin 1a0.012
bcdo2lbeta-carotene 15, 15-dioxygenase 2, like0.012
atp1a1a.3ATPase, Na+/K+ transporting, alpha 1a.3 polypeptide0.012
synpo2lbsynaptopodin 2-like b0.011
mbnl2muscleblind-like 2 (Drosophila)0.011
jam2ajunctional adhesion molecule 2a0.011
pabpc4poly(A) binding protein, cytoplasmic 4 (inducible form)0.011
rbm24bRNA binding motif protein 24b0.011
lrrc10leucine rich repeat containing 100.011
actn3bactinin alpha 3b0.010
spock3sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 30.010
cav1caveolin 10.010
nkx2.5NK2 transcription factor related 50.010
krt8keratin 80.010
zerg24potassium voltage-gated channel zerg240.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ryr2ryanodine receptor 2, cardiac0.999
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.996
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.989
Scn5asodium channel, voltage-gated, type V, alpha0.960
Klk1b5kallikrein 1-related peptidase b50.905
Ldb3LIM domain binding 30.895
Mef2dmyocyte enhancer factor 2D0.849
Tbx5T-box 50.822
Mybpc3myosin binding protein C, cardiac0.772
Myl3myosin, light polypeptide 30.749
Gja5gap junction protein, alpha 50.747
Kcnk3potassium channel, subfamily K, member 30.720
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.712
Casq2calsequestrin 20.708
Gata6GATA binding protein 60.700
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.682
Actn2actinin alpha 20.682
Gata4GATA binding protein 40.641
Pygmmuscle glycogen phosphorylase0.624
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.592
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.590
Klk1b11kallikrein 1-related peptidase b110.584
Klk1b8kallikrein 1-related peptidase b80.573
Pcdh12protocadherin 120.551
Actc1actin, alpha, cardiac muscle 10.544
Ckmt2creatine kinase, mitochondrial 20.542
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.533
Klk1b1kallikrein 1-related peptidase b10.506
5430421N21RikRIKEN cDNA 5430421N21 gene0.483
Xirp1xin actin-binding repeat containing 10.482
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.464
Klk1kallikrein 10.455
Notch2Notch gene homolog 2 (Drosophila)0.437
Cacna2d2calcium channel, voltage-dependent, alpha 2/delta subunit 20.434
Klk1b26kallikrein 1-related petidase b260.429
Klk1b21kallikrein 1-related peptidase b210.410
Axin1axin 10.409
Gjb6gap junction protein, beta 60.404
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.403
Dmddystrophin, muscular dystrophy0.398
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.397
Hrchistidine rich calcium binding protein0.386
Myom2myomesin 20.374
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.368
Tnnt2troponin T2, cardiac0.362
Cnn1calponin 10.359
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.336
Smad1MAD homolog 1 (Drosophila)0.334
Phkg1phosphorylase kinase gamma 10.327
Tnni2troponin I, skeletal, fast 20.318
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.306
Mef2cmyocyte enhancer factor 2C0.287
Ctnnb1catenin (cadherin associated protein), beta 10.279
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.270
Acta1actin, alpha 1, skeletal muscle0.269
Pgam2phosphoglycerate mutase 20.261
Tnnc1troponin C, cardiac/slow skeletal0.256
Hspb2heat shock protein 20.255
Klk1b3kallikrein 1-related peptidase b30.254
Ckmcreatine kinase, muscle0.250
Cckbrcholecystokinin B receptor0.246
Art1ADP-ribosyltransferase 10.245
Actr3ARP3 actin-related protein 3 homolog (yeast)0.243
Smurf1SMAD specific E3 ubiquitin protein ligase 10.239
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.232
Pthlhparathyroid hormone-like peptide0.229
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.221
Rtn2reticulon 2 (Z-band associated protein)0.217
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.216
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide 20.215
Sstr3somatostatin receptor 30.214
Tjp1tight junction protein 10.208
Cdh13cadherin 130.208
Eef1a2eukaryotic translation elongation factor 1 alpha 20.207
Epas1endothelial PAS domain protein 10.207
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.202
Csrp3cysteine and glycine-rich protein 30.197
Erbb2ipErbb2 interacting protein0.193
Prkg1protein kinase, cGMP-dependent, type I0.193
Tbx3T-box 30.192
Cav3caveolin 30.190
Tff2trefoil factor 2 (spasmolytic protein 1)0.182
Hspb7heat shock protein family, member 7 (cardiovascular)0.181
Aph1aanterior pharynx defective 1a homolog (C. elegans)0.181
Cxadrcoxsackie virus and adenovirus receptor0.179
Tcf15transcription factor 150.178
Abcc8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.177
Art5ADP-ribosyltransferase 50.177
Hand2heart and neural crest derivatives expressed transcript 20.176
Dmpkdystrophia myotonica-protein kinase0.173
Srpk3serine/arginine-rich protein specific kinase 30.173
Add2adducin 2 (beta)0.168
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.167
Gja1gap junction protein, alpha 10.167
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.167
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.165
Nppanatriuretic peptide type A0.162
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Actc1actin, alpha, cardiac muscle 10.924
Casq2calsequestrin 2 (cardiac muscle)0.918
Ckmcreatine kinase, muscle0.813
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.774
Myl9myosin, light chain 9, regulatory0.718
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.655
Hspa8heat shock protein 80.564
Ldb3LIM domain binding 30.553
Myl1myosin, light chain 10.533
Tpm3tropomyosin 3, gamma0.512
Scn5asodium channel, voltage-gated, type V, alpha subunit0.502
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.408
Acta2smooth muscle alpha-actin0.396
Acta1actin, alpha 1, skeletal muscle0.395
Pde5aphosphodiesterase 5A, cGMP-specific0.394
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.379
Myh7myosin, heavy chain 7, cardiac muscle, beta0.370
Fgf16fibroblast growth factor 160.366
Myl7myosin, light chain 7, regulatory0.363
Cav1caveolin 1, caveolae protein0.342
Actbactin, beta0.339
Mybpc2myosin binding protein C, fast-type0.327
Tnni3troponin I type 3 (cardiac)0.326
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.311
Csrp3cysteine and glycine-rich protein 30.310
Tpm1tropomyosin 1, alpha0.304
Lim2lens intrinsic membrane protein 20.297
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.259
Edn1endothelin 10.257
Emp1epithelial membrane protein 10.237
Actn2actinin alpha 20.234
Slc14a2solute carrier family 14 (urea transporter), member 20.222
Pygmphosphorylase, glycogen, muscle0.222
Arandrogen receptor0.208
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.204
Smpxsmall muscle protein, X-linked0.204
Myoz2myozenin 20.196
Rab20RAB20, member RAS oncogene family0.177
Tnnc2troponin C type 2 (fast)0.175
Sh3bgrSH3 domain binding glutamic acid-rich protein0.174
Cd8aCD8a molecule0.168
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.166
Mchr1melanin-concentrating hormone receptor 10.166
Foxi2forkhead box I20.163
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.159
Ckmt2creatine kinase, mitochondrial 2, sarcomeric0.152
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.152
Vom1r102vomeronasal 1 receptor 1020.146
Gzmkgranzyme K0.143
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 20.141
Ccr3chemokine (C-C motif) receptor 30.140
Nppanatriuretic peptide precursor A0.138
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.137
Myh2myosin, heavy chain 2, skeletal muscle, adult0.136
Fgf14fibroblast growth factor 140.135
Col10a1collagen, type X, alpha 10.134
Cnn1calponin 1, basic, smooth muscle0.133
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.133
Hspb7heat shock protein family, member 7 (cardiovascular)0.131
Notch3Notch homolog 3 (Drosophila)0.131
Tmem38atransmembrane protein 38a0.131
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.131
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.129
Ncr1natural cytotoxicity triggering receptor 10.126
Hspb2heat shock protein beta 20.125
Actg1actin, gamma 10.125
Nptxrneuronal pentraxin receptor0.124
Scn4bsodium channel, voltage-gated, type IV, beta0.122
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.117
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.115
Pgam2phosphoglycerate mutase 2 (muscle)0.114
Mc4rmelanocortin 4 receptor0.113
Lrrc4bleucine rich repeat containing 4B0.112
Prss1protease, serine, 1 (trypsin 1)0.112
Prkcgprotein kinase C, gamma0.110
Chp2calcineurin B homologous protein 20.109
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.108
Tgfb3transforming growth factor, beta 30.106
Hsph1heat shock 105/110 protein 10.105
Tbx19T-box 190.105
Myom2myomesin 20.099
Grik3glutamate receptor, ionotropic, kainate 30.098
Myh11myosin, heavy chain 11, smooth muscle0.097
Cox8bcytochrome c oxidase, subunit VIIIb0.095
Lmod2leiomodin 2 (cardiac)0.095
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.093
Gna15guanine nucleotide binding protein, alpha 150.091
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.089
Figfc-fos induced growth factor0.088
Fgf7fibroblast growth factor 70.088
Gja1gap junction protein, alpha 10.086
Adora1adenosine A1 receptor0.086
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.085
Tagln2transgelin 20.084
Gnrh1gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)0.083
Itgb1bp2integrin beta 1 binding protein 20.083
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism