The network for 'establishment of planar polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of planar polarity

Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.

NameDescriptionProbabilityFunc Analog Organism
ARHGAP1Rho GTPase activating protein 10.983
RHOAras homolog gene family, member A0.959
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.947
GDAguanine deaminase0.873
LRRK2leucine-rich repeat kinase 20.650
TPBGtrophoblast glycoprotein0.632
AFF4AF4/FMR2 family, member 40.558
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.543
AFF1AF4/FMR2 family, member 10.513
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.459
RIN1Ras and Rab interactor 10.415
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.413
APCadenomatous polyposis coli0.389
KRT5keratin 50.361
EGFRepidermal growth factor receptor0.356
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.336
CABLES1Cdk5 and Abl enzyme substrate 10.315
TSG101tumor susceptibility gene 1010.276
PRKCZprotein kinase C, zeta0.271
DVL3dishevelled, dsh homolog 3 (Drosophila)0.257
SEC23ASec23 homolog A (S. cerevisiae)0.253
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.229
JUPjunction plakoglobin0.220
MMP14matrix metallopeptidase 14 (membrane-inserted)0.211
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 110.206
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.200
FZD1frizzled homolog 1 (Drosophila)0.186
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.181
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.178
NCKAP1NCK-associated protein 10.171
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.168
SMAD2SMAD family member 20.162
SATB2SATB homeobox 20.160
AXIN1axin 10.151
WNT3Awingless-type MMTV integration site family, member 3A0.149
SOX4SRY (sex determining region Y)-box 40.149
SORBS3sorbin and SH3 domain containing 30.147
MYO6myosin VI0.139
CSNK1Ecasein kinase 1, epsilon0.135
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.129
DKK1dickkopf homolog 1 (Xenopus laevis)0.126
UBE2R2ubiquitin-conjugating enzyme E2R 20.124
JAM2junctional adhesion molecule 20.123
SHC1SHC (Src homology 2 domain containing) transforming protein 10.120
CEP164centrosomal protein 164kDa0.119
TTC30Btetratricopeptide repeat domain 30B0.119
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.116
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.115
PRKCIprotein kinase C, iota0.113
MED29mediator complex subunit 290.113
PLCB3phospholipase C, beta 3 (phosphatidylinositol-specific)0.113
WNT5Awingless-type MMTV integration site family, member 5A0.111
TYRP1tyrosinase-related protein 10.109
JUBjub, ajuba homolog (Xenopus laevis)0.107
LRP6low density lipoprotein receptor-related protein 60.107
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.105
CSNK1Dcasein kinase 1, delta0.105
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.103
CAV1caveolin 1, caveolae protein, 22kDa0.101
MED24mediator complex subunit 240.101
WT1Wilms tumor 10.100
MLLT6myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 60.100
BCL6B-cell CLL/lymphoma 60.098
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.098
CFL1cofilin 1 (non-muscle)0.096
TJP2tight junction protein 2 (zona occludens 2)0.096
CAPN1calpain 1, (mu/I) large subunit0.095
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.094
MAP2K6mitogen-activated protein kinase kinase 60.092
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.092
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.090
PTPRFprotein tyrosine phosphatase, receptor type, F0.089
RAC3ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)0.089
GSK3Bglycogen synthase kinase 3 beta0.088
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.087
SH3RF3SH3 domain containing ring finger 30.086
BAK1BCL2-antagonist/killer 10.085
APPBP2amyloid beta precursor protein (cytoplasmic tail) binding protein 20.084
TRIP6thyroid hormone receptor interactor 60.083
SMURF2SMAD specific E3 ubiquitin protein ligase 20.082
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.081
DVL1dishevelled, dsh homolog 1 (Drosophila)0.080
SMAD1SMAD family member 10.075
MAPTmicrotubule-associated protein tau0.075
ABI2abl-interactor 20.073
WASF1WAS protein family, member 10.072
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.071
CDH5cadherin 5, type 2 (vascular endothelium)0.069
HIPK3homeodomain interacting protein kinase 30.067
CDK6cyclin-dependent kinase 60.063
CCNT1cyclin T10.062
IQGAP1IQ motif containing GTPase activating protein 10.060
IFNAR2interferon (alpha, beta and omega) receptor 20.059
ERBB2IPerbb2 interacting protein0.059
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.059
TGFBR1transforming growth factor, beta receptor 10.057
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wnt11wingless-type MMTV integration site family, member 110.011
lama1laminin, alpha 10.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rac1CG2248 gene product from transcript CG2248-RA0.997
Rho1CG8416 gene product from transcript CG8416-RB0.984
stanstarry night0.981
aopanterior open0.944
Akt1CG4006 gene product from transcript CG4006-RA0.938
PknProtein kinase related to protein kinase N0.929
VangVan Gogh0.904
cindrCIN85 and CD2AP orthologue0.897
CG32556CG32556 gene product from transcript CG32556-RB0.863
CG42251CG42251 gene product from transcript CG42251-RC0.856
ovoCG6824 gene product from transcript CG6824-RE0.840
ShcSHC-adaptor protein0.765
Fas2Fasciclin 20.756
G-oalpha47AG protein oalpha 47A0.745
Mob2CG11711 gene product from transcript CG11711-RC0.736
argosCG4531 gene product from transcript CG4531-RA0.711
mwhmultiple wing hairs0.668
POSHPlenty of SH3s0.654
Traf4TNF-receptor-associated factor 40.543
CG31687CG31687 gene product from transcript CG31687-RA0.532
Wnt4Wnt oncogene analog 40.494
Cdc42CG12530 gene product from transcript CG12530-RA0.484
frcfringe connection0.478
PebProtein ejaculatory bulb0.457
toetwin of eyg0.434
trptransient receptor potential0.428
fz2frizzled 20.418
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.407
aPKCatypical protein kinase C0.363
edlETS-domain lacking0.334
towtarget of wingless0.315
JraJun-related antigen0.301
svpseven up0.294
HopHsp70/Hsp90 organizing protein homolog0.289
ParpPoly-(ADP-ribose) polymerase0.279
CG14168CG14168 gene product from transcript CG14168-RA0.276
yuCG3249 gene product from transcript CG3249-RA0.269
CG15730CG15730 gene product from transcript CG15730-RA0.266
EgfrEpidermal growth factor receptor0.265
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.255
Or22aOdorant receptor 22a0.239
MsiMale-specific insect derived growth factor0.236
CG14905CG14905 gene product from transcript CG14905-RA0.224
amosabsent MD neurons and olfactory sensilla0.216
S6kIIRPS6-protein kinase-II0.211
TolloCG6890 gene product from transcript CG6890-RA0.205
trioCG18214 gene product from transcript CG18214-RA0.201
kermitCG11546 gene product from transcript CG11546-RB0.198
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Dvl2dishevelled 2, dsh homolog (Drosophila)1.000
Ptk7PTK7 protein tyrosine kinase 70.998
Wnt3awingless-related MMTV integration site 3A0.995
Dvl3dishevelled 3, dsh homolog (Drosophila)0.995
Gli3GLI-Kruppel family member GLI30.982
Fgfr2fibroblast growth factor receptor 20.963
Wnt5awingless-related MMTV integration site 5A0.957
Dlg4discs, large homolog 4 (Drosophila)0.935
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.894
Shhsonic hedgehog0.884
Fzd1frizzled homolog 1 (Drosophila)0.883
Vangl1vang-like 1 (van gogh, Drosophila)0.878
Gli2GLI-Kruppel family member GLI20.850
Sfrp2secreted frizzled-related protein 20.828
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.801
Axin1axin 10.790
Ctnnb1catenin (cadherin associated protein), beta 10.764
Tbx3T-box 30.727
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.725
Dkk1dickkopf homolog 1 (Xenopus laevis)0.724
Pax2paired box gene 20.715
Foxc1forkhead box C10.682
Fgfr1fibroblast growth factor receptor 10.647
Smurf2SMAD specific E3 ubiquitin protein ligase 20.646
Gopcgolgi associated PDZ and coiled-coil motif containing0.621
Ror1receptor tyrosine kinase-like orphan receptor 10.595
Wnt4wingless-related MMTV integration site 40.519
Tbx2T-box 20.495
Pcsk5proprotein convertase subtilisin/kexin type 50.490
Sfrp1secreted frizzled-related protein 10.480
Retret proto-oncogene0.468
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.462
Gdnfglial cell line derived neurotrophic factor0.447
Ntf3neurotrophin 30.434
Lama5laminin, alpha 50.425
Gpc3glypican 30.423
Dll1delta-like 1 (Drosophila)0.417
Itga3integrin alpha 30.408
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.400
Ptenphosphatase and tensin homolog0.387
Fgfr3fibroblast growth factor receptor 30.364
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.353
Trp63transformation related protein 630.341
Fzd2frizzled homolog 2 (Drosophila)0.327
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.324
Tgfatransforming growth factor alpha0.311
Rnd3Rho family GTPase 30.297
Twist2twist homolog 2 (Drosophila)0.294
Hoxb6homeobox B60.292
Sall4sal-like 4 (Drosophila)0.286
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.281
Foxf1aforkhead box F1a0.278
Gli1GLI-Kruppel family member GLI10.270
Lhx1LIM homeobox protein 10.262
Sox11SRY-box containing gene 110.255
Smad3MAD homolog 3 (Drosophila)0.254
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.254
Grb10growth factor receptor bound protein 100.251
Efna2ephrin A20.248
Fzd7frizzled homolog 7 (Drosophila)0.244
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.230
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.228
Fjx1four jointed box 1 (Drosophila)0.218
Hoxd9homeobox D90.214
Celsr1cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)0.214
Lef1lymphoid enhancer binding factor 10.209
Efna4ephrin A40.203
Dact3dapper homolog 3, antagonist of beta-catenin (xenopus)0.203
Msx2homeobox, msh-like 20.201
Fgf8fibroblast growth factor 80.201
Sema5asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A0.198
Phox2apaired-like homeobox 2a0.198
Ptch1patched homolog 10.193
En1engrailed 10.187
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.184
Lrp6low density lipoprotein receptor-related protein 60.182
Fzd8frizzled homolog 8 (Drosophila)0.181
Zfp185zinc finger protein 1850.179
Myo6myosin VI0.178
Npr3natriuretic peptide receptor 30.177
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.174
Rarbretinoic acid receptor, beta0.173
Lrp2low density lipoprotein receptor-related protein 20.167
Nrcamneuron-glia-CAM-related cell adhesion molecule0.166
Irx2Iroquois related homeobox 2 (Drosophila)0.165
Esr2estrogen receptor 2 (beta)0.161
Egfrepidermal growth factor receptor0.161
Fgf18fibroblast growth factor 180.160
Tead2TEA domain family member 20.159
Wnt10bwingless related MMTV integration site 10b0.153
Arhgap1Rho GTPase activating protein 10.150
Smad6MAD homolog 6 (Drosophila)0.143
Hoxa5homeobox A50.142
Wnt7bwingless-related MMTV integration site 7B0.135
Plxna3plexin A30.134
Dlg1discs, large homolog 1 (Drosophila)0.131
Lrp5low density lipoprotein receptor-related protein 50.131
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ednrbendothelin receptor type B0.079
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.053
Baiap2BAI1-associated protein 20.040
Myl9myosin, light chain 9, regulatory0.039
Nfianuclear factor I/A0.038
Cnp2',3'-cyclic nucleotide 3' phosphodiesterase0.037
Fgfr1Fibroblast growth factor receptor 10.037
Id3inhibitor of DNA binding 30.037
Spon1spondin 1, extracellular matrix protein0.031
Lrfn2leucine rich repeat and fibronectin type III domain containing 20.031
Bocbiregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein0.030
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.030
Plagl1pleiomorphic adenoma gene-like 10.029
Lrpap1low density lipoprotein receptor-related protein associated protein 10.027
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.027
Arl5aADP-ribosylation factor-like 5A0.026
Gnsglucosamine (N-acetyl)-6-sulfatase0.024
Ssbp4single stranded DNA binding protein 40.024
Fndc3bfibronectin type III domain containing 3B0.024
Hspb7heat shock protein family, member 7 (cardiovascular)0.024
Paqr5progestin and adipoQ receptor family member V0.023
Sostdc1sclerostin domain containing 10.023
Il6stinterleukin 6 signal transducer0.023
Cbx2chromobox homolog 2 (Pc class homolog, Drosophila)0.023
Add3adducin 3 (gamma)0.023
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.022
C1rcomplement component 1, r subcomponent0.022
Marcksmyristoylated alanine rich protein kinase C substrate0.022
Gja1gap junction protein, alpha 10.022
Lgals7lectin, galactoside-binding, soluble, 70.022
Sox12SRY (sex determining region Y)-box 120.021
RGD1559896similar to RIKEN cDNA 2310022B050.021
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.021
Glud1glutamate dehydrogenase 10.021
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.021
Fam129bfamily with sequence similarity 129, member B0.020
Golph3golgi phosphoprotein 3 (coat-protein)0.020
Nr2f2nuclear receptor subfamily 2, group F, member 20.020
Plk5polo-like kinase 50.020
Mcammelanoma cell adhesion molecule0.020
Zfp278zinc finger protein 2780.020
Scamp2secretory carrier membrane protein 20.020
Fam46bfamily with sequence similarity 46, member B0.020
Bnc1basonuclin 10.019
Rgs19regulator of G-protein signaling 190.019
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.019
Fgf23fibroblast growth factor 230.019
Sorcs2sortilin-related VPS10 domain containing receptor 20.019
Bmp4bone morphogenetic protein 40.019
Lce1flate cornified envelope 1F0.018
Ppp4r1protein phosphatase 4, regulatory subunit 10.018
Slc15a2solute carrier family 15 (H+/peptide transporter), member 20.018
Arf6ADP-ribosylation factor 60.018
LOC688455hypothetical protein LOC6884550.018
Aifm3apoptosis-inducing factor, mitochondrion-associated 30.018
Prkag3protein kinase, AMP-activated, gamma 3 non-catalytic subunit0.018
Thrbthyroid hormone receptor beta0.018
Fzd1frizzled homolog 1 (Drosophila)0.018
M6prmannose-6-phosphate receptor, cation dependent0.018
Spata2Lspermatogenesis associated 2-like0.017
Eif2b2eukaryotic translation initiation factor 2B, subunit 2 beta0.017
Tpm1tropomyosin 1, alpha0.017
Sc65synaptonemal complex protein SC650.017
Cd9CD9 molecule0.017
Cd82Cd82 molecule0.017
Efemp1EGF-containing fibulin-like extracellular matrix protein 10.017
Tpm3tropomyosin 3, gamma0.017
Ube2q1ubiquitin-conjugating enzyme E2Q family member 10.017
Acvr1activin A receptor, type I0.017
Spry1sprouty homolog 1, antagonist of FGF signaling (Drosophila)0.017
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.017
Lmcd1LIM and cysteine-rich domains 10.017
Nrp1neuropilin 10.017
Nraddneurotrophin receptor associated death domain0.017
Galnt1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)0.016
Cugbp2CUG triplet repeat, RNA binding protein 20.016
Hoxb13homeo box B130.016
Slc39a14solute carrier family 39 (zinc transporter), member 140.016
Mapk1mitogen activated protein kinase 10.016
Gpc3glypican 30.016
Stxbp5syntaxin binding protein 5 (tomosyn)0.016
Tcfe2atranscription factor E2a0.016
Kcng3potassium voltage-gated channel, subfamily G, member 30.016
Arvcfarmadillo repeat gene deleted in velo-cardio-facial syndrome0.016
Jubjub, ajuba homolog (Xenopus laevis)0.016
Cxcl12chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)0.016
Matn3matrilin 30.016
Kbtbd10kelch repeat and BTB (POZ) domain containing 100.016
Ntf3neurotrophin 30.016
Tead2TEA domain family member 20.016
Krt7keratin 70.016
Cpa4carboxypeptidase A40.015
Ptk7PTK7 protein tyrosine kinase 70.015
Ddah1dimethylarginine dimethylaminohydrolase 10.015
Akirin2akirin 20.015
Nedd4neural precursor cell expressed, developmentally down-regulated 40.015
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism