The network for 'alpha amino acid catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

alpha amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid.

NameDescriptionProbabilityFunc Analog Organism
CASP9caspase 9, apoptosis-related cysteine peptidase0.978
NOSTRINnitric oxide synthase trafficker0.686
ALDOBaldolase B, fructose-bisphosphate0.612
GARSglycyl-tRNA synthetase0.544
YARStyrosyl-tRNA synthetase0.369
VAC14Vac14 homolog (S. cerevisiae)0.334
CASP3caspase 3, apoptosis-related cysteine peptidase0.299
PCK2phosphoenolpyruvate carboxykinase 2 (mitochondrial)0.180
GCDHglutaryl-CoA dehydrogenase0.174
XIAPX-linked inhibitor of apoptosis0.154
EIF4EBP1eukaryotic translation initiation factor 4E binding protein 10.128
PHGDHphosphoglycerate dehydrogenase0.127
DLG2discs, large homolog 2 (Drosophila)0.122
CALCAcalcitonin-related polypeptide alpha0.121
AARSalanyl-tRNA synthetase0.108
EPT1ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)0.088
TOM1L1target of myb1 (chicken)-like 10.082
MARSmethionyl-tRNA synthetase0.078
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.076
GLUD1glutamate dehydrogenase 10.075
GLUD2glutamate dehydrogenase 20.070
GLYATglycine-N-acyltransferase0.070
HADHhydroxyacyl-CoA dehydrogenase0.070
ACADSBacyl-CoA dehydrogenase, short/branched chain0.064
AIFM1apoptosis-inducing factor, mitochondrion-associated, 10.061
MAP2K5mitogen-activated protein kinase kinase 50.053
MASP2mannan-binding lectin serine peptidase 20.048
LONP1lon peptidase 1, mitochondrial0.046
DNAJA3DnaJ (Hsp40) homolog, subfamily A, member 30.037
TMEM97transmembrane protein 970.036
C21orf33chromosome 21 open reading frame 330.034
APEHN-acylaminoacyl-peptide hydrolase0.033
CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 10.032
NR1I3nuclear receptor subfamily 1, group I, member 30.032
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 20.031
SLC28A1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.030
PSAT1phosphoserine aminotransferase 10.030
SUPV3L1suppressor of var1, 3-like 1 (S. cerevisiae)0.029
CA5Acarbonic anhydrase VA, mitochondrial0.029
PAHphenylalanine hydroxylase0.028
ATF2activating transcription factor 20.027
PLGplasminogen0.027
BCKDHBbranched chain keto acid dehydrogenase E1, beta polypeptide0.025
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.024
GARTphosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase0.024
ALDH1L1aldehyde dehydrogenase 1 family, member L10.023
DLG1discs, large homolog 1 (Drosophila)0.023
PCYOX1prenylcysteine oxidase 10.022
PTDSS1phosphatidylserine synthase 10.022
SLC22A7solute carrier family 22 (organic anion transporter), member 70.022
SORDsorbitol dehydrogenase0.021
SARSseryl-tRNA synthetase0.020
ASNSasparagine synthetase (glutamine-hydrolyzing)0.020
PON1paraoxonase 10.020
VDAC1voltage-dependent anion channel 10.020
SARDHsarcosine dehydrogenase0.019
MLECmalectin0.019
AGXTalanine-glyoxylate aminotransferase0.019
KNG1kininogen 10.019
SLC25A15solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 150.019
TIMM44translocase of inner mitochondrial membrane 44 homolog (yeast)0.019
NOS1APnitric oxide synthase 1 (neuronal) adaptor protein0.019
IGFALSinsulin-like growth factor binding protein, acid labile subunit0.019
SLC37A4solute carrier family 37 (glucose-6-phosphate transporter), member 40.018
HNF4Ahepatocyte nuclear factor 4, alpha0.018
ATP5BATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.018
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.018
OGFOD12-oxoglutarate and iron-dependent oxygenase domain containing 10.018
HAAO3-hydroxyanthranilate 3,4-dioxygenase0.018
DHTKD1dehydrogenase E1 and transketolase domain containing 10.018
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.018
ECI2enoyl-CoA delta isomerase 20.017
HMGCL3-hydroxymethyl-3-methylglutaryl-CoA lyase0.017
HAX1HCLS1 associated protein X-10.017
MBL2mannose-binding lectin (protein C) 2, soluble0.017
HABP2hyaluronan binding protein 20.017
BDH13-hydroxybutyrate dehydrogenase, type 10.016
BHMTbetaine--homocysteine S-methyltransferase0.016
MAT1Amethionine adenosyltransferase I, alpha0.016
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.016
APOC2apolipoprotein C-II0.016
MCCC1methylcrotonoyl-CoA carboxylase 1 (alpha)0.016
PDHA1pyruvate dehydrogenase (lipoamide) alpha 10.016
PKLRpyruvate kinase, liver and RBC0.016
ALDOAaldolase A, fructose-bisphosphate0.016
SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.016
C8Acomplement component 8, alpha polypeptide0.015
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)0.015
ELAVL3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.015
APOA5apolipoprotein A-V0.015
ECHS1enoyl CoA hydratase, short chain, 1, mitochondrial0.015
CARScysteinyl-tRNA synthetase0.015
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)0.015
C17orf28chromosome 17 open reading frame 280.015
IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha0.014
G6PCglucose-6-phosphatase, catalytic subunit0.014
OSBPL8oxysterol binding protein-like 80.014
SLC16A1solute carrier family 16, member 1 (monocarboxylic acid transporter 1)0.014
CTHcystathionase (cystathionine gamma-lyase)0.014
MAP3K1mitogen-activated protein kinase kinase kinase 10.014
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
gpd-3Protein GPD-30.013
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Esr1estrogen receptor 1 (alpha)0.507
Mmp9matrix metallopeptidase 90.394
Il6interleukin 60.322
Slc12a1solute carrier family 12, member 10.280
Leprleptin receptor0.245
Il10interleukin 100.239
Ptgs2prostaglandin-endoperoxide synthase 20.232
Apoeapolipoprotein E0.213
Prlrprolactin receptor0.202
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.190
Lepleptin0.175
Vdrvitamin D receptor0.172
Mdh1malate dehydrogenase 1, NAD (soluble)0.149
Cav1caveolin 1, caveolae protein0.145
Plgplasminogen0.143
Mccc1methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)0.135
Vegfavascular endothelial growth factor A0.135
Ivdisovaleryl coenzyme A dehydrogenase0.125
Nos3nitric oxide synthase 3, endothelial cell0.122
Itgb1integrin beta 1 (fibronectin receptor beta)0.109
Catcatalase0.089
Gabrdgamma-aminobutyric acid (GABA) A receptor, subunit delta0.089
Pxmp2peroxisomal membrane protein 20.087
Acadsbacyl-Coenzyme A dehydrogenase, short/branched chain0.087
Srebf2sterol regulatory element binding factor 20.082
Npy2rneuropeptide Y receptor Y20.081
Ldlrlow density lipoprotein receptor0.078
Gcdhglutaryl-Coenzyme A dehydrogenase0.076
Ppargperoxisome proliferator activated receptor gamma0.073
Ak3adenylate kinase 30.066
Mccc2methylcrotonoyl-Coenzyme A carboxylase 2 (beta)0.064
Tdo2tryptophan 2,3-dioxygenase0.063
Acy1aminoacylase 10.063
Cbscystathionine beta-synthase0.063
Nos1nitric oxide synthase 1, neuronal0.058
Timp4tissue inhibitor of metalloproteinase 40.054
Mutmethylmalonyl-Coenzyme A mutase0.054
Adora2aadenosine A2a receptor0.053
Pipoxpipecolic acid oxidase0.050
Tstthiosulfate sulfurtransferase, mitochondrial0.047
Immtinner membrane protein, mitochondrial0.044
Gstz1glutathione transferase zeta 1 (maleylacetoacetate isomerase)0.044
Gstk1glutathione S-transferase kappa 10.044
Ccl2chemokine (C-C motif) ligand 20.043
Ndrg2N-myc downstream regulated gene 20.042
Adck3aarF domain containing kinase 30.040
Pcxpyruvate carboxylase0.039
Ftcdformiminotransferase cyclodeaminase0.039
Hibadh3-hydroxyisobutyrate dehydrogenase0.039
Slc4a5solute carrier family 4, sodium bicarbonate cotransporter, member 50.038
Adhfe1alcohol dehydrogenase, iron containing, 10.038
Bckdhabranched chain ketoacid dehydrogenase E1, alpha polypeptide0.038
Dbtdihydrolipoamide branched chain transacylase E20.037
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.035
Asgr2asialoglycoprotein receptor 20.035
Ccbl2cysteine conjugate-beta lyase 20.035
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.034
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.034
Cps1carbamoyl-phosphate synthetase 10.034
Upp2uridine phosphorylase 20.034
Tgfb1transforming growth factor, beta 10.033
Acadmacyl-Coenzyme A dehydrogenase, medium chain0.033
Ccr2chemokine (C-C motif) receptor 20.032
Plauplasminogen activator, urokinase0.032
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.032
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.032
Gnmtglycine N-methyltransferase0.032
Echdc3enoyl Coenzyme A hydratase domain containing 30.032
Prkg1protein kinase, cGMP-dependent, type I0.031
Ifnginterferon gamma0.031
Gpld1glycosylphosphatidylinositol specific phospholipase D10.031
Nos2nitric oxide synthase 2, inducible0.031
Bckdhbbranched chain ketoacid dehydrogenase E1, beta polypeptide0.031
Trpv1transient receptor potential cation channel, subfamily V, member 10.031
Smad3MAD homolog 3 (Drosophila)0.030
Gjb1gap junction protein, beta 10.030
Slc38a3solute carrier family 38, member 30.029
Aldh7a1aldehyde dehydrogenase family 7, member A10.028
Got1glutamate oxaloacetate transaminase 1, soluble0.028
Acad11acyl-Coenzyme A dehydrogenase family, member 110.028
Nr1h4nuclear receptor subfamily 1, group H, member 40.028
Csf1colony stimulating factor 1 (macrophage)0.027
Fgf1fibroblast growth factor 10.027
Aldh2aldehyde dehydrogenase 2, mitochondrial0.026
Acadsacyl-Coenzyme A dehydrogenase, short chain0.026
Qprtquinolinate phosphoribosyltransferase0.026
Sordsorbitol dehydrogenase0.026
Slc25a15solute carrier family 25 (mitochondrial carrier ornithine transporter), member 150.025
Foxg1forkhead box G10.025
Pccbpropionyl Coenzyme A carboxylase, beta polypeptide0.025
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.025
1300001I01RikRIKEN cDNA 1300001I01 gene0.024
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.024
Gstm1glutathione S-transferase, mu 10.024
FasFas (TNF receptor superfamily member 6)0.024
Ppt2palmitoyl-protein thioesterase 20.023
Mosc1MOCO sulphurase C-terminal domain containing 10.022
Hgdhomogentisate 1, 2-dioxygenase0.022
Tph2tryptophan hydroxylase 20.022
Bhmt2betaine-homocysteine methyltransferase 20.022
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.783
Glud1glutamate dehydrogenase 10.672
Adkadenosine kinase0.482
Gcdhglutaryl-Coenzyme A dehydrogenase0.414
Ass1argininosuccinate synthetase 10.238
Suclg2succinate-CoA ligase, GDP-forming, beta subunit0.214
Azgp1alpha-2-glycoprotein 1, zinc-binding0.183
Acy1aminoacylase 10.163
Dhtkd1dehydrogenase E1 and transketolase domain containing 10.161
Cbscystathionine beta synthase0.141
Bckdhabranched chain ketoacid dehydrogenase E1, alpha polypeptide0.140
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.121
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.107
Dpysdihydropyrimidinase0.106
Gnmtglycine N-methyltransferase0.104
Sardhsarcosine dehydrogenase0.102
Mat1amethionine adenosyltransferase I, alpha0.101
Haghhydroxyacyl glutathione hydrolase0.101
Mccc2methylcrotonoyl-Coenzyme A carboxylase 2 (beta)0.098
Aqp8aquaporin 80.096
Aldh9a1aldehyde dehydrogenase 9 family, member A10.084
Fbp1fructose-1,6-bisphosphatase 10.083
Agxt2alanine-glyoxylate aminotransferase 20.075
Tdo2tryptophan 2,3-dioxygenase0.074
Gstk1glutathione S-transferase kappa 10.072
Adhfe1alcohol dehydrogenase, iron containing, 10.072
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.072
Acsm2acyl-CoA synthetase medium-chain family member 20.071
Afmafamin0.070
Mipepmitochondrial intermediate peptidase0.069
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.066
Afpalpha-fetoprotein0.065
Pahphenylalanine hydroxylase0.065
Uoxurate oxidase0.065
Car5acarbonic anhydrase 5a, mitochondrial0.064
Aadataminoadipate aminotransferase0.060
Gys2glycogen synthase 20.059
Slc17a1solute carrier family 17 (sodium phosphate), member 10.055
Dcxrdicarbonyl L-xylulose reductase0.055
Ube4aubiquitination factor E4A (UFD2 homolog, yeast)0.053
Nntnicotinamide nucleotide transhydrogenase0.053
Dlstdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)0.053
Aldh7a1aldehyde dehydrogenase 7 family, member A10.052
Cps1carbamoyl-phosphate synthetase 10.051
Aldh1l1aldehyde dehydrogenase 1 family, member L10.050
Vdac1voltage-dependent anion channel 10.050
Tstthiosulfate sulfurtransferase0.050
Slc7a1solute carrier family 7 (cationic amino acid transporter, y+ system), member 10.050
Scp2sterol carrier protein 20.050
Slco2a1solute carrier organic anion transporter family, member 2a10.049
Upb1ureidopropionase, beta0.049
Nipsnap1nipsnap homolog 1 (C. elegans)0.048
Pfkmphosphofructokinase, muscle0.047
Ndrg2N-myc downstream regulated gene 20.047
Bckdhbbranched chain keto acid dehydrogenase E1, beta polypeptide0.046
Pck1phosphoenolpyruvate carboxykinase 1 (soluble)0.046
Fgafibrinogen alpha chain0.046
Mtmr7myotubularin related protein 70.045
Pik3c2gphosphoinositide-3-kinase, class 2, gamma polypeptide0.044
RGD1564865similar to 20-alpha-hydroxysteroid dehydrogenase0.044
Hao2hydroxyacid oxidase 2 (long chain)0.044
Gulogulonolactone (L-) oxidase0.044
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.044
Fahfumarylacetoacetate hydrolase0.043
Aldh4a1aldehyde dehydrogenase 4 family, member A10.043
Ptgfrprostaglandin F receptor0.043
Gstm7glutathione S-transferase, mu 70.041
Gcgroup specific component0.041
Abhd14babhydrolase domain containing 14b0.040
Dhfrdihydrofolate reductase0.040
Aldobaldolase B, fructose-bisphosphate0.040
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.039
Hrsp12heat-responsive protein 120.039
Aldh2aldehyde dehydrogenase 2 family (mitochondrial)0.039
Haao3-hydroxyanthranilate 3,4-dioxygenase0.037
Dnase1l3deoxyribonuclease 1-like 30.037
Senp2Sumo1/sentrin/SMT3 specific peptidase 20.037
Fgd4FYVE, RhoGEF and PH domain containing 40.036
Nfianuclear factor I/A0.036
Ttc36tetratricopeptide repeat domain 360.036
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.036
Hspa9heat shock protein 90.035
Olr1654olfactory receptor 16540.035
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.035
Acmsdaminocarboxymuconate semialdehyde decarboxylase0.035
Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.035
Rbp4retinol binding protein 4, plasma0.034
Ahcyadenosylhomocysteinase0.033
Aadacarylacetamide deacetylase (esterase)0.032
Gabrb2gamma-aminobutyric acid (GABA) A receptor, beta 20.032
Qdprquinoid dihydropteridine reductase0.032
Cdo1cysteine dioxygenase, type I0.032
Cmblcarboxymethylenebutenolidase homolog (Pseudomonas)0.031
Tfrctransferrin receptor0.031
Khkketohexokinase0.031
Isoc1isochorismatase domain containing 10.031
Nox4NADPH oxidase 40.030
Scn2bsodium channel, voltage-gated, type II, beta0.030
Rc3h2ring finger and CCCH-type zinc finger domains 20.030
Klkb1kallikrein B, plasma 10.030
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ASP3-4Asp3-4p0.672
ASP3-2Asp3-2p0.511
ASP3-3Asp3-3p0.510
ASP3-1Asp3-1p0.404
PDC5Pdc5p0.325
GCV1Gcv1p0.280
ARG81Arg81p0.256
ARO9Aro9p0.223
BAT2Bat2p0.206
HSP60Hsp60p0.154
UGA1Uga1p0.142
SHM2Shm2p0.123
YDL157Chypothetical protein0.107
PUT1Put1p0.105
LSC2Lsc2p0.095
TRM5Trm5p0.081
PYC1Pyc1p0.076
SCC4Scc4p0.075
GCV2Gcv2p0.074
YBR238Chypothetical protein0.063
CAR2Car2p0.063
GCV3Gcv3p0.058
YHB1Yhb1p0.057
ERG13Erg13p0.055
GDH1Gdh1p0.048
MET3Met3p0.048
FMO1Fmo1p0.046
CAR1Car1p0.045
ATO3Ato3p0.043
THR4Thr4p0.042
SUL1Sul1p0.041
ATF2Atf2p0.041
BIO2Bio2p0.040
MET6Met6p0.039
UTR2Utr2p0.039
ILV3Ilv3p0.039
ARO2Aro2p0.038
HEM13Hem13p0.038
BAT1Bat1p0.036
LEU2Leu2p0.036
LEU9Leu9p0.036
YKL023Whypothetical protein0.035
AVT7Avt7p0.034
ERG1Erg1p0.034
CPS1Cps1p0.034
PHO11Pho11p0.034
DUR1,2Dur1,2p0.034
HIP1Hip1p0.032
BDH1Bdh1p0.032
PEP1Pep1p0.032
YCT1Yct1p0.032
FBA1Fba1p0.031
VMA13Vma13p0.031
YLR264C-Ahypothetical protein0.030
ARG3Arg3p0.029
MVD1Mvd1p0.029
MET28Met28p0.029
ZWF1Zwf1p0.029
SPE3Spe3p0.028
HXT3Hxt3p0.027
ADE17Ade17p0.027
GND1Gnd1p0.027
PUT2Put2p0.026
YLR162Whypothetical protein0.026
SRD1Srd1p0.026
YDL086Whypothetical protein0.026
CUP1-1Cup1-1p0.025
PTI1Pti1p0.025
AUA1Aua1p0.025
FIT2Fit2p0.025
YJL218Whypothetical protein0.025
TAF5Taf5p0.025
PMA2Pma2p0.025
ARG8Arg8p0.025
DDR48Ddr48p0.024
YOL038C-Ahypothetical protein0.024
PLB1Plb1p0.024
YOL014Whypothetical protein0.024
BNA2Bna2p0.023
MDS3Mds3p0.023
ADE5,7Ade5,7p0.023
ADH2Adh2p0.023
PCL9Pcl9p0.023
TRL1Trl1p0.023
REE1Ree1p0.023
LAP4Lap4p0.023
MER1Mer1p0.023
PBA1Pba1p0.022
ARP10Arp10p0.022
NTA1Nta1p0.022
XDJ1Xdj1p0.022
PDC1Pdc1p0.021
URA8Ura8p0.021
YDR034W-Bhypothetical protein0.021
URA3Ura3p0.021
MET12Met12p0.021
YMR086Whypothetical protein0.021
YPR157Whypothetical protein0.021
ZPS1Zps1p0.021
LAT1Lat1p0.020