The network for 'negative regulation of smooth muscle cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of smooth muscle cell proliferation

Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.

NameDescriptionProbabilityFunc Analog Organism
C1QAcomplement component 1, q subcomponent, A chain0.993
ESR1estrogen receptor 10.984
NCOR2nuclear receptor corepressor 20.949
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.765
C1QCcomplement component 1, q subcomponent, C chain0.707
NOSTRINnitric oxide synthase trafficker0.562
NCOA1nuclear receptor coactivator 10.427
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.336
PTGIRprostaglandin I2 (prostacyclin) receptor (IP)0.233
TAX1BP1Tax1 (human T-cell leukemia virus type I) binding protein 10.230
C1QBcomplement component 1, q subcomponent, B chain0.205
TBXA2Rthromboxane A2 receptor0.189
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.182
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.174
KLF6Kruppel-like factor 60.173
IL23Ainterleukin 23, alpha subunit p190.137
HNF4Ahepatocyte nuclear factor 4, alpha0.127
PPP5Cprotein phosphatase 5, catalytic subunit0.118
RXRAretinoid X receptor, alpha0.070
IGF2insulin-like growth factor 2 (somatomedin A)0.067
RARAretinoic acid receptor, alpha0.067
HRhairless homolog (mouse)0.065
INO80BINO80 complex subunit B0.054
ATF5activating transcription factor 50.047
CTBP1C-terminal binding protein 10.047
JUNjun proto-oncogene0.045
DCNdecorin0.041
CHD9chromodomain helicase DNA binding protein 90.041
IL12Ainterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)0.041
PRKCAprotein kinase C, alpha0.040
PARVAparvin, alpha0.040
MED25mediator complex subunit 250.036
ESRRGestrogen-related receptor gamma0.032
IGF1insulin-like growth factor 1 (somatomedin C)0.032
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.031
MYLK2myosin light chain kinase 20.029
TNIP2TNFAIP3 interacting protein 20.029
A2Malpha-2-macroglobulin0.028
KLF5Kruppel-like factor 5 (intestinal)0.027
NCOA2nuclear receptor coactivator 20.027
JUNBjun B proto-oncogene0.027
OMDosteomodulin0.026
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.026
TRAF6TNF receptor-associated factor 60.025
IRAK2interleukin-1 receptor-associated kinase 20.025
ADAM12ADAM metallopeptidase domain 120.024
TFtransferrin0.023
PLCG1phospholipase C, gamma 10.023
IRS1insulin receptor substrate 10.022
MDM2Mdm2 p53 binding protein homolog (mouse)0.022
APOEapolipoprotein E0.021
PGRprogesterone receptor0.021
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.020
AP2M1adaptor-related protein complex 2, mu 1 subunit0.020
EP300E1A binding protein p3000.020
CALM1calmodulin 1 (phosphorylase kinase, delta)0.019
SP1Sp1 transcription factor0.019
CXCL12chemokine (C-X-C motif) ligand 120.018
DUSP5dual specificity phosphatase 50.017
COL1A1collagen, type I, alpha 10.016
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.016
MARCOmacrophage receptor with collagenous structure0.016
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.016
ARL4CADP-ribosylation factor-like 4C0.016
DUSP1dual specificity phosphatase 10.016
KLF4Kruppel-like factor 4 (gut)0.016
PPARGperoxisome proliferator-activated receptor gamma0.016
MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)0.015
MAP2K3mitogen-activated protein kinase kinase 30.015
GHRLghrelin/obestatin prepropeptide0.015
FTH1ferritin, heavy polypeptide 10.015
TDGF1teratocarcinoma-derived growth factor 10.014
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.014
RNH1ribonuclease/angiogenin inhibitor 10.014
AP2B1adaptor-related protein complex 2, beta 1 subunit0.014
PXNpaxillin0.014
CD34CD34 molecule0.014
GPX3glutathione peroxidase 3 (plasma)0.013
WISP2WNT1 inducible signaling pathway protein 20.013
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.013
GRB10growth factor receptor-bound protein 100.013
APODapolipoprotein D0.012
ICAM1intercellular adhesion molecule 10.012
STAT5Asignal transducer and activator of transcription 5A0.012
STAB1stabilin 10.012
ANXA1annexin A10.012
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.012
DUSP23dual specificity phosphatase 230.012
NCK2NCK adaptor protein 20.012
HECTD1HECT domain containing 10.011
EGR1early growth response 10.011
HIPK2homeodomain interacting protein kinase 20.011
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.011
IGFBP5insulin-like growth factor binding protein 50.011
ATF3activating transcription factor 30.011
PELP1proline, glutamate and leucine rich protein 10.011
DDR2discoidin domain receptor tyrosine kinase 20.011
PARVBparvin, beta0.010
PDZD3PDZ domain containing 30.010
NCOR1nuclear receptor corepressor 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.513
Cav2caveolin 20.219
LOC100362824caveolin 2-like0.055
Sdprserum deprivation response0.042
Agxt2alanine-glyoxylate aminotransferase 20.035
Emp1epithelial membrane protein 10.035
Litaflipopolysaccharide-induced TNF factor0.030
Ucnurocortin0.028
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.027
Omdosteomodulin0.027
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.026
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.025
Prlhrprolactin releasing hormone receptor0.024
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.023
Prl6a1prolactin family 6, subfamily a, member 10.022
Notch3Notch homolog 3 (Drosophila)0.021
RT1-BaRT1 class II, locus Ba0.021
Slc22a6solute carrier family 22 (organic anion transporter), member 60.021
Tgfbr3transforming growth factor, beta receptor III0.021
Gpr1G protein-coupled receptor 10.021
Timp3TIMP metallopeptidase inhibitor 30.021
Cysscystatin S0.021
Vom2r32vomeronasal 2 receptor, 320.020
Flt1FMS-related tyrosine kinase 10.020
Cntfrciliary neurotrophic factor receptor0.020
Hoxc4homeo box C40.019
Rararetinoic acid receptor, alpha0.019
Ptprhprotein tyrosine phosphatase, receptor type, H0.019
Atxn3ataxin 30.018
Ehd2EH-domain containing 20.018
Slco2a1solute carrier organic anion transporter family, member 2a10.018
Nedd4neural precursor cell expressed, developmentally down-regulated 40.018
Ptbp1polypyrimidine tract binding protein 10.018
Ompolfactory marker protein0.018
KitlgKIT ligand0.018
Map3k3mitogen activated protein kinase kinase kinase 30.018
MrgprfMAS-related GPR, member F0.017
Lamc1laminin, gamma 10.017
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.017
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.017
Acot12acyl-CoA thioesterase 120.017
Gucy2eguanylate cyclase 2E0.017
Dlstdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)0.017
Hrh2histamine receptor H 20.017
Nf1neurofibromin 10.016
Umoduromodulin0.016
Lamb2laminin, beta 20.016
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.016
RGD1565927similar to 4631422O05Rik protein0.016
Cd40lgCD40 ligand0.015
Ctsjcathepsin J0.015
JunJun oncogene0.015
Aspnasporin0.015
Smad1SMAD family member 10.015
Dusp1dual specificity phosphatase 10.015
Kcnj15potassium inwardly-rectifying channel, subfamily J, member 150.015
Bcl2B-cell CLL/lymphoma 20.015
Bcl2l1Bcl2-like 10.014
Tpothyroid peroxidase0.014
Pitx3paired-like homeodomain 30.014
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.014
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.014
PawrPRKC, apoptosis, WT1, regulator0.014
Cdk4cyclin-dependent kinase 40.014
Plinperilipin0.014
Prdm2PR domain containing 2, with ZNF domain0.014
Il1ainterleukin 1 alpha0.014
Irs1insulin receptor substrate 10.014
Ednraendothelin receptor type A0.014
FaslgFas ligand (TNF superfamily, member 6)0.014
Mef2dmyocyte enhancer factor 2D0.014
Utrnutrophin0.014
Gja6gap junction protein, alpha 60.014
Pklrpyruvate kinase, liver and RBC0.014
Mtus1mitochondrial tumor suppressor 10.013
Adra2badrenergic, alpha-2B-, receptor0.013
Hrh3histamine receptor H30.013
Myl7myosin, light chain 7, regulatory0.013
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.013
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.013
Agtr1aangiotensin II receptor, type 1a0.013
Impg2interphotoreceptor matrix proteoglycan 20.013
Atp2a3ATPase, Ca++ transporting, ubiquitous0.013
Hand2heart and neural crest derivatives expressed 20.013
Gpr116G protein-coupled receptor 1160.013
Synposynaptopodin0.013
Itpr2inositol 1,4,5-triphosphate receptor, type 20.013
Pecam1platelet/endothelial cell adhesion molecule 10.013
Hspb2heat shock protein beta 20.013
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive0.013
Tgfbr2transforming growth factor, beta receptor II0.012
Cntn5contactin 50.012
Nficnuclear factor I/C0.012
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.012
Bmpr1abone morphogenetic protein receptor, type IA0.012
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.012
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.012
Chrnecholinergic receptor, nicotinic, epsilon0.012
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.012
Myo1bmyosin Ib0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism