The network for 'regulation of cell cycle g1 s phase transition' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cell cycle g1 s phase transition

Any process that modulates the frequency, rate or extent of cell cycle G1/S phase transition.

NameDescriptionProbabilityFunc Analog Organism
MDM2Mdm2 p53 binding protein homolog (mouse)0.999
RB1retinoblastoma 10.998
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.976
CASP8caspase 8, apoptosis-related cysteine peptidase0.972
CASP3caspase 3, apoptosis-related cysteine peptidase0.963
RBL2retinoblastoma-like 2 (p130)0.960
E2F1E2F transcription factor 10.953
CDK2cyclin-dependent kinase 20.917
JAG1jagged 10.899
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.784
XIAPX-linked inhibitor of apoptosis0.759
EGFRepidermal growth factor receptor0.751
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.615
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.555
TFDP1transcription factor Dp-10.523
CCND1cyclin D10.520
TP53tumor protein p530.498
ACTN2actinin, alpha 20.491
FASFas (TNF receptor superfamily, member 6)0.479
ARandrogen receptor0.468
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.449
TFDP2transcription factor Dp-2 (E2F dimerization partner 2)0.447
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.445
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.407
HBP1HMG-box transcription factor 10.402
CASP2caspase 2, apoptosis-related cysteine peptidase0.394
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.385
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.384
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.379
SOS1son of sevenless homolog 1 (Drosophila)0.327
CCND3cyclin D30.316
UHRF2ubiquitin-like with PHD and ring finger domains 20.287
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.279
HEXIM1hexamethylene bis-acetamide inducible 10.278
CDK6cyclin-dependent kinase 60.271
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.264
SKP2S-phase kinase-associated protein 2 (p45)0.258
RBL1retinoblastoma-like 1 (p107)0.244
EP300E1A binding protein p3000.241
HNRNPUL1heterogeneous nuclear ribonucleoprotein U-like 10.240
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.238
APAF1apoptotic peptidase activating factor 10.232
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.221
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.214
CNOT1CCR4-NOT transcription complex, subunit 10.208
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.206
SMC1Astructural maintenance of chromosomes 1A0.198
CNOT8CCR4-NOT transcription complex, subunit 80.196
INADLInaD-like (Drosophila)0.195
SMAD2SMAD family member 20.192
SMAD3SMAD family member 30.191
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.185
NCOA1nuclear receptor coactivator 10.181
CHEK2CHK2 checkpoint homolog (S. pombe)0.179
RBBP8retinoblastoma binding protein 80.177
FADDFas (TNFRSF6)-associated via death domain0.173
DDB1damage-specific DNA binding protein 1, 127kDa0.170
PLCG1phospholipase C, gamma 10.165
DDB2damage-specific DNA binding protein 2, 48kDa0.161
PDE4DIPphosphodiesterase 4D interacting protein0.160
IER3immediate early response 30.158
NAP1L1nucleosome assembly protein 1-like 10.157
CSNK1A1casein kinase 1, alpha 10.157
CHEK1CHK1 checkpoint homolog (S. pombe)0.152
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.142
IRAK2interleukin-1 receptor-associated kinase 20.139
POU3F2POU class 3 homeobox 20.138
CAV1caveolin 1, caveolae protein, 22kDa0.138
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.138
SMAD7SMAD family member 70.137
NCOR1nuclear receptor corepressor 10.136
NR2E3nuclear receptor subfamily 2, group E, member 30.133
YAP1Yes-associated protein 10.126
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.126
CFLARCASP8 and FADD-like apoptosis regulator0.122
E2F3E2F transcription factor 30.122
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.121
ESR1estrogen receptor 10.116
CTR9Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.116
UBE3Aubiquitin protein ligase E3A0.115
MAML1mastermind-like 1 (Drosophila)0.115
CDK9cyclin-dependent kinase 90.113
PTCH1patched 10.111
GAB1GRB2-associated binding protein 10.110
TAL1T-cell acute lymphocytic leukemia 10.109
RBBP4retinoblastoma binding protein 40.109
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.107
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.106
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.105
PAFAH1B3platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)0.104
MCM7minichromosome maintenance complex component 70.102
NXF1nuclear RNA export factor 10.101
BCL2B-cell CLL/lymphoma 20.101
PKD1polycystic kidney disease 1 (autosomal dominant)0.095
CDC25Acell division cycle 25 homolog A (S. pombe)0.095
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.094
SPENspen homolog, transcriptional regulator (Drosophila)0.092
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.090
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.089
BTRCbeta-transducin repeat containing0.089
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
npp-1Protein NPP-10.012
xpo-1Protein XPO-10.011
pha-4Protein PHA-40.010
elt-6Protein ELT-60.010
flh-1Protein FLH-10.010
lig-1Protein LIG-10.010
elc-1Protein ELC-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.991
RbfRetinoblastoma-family protein0.969
DpDP transcription factor0.750
phlpole hole0.702
Akt1CG4006 gene product from transcript CG4006-RA0.437
imdimmune deficiency0.411
Myd88CG2078 gene product from transcript CG2078-RA0.337
CycACyclin A0.324
p53CG33336 gene product from transcript CG33336-RB0.262
CG3508CG3508 gene product from transcript CG3508-RB0.240
CycECyclin E0.210
e(y)3enhancer of yellow 30.207
Cdk4Cyclin-dependent kinase 40.197
rapretina aberrant in pattern0.185
CycDCyclin D0.163
Caf1Chromatin assembly factor 1 subunit0.147
Su(z)12CG8013 gene product from transcript CG8013-RA0.140
cdc2CG5363 gene product from transcript CG5363-RA0.138
CG15220CG15220 gene product from transcript CG15220-RA0.125
RecQ4CG7487 gene product from transcript CG7487-RA0.119
CtBPC-terminal Binding Protein0.116
cicubitus interruptus0.113
polybromoCG11375 gene product from transcript CG11375-RA0.112
MadMothers against dpp0.107
Mcm2Minichromosome maintenance 20.105
CG9772CG9772 gene product from transcript CG9772-RB0.105
Pabp2CG2163 gene product from transcript CG2163-RA0.089
SpxSpliceosomal protein on the X0.085
myoglianinCG1838 gene product from transcript CG1838-RD0.084
CycBCyclin B0.080
TER94CG2331 gene product from transcript CG2331-RA0.080
CblCG7037 gene product from transcript CG7037-RB0.079
RpL39Ribosomal protein L390.077
CragCalmodulin-binding protein related to a Rab3 GDP/GTP exchange protein0.076
GATAdCG5034 gene product from transcript CG5034-RA0.071
RASSF8CG5053 gene product from transcript CG5053-RA0.070
EcREcdysone receptor0.068
Gnf1Germ line transcription factor 10.067
SAKSak kinase0.067
mus205mutagen-sensitive 2050.066
Rac1CG2248 gene product from transcript CG2248-RA0.066
CG4973CG4973 gene product from transcript CG4973-RA0.062
Trf2TATA box binding protein-related factor 20.061
His2AvHistone H2A variant0.061
CG11266CG11266 gene product from transcript CG11266-RD0.059
jubAjuba LIM protein0.054
Atg1Autophagy-specific gene 10.054
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.054
Tao-1CG14217 gene product from transcript CG14217-RF0.054
Hsp27Heat shock protein 270.050
Mes2CG11100 gene product from transcript CG11100-RB0.049
MED26Mediator complex subunit 260.047
Pi3K92ECG4141 gene product from transcript CG4141-RB0.045
CG8486CG8486 gene product from transcript CG8486-RE0.045
Gap1GTPase-activating protein 10.043
CG9601CG9601 gene product from transcript CG9601-RA0.043
ftz-f1ftz transcription factor 10.043
Smg1CG32743 gene product from transcript CG32743-RA0.042
CG1910CG1910 gene product from transcript CG1910-RB0.041
MED19Mediator complex subunit 190.041
Psf3CG2222 gene product from transcript CG2222-RA0.041
Bj1Bj1 protein0.039
PEKpancreatic eIF-2alpha kinase0.038
Caf1-105CG12892 gene product from transcript CG12892-RA0.038
RfC3Replication factor C subunit 30.037
asf1anti-silencing factor 10.036
TH1CG9984 gene product from transcript CG9984-RA0.035
Nf-YANuclear factor Y-box A0.035
CG13043CG13043 gene product from transcript CG13043-RA0.035
gbbglass bottom boat0.034
spn-Aspindle A0.034
CG13373CG13373 gene product from transcript CG13373-RB0.034
Slip1CG1783 gene product from transcript CG1783-RA0.033
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Rb1retinoblastoma 10.995
Mdm2transformed mouse 3T3 cell double minute 20.893
Ptenphosphatase and tensin homolog0.867
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.792
Notch1Notch gene homolog 1 (Drosophila)0.764
Ccnd1cyclin D10.547
Arid1bAT rich interactive domain 1B (SWI-like)0.543
Cdkn1bcyclin-dependent kinase inhibitor 1B0.524
BaxBCL2-associated X protein0.430
Suz12suppressor of zeste 12 homolog (Drosophila)0.405
Cdk6cyclin-dependent kinase 60.402
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.395
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.383
Brca1breast cancer 10.372
Cdk4cyclin-dependent kinase 40.363
Cdk2cyclin-dependent kinase 20.349
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.322
Psen1presenilin 10.319
Itgb1integrin beta 1 (fibronectin receptor beta)0.315
Nf1neurofibromatosis 10.314
E2f1E2F transcription factor 10.295
Ctnnb1catenin (cadherin associated protein), beta 10.287
Mdm4transformed mouse 3T3 cell double minute 40.265
Bcl2B-cell leukemia/lymphoma 20.245
Msh2mutS homolog 2 (E. coli)0.213
Ccnd2cyclin D20.205
Ccne1cyclin E10.199
Cd80CD80 antigen0.187
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.173
Jarid2jumonji, AT rich interactive domain 20.135
Tgfb2transforming growth factor, beta 20.134
Smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.133
Cdkn2acyclin-dependent kinase inhibitor 2A0.132
Mtf2metal response element binding transcription factor 20.126
Grb2growth factor receptor bound protein 20.125
Map3k7mitogen-activated protein kinase kinase kinase 70.123
Fgfr2fibroblast growth factor receptor 20.119
Pkd1polycystic kidney disease 1 homolog0.111
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.106
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.106
Vegfavascular endothelial growth factor A0.104
Hdac2histone deacetylase 20.101
Ptpn11protein tyrosine phosphatase, non-receptor type 110.100
Hif1ahypoxia inducible factor 1, alpha subunit0.098
Hdac1histone deacetylase 10.094
Lrrc58leucine rich repeat containing 580.092
Ptpn13protein tyrosine phosphatase, non-receptor type 130.089
CblCasitas B-lineage lymphoma0.087
Stk11serine/threonine kinase 110.087
Rbl2retinoblastoma-like 20.085
Arid1aAT rich interactive domain 1A (SWI-like)0.082
DaxxFas death domain-associated protein0.080
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.080
Gtse1G two S phase expressed protein 10.079
S100a10S100 calcium binding protein A10 (calpactin)0.078
BrafBraf transforming gene0.075
Ezh2enhancer of zeste homolog 2 (Drosophila)0.073
Mybl2myeloblastosis oncogene-like 20.073
Fgfr1fibroblast growth factor receptor 10.071
Ikzf1IKAROS family zinc finger 10.064
Shhsonic hedgehog0.064
Dok1docking protein 10.064
Stk38serine/threonine kinase 380.063
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.062
Lgals3lectin, galactose binding, soluble 30.062
Rbl1retinoblastoma-like 1 (p107)0.062
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.060
Ptch1patched homolog 10.059
Thbs1thrombospondin 10.057
Dkc1dyskeratosis congenita 1, dyskerin homolog (human)0.056
Ighimmunoglobulin heavy chain complex0.055
Bak1BCL2-antagonist/killer 10.053
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.053
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.053
Smn1survival motor neuron 10.052
Plcb3phospholipase C, beta 30.051
Atmataxia telangiectasia mutated homolog (human)0.051
Gli3GLI-Kruppel family member GLI30.051
Dll1delta-like 1 (Drosophila)0.051
Vav1vav 1 oncogene0.050
Vhlvon Hippel-Lindau tumor suppressor0.049
Aebp2AE binding protein 20.047
Numa1nuclear mitotic apparatus protein 10.047
Hes1hairy and enhancer of split 1 (Drosophila)0.047
S100a11S100 calcium binding protein A11 (calgizzarin)0.044
Kitkit oncogene0.043
Apcadenomatosis polyposis coli0.042
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.041
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.041
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.041
Gli2GLI-Kruppel family member GLI20.040
Hprthypoxanthine guanine phosphoribosyl transferase0.040
Pkdccprotein kinase domain containing, cytoplasmic0.039
Notch2Notch gene homolog 2 (Drosophila)0.038
Chd7chromodomain helicase DNA binding protein 70.038
Plk1polo-like kinase 1 (Drosophila)0.038
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Arhgef1Rho guanine nucleotide exchange factor (GEF) 10.088
Cdk2cyclin dependent kinase 20.071
Slfn2schlafen 20.056
Phaxphosphorylated adaptor for RNA export0.048
Cdk4cyclin-dependent kinase 40.048
Tcfe2atranscription factor E2a0.047
Supt16hsuppressor of Ty 16 homolog (S. cerevisiae)0.044
Mbtps1membrane-bound transcription factor peptidase, site 10.043
Haao3-hydroxyanthranilate 3,4-dioxygenase0.040
Il18interleukin 180.040
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.036
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.030
Glra3glycine receptor, alpha 30.029
Rararetinoic acid receptor, alpha0.029
Fgf14fibroblast growth factor 140.026
Ssrp1structure specific recognition protein 10.023
Shank1SH3 and multiple ankyrin repeat domains 10.023
Eif4a2eukaryotic translation initiation factor 4A, isoform 20.023
Parp1poly (ADP-ribose) polymerase 10.022
Ptprcprotein tyrosine phosphatase, receptor type, C0.021
Sfrs1splicing factor, arginine/serine-rich 10.020
Ispdisoprenoid synthase domain containing0.020
Cd37CD37 molecule0.019
Rgl2ral guanine nucleotide dissociation stimulator-like 20.019
Dlgap1discs, large (Drosophila) homolog-associated protein 10.018
Phf12PHD finger protein 120.018
Pcmtd2protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 20.018
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.018
Eif4heukaryotic translation initiation factor 4H0.017
Lmnb1lamin B10.017
Odz2odz, odd Oz/ten-m homolog 2 (Drosophila)0.016
Tcf4transcription factor 40.016
Gjd2gap junction protein, delta 20.015
Pcnxl3pecanex-like 3 (Drosophila)0.015
Tp53tumor protein p530.014
Rin1Ras and Rab interactor 10.014
Pax8paired box 80.014
Rfc1replication factor C (activator 1) 10.013
Ubtfupstream binding transcription factor, RNA polymerase I0.013
Whsc2Wolf-Hirschhorn syndrome candidate 2 (human)0.013
Gata4GATA binding protein 40.013
Pcafp300/CBP-associated factor0.013
CamkvCaM kinase-like vesicle-associated0.013
Cbfbcore-binding factor, beta subunit0.013
Gtf2igeneral transcription factor II I0.013
Gcs1glucosidase 10.013
Syt6synaptotagmin VI0.012
Dgkbdiacylglycerol kinase, beta0.012
Itpr1inositol 1,4,5-triphosphate receptor, type 10.012
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.012
March8membrane-associated ring finger (C3HC4) 80.012
Tead3TEA domain family member 30.012
Cnot6CCR4-NOT transcription complex, subunit 60.012
Opcmlopioid binding protein/cell adhesion molecule-like0.012
Cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.012
Cntn3contactin 3 (plasmacytoma associated)0.012
Tacr2tachykinin receptor 20.011
Apba3amyloid beta (A4) precursor protein-binding, family A, member 30.011
Tnks2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.011
Jubjub, ajuba homolog (Xenopus laevis)0.011
Zhx1zinc fingers and homeoboxes 10.011
Bmp7bone morphogenetic protein 70.011
Gata3GATA binding protein 30.011
Elk4ELK4, ETS-domain protein (SRF accessory protein 1)0.011
Inppl1inositol polyphosphate phosphatase-like 10.010
Hckhemopoietic cell kinase0.010
Ddx54DEAD (Asp-Glu-Ala-Asp) box polypeptide 540.010
Ccnd2cyclin D20.010
Pabpc1poly(A) binding protein, cytoplasmic 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism