The network for 'negative regulation of nuclear division' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of nuclear division

Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.

NameDescriptionProbabilityFunc Analog Organism
RPL14ribosomal protein L140.028
RPL15ribosomal protein L150.025
RPL31ribosomal protein L310.023
RPL13Aribosomal protein L13a0.020
EEF1A1eukaryotic translation elongation factor 1 alpha 10.018
RPL23ribosomal protein L230.018
NME1non-metastatic cells 1, protein (NM23A) expressed in0.015
CAND1cullin-associated and neddylation-dissociated 10.014
RPS15ribosomal protein S150.012
PUM2pumilio homolog 2 (Drosophila)0.011
FARSAphenylalanyl-tRNA synthetase, alpha subunit0.011
RUVBL2RuvB-like 2 (E. coli)0.011
SEC24BSEC24 family, member B (S. cerevisiae)0.010
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
his-6Protein HIS-60.071
gpr-2Protein GPR-20.070
his-42Protein HIS-420.055
cdl-1Protein CDL-10.042
ani-1Protein ANI-10.034
ZK507.6Protein ZK507.60.033
htp-1Protein HTP-10.033
CELE_C24H12.5Protein C24H12.50.023
mus-101Protein MUS-1010.022
his-32Protein HIS-320.021
fli-1Protein FLI-10.019
C49H3.9Protein C49H3.90.019
CELE_F52C6.3Protein F52C6.30.018
lin-8Protein LIN-80.018
brc-1Protein BRC-10.015
rnr-1Protein RNR-10.013
aipl-1Protein AIPL-10.013
npp-11Protein NPP-110.013
uaf-1Protein UAF-10.013
pqn-51Protein PQN-510.013
CELE_T02C12.3Protein T02C12.30.012
mcm-5Protein MCM-50.012
F12F6.1Protein F12F6.10.012
let-502Protein LET-5020.012
spdl-1Protein SPDL-10.012
hcp-1Protein HCP-10.012
air-1Protein AIR-10.011
ZC410.3Protein ZC410.30.011
T22C1.1Protein T22C1.10.010
sas-5Protein SAS-50.010
dcp-66Protein DCP-660.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
smc4structural maintenance of chromosomes 40.941
ccnb1cyclin B10.932
wnt4awingless-type MMTV integration site family, member 4a0.912
wnt10awingless-type MMTV integration site family, member 10a0.797
dbx1adeveloping brain homeobox 1a0.649
hmx4H6 family homeobox 40.565
plk1polo-like kinase 1 (Drosophila)0.555
wnt7bawingless-type MMTV integration site family, member 7Ba0.539
tcf21transcription factor 210.536
dkk1bdickkopf 1b0.458
mcl1bmyeloid cell leukemia sequence 1b0.450
dccdeleted in colorectal carcinoma0.447
ccna2cyclin A20.447
bcl2B-cell leukemia/lymphoma 20.430
wnt7aawingless-type MMTV integration site family, member 7Aa0.424
wnt9bwingless-type MMTV integration site family, member 9B0.419
nusap1nucleolar and spindle associated protein 10.415
wnt8bwingless-type MMTV integration site family, member 8b0.400
si:ch211-173o4.2si:ch211-173o4.20.397
wnt3awingless-type MMTV integration site family, member 3A0.392
sfrp1asecreted frizzled-related protein 1a0.391
hmx1H6 homeo box 10.389
wnt3wingless-type MMTV integration site family, member 30.386
wnt11rwingless-type MMTV integration site family, member 11, related0.376
flhfloating head0.338
si:ch211-69g19.2si:ch211-69g19.20.331
cdt1chromatin licensing and DNA replication factor 10.320
dtldenticleless homolog (Drosophila)0.303
g2e3G2/M-phase specific E3 ubiquitin ligase0.301
fgf17fibroblast growth factor 170.290
suv39h1bsuppressor of variegation 3-9 homolog 1b0.282
tacc3transforming, acidic coiled-coil containing protein 30.281
wdhd1WD repeat and HMG-box DNA binding protein 10.270
wnt16wingless-type MMTV integration site family, member 160.256
wnt2wingless-type MMTV integration site family member 20.237
baxabcl2-associated X protein, a0.231
vcanaversican a0.207
mcl1amyeloid cell leukemia sequence 1a0.207
cdca8cell division cycle associated 80.197
orc1origin recognition complex, subunit 10.197
ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.194
wnt7bbwingless-type MMTV integration site family, member 7Bb0.185
LOC566708FL cytokine receptor-like0.184
ccnb2cyclin B20.180
cep55lcentrosomal protein 55 like0.169
oprk1opioid receptor, kappa 10.168
pcsk5bproprotein convertase subtilisin/kexin type 5b0.166
optcopticin0.160
csnk1dacasein kinase 1, delta a0.159
wnt5bwingless-type MMTV integration site family, member 5b0.157
mbnl2muscleblind-like 2 (Drosophila)0.154
gmnngeminin, DNA replication inhibitor0.153
ubinataxin-1 ubiquitin-like interacting protein0.153
sox2SRY-box containing gene 20.153
dmrt3adoublesex and mab-3 related transcription factor 3a0.150
sfrp1bsecreted frizzled-related protein 1b0.150
mapk7mitogen-activated protein kinase 70.141
notch1anotch homolog 1a0.141
bidaBH3 interacting domain death agonist0.136
zgc:113143zgc:1131430.134
mapk12mitogen-activated protein kinase 120.134
cdc20cell division cycle 20 homolog0.133
e2f5E2F transcription factor 50.132
cstf1cleavage stimulation factor, 3' pre-RNA, subunit 10.130
smad9MAD homolog 9 (Drosophila)0.127
map2k7mitogen-activated protein kinase kinase 70.125
LOC100536090targeting protein for Xklp2-B-like0.124
rad54lRAD54-like (S. cerevisiae)0.124
zgc:56200zgc:562000.123
twist1btwist1b0.123
sass6spindle assembly 6 homolog (C. elegans)0.122
wnt9awingless-type MMTV integration site family, member 9A0.122
wnt10bwingless-type MMTV integration site family, member 10b0.120
ncapd2non-SMC condensin I complex, subunit D20.119
spry4sprouty (Drosophila) homolog 40.116
ncapgnon-SMC condensin I complex, subunit G0.116
polr2bpolymerase (RNA) II (DNA directed) polypeptide B0.114
melkmaternal embryonic leucine zipper kinase0.113
gtf2h2general transcription factor IIH, polypeptide 20.112
sid4secreted immunoglobulin domain 40.112
si:dkey-273o13.1si:dkey-273o13.10.111
map2k4bmitogen-activated protein kinase kinase 4b0.110
map2k4amitogen-activated protein kinase kinase 4a0.109
sfrs3bsplicing factor, arginine/serine-rich 3b0.108
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.107
fbxl14aF-box and leucine-rich repeat protein 14a0.106
mecomMDS1 and EVI1 complex locus0.104
usp5ubiquitin specific protease 50.103
sephs1selenophosphate synthetase 10.102
zgc:174506zgc:1745060.101
trip13thyroid hormone receptor interactor 130.100
zgc:55521zgc:555210.099
kif23kinesin family member 230.099
entpd4ectonucleoside triphosphate diphosphohydrolase 40.097
kpna2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.095
hnf1baHNF1 homeobox Ba0.094
egr2bearly growth response 2b0.094
tgfb3transforming growth factor, beta 30.093
zgc:55671zgc:556710.090
oepone-eyed pinhead0.087
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CycBCyclin B0.052
HLHm7E(spl) region transcript m70.024
tldtolloid0.023
E(spl)Enhancer of split0.022
fzyfizzy0.020
bambag of marbles0.019
poloCG12306 gene product from transcript CG12306-RA0.016
oskoskar0.016
Cap-GCG34438 gene product from transcript CG34438-RF0.015
spn-Dspindle D0.014
CycB3Cyclin B30.014
KrnKeren0.011
CycACyclin A0.011
DNApol-alpha60DNA polymerase alpha 60kD0.011
nbsCG6754 gene product from transcript CG6754-RC0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.987
Trp53transformation related protein 530.982
Gli3GLI-Kruppel family member GLI30.612
Bmp4bone morphogenetic protein 40.600
Fgfr2fibroblast growth factor receptor 20.564
Brca1breast cancer 10.536
Sox9SRY-box containing gene 90.516
Ctnnb1catenin (cadherin associated protein), beta 10.451
C330027C09RikRIKEN cDNA C330027C09 gene0.412
Lin9lin-9 homolog (C. elegans)0.405
Cdk4cyclin-dependent kinase 40.342
Cdk2cyclin-dependent kinase 20.329
Ccnb1cyclin B10.252
Cenpecentromere protein E0.247
Atf4activating transcription factor 40.230
Brca2breast cancer 20.229
Hellshelicase, lymphoid specific0.221
Trim59tripartite motif-containing 590.221
Sgol1shugoshin-like 1 (S. pombe)0.213
Ccne2cyclin E20.211
Ncoa3nuclear receptor coactivator 30.210
Pthlhparathyroid hormone-like peptide0.198
Wdhd1WD repeat and HMG-box DNA binding protein 10.189
Plk4polo-like kinase 4 (Drosophila)0.158
Rb1retinoblastoma 10.151
Rpa3replication protein A30.151
Trp63transformation related protein 630.150
Cdkn2acyclin-dependent kinase inhibitor 2A0.147
Chek1checkpoint kinase 1 homolog (S. pombe)0.140
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.140
Sgol2shugoshin-like 2 (S. pombe)0.137
Msx1homeobox, msh-like 10.130
Mdm2transformed mouse 3T3 cell double minute 20.126
Ergavian erythroblastosis virus E-26 (v-ets) oncogene related0.124
Mastlmicrotubule associated serine/threonine kinase-like0.121
Rararetinoic acid receptor, alpha0.117
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.116
Ptch1patched homolog 10.116
Cenpkcentromere protein K0.112
Runx2runt related transcription factor 20.111
Spag5sperm associated antigen 50.109
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.106
Anlnanillin, actin binding protein0.106
Dtldenticleless homolog (Drosophila)0.102
Otx2orthodenticle homolog 2 (Drosophila)0.098
BlmBloom syndrome, RecQ helicase-like0.098
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.096
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.094
Mdm4transformed mouse 3T3 cell double minute 40.092
4632434I11RikRIKEN cDNA 4632434I11 gene0.092
Dbf4DBF4 homolog (S. cerevisiae)0.087
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.086
Cenpjcentromere protein J0.082
Cdkn1bcyclin-dependent kinase inhibitor 1B0.082
RecqlRecQ protein-like0.079
Mis18bp1MIS18 binding protein 10.079
Foxc1forkhead box C10.079
Ooepoocyte expressed protein homolog (dog)0.077
Nlrp5NLR family, pyrin domain containing 50.074
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.073
Lrrk2leucine-rich repeat kinase 20.068
Sae1SUMO1 activating enzyme subunit 10.067
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.065
Prrx1paired related homeobox 10.064
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.063
Hand1heart and neural crest derivatives expressed transcript 10.061
Cdk1cyclin-dependent kinase 10.058
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.058
Ncapgnon-SMC condensin I complex, subunit G0.057
Trip13thyroid hormone receptor interactor 130.055
Haus6HAUS augmin-like complex, subunit 60.055
Aurkaaurora kinase A0.053
Ncapg2non-SMC condensin II complex, subunit G20.053
Rbl1retinoblastoma-like 1 (p107)0.049
Tsc2tuberous sclerosis 20.049
Kif20akinesin family member 20A0.049
Kif23kinesin family member 230.048
Ect2ect2 oncogene0.048
Fbxo5F-box protein 50.048
Tsc1tuberous sclerosis 10.047
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.047
Bmp7bone morphogenetic protein 70.046
Ccna2cyclin A20.044
Kif2ckinesin family member 2C0.044
Prrx2paired related homeobox 20.044
Ccne1cyclin E10.043
Smc2structural maintenance of chromosomes 20.043
E2f8E2F transcription factor 80.042
Ccnfcyclin F0.042
Cdca8cell division cycle associated 80.041
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.041
Rpgrip1lRpgrip1-like0.040
Ncapd3non-SMC condensin II complex, subunit D30.040
Arl6ip6ADP-ribosylation factor-like 6 interacting protein 60.039
Suv39h2suppressor of variegation 3-9 homolog 2 (Drosophila)0.038
Smc4structural maintenance of chromosomes 40.038
Hmgb2high mobility group box 20.038
Mns1meiosis-specific nuclear structural protein 10.037
Fgfr1fibroblast growth factor receptor 10.037
Alx1ALX homeobox 10.037
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Plk1polo-like kinase 1 (Drosophila)0.043
Ccnb1cyclin B10.034
Kifc1kinesin family member C10.032
Dhfrdihydrofolate reductase0.031
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.029
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.028
Foxe3forkhead box E30.025
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.025
Dlgap5discs, large (Drosophila) homolog-associated protein 50.022
Arf1ADP-ribosylation factor 10.022
Rad51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.021
Top2atopoisomerase (DNA) II alpha0.019
Cenpicentromere protein I0.018
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.018
Mapre1microtubule-associated protein, RP/EB family, member 10.017
Spag5sperm associated antigen 50.017
Aurkbaurora kinase B0.016
Gins4GINS complex subunit 4 (Sld5 homolog)0.016
Espl1extra spindle pole bodies homolog 1 (S. cerevisiae)0.016
Mcm5minichromosome maintenance complex component 50.015
Haus4HAUS augmin-like complex, subunit 40.015
Foxm1forkhead box M10.015
Kif2ckinesin family member 2C0.014
Ska1spindle and kinetochore associated complex subunit 10.014
Pttg1pituitary tumor-transforming 10.014
Depdc1DEP domain containing 10.014
Picalmphosphatidylinositol binding clathrin assembly protein0.013
NsfN-ethylmaleimide-sensitive factor0.013
Mybl2myeloblastosis oncogene-like 20.013
Aspmasp (abnormal spindle) homolog, microcephaly associated (Drosophila)0.013
Brca2breast cancer 20.013
Bmp7bone morphogenetic protein 70.013
Birc5baculoviral IAP repeat-containing 50.013
Ect2epithelial cell transforming sequence 2 oncogene0.012
Otub1OTU domain, ubiquitin aldehyde binding 10.012
Kif18bkinesin family member 18B0.012
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.012
Cortcortistatin0.012
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.012
Ccnb2cyclin B20.012
Itpr2inositol 1,4,5-triphosphate receptor, type 20.012
Cenpmcentromere protein M0.012
Dhodhdihydroorotate dehydrogenase0.012
Hspbp1HSPA binding protein, cytoplasmic cochaperone 10.012
Dhdpsldihydrodipicolinate synthase-like, mitochondrial0.012
Notch3Notch homolog 3 (Drosophila)0.011
MGC112830similar to transcription factor0.011
Cd8bCD8b molecule0.011
Mcm7minichromosome maintenance complex component 70.011
Phldb1pleckstrin homology-like domain, family B, member 10.011
Tk1thymidine kinase 1, soluble0.011
Sssca1Sjogren's syndrome/scleroderma autoantigen 1 homolog (human)0.011
Prkaa1protein kinase, AMP-activated, alpha 1 catalytic subunit0.011
Cdk1cyclin-dependent kinase 10.011
Nudt1nudix (nucleoside diphosphate linked moiety X)-type motif 10.011
Cdca2cell division cycle associated 20.010
Hapln1hyaluronan and proteoglycan link protein 10.010
Traf4af1TRAF4 associated factor 10.010
Racgap1Rac GTPase-activating protein 10.010
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.010
Galnt10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)0.010
Atp2c1ATPase, Ca++ transporting, type 2C, member 10.010
Troaptrophinin associated protein0.010
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PPH22Pph22p0.954
HXT4Hxt4p0.906
GLC7Glc7p0.905
RED1Red1p0.856
PPH21Pph21p0.789
CDC20Cdc20p0.755
KIN1Kin1p0.751
ZDS1Zds1p0.680
CIN8Cin8p0.622
HXT2Hxt2p0.609
SLK19Slk19p0.581
CMD1Cmd1p0.554
STE4Ste4p0.539
MTH1Mth1p0.524
MAD1Mad1p0.498
HOS4Hos4p0.466
KEL1Kel1p0.435
SET1Set1p0.422
DMA2Dma2p0.413
CTF13Ctf13p0.411
SIF2Sif2p0.381
SNT1Snt1p0.348
TPD3Tpd3p0.348
GAC1Gac1p0.328
GIC1Gic1p0.316
BFA1Bfa1p0.312
RAD9Rad9p0.305
ZDS2Zds2p0.303
HHF2Hhf2p0.281
IML3Iml3p0.261
MEK1Mek1p0.254
PDS1Pds1p0.248
CCT2Cct2p0.245
GAL2Gal2p0.237
HSL1Hsl1p0.236
HOS2Hos2p0.230
BUB3Bub3p0.230
CTF19Ctf19p0.227
MAD2Mad2p0.218
SMC4Smc4p0.214
CHL4Chl4p0.213
PSY4Psy4p0.210
HXT1Hxt1p0.206
YAR028Whypothetical protein0.203
ZIP1Zip1p0.201
BMH1Bmh1p0.189
CDC55Cdc55p0.186
PIG2Pig2p0.185
PHO81Pho81p0.181
HXT3Hxt3p0.180
GIP4Gip4p0.177
PCL10Pcl10p0.172
PPZ2Ppz2p0.170
NEO1Neo1p0.169
DBF4Dbf4p0.159
CHL1Chl1p0.158
RTS1Rts1p0.155
SOR1Sor1p0.155
FMP48Fmp48p0.154
NSL1Nsl1p0.154
MBP1Mbp1p0.153
BUD5Bud5p0.153
SMC6Smc6p0.149
HOP1Hop1p0.149
DAM1Dam1p0.148
SKO1Sko1p0.148
SET3Set3p0.148
CPR1Cpr1p0.144
KIC1Kic1p0.143
YPI1Ypi1p0.139
UBP12Ubp12p0.138
MAL11Mal11p0.138
MAD3Mad3p0.131
SKP2Skp2p0.131
HXT8Hxt8p0.130
SPC110Spc110p0.130
CIN1Cin1p0.128
YGL082Whypothetical protein0.127
NDT80Ndt80p0.125
CDC15Cdc15p0.120
SKP1Skp1p0.118
PSD2Psd2p0.117
MUS81Mus81p0.117
CMK2Cmk2p0.116
RCO1Rco1p0.114
REG1Reg1p0.114
HXT15Hxt15p0.113
BUB1Bub1p0.110
SPL2Spl2p0.109
HST1Hst1p0.109
BUB2Bub2p0.109
DMC1Dmc1p0.107
ESP1Esp1p0.103
GIS4Gis4p0.103
JIP4Jip4p0.097
SMC3Smc3p0.096
MNR2Mnr2p0.095
KIP1Kip1p0.095
SCS7Scs7p0.093
SNF3Snf3p0.092