The network for 'somatic muscle development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

somatic muscle development

The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor0.958
FGF1fibroblast growth factor 1 (acidic)0.952
ALDOAaldolase A, fructose-bisphosphate0.932
INSRinsulin receptor0.912
PGK1phosphoglycerate kinase 10.900
IRS2insulin receptor substrate 20.890
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.890
YAP1Yes-associated protein 10.887
ENO1enolase 1, (alpha)0.878
MEIS1Meis homeobox 10.834
PGAM1phosphoglycerate mutase 1 (brain)0.801
EGR1early growth response 10.800
CREBBPCREB binding protein0.738
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.696
GLIS2GLIS family zinc finger 20.662
LDHAlactate dehydrogenase A0.656
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.655
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.652
SRFserum response factor (c-fos serum response element-binding transcription factor)0.648
PDPK13-phosphoinositide dependent protein kinase-10.625
AKT1v-akt murine thymoma viral oncogene homolog 10.594
MEIS2Meis homeobox 20.587
RFX1regulatory factor X, 1 (influences HLA class II expression)0.587
FGFR2fibroblast growth factor receptor 20.506
RICTORRPTOR independent companion of MTOR, complex 20.488
GPIglucose-6-phosphate isomerase0.484
GIT2G protein-coupled receptor kinase interacting ArfGAP 20.456
RBPMSRNA binding protein with multiple splicing0.398
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.389
COASYCoA synthase0.377
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.373
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.372
MEOX1mesenchyme homeobox 10.372
SPECC1Lsperm antigen with calponin homology and coiled-coil domains 1-like0.346
IL4Rinterleukin 4 receptor0.319
KAT2BK(lysine) acetyltransferase 2B0.316
CAV1caveolin 1, caveolae protein, 22kDa0.274
GIT1G protein-coupled receptor kinase interacting ArfGAP 10.256
NCOA2nuclear receptor coactivator 20.239
TPM4tropomyosin 40.231
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.230
NCOA1nuclear receptor coactivator 10.216
TSC2tuberous sclerosis 20.206
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.200
LRRFIP1leucine rich repeat (in FLII) interacting protein 10.199
ECT2epithelial cell transforming sequence 2 oncogene0.199
FOXO1forkhead box O10.195
ADRBK1adrenergic, beta, receptor kinase 10.193
IRS1insulin receptor substrate 10.189
FGF10fibroblast growth factor 100.182
KIF23kinesin family member 230.181
PKM2pyruvate kinase, muscle0.179
SNAI1snail homolog 1 (Drosophila)0.179
EGR3early growth response 30.175
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.171
JAK2Janus kinase 20.161
LRRFIP2leucine rich repeat (in FLII) interacting protein 20.158
ARandrogen receptor0.155
MAPTmicrotubule-associated protein tau0.145
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.136
IGF1Rinsulin-like growth factor 1 receptor0.134
STAT5Bsignal transducer and activator of transcription 5B0.134
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.132
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.131
EIF4EBP1eukaryotic translation initiation factor 4E binding protein 10.128
IL2RBinterleukin 2 receptor, beta0.128
SUFUsuppressor of fused homolog (Drosophila)0.126
STAT5Asignal transducer and activator of transcription 5A0.125
GPSM2G-protein signaling modulator 20.125
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.122
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.116
EGR2early growth response 20.114
PCBP1poly(rC) binding protein 10.110
TUBA1Ctubulin, alpha 1c0.108
STAP2signal transducing adaptor family member 20.107
CFL1cofilin 1 (non-muscle)0.106
MAPKAPK3mitogen-activated protein kinase-activated protein kinase 30.105
LATlinker for activation of T cells0.104
PTPN14protein tyrosine phosphatase, non-receptor type 140.104
IFNAR2interferon (alpha, beta and omega) receptor 20.103
IRF3interferon regulatory factor 30.101
DCTN1dynactin 10.101
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.100
HOXA9homeobox A90.098
TNIP1TNFAIP3 interacting protein 10.096
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.092
KIF5Bkinesin family member 5B0.088
PPIApeptidylprolyl isomerase A (cyclophilin A)0.085
GRB10growth factor receptor-bound protein 100.084
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.081
SH3RF1SH3 domain containing ring finger 10.080
CDC25Bcell division cycle 25 homolog B (S. pombe)0.079
MPRIPmyosin phosphatase Rho interacting protein0.079
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 20.078
PI4KBphosphatidylinositol 4-kinase, catalytic, beta0.078
NEDD4neural precursor cell expressed, developmentally down-regulated 40.077
KIF1Bkinesin family member 1B0.076
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
aldo-1Protein ALDO-10.062
egl-13Protein EGL-130.057
unc-15Protein UNC-150.050
T21B6.3Protein T21B6.30.044
emb-9Protein EMB-90.042
myo-3Protein MYO-30.042
unc-73Protein UNC-730.037
vab-3Protein VAB-30.036
F35A5.1Protein F35A5.10.028
ncx-2Protein NCX-20.028
pat-12Protein PAT-120.027
alh-8Protein ALH-80.027
K10D6.4Protein K10D6.40.023
F46H5.3Protein F46H5.30.023
pha-4Protein PHA-40.023
K07E3.4Protein K07E3.40.022
cwn-1Protein CWN-10.022
vab-23Protein VAB-230.021
tni-4Protein TNI-40.021
CELE_Y53F4B.9Protein Y53F4B.90.020
T12D8.9Protein T12D8.90.020
tnt-4Protein TNT-40.020
T22B11.4Protein T22B11.40.020
camt-1Protein CAMT-10.020
dig-1Protein DIG-10.019
myo-2Protein MYO-20.018
let-2Protein LET-20.018
C53C9.2Protein C53C9.20.018
ogt-1Protein OGT-10.018
T25F10.6Protein T25F10.60.018
egl-30Protein EGL-300.018
R03H10.2Protein R03H10.20.017
klp-19Protein KLP-190.017
fln-2Protein FLN-20.017
tag-241Protein TAG-2410.017
phat-4Protein PHAT-40.017
unc-54Protein UNC-540.017
unc-95Protein UNC-950.017
sup-12Protein SUP-120.016
ubr-1Protein UBR-10.016
egl-8Protein EGL-80.016
skn-1Protein SKN-10.016
lin-7Protein LIN-70.016
sorb-1Protein SORB-10.016
T05F1.2Protein T05F1.20.016
ztf-19Protein ZTF-190.016
egl-18Protein EGL-180.016
smg-1Protein SMG-10.016
C50E3.5Protein C50E3.50.015
T13C2.3Protein T13C2.30.015
fkh-7Protein FKH-70.015
Y45G5AM.6Protein Y45G5AM.60.015
dim-1Protein DIM-10.015
K09A9.6Protein K09A9.60.015
col-43Protein COL-430.015
egl-38Protein EGL-380.015
mes-3Protein MES-30.015
gly-13Protein GLY-130.015
twk-18Protein TWK-180.015
ifg-1Protein IFG-10.015
cpna-2Protein CPNA-20.015
mup-2Protein MUP-20.014
zyx-1Protein ZYX-10.014
egl-36Protein EGL-360.014
nhr-107Protein NHR-1070.014
ZC449.5Protein ZC449.50.014
dgk-4Protein DGK-40.014
sel-1Protein SEL-10.014
T19D12.2Protein T19D12.20.014
lin-9Protein LIN-90.014
let-268Protein LET-2680.014
F21C10.7Protein F21C10.70.014
lig-1Protein LIG-10.014
F18H3.4Protein F18H3.40.014
mig-38Protein MIG-380.014
unc-43Protein UNC-430.014
myo-5Protein MYO-50.014
C18B2.3Protein C18B2.30.013
mdh-2Protein MDH-20.013
ZK662.2Protein ZK662.20.013
csq-1Protein CSQ-10.013
czw-1Protein CZW-10.013
syd-2Protein SYD-20.013
elt-6Protein ELT-60.013
F44B9.2Protein F44B9.20.013
pde-2Protein PDE-20.013
gly-6Protein GLY-60.013
epi-1Protein EPI-10.013
sax-7Protein SAX-70.013
math-24Protein MATH-240.013
lin-29Protein LIN-290.013
gcl-1Protein GCL-10.013
idhb-1Protein IDHB-10.013
F47B7.7Protein F47B7.70.013
lin-59Protein LIN-590.013
pat-10Protein PAT-100.013
nhr-154Protein NHR-1540.013
nob-1Protein NOB-10.012
pqn-22Protein PQN-220.012
C36E8.1Protein C36E8.10.012
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
smyhc2slow myosin heavy chain 20.907
myf5myogenic factor 50.894
eng2aengrailed 2a0.881
myhz2myosin, heavy polypeptide 2, fast muscle specific0.872
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.853
six1bsine oculis homeobox homolog 1b0.812
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.790
mef2dmyocyte enhancer factor 2d0.689
smyd1bSET and MYND domain containing 1b0.652
tnni1btroponin I, skeletal, slow b0.573
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.572
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.568
tnni2a.4troponin I, skeletal, fast 2a.40.557
tnni1altroponin I, skeletal, slow like0.551
muskmuscle, skeletal, receptor tyrosine kinase0.490
smyhc1lslow myosin heavy chain 1, like0.462
tbx2bT-box 2b0.416
lama4laminin, alpha 40.413
unc45bunc-45 homolog B (C. elegans)0.410
pcdh19protocadherin 190.387
flot2aflotillin 2a0.374
myod1myogenic differentiation 10.339
tnnc1btroponin C type 1b (slow)0.337
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.329
lbx2ladybird homeobox homolog 2 (Drosophila)0.304
tbx1T-box 10.303
tbx2aT-box gene 2a0.301
pcdh8protocadherin 80.271
smyhc1slow myosin heavy chain 10.268
eomesaeomesodermin homolog a0.267
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.264
tnnt1troponin T1, skeletal, slow0.260
her1hairy-related 10.251
ttnatitin a0.245
gro1groucho 10.236
ryr1bryanodine receptor 1b (skeletal)0.227
hbbe1.1hemoglobin beta embryonic-1.10.220
tgfb3transforming growth factor, beta 30.216
has2hyaluronan synthase 20.210
sema3aasemaphorin 3aa0.198
ankrd6ankyrin repeat domain 60.198
restRE1-silencing transcription factor0.189
fgf8bfibroblast growth factor 8 b0.188
vdravitamin D receptor a0.187
myhc4myosin heavy chain 40.178
flot1bflotillin 1b0.173
spry4sprouty (Drosophila) homolog 40.170
tbx16T-box gene 160.169
tead3aTEA domain family member 3 a0.168
cftrcystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)0.161
egr1early growth response 10.157
znfl2azinc finger-like gene 2a0.154
pdlim7PDZ and LIM domain 70.154
pacsin3protein kinase C and casein kinase substrate in neurons 30.149
eng2bengrailed 2b0.148
rxrbbretinoid x receptor, beta b0.147
emx3empty spiracles homeobox 30.147
vmhcventricular myosin heavy chain0.145
zeb1zinc finger E-box binding homeobox 10.143
actn2actinin, alpha 20.139
popdc2popeye domain containing 20.133
frem3Fras1 related extracellular matrix 30.126
zbtb4zinc finger and BTB domain containing 40.126
fgfr4fibroblast growth factor receptor 40.126
pgk1phosphoglycerate kinase 10.124
msgn1mesogenin 10.119
gro2groucho 20.118
h1mlinker histone H1M0.118
mespamesoderm posterior a0.117
slc4a1asolute carrier family 4, anion exchanger, member 1a0.117
ptprfprotein tyrosine phosphatase, receptor type, F0.116
cx39.9connexin 39.90.116
tnnt3btroponin T3b, skeletal, fast0.109
pdlim3bPDZ and LIM domain 3b0.109
cacnb4acalcium channel, voltage-dependent, beta 4a subunit0.107
spon2aspondin 2a, extracellular matrix protein0.107
hsp90a.1heat shock protein 90-alpha 10.106
tll1tolloid-like 10.105
ncoa2nuclear receptor coactivator 20.105
xirp2axin actin-binding repeat containing 2a0.103
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.102
fmr1fragile X mental retardation 10.098
ap2m1aadaptor-related protein complex 2, mu 1 subunit, a0.098
hspb8heat shock protein, alpha-crystallin-related, b80.098
slc25a37solute carrier family 25, member 370.097
actn3bactinin alpha 3b0.096
rbpjarecombination signal binding protein for immunoglobulin kappa J region a0.095
zdhhc8bzinc finger, DHHC-type containing 8b0.092
zeb2azinc finger E-box binding homeobox 2a0.091
spry2sprouty homolog 20.090
her7hairy and enhancer of split related-70.088
ryr1aryanodine receptor 1a (skeletal)0.088
ret1receptor tyrosine kinase0.088
traf4atnf receptor-associated factor 4a0.088
LOC566969similar to MOX-2 protein0.085
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MhcMyosin heavy chain0.987
Mef2Myocyte enhancer factor 20.925
PyKPyruvate kinase0.902
S6kRPS6-p70-protein kinase0.811
Zasp52Z band alternatively spliced PDZ-motif protein 520.797
CanB2Calcineurin B20.787
Sema-2aCG4700 gene product from transcript CG4700-RC0.675
wupAwings up A0.656
Vrp1Verprolin 10.615
Act88FActin 88F0.609
Cf2Chorion factor 20.522
CG3371CG3371 gene product from transcript CG3371-RA0.514
cicubitus interruptus0.442
LanB2Laminin B20.435
GripGlutamate receptor binding protein0.411
ewgerect wing0.381
LrtLeucine-rich tendon-specific protein0.360
Gapdh1Glyceraldehyde 3 phosphate dehydrogenase 10.337
snssticks and stones0.333
MicalMolecule interacting with CasL0.322
Lim3CG10699 gene product from transcript CG10699-RB0.320
ScgdeltaSarcoglycan delta0.286
GpdhGlycerol 3 phosphate dehydrogenase0.280
stumpsCG31317 gene product from transcript CG31317-RC0.275
abd-Aabdominal A0.254
blowblown fuse0.239
aopanterior open0.228
lbeladybird early0.220
Actnalpha actinin0.217
wbwing blister0.205
AlkCG8250 gene product from transcript CG8250-RA0.200
Rac2CG8556 gene product from transcript CG8556-RA0.200
GlyPGlycogen phosphorylase0.178
CG8578CG8578 gene product from transcript CG8578-RA0.171
Pink1PTEN-induced putative kinase 10.166
beat-Iabeaten path Ia0.163
drkdownstream of receptor kinase0.160
Zasp66Z band alternatively spliced PDZ-motif protein 660.160
TpiTriose phosphate isomerase0.159
bibbig brain0.147
HcfHost cell factor0.146
foxoforkhead box, sub-group O0.144
PoxmPox meso0.140
Mlp84BMuscle LIM protein at 84B0.139
mib2mind bomb 20.138
Wnt2Wnt oncogene analog 20.135
Msp-300Muscle-specific protein 3000.134
singsingles bar0.132
Mlc2Myosin light chain 20.131
CG3880CG3880 gene product from transcript CG3880-RA0.129
rolsrolling pebbles0.128
Gyc76CGuanylyl cyclase at 76C0.126
AtpalphaNa pump alpha subunit0.123
ash2absent, small, or homeotic discs 20.120
wechCG42396 gene product from transcript CG42396-RC0.114
GitCG16728 gene product from transcript CG16728-RA0.113
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.111
Pabp2CG2163 gene product from transcript CG2163-RA0.111
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism