The network for 'negative regulation of epithelial cell migration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of epithelial cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.

NameDescriptionProbabilityFunc Analog Organism
TGFB1transforming growth factor, beta 10.999
FGFR2fibroblast growth factor receptor 20.999
JAG1jagged 10.997
TEKTEK tyrosine kinase, endothelial0.992
RARAretinoic acid receptor, alpha0.986
FGF1fibroblast growth factor 1 (acidic)0.958
BMP2bone morphogenetic protein 20.898
TGFB3transforming growth factor, beta 30.888
RXRAretinoid X receptor, alpha0.881
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.877
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.837
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.835
FGAfibrinogen alpha chain0.824
NOTCH3notch 30.807
FKBP1AFK506 binding protein 1A, 12kDa0.794
FGFR1fibroblast growth factor receptor 10.787
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.775
NOTCH1notch 10.770
NRP1neuropilin 10.766
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.640
DUSP1dual specificity phosphatase 10.617
TGFBR1transforming growth factor, beta receptor 10.579
FN1fibronectin 10.559
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.540
MED25mediator complex subunit 250.535
BMPR1Bbone morphogenetic protein receptor, type IB0.497
MEF2Cmyocyte enhancer factor 2C0.487
MAP3K2mitogen-activated protein kinase kinase kinase 20.451
MAP3K3mitogen-activated protein kinase kinase kinase 30.441
GDF5growth differentiation factor 50.440
FGF10fibroblast growth factor 100.424
VCAM1vascular cell adhesion molecule 10.383
ACVR1activin A receptor, type I0.369
MEF2Amyocyte enhancer factor 2A0.366
SPTBN1spectrin, beta, non-erythrocytic 10.321
ANGPT2angiopoietin 20.305
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.298
FSTL1follistatin-like 10.254
BMP4bone morphogenetic protein 40.250
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.248
PTPN1protein tyrosine phosphatase, non-receptor type 10.240
KLF4Kruppel-like factor 4 (gut)0.234
FBLN1fibulin 10.229
BCL6B-cell CLL/lymphoma 60.223
CHMP4Bchromatin modifying protein 4B0.217
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.215
MAP3K5mitogen-activated protein kinase kinase kinase 50.210
PRKD2protein kinase D20.208
CSNK1Ecasein kinase 1, epsilon0.208
SFRP4secreted frizzled-related protein 40.200
THBS1thrombospondin 10.199
SMAD7SMAD family member 70.197
DLL1delta-like 1 (Drosophila)0.184
APOC1apolipoprotein C-I0.171
SPOPspeckle-type POZ protein0.169
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.162
CD9CD9 molecule0.159
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.156
FGGfibrinogen gamma chain0.152
ALKanaplastic lymphoma receptor tyrosine kinase0.147
NOTCH2notch 20.147
MAPK7mitogen-activated protein kinase 70.139
SP100SP100 nuclear antigen0.137
GFI1Bgrowth factor independent 1B transcription repressor0.137
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.136
HDAC4histone deacetylase 40.128
FEZ1fasciculation and elongation protein zeta 1 (zygin I)0.126
PROX1prospero homeobox 10.124
FGF2fibroblast growth factor 2 (basic)0.118
TSC22D1TSC22 domain family, member 10.117
NCOA1nuclear receptor coactivator 10.116
VEGFCvascular endothelial growth factor C0.115
VEGFAvascular endothelial growth factor A0.112
BAIAP2BAI1-associated protein 20.110
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.104
ITGA6integrin, alpha 60.102
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 400.101
FGF7fibroblast growth factor 70.097
KLF6Kruppel-like factor 60.097
TGFB2transforming growth factor, beta 20.096
PTGISprostaglandin I2 (prostacyclin) synthase0.095
RBMS3RNA binding motif, single stranded interacting protein 30.094
WWP2WW domain containing E3 ubiquitin protein ligase 20.093
EHMT2euchromatic histone-lysine N-methyltransferase 20.089
LAMA4laminin, alpha 40.083
LAMB1laminin, beta 10.079
TIE1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.078
S100BS100 calcium binding protein B0.077
TLN1talin 10.076
TIMP3TIMP metallopeptidase inhibitor 30.076
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
notch3notch homolog 30.888
kdrlkinase insert domain receptor like0.789
notch1anotch homolog 1a0.719
gli2aGLI-Kruppel family member GLI2a0.572
ascl1aachaete-scute complex-like 1a (Drosophila)0.436
antxr1anthrax toxin receptor 10.359
ntn1anetrin 1a0.322
egr1early growth response 10.277
eya1eyes absent homolog 10.260
mibmind bomb0.253
skianuclear oncoprotein skia0.252
vegfcvascular endothelial growth factor c0.243
ccm2cerebral cavernous malformation 20.241
her6hairy-related 60.239
fgfr2fibroblast growth factor receptor 20.205
prox1prospero-related homeobox gene 10.179
jag1bjagged 1b0.176
fgfr3fibroblast growth factor receptor 30.167
slit3slit (Drosophila) homolog 30.165
tal1T-cell acute lymphocytic leukemia 10.148
sox9aSRY-box containing gene 9a0.139
neurog1neurogenin 10.133
sox3SRY-box containing gene 30.127
edn1endothelin 10.111
alcamaactivated leukocyte cell adhesion molecule a0.105
ascl1bachaete-scute complex-like 1b (Drosophila)0.103
bocbrother of CDO0.097
gdnfglial cell derived neurotrophic factor0.097
sall1asal-like 1a (Drosophila)0.090
dll4delta-like 4 (Drosophila)0.090
nrp2bneuropilin 2b0.090
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.089
nrarpanotch-regulated ankyrin repeat protein a0.088
insm1binsulinoma-associated 1b0.088
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.083
efnb2aephrin B2a0.081
tbx18T-box 180.080
lmx1b.1LIM homeobox transcription factor 1, beta 10.080
nova2neuro-oncological ventral antigen 20.078
pax7apaired box gene 7a0.078
birc2baculoviral IAP repeat-containing 20.075
cxcr4bchemokine (C-X-C motif), receptor 4b0.075
pitx3paired-like homeodomain transcription factor 30.071
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.067
dlx5adistal-less homeobox gene 5a0.066
plxna3plexin A30.065
efnb3bephrin B3b0.062
plcg1phospholipase C, gamma 10.062
hey1hairy/enhancer-of-split related with YRPW motif 10.062
ptrfbpolymerase I and transcript release factor b0.061
col4a6collagen, type IV, alpha 60.059
myod1myogenic differentiation 10.059
ptf1apancreas specific transcription factor, 1a0.057
egr2bearly growth response 2b0.057
mycamyelocytomatosis oncogene a0.056
foxn4forkhead box N40.055
prkciprotein kinase C, iota0.055
sox11aSRY-box containing gene 11a0.054
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.052
mpzmyelin protein zero0.051
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.050
neurod4neurogenic differentiation 40.050
ldb2aLIM-domain binding factor 2a0.050
terttelomerase reverse transcriptase0.049
thrbthyroid hormone receptor beta0.049
sfrp5secreted frizzled-related protein 50.047
metmet proto-oncogene (hepatocyte growth factor receptor)0.047
nup50nucleoporin 500.046
fstafollistatin a0.044
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.043
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.043
tnnt2atroponin T2a, cardiac0.043
cyp1acytochrome P450, family 1, subfamily A0.043
fabp11afatty acid binding protein 11a0.043
ca2carbonic anhydrase II0.042
pou3f1POU class 3 homeobox 10.042
efnb1ephrin B10.042
mdkamidkine-related growth factor0.042
jag1ajagged 1a0.040
cd99l2CD99 antigen-like 20.040
supt6hsuppressor of Ty 6 homolog0.040
pax6apaired box gene 6a0.039
her4.2hairy-related 4.20.039
rspo1R-spondin homolog (Xenopus laevis)0.038
vaspvasodilator-stimulated phosphoprotein0.038
crb2acrumbs homolog 2a0.038
ptmaaprothymosin, alpha a0.037
angpt1angiopoietin 10.037
pcdh18aprotocadherin 18a0.036
grem2gremlin 2, cysteine knot superfamily0.036
rapsnreceptor-associated protein of the synapse, 43kD0.036
meis1myeloid ecotropic viral integration 10.036
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.753
Ras85DRas oncogene at 85D0.665
aopanterior open0.191
EgfrEpidermal growth factor receptor0.165
Pi3K92ECG4141 gene product from transcript CG4141-RB0.155
Su(H)Suppressor of Hairless0.126
Src64BSrc oncogene at 64B0.098
InRInsulin-like receptor0.088
trioCG18214 gene product from transcript CG18214-RA0.072
Stat92ESignal-transducer and activator of transcription protein at 92E0.069
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.058
lolalongitudinals lacking0.049
Sema-1aCG18405 gene product from transcript CG18405-RD0.046
l(2)gllethal (2) giant larvae0.044
pod1CG4532 gene product from transcript CG4532-RF0.042
Fas3Fasciclin 30.041
Sra-1specifically Rac1-associated protein 10.041
Ptp69DProtein tyrosine phosphatase 69D0.037
AblAbl tyrosine kinase0.034
EcREcdysone receptor0.031
ovoCG6824 gene product from transcript CG6824-RE0.030
gekgenghis khan0.029
rapretina aberrant in pattern0.028
Bj1Bj1 protein0.027
CG4699CG4699 gene product from transcript CG4699-RJ0.026
SaraSmad anchor for receptor activation0.025
SosSon of sevenless0.025
phlpole hole0.023
Pp2B-14DProtein phosphatase 2B at 14D0.023
ninaBneither inactivation nor afterpotential B0.022
MrtfMyocardin-related transcription factor0.021
pgant3polypeptide GalNAc transferase 30.020
CapsCalcium activated protein for secretion0.020
zfh1Zn finger homeodomain 10.020
cnkconnector enhancer of ksr0.020
slmbsupernumerary limbs0.018
witwishful thinking0.018
Akt1CG4006 gene product from transcript CG4006-RA0.018
hipkhomeodomain interacting protein kinase0.017
maskmultiple ankyrin repeats single KH domain0.017
htshu li tai shao0.016
Gap1GTPase-activating protein 10.016
enokenoki mushroom0.015
myoglianinCG1838 gene product from transcript CG1838-RD0.015
tefutelomere fusion0.014
RglRal guanine nucleotide exchange factor0.014
endoAendophilin A0.014
Kap-alpha3karyopherin alpha30.014
snostrawberry notch0.013
HLH106Helix loop helix protein 1060.013
CG9063CG9063 gene product from transcript CG9063-RA0.012
numbCG3779 gene product from transcript CG3779-RB0.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Notch1Notch gene homolog 1 (Drosophila)1.000
Dll1delta-like 1 (Drosophila)0.957
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.936
Notch2Notch gene homolog 2 (Drosophila)0.886
Nos3nitric oxide synthase 3, endothelial cell0.824
Tgfbr2transforming growth factor, beta receptor II0.626
Dll4delta-like 4 (Drosophila)0.550
Psen1presenilin 10.517
Acvrl1activin A receptor, type II-like 10.509
Fgfr1fibroblast growth factor receptor 10.360
Chd7chromodomain helicase DNA binding protein 70.349
Efnb2ephrin B20.292
Cdh5cadherin 50.266
Fzd1frizzled homolog 1 (Drosophila)0.116
Robo1roundabout homolog 1 (Drosophila)0.115
Jag2jagged 20.100
Slit3slit homolog 3 (Drosophila)0.085
Jag1jagged 10.083
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.083
Prl7a1prolactin family 7, subfamily a, member 10.080
Prl8a2prolactin family 8, subfamily a, member 20.075
Rb1retinoblastoma 10.070
Prl7d1prolactin family 7, subfamily d, member 10.068
Hand2heart and neural crest derivatives expressed transcript 20.060
Loxlysyl oxidase0.057
Olfr64olfactory receptor 640.052
Vaspvasodilator-stimulated phosphoprotein0.051
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.050
Ptprbprotein tyrosine phosphatase, receptor type, B0.043
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.040
Tcte3t-complex-associated testis expressed 30.040
Vegfavascular endothelial growth factor A0.038
Erv3endogenous retroviral sequence 30.036
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.036
Tgfb2transforming growth factor, beta 20.035
Flt4FMS-like tyrosine kinase 40.034
Ctsrcathepsin R0.033
Bcl6bB-cell CLL/lymphoma 6, member B0.033
Egfrepidermal growth factor receptor0.032
Adcy4adenylate cyclase 40.032
Ncor2nuclear receptor co-repressor 20.031
Hes1hairy and enhancer of split 1 (Drosophila)0.031
Foxg1forkhead box G10.030
Prl2b1prolactin family 2, subfamily b, member 10.028
Mef2dmyocyte enhancer factor 2D0.028
Klf2Kruppel-like factor 2 (lung)0.028
Col13a1collagen, type XIII, alpha 10.028
Enahenabled homolog (Drosophila)0.028
Ednrbendothelin receptor type B0.028
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.027
Robo2roundabout homolog 2 (Drosophila)0.027
Kdrkinase insert domain protein receptor0.026
Ccbp2chemokine binding protein 20.026
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.026
Ece1endothelin converting enzyme 10.026
Zfpm2zinc finger protein, multitype 20.025
Tpbpatrophoblast specific protein alpha0.025
Nr2f1nuclear receptor subfamily 2, group F, member 10.025
Cdkn1bcyclin-dependent kinase inhibitor 1B0.025
Rasip1Ras interacting protein 10.024
Pax3paired box gene 30.024
Psen2presenilin 20.024
Eya1eyes absent 1 homolog (Drosophila)0.023
FosFBJ osteosarcoma oncogene0.022
Sox17SRY-box containing gene 170.022
Efnb1ephrin B10.022
Hdac1histone deacetylase 10.021
Epas1endothelial PAS domain protein 10.021
Flt1FMS-like tyrosine kinase 10.020
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.020
Acvr1activin A receptor, type 10.020
Rhox9reproductive homeobox 90.020
Hey2hairy/enhancer-of-split related with YRPW motif 20.020
Prl2a1prolactin family 2, subfamily a, member 10.019
Esamendothelial cell-specific adhesion molecule0.019
Arpc4actin related protein 2/3 complex, subunit 40.019
Egfl7EGF-like domain 70.019
Prl7c1prolactin family 7, subfamily c, member 10.019
Mmp1amatrix metallopeptidase 1a (interstitial collagenase)0.019
Cldn5claudin 50.018
Pdgfbplatelet derived growth factor, B polypeptide0.018
Foxf1aforkhead box F1a0.018
Tnks1bp1tankyrase 1 binding protein 10.018
Pde3aphosphodiesterase 3A, cGMP inhibited0.017
Itga5integrin alpha 5 (fibronectin receptor alpha)0.017
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.017
BC014805cDNA sequence BC0148050.016
Apoa1apolipoprotein A-I0.016
Tgfbr1transforming growth factor, beta receptor I0.016
Timp3tissue inhibitor of metalloproteinase 30.016
Cxcr7chemokine (C-X-C motif) receptor 70.016
NrarpNotch-regulated ankyrin repeat protein0.015
Foxc1forkhead box C10.015
Serpinb9cserine (or cysteine) peptidase inhibitor, clade B, member 9c0.015
Git1G protein-coupled receptor kinase-interactor 10.015
Tbx10T-box 100.015
Ap2s1adaptor-related protein complex 2, sigma 1 subunit0.015
Slit1slit homolog 1 (Drosophila)0.015
Ednraendothelin receptor type A0.014
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
C1rcomplement component 1, r subcomponent0.026
C1scomplement component 1, s subcomponent0.020
Cfbcomplement factor B0.014
Ndfip1Nedd4 family interacting protein 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism