The network for 'cardiovascular system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiovascular system development

The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
EP300E1A binding protein p3001.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
SMAD3SMAD family member 30.999
SMAD2SMAD family member 20.999
TRIM63tripartite motif containing 630.998
SP1Sp1 transcription factor0.998
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.996
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.994
VEGFAvascular endothelial growth factor A0.992
TTNtitin0.989
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.988
ESR1estrogen receptor 10.988
NOTCH1notch 10.987
MYOD1myogenic differentiation 10.987
FHL2four and a half LIM domains 20.986
TAL1T-cell acute lymphocytic leukemia 10.985
XIAPX-linked inhibitor of apoptosis0.985
SRFserum response factor (c-fos serum response element-binding transcription factor)0.984
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.984
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.983
PTPN1protein tyrosine phosphatase, non-receptor type 10.982
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.981
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.980
METmet proto-oncogene (hepatocyte growth factor receptor)0.977
NCOR2nuclear receptor corepressor 20.976
NR4A1nuclear receptor subfamily 4, group A, member 10.975
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.972
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.971
CSNK1Ecasein kinase 1, epsilon0.970
FGFR2fibroblast growth factor receptor 20.966
PAX3paired box 30.965
BBS10Bardet-Biedl syndrome 100.964
CTGFconnective tissue growth factor0.964
YAP1Yes-associated protein 10.962
JAG1jagged 10.961
CAV1caveolin 1, caveolae protein, 22kDa0.961
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.960
FOSFBJ murine osteosarcoma viral oncogene homolog0.952
CDH5cadherin 5, type 2 (vascular endothelium)0.947
COL1A1collagen, type I, alpha 10.942
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.942
ANXA1annexin A10.940
CALM1calmodulin 1 (phosphorylase kinase, delta)0.937
FN1fibronectin 10.931
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.929
FBN1fibrillin 10.927
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.926
RXRAretinoid X receptor, alpha0.925
NOTCH3notch 30.923
FLNAfilamin A, alpha0.918
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.916
HOXB5homeobox B50.913
TPM1tropomyosin 1 (alpha)0.907
THBS1thrombospondin 10.905
ENGendoglin0.904
RUNX1runt-related transcription factor 10.903
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.902
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.901
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.901
FGFR1fibroblast growth factor receptor 10.901
NCK1NCK adaptor protein 10.893
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.893
PKD2polycystic kidney disease 2 (autosomal dominant)0.892
BCL2L1BCL2-like 10.887
NCOA1nuclear receptor coactivator 10.884
SMAD1SMAD family member 10.884
FASFas (TNF receptor superfamily, member 6)0.881
MDM2Mdm2 p53 binding protein homolog (mouse)0.877
FGF1fibroblast growth factor 1 (acidic)0.875
VCANversican0.874
TGFB1transforming growth factor, beta 10.874
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.871
CAV2caveolin 20.870
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.870
MEF2Cmyocyte enhancer factor 2C0.869
RASSF5Ras association (RalGDS/AF-6) domain family member 50.869
H2AFXH2A histone family, member X0.866
NRP1neuropilin 10.861
JUPjunction plakoglobin0.861
ARandrogen receptor0.854
NCOR1nuclear receptor corepressor 10.851
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.851
COL4A2collagen, type IV, alpha 20.847
DUSP1dual specificity phosphatase 10.841
DSPdesmoplakin0.840
FKBP8FK506 binding protein 8, 38kDa0.840
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.840
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homolog0.838
TP53tumor protein p530.838
CD34CD34 molecule0.837
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.834
PDX1pancreatic and duodenal homeobox 10.833
TNNI1troponin I type 1 (skeletal, slow)0.832
EPAS1endothelial PAS domain protein 10.821
JUNjun proto-oncogene0.821
BMP2bone morphogenetic protein 20.820
TP73tumor protein p730.815
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.806
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.805
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
exexpanded0.997
MadMothers against dpp0.989
sdscalloped0.988
EgfrEpidermal growth factor receptor0.986
UbxUltrabithorax0.985
cicubitus interruptus0.982
NNotch0.981
wgwingless0.979
eyaeyes absent0.970
ushu-shaped0.958
apapterous0.953
stumpsCG31317 gene product from transcript CG31317-RC0.914
pnrpannier0.879
tintinman0.869
inscinscuteable0.852
shnschnurri0.851
mysmyospheroid0.847
nkdnaked cuticle0.843
LanB2Laminin B20.838
nmonemo0.837
dshdishevelled0.832
dppdecapentaplegic0.826
tkvthickveins0.820
DadDaughters against dpp0.814
armarmadillo0.791
Doc2Dorsocross20.747
slp1sloppy paired 10.747
linlines0.743
Ggamma1G protein gamma 10.741
spispitz0.733
MhcMyosin heavy chain0.732
twitwist0.730
dysdysfusion0.695
stcksteamer duck0.693
htlheartless0.683
bab2CG9102 gene product from transcript CG9102-RA0.668
AlkCG8250 gene product from transcript CG8250-RA0.652
AntpAntennapedia0.643
slouslouch0.637
naunautilus0.632
mewmultiple edematous wings0.629
dacdachshund0.617
LanB1CG7123 gene product from transcript CG7123-RA0.601
agoarchipelago0.599
HLH54FCG5005 gene product from transcript CG5005-RA0.594
Rac1CG2248 gene product from transcript CG2248-RA0.580
binbiniou0.578
vgvestigial0.567
fngfringe0.561
G-oalpha47AG protein oalpha 47A0.561
srstripe0.551
bskbasket0.549
lealeak0.546
zfh1Zn finger homeodomain 10.543
rlrolled0.533
Stat92ESignal-transducer and activator of transcription protein at 92E0.523
saxsaxophone0.508
ssspineless0.484
wbwing blister0.460
dallydivision abnormally delayed0.450
NetBNetrin-B0.450
smosmoothened0.443
HmgcrHMG Coenzyme A reductase0.432
CkIIalphaCasein kinase II alpha subunit0.414
panpangolin0.408
DllDistal-less0.407
coroCG9446 gene product from transcript CG9446-RC0.406
jebjelly belly0.401
wunwunen0.399
Atg1Autophagy-specific gene 10.399
snssticks and stones0.396
dcodiscs overgrown0.394
arrarrow0.391
shishibire0.391
MrtfMyocardin-related transcription factor0.391
slmbsupernumerary limbs0.388
Fmr1CG6203 gene product from transcript CG6203-RC0.387
AtpalphaNa pump alpha subunit0.386
numbCG3779 gene product from transcript CG3779-RB0.386
sqzsqueeze0.382
kuzkuzbanian0.377
Tif-IACG3278 gene product from transcript CG3278-RA0.372
gsbgooseberry0.368
NFATNFAT homolog0.365
osaCG7467 gene product from transcript CG7467-RD0.354
G-salpha60AG protein salpha 60A0.350
walwalrus0.350
cswcorkscrew0.347
tshteashirt0.347
howheld out wings0.347
babobaboon0.346
CaMKIICalcium/calmodulin-dependent protein kinase II0.344
Sema-1aCG18405 gene product from transcript CG18405-RD0.343
enengrailed0.338
HandCG18144 gene product from transcript CG18144-RA0.329
putpunt0.328
Sin3ACG8815 gene product from transcript CG8815-RC0.325
TolloCG6890 gene product from transcript CG6890-RA0.321
SmoxSmad on X0.285
eveeven skipped0.283
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.516
Dab2disabled homolog 2 (Drosophila)0.470
Nr4a3nuclear receptor subfamily 4, group A, member 30.462
Pitx3paired-like homeodomain 30.456
Mmp10matrix metallopeptidase 100.456
Id3inhibitor of DNA binding 30.409
Itgadintegrin, alpha D0.397
F13a1coagulation factor XIII, A1 polypeptide0.380
Fgfr1Fibroblast growth factor receptor 10.367
Col1a1collagen, type I, alpha 10.365
Albalbumin0.358
Hsp90b1heat shock protein 90, beta, member 10.354
Ptafrplatelet-activating factor receptor0.350
Twist2twist homolog 2 (Drosophila)0.342
Adra1aadrenergic, alpha-1A-, receptor0.334
Cd4Cd4 molecule0.331
Utrnutrophin0.325
Bcl2B-cell CLL/lymphoma 20.324
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.322
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.319
Egr2early growth response 20.317
Muskmuscle, skeletal, receptor tyrosine kinase0.315
Sdc3syndecan 30.315
Ptgfrprostaglandin F receptor0.313
Ccl4chemokine (C-C motif) ligand 40.311
FosFBJ osteosarcoma oncogene0.295
Tacr2tachykinin receptor 20.292
Sellselectin L0.290
Aqp1aquaporin 10.285
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.285
Gnrhrgonadotropin releasing hormone receptor0.284
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.281
F2rcoagulation factor II (thrombin) receptor0.279
Tgfbr2transforming growth factor, beta receptor II0.279
Nrp1neuropilin 10.276
Sox13SRY (sex determining region Y)-box 130.274
Ednrbendothelin receptor type B0.268
Dchs1dachsous 1 (Drosophila)0.263
Slit3slit homolog 3 (Drosophila)0.261
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.258
F2rl1coagulation factor II (thrombin) receptor-like 10.256
Ngfnerve growth factor (beta polypeptide)0.256
GperG protein-coupled estrogen receptor 10.251
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.249
Fgfr2fibroblast growth factor receptor 20.246
Cgaglycoprotein hormones, alpha polypeptide0.244
Ghrgrowth hormone receptor0.243
Irs1insulin receptor substrate 10.240
Mpripmyosin phosphatase Rho interacting protein0.238
Casq2calsequestrin 2 (cardiac muscle)0.235
Fstl1follistatin-like 10.229
Eporerythropoietin receptor0.227
Flt1FMS-related tyrosine kinase 10.224
Col8a1collagen, type VIII, alpha 10.223
Chrnb1cholinergic receptor, nicotinic, beta 1 (muscle)0.221
Fzd2frizzled homolog 2 (Drosophila)0.216
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.215
Atp12aATPase, H+/K+ transporting, nongastric, alpha polypeptide0.213
Slc1a3solute carrier family 1 (glial high affinity glutamate transporter), member 30.208
Metmet proto-oncogene0.208
Fermt2fermitin family homolog 2 (Drosophila)0.206
Ptger4prostaglandin E receptor 4 (subtype EP4)0.205
Egr1early growth response 10.205
Galr2galanin receptor 20.203
Nfibnuclear factor I/B0.203
Plxnd1plexin D10.201
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.201
Vegfavascular endothelial growth factor A0.201
Smad3SMAD family member 30.200
Egfl7EGF-like-domain, multiple 70.199
Il7interleukin 70.199
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.198
Acvrl1activin A receptor type II-like 10.197
Trib1tribbles homolog 1 (Drosophila)0.196
Ifitm3interferon induced transmembrane protein 30.193
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.193
Pipprolactin induced protein0.193
Col12a1collagen, type XII, alpha 10.192
Actc1actin, alpha, cardiac muscle 10.190
Plb1phospholipase B10.190
Il12binterleukin 12B0.188
Tcfe2atranscription factor E2a0.188
Agtr1aangiotensin II receptor, type 1a0.182
Egr3early growth response 30.182
Mapk3mitogen activated protein kinase 30.181
Pgcprogastricsin (pepsinogen C)0.180
Lims1LIM and senescent cell antigen-like domains 10.177
Vcanversican0.177
Ccnd1cyclin D10.177
Il1r1interleukin 1 receptor, type I0.176
Ccl2chemokine (C-C motif) ligand 20.176
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.176
Arntaryl hydrocarbon receptor nuclear translocator0.174
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.173
Nos3nitric oxide synthase 3, endothelial cell0.172
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.171
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.170
Hoxa2homeo box A20.169
Prrx1paired related homeobox 10.167
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.167
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism