The network for 'positive regulation of protein serine threonine kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein serine threonine kinase activity

Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence1.000
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.997
FGFR2fibroblast growth factor receptor 20.996
CASP8caspase 8, apoptosis-related cysteine peptidase0.995
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.994
AKT1v-akt murine thymoma viral oncogene homolog 10.993
FGFR1fibroblast growth factor receptor 10.987
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.986
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.985
FGF1fibroblast growth factor 1 (acidic)0.958
TRAF6TNF receptor-associated factor 60.953
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.950
LRRK2leucine-rich repeat kinase 20.948
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.946
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.943
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.939
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.935
APPamyloid beta (A4) precursor protein0.932
BBS10Bardet-Biedl syndrome 100.927
TRAF2TNF receptor-associated factor 20.922
CDC37cell division cycle 37 homolog (S. cerevisiae)0.921
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.920
LATlinker for activation of T cells0.919
SHC1SHC (Src homology 2 domain containing) transforming protein 10.914
METmet proto-oncogene (hepatocyte growth factor receptor)0.910
STK11serine/threonine kinase 110.906
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.897
TRAF1TNF receptor-associated factor 10.894
MAP3K3mitogen-activated protein kinase kinase kinase 30.889
MAP3K5mitogen-activated protein kinase kinase kinase 50.888
CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.862
PLCG1phospholipase C, gamma 10.842
CSNK1Ecasein kinase 1, epsilon0.838
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.835
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.831
VEGFAvascular endothelial growth factor A0.825
SH3KBP1SH3-domain kinase binding protein 10.812
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.811
TGFB1transforming growth factor, beta 10.797
CASP10caspase 10, apoptosis-related cysteine peptidase0.797
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.783
IL1R1interleukin 1 receptor, type I0.779
CDK14cyclin-dependent kinase 140.777
CAV1caveolin 1, caveolae protein, 22kDa0.753
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.744
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.743
TRAF5TNF receptor-associated factor 50.723
GRB2growth factor receptor-bound protein 20.696
INSRinsulin receptor0.688
DVL3dishevelled, dsh homolog 3 (Drosophila)0.680
NCF1neutrophil cytosolic factor 10.645
PDPK13-phosphoinositide dependent protein kinase-10.640
NTRK1neurotrophic tyrosine kinase, receptor, type 10.619
MAP3K14mitogen-activated protein kinase kinase kinase 140.613
CALM1calmodulin 1 (phosphorylase kinase, delta)0.610
RHOAras homolog gene family, member A0.600
GAB1GRB2-associated binding protein 10.591
MAPTmicrotubule-associated protein tau0.585
DLG1discs, large homolog 1 (Drosophila)0.584
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.575
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.573
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.551
NRP1neuropilin 10.549
MTORmechanistic target of rapamycin (serine/threonine kinase)0.546
CDK2cyclin-dependent kinase 20.535
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.510
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.509
NTRK2neurotrophic tyrosine kinase, receptor, type 20.509
BMPR1Abone morphogenetic protein receptor, type IA0.506
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.502
IGF1Rinsulin-like growth factor 1 receptor0.501
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.498
SMN1survival of motor neuron 1, telomeric0.481
GSK3Bglycogen synthase kinase 3 beta0.479
WASLWiskott-Aldrich syndrome-like0.476
MYD88myeloid differentiation primary response gene (88)0.473
MAP3K11mitogen-activated protein kinase kinase kinase 110.449
GAB2GRB2-associated binding protein 20.447
MAPK8mitogen-activated protein kinase 80.444
CCND3cyclin D30.444
SQSTM1sequestosome 10.426
MAP2K7mitogen-activated protein kinase kinase 70.401
TNFtumor necrosis factor0.395
SMAD7SMAD family member 70.393
SMAD3SMAD family member 30.392
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.391
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.386
PSEN2presenilin 2 (Alzheimer disease 4)0.383
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.380
AKT1S1AKT1 substrate 1 (proline-rich)0.369
FASFas (TNF receptor superfamily, member 6)0.368
TNIP2TNFAIP3 interacting protein 20.357
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.355
VAV1vav 1 guanine nucleotide exchange factor0.354
NEDD4neural precursor cell expressed, developmentally down-regulated 40.351
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.350
UBCubiquitin C0.323
PKD1polycystic kidney disease 1 (autosomal dominant)0.317
SOS1son of sevenless homolog 1 (Drosophila)0.315
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
unc-73Protein UNC-730.043
egl-18Protein EGL-180.025
bar-1Protein BAR-10.022
sax-7Protein SAX-70.017
lin-36Protein LIN-360.017
cdf-1Protein CDF-10.017
lin-45Protein LIN-450.016
plc-3Protein PLC-30.016
obr-3Protein OBR-30.016
sur-2Protein SUR-20.016
pqn-44Protein PQN-440.014
lin-53Protein LIN-530.014
egl-3Protein EGL-30.013
ina-1Protein INA-10.013
mek-2Protein MEK-20.012
mlk-1Protein MLK-10.012
let-60Protein LET-600.011
mpk-1Protein MPK-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.999
bskbasket0.626
Pi3K92ECG4141 gene product from transcript CG4141-RB0.452
Rac1CG2248 gene product from transcript CG2248-RA0.451
Akt1CG4006 gene product from transcript CG4006-RA0.360
rlrolled0.347
HLHmgammaE(spl) region transcript mgamma0.342
Rab5Rab-protein 50.288
MadMothers against dpp0.252
phlpole hole0.234
HLHmdeltaE(spl) region transcript mdelta0.217
par-1CG8201 gene product from transcript CG8201-RA0.214
aopanterior open0.199
SmoxSmad on X0.172
G-oalpha47AG protein oalpha 47A0.170
CkIIalphaCasein kinase II alpha subunit0.126
ttktramtrack0.120
E(spl)Enhancer of split0.117
Atg1Autophagy-specific gene 10.109
HLHmbetaE(spl) region transcript mbeta0.106
armarmadillo0.090
HLHm5E(spl) region transcript m50.088
spispitz0.087
S6kRPS6-p70-protein kinase0.084
lqfliquid facets0.082
chicoCG5686 gene product from transcript CG5686-RB0.081
HLHm7E(spl) region transcript m70.080
HLHm3E(spl) region transcript m30.079
Rac2CG8556 gene product from transcript CG8556-RA0.078
pntpointed0.077
Cdc42CG12530 gene product from transcript CG12530-RA0.074
CdsACDP diglyceride synthetase0.073
Gp150CG5820 gene product from transcript CG5820-RA0.073
CG5794CG5794 gene product from transcript CG5794-RB0.072
kaykayak0.071
EgfrEpidermal growth factor receptor0.057
dmdiminutive0.055
stcksteamer duck0.054
chicchickadee0.054
RalaRas-related protein0.053
ykiyorkie0.052
putpunt0.052
sinaseven in absentia0.051
Vap-33-1CG5014 gene product from transcript CG5014-RB0.047
Cdk4Cyclin-dependent kinase 40.045
dshdishevelled0.045
p120ctnAdherens junction protein p1200.044
Galpha49BG protein alpha49B0.042
krzkurtz0.040
btlbreathless0.039
kek5kekkon50.039
debcldeath executioner Bcl-2 homologue0.036
myoglianinCG1838 gene product from transcript CG1838-RD0.035
SaraSmad anchor for receptor activation0.035
mbcmyoblast city0.034
ApcAPC-like0.034
CG33523CG33523 gene product from transcript CG33523-RD0.034
srstripe0.034
drkdownstream of receptor kinase0.033
malphaE(spl) region transcript malpha0.033
EphrinCG1862 gene product from transcript CG1862-RA0.032
Stat92ESignal-transducer and activator of transcription protein at 92E0.032
hephemipterous0.031
babobaboon0.031
WnkCG7177 gene product from transcript CG7177-RA0.031
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.031
gekgenghis khan0.030
PtenCG5671 gene product from transcript CG5671-RB0.030
JraJun-related antigen0.029
LanB2Laminin B20.028
rheaCG6831 gene product from transcript CG6831-RA0.028
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.027
cpbcapping protein beta0.026
klarklarsicht0.026
DadDaughters against dpp0.026
Myo31DFMyosin 31DF0.026
Rho1CG8416 gene product from transcript CG8416-RB0.026
FhosCG42610 gene product from transcript CG42610-RC0.025
Rab7Rab-protein 70.025
unc-13CG2999 gene product from transcript CG2999-RA0.025
m2E(spl) region transcript m20.025
LLobe0.025
mttmangetout0.025
msnmisshapen0.025
kuzkuzbanian0.024
auxauxillin0.024
mysmyospheroid0.024
ninaEneither inactivation nor afterpotential E0.023
gbbglass bottom boat0.023
ShcSHC-adaptor protein0.022
Rab30CG9100 gene product from transcript CG9100-RB0.021
emcextra macrochaetae0.021
ckcrinkled0.020
NijANinjurin A0.019
scscute0.019
Socs36ESuppressor of cytokine signaling at 36E0.019
TomTwin of m40.019
Cdlc2Cytoplasmic dynein light chain 20.019
sbbscribbler0.019
p38bCG7393 gene product from transcript CG7393-RA0.019
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.998
Leprleptin receptor0.997
Tnftumor necrosis factor0.990
CblCasitas B-lineage lymphoma0.982
Traf6TNF receptor-associated factor 60.982
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.982
Grb2growth factor receptor bound protein 20.980
Ptenphosphatase and tensin homolog0.978
Itgb1integrin beta 1 (fibronectin receptor beta)0.959
Jag1jagged 10.959
Axin1axin 10.953
SrcRous sarcoma oncogene0.952
Ephb2Eph receptor B20.952
Efnb2ephrin B20.950
Inpp5dinositol polyphosphate-5-phosphatase D0.941
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.940
Fras1Fraser syndrome 1 homolog (human)0.932
Csf1colony stimulating factor 1 (macrophage)0.929
Cd40CD40 antigen0.923
Map3k7mitogen-activated protein kinase kinase kinase 70.912
Rac1RAS-related C3 botulinum substrate 10.912
Tgfb2transforming growth factor, beta 20.902
Nos1nitric oxide synthase 1, neuronal0.876
Dvl2dishevelled 2, dsh homolog (Drosophila)0.867
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.862
Plcg1phospholipase C, gamma 10.860
Dok1docking protein 10.847
Fcgr2bFc receptor, IgG, low affinity IIb0.846
Notch2Notch gene homolog 2 (Drosophila)0.845
Grip1glutamate receptor interacting protein 10.841
Ednrbendothelin receptor type B0.810
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.808
Yap1yes-associated protein 10.806
Apoeapolipoprotein E0.790
Cd22CD22 antigen0.781
Cd44CD44 antigen0.779
Irs1insulin receptor substrate 10.771
Nos3nitric oxide synthase 3, endothelial cell0.770
Shc3src homology 2 domain-containing transforming protein C30.768
Efnb1ephrin B10.767
AxlAXL receptor tyrosine kinase0.748
Nos2nitric oxide synthase 2, inducible0.746
Egfrepidermal growth factor receptor0.733
Retret proto-oncogene0.722
Cx3cr1chemokine (C-X3-C) receptor 10.722
Wwtr1WW domain containing transcription regulator 10.689
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.685
Cdkn1bcyclin-dependent kinase inhibitor 1B0.680
Vangl2vang-like 2 (van gogh, Drosophila)0.678
C1qbcomplement component 1, q subcomponent, beta polypeptide0.672
Mmp9matrix metallopeptidase 90.666
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.662
Cdk4cyclin-dependent kinase 40.634
Smad3MAD homolog 3 (Drosophila)0.632
Ptch1patched homolog 10.618
Psen1presenilin 10.616
Dok2docking protein 20.611
Ptpn11protein tyrosine phosphatase, non-receptor type 110.603
Il1r1interleukin 1 receptor, type I0.601
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.600
Tnfaip3tumor necrosis factor, alpha-induced protein 30.599
Trp53transformation related protein 530.599
Tead2TEA domain family member 20.597
Nr2f2nuclear receptor subfamily 2, group F, member 20.591
Ephb3Eph receptor B30.588
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.586
Smad6MAD homolog 6 (Drosophila)0.583
C3ar1complement component 3a receptor 10.555
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.535
Prkceprotein kinase C, epsilon0.531
Csf1rcolony stimulating factor 1 receptor0.521
Socs1suppressor of cytokine signaling 10.516
Kitkit oncogene0.513
Map3k1mitogen-activated protein kinase kinase kinase 10.501
Mapk8mitogen-activated protein kinase 80.500
Klc1kinesin light chain 10.498
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.494
Spry4sprouty homolog 4 (Drosophila)0.485
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.484
Fgfr2fibroblast growth factor receptor 20.481
Grb10growth factor receptor bound protein 100.481
Wnt4wingless-related MMTV integration site 40.477
Plauplasminogen activator, urokinase0.470
Ccnd1cyclin D10.465
Fbn1fibrillin 10.465
Epha4Eph receptor A40.447
Rb1retinoblastoma 10.446
Ptpn14protein tyrosine phosphatase, non-receptor type 140.429
Tgfatransforming growth factor alpha0.427
FynFyn proto-oncogene0.426
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.423
Pcsk5proprotein convertase subtilisin/kexin type 50.421
Dab1disabled homolog 1 (Drosophila)0.420
Ikbkbinhibitor of kappaB kinase beta0.411
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.409
Folr2folate receptor 2 (fetal)0.405
Cxcl13chemokine (C-X-C motif) ligand 130.405
Esr1estrogen receptor 1 (alpha)0.402
Ror2receptor tyrosine kinase-like orphan receptor 20.400
Unc93b1unc-93 homolog B1 (C. elegans)0.398
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.610
Utrnutrophin0.364
Cd38CD38 molecule0.347
RGD1564664similar to LOC387763 protein0.286
Ptafrplatelet-activating factor receptor0.275
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.242
Folh1folate hydrolase 10.213
Prkcdprotein kinase C, delta0.210
RT1-BaRT1 class II, locus Ba0.203
Mpeg1macrophage expressed 10.192
Mpripmyosin phosphatase Rho interacting protein0.189
Fgf7fibroblast growth factor 70.177
Homer1homer homolog 1 (Drosophila)0.175
Gna12guanine nucleotide binding protein (G protein) alpha 120.173
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.173
Jak2Janus kinase 20.158
Scarb1scavenger receptor class B, member 10.157
Ptk2bPTK2B protein tyrosine kinase 2 beta0.149
Inpp5dinositol polyphosphate-5-phosphatase D0.146
Sox17SRY (sex determining region Y)-box 170.138
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.135
Sirpasignal-regulatory protein alpha0.134
Tgfb1transforming growth factor, beta 10.133
Dapk3death-associated protein kinase 30.127
Hckhemopoietic cell kinase0.121
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.118
Anpepalanyl (membrane) aminopeptidase0.117
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.115
Nudt3nudix (nucleoside diphosphate linked moiety X)-type motif 30.111
Cfpcomplement factor properdin0.110
Leprleptin receptor0.110
Cd4Cd4 molecule0.108
Metmet proto-oncogene0.108
Arandrogen receptor0.103
Ptprcprotein tyrosine phosphatase, receptor type, C0.102
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.102
Trhrthyrotropin releasing hormone receptor0.101
Il2rginterleukin 2 receptor, gamma0.098
Rgs14regulator of G-protein signaling 140.098
Agtr1aangiotensin II receptor, type 1a0.098
Olfml2bolfactomedin-like 2B0.095
Pou2f2POU class 2 homeobox 20.094
Ptp4a2protein tyrosine phosphatase 4a20.092
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.091
Smad7SMAD family member 70.090
Mapk1mitogen activated protein kinase 10.089
Hk1hexokinase 10.088
Hpcal4hippocalcin-like 40.087
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.086
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.085
Pde5aphosphodiesterase 5A, cGMP-specific0.085
Fkbp1aFK506 binding protein 1a0.084
Prkg2protein kinase, cGMP-dependent, type II0.083
Cxcr4chemokine (C-X-C motif) receptor 40.083
Dact3dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)0.082
Hsph1heat shock 105/110 protein 10.080
Cd8bCD8b molecule0.079
Calcrlcalcitonin receptor-like0.078
Ccnd3cyclin D30.077
Wt1Wilms tumor 10.076
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.072
Ptgfrprostaglandin F receptor0.072
Olr416olfactory receptor 4160.071
Ralav-ral simian leukemia viral oncogene homolog A (ras related)0.071
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.071
Tpm3tropomyosin 3, gamma0.070
Slit3slit homolog 3 (Drosophila)0.070
Trpc4transient receptor potential cation channel, subfamily C, member 40.070
S1pr2sphingosine-1-phosphate receptor 20.069
Ptpn6protein tyrosine phosphatase, non-receptor type 60.068
Adora2aadenosine A2a receptor0.068
Pou3f2POU class 3 homeobox 20.068
Grm7glutamate receptor, metabotropic 70.068
Hspd1heat shock protein 1 (chaperonin)0.067
Otx1orthodenticle homeobox 10.067
Usf2upstream transcription factor 2, c-fos interacting0.067
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.066
RGD1307722similar to hypothetical protein MGC207000.066
Bmp6bone morphogenetic protein 60.065
Cpdcarboxypeptidase D0.064
Cx3cr1chemokine (C-X3-C motif) receptor 10.063
Stip1stress-induced phosphoprotein 10.063
Fkbp4FK506 binding protein 40.063
Uhmk1U2AF homology motif (UHM) kinase 10.063
Slco2b1solute carrier organic anion transporter family, member 2b10.063
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.063
Myo1emyosin IE0.062
Ly86lymphocyte antigen 860.062
Gja4gap junction protein, alpha 40.061
Nlgn2neuroligin 20.061
Prkcaprotein kinase C, alpha0.060
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.060
Efnb1ephrin B10.060
Phkg1phosphorylase kinase, gamma 10.059
RT1-BbRT1 class II, locus Bb0.059
Vav1vav 1 guanine nucleotide exchange factor0.059
Snx18sorting nexin 180.059
Il7interleukin 70.059
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.059
Cd37CD37 molecule0.058
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PBS2Pbs2p0.404
SSK2Ssk2p0.043
BCK1Bck1p0.035
RPN14Rpn14p0.022
RPN2Rpn2p0.020
TCO89Tco89p0.018
MSG5Msg5p0.018
NBP2Nbp2p0.018
SSK22Ssk22p0.015
STT4Stt4p0.015
BEM3Bem3p0.012
RGD1Rgd1p0.011