The network for 'negative regulation of protein serine threonine kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein serine threonine kinase activity

Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.

NameDescriptionProbabilityFunc Analog Organism
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence1.000
MAPK14mitogen-activated protein kinase 141.000
MAPK1mitogen-activated protein kinase 11.000
MAPK8mitogen-activated protein kinase 80.998
ZNF43zinc finger protein 430.986
SH3KBP1SH3-domain kinase binding protein 10.971
MAP3K5mitogen-activated protein kinase kinase kinase 50.967
FYNFYN oncogene related to SRC, FGR, YES0.965
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.959
MAP2K4mitogen-activated protein kinase kinase 40.957
SRFserum response factor (c-fos serum response element-binding transcription factor)0.956
GSK3Bglycogen synthase kinase 3 beta0.954
RB1retinoblastoma 10.952
ZNF253zinc finger protein 2530.949
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.935
IRAK2interleukin-1 receptor-associated kinase 20.934
EGFRepidermal growth factor receptor0.925
DUSP1dual specificity phosphatase 10.869
ZNF273zinc finger protein 2730.860
APPamyloid beta (A4) precursor protein0.859
CCND1cyclin D10.856
CDK6cyclin-dependent kinase 60.845
CCND3cyclin D30.840
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.836
MAPK3mitogen-activated protein kinase 30.824
RARAretinoic acid receptor, alpha0.823
ATF2activating transcription factor 20.805
LARP7La ribonucleoprotein domain family, member 70.799
PTK2PTK2 protein tyrosine kinase 20.793
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.776
CDC37cell division cycle 37 homolog (S. cerevisiae)0.775
ARRB1arrestin, beta 10.772
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.759
MAP2K1mitogen-activated protein kinase kinase 10.756
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.718
JUNjun proto-oncogene0.713
ZNF675zinc finger protein 6750.660
BMPR1Abone morphogenetic protein receptor, type IA0.660
CREBBPCREB binding protein0.659
XIAPX-linked inhibitor of apoptosis0.621
PTPN1protein tyrosine phosphatase, non-receptor type 10.620
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.619
A2Malpha-2-macroglobulin0.603
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.555
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.552
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.541
IL1R1interleukin 1 receptor, type I0.513
AKAP1A kinase (PRKA) anchor protein 10.503
METmet proto-oncogene (hepatocyte growth factor receptor)0.498
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.493
LCKlymphocyte-specific protein tyrosine kinase0.484
DUSP6dual specificity phosphatase 60.473
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.472
TRAF6TNF receptor-associated factor 60.439
NOXA1NADPH oxidase activator 10.437
ARRB2arrestin, beta 20.423
PHLDA1pleckstrin homology-like domain, family A, member 10.417
MYD88myeloid differentiation primary response gene (88)0.413
CDK4cyclin-dependent kinase 40.406
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.404
ZNF430zinc finger protein 4300.384
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.384
ZNF254zinc finger protein 2540.380
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.370
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.341
HSPA8heat shock 70kDa protein 80.334
PRKCZprotein kinase C, zeta0.333
SHC1SHC (Src homology 2 domain containing) transforming protein 10.333
LAMP1lysosomal-associated membrane protein 10.333
ZNF91zinc finger protein 910.322
MAP2K7mitogen-activated protein kinase kinase 70.311
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.306
AXIN1axin 10.301
GHRgrowth hormone receptor0.299
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.298
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.296
EGR2early growth response 20.289
CHUKconserved helix-loop-helix ubiquitous kinase0.288
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.283
AKT1v-akt murine thymoma viral oncogene homolog 10.274
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.266
ZNF85zinc finger protein 850.258
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.251
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.249
PLCG1phospholipase C, gamma 10.244
CTNND1catenin (cadherin-associated protein), delta 10.237
NLRC4NLR family, CARD domain containing 40.233
IRAK1interleukin-1 receptor-associated kinase 10.233
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.223
IER2immediate early response 20.217
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.212
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.208
RICTORRPTOR independent companion of MTOR, complex 20.204
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.203
ZNF117zinc finger protein 1170.203
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.197
PKM2pyruvate kinase, muscle0.196
ZNF93zinc finger protein 930.193
YAP1Yes-associated protein 10.191
NR1H2nuclear receptor subfamily 1, group H, member 20.190
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
mec-2Protein MEC-20.138
inx-12Protein INX-120.042
ape-1Protein APE-10.040
ajm-1Protein AJM-10.039
unc-53Protein UNC-530.030
vab-3Protein VAB-30.027
R03H10.2Protein R03H10.20.026
inx-13Protein INX-130.020
inx-1Protein INX-10.020
glr-5Protein GLR-50.020
eat-4Protein EAT-40.017
ger-1Protein GER-10.015
CELE_F20D1.3Protein F20D1.30.014
mel-26Protein MEL-260.014
cnb-1Protein CNB-10.012
CELE_M176.5Protein M176.50.011
Y104H12D.2Protein Y104H12D.20.011
pde-4Protein PDE-40.011
C06G3.5Protein C06G3.50.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ntn2netrin 20.312
dusp6dual specificity phosphatase 60.291
rhoabras homolog gene family, member Ab0.280
fgf3fibroblast growth factor 30.273
nrg2aneuregulin 2a0.252
bmp2bbone morphogenetic protein 2b0.191
prox1prospero-related homeobox gene 10.186
efnb2aephrin B2a0.186
b3gat3beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) and beta3-glucuronyltransferase0.184
nf1aneurofibromin 1a0.180
spry4sprouty (Drosophila) homolog 40.168
egr1early growth response 10.166
acvr2aactivin receptor IIa0.166
tnfatumor necrosis factor a (TNF superfamily, member 2)0.131
epha4aeph receptor A4a0.125
fzd7bfrizzled homolog 7b0.125
adipoqladiponectin, C1Q and collagen domain containing, like0.118
ahsa1lAHA1, activator of heat shock protein ATPase homolog 1, like0.117
pea3ETS-domain transcription factor pea30.113
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.108
mapk3mitogen-activated protein kinase 30.106
sox3SRY-box containing gene 30.104
gli3GLI-Kruppel family member GLI30.101
myod1myogenic differentiation 10.099
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.094
nf1bneurofibromin 1b0.092
ficdFIC domain containing0.090
phf23aPHD finger protein 23a0.090
rarabretinoic acid receptor, alpha b0.090
btg2B-cell translocation gene 20.084
homezhomeodomain leucine zipper gene0.083
hoxa13ahomeo box A13a0.083
fam49bafamily with sequence similarity 49, member Ba0.083
mbtps1membrane-bound transcription factor protease, site 10.080
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.077
notum3notum 30.077
plk3polo-like kinase 3 (Drosophila)0.071
adipor2adiponectin receptor 20.071
rab22aRAB22A, member RAS oncogene family0.070
bcl2l1bcl2-like 10.070
adipoql2adiponectin, C1Q and collagen domain containing, like 20.069
sema3dsemaphorin 3d0.069
mcm6lMCM6 minichromosome maintenance deficient 6, like0.068
stau2staufen, RNA binding protein, homolog 2 (Drosophila)0.068
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.066
rasl11bRAS-like, family 11, member B0.065
slc25a25asolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a0.063
vcanaversican a0.062
papolbpoly(A) polymerase beta (testis specific)0.062
tie2endothelium-specific receptor tyrosine kinase 20.062
hoxc12bhomeo box C12b0.062
pfn1profilin 10.062
ptpraprotein tyrosine phosphatase, receptor type, A0.061
etv5aets variant 5a0.061
ahcyl1S-adenosylhomocysteine hydrolase-like 10.061
mapk6mitogen-activated protein kinase 60.060
ctsbacathepsin B, a0.060
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.060
wu:fi25h02wu:fi25h020.060
sall1asal-like 1a (Drosophila)0.059
snai1asnail homolog 1a (Drosophila)0.058
il17rdinterleukin 17 receptor D0.057
frem3Fras1 related extracellular matrix 30.056
mapk7mitogen-activated protein kinase 70.054
cps1carbamoyl-phosphate synthase 1, mitochondrial0.053
id1inhibitor of DNA binding 10.053
slc4a1bsolute carrier family 4, anion exchanger, member 1b0.053
gscgoosecoid0.053
mapk1mitogen-activated protein kinase 10.052
zgc:92380zgc:923800.052
nrarpanotch-regulated ankyrin repeat protein a0.052
grnbgranulin b0.051
thy1Thy-1 cell surface antigen0.050
cdc25cell division cycle 25 homolog0.050
hspa5heat shock protein 50.050
hspb11heat shock protein, alpha-crystallin-related, b110.050
dennd5bDENN/MADD domain containing 5B0.049
ppp6r3protein phosphatase 6, regulatory subunit 30.049
efna2ephrin A20.049
dnajb1aDnaJ (Hsp40) homolog, subfamily B, member 1a0.048
dusp5dual specificity phosphatase 50.048
wnt1wingless-type MMTV integration site family, member 10.048
foxi3bforkhead box I3b0.048
mapk12mitogen-activated protein kinase 120.047
myogmyogenin0.047
arl5cADP-ribosylation factor-like 5C0.047
tnrc5trinucleotide repeat containing 50.046
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.046
caspacaspase a0.045
LOC555739serine/threonine-protein kinase LMTK1-like0.045
capns1acalpain, small subunit 1 a0.044
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.044
ip6k2inositol hexaphosphate kinase 20.043
cotl1coactosin-like 1 (Dictyostelium)0.043
si:ch73-60i13.2si:ch73-60i13.20.043
atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.042
prkcqprotein kinase C, theta0.042
zgc:92851zgc:928510.042
nrg2bneuregulin 2b0.042
pacsin3protein kinase C and casein kinase substrate in neurons 30.041
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Ctnnb1catenin (cadherin associated protein), beta 10.999
Rb1retinoblastoma 10.989
Apcadenomatosis polyposis coli0.986
Cdkn1bcyclin-dependent kinase inhibitor 1B0.985
Ptenphosphatase and tensin homolog0.978
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.928
Mdm2transformed mouse 3T3 cell double minute 20.924
Ighimmunoglobulin heavy chain complex0.911
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.892
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.877
Prkceprotein kinase C, epsilon0.861
Traf6TNF receptor-associated factor 60.848
Ikzf1IKAROS family zinc finger 10.842
BlnkB-cell linker0.819
Ptpn11protein tyrosine phosphatase, non-receptor type 110.781
Nf2neurofibromatosis 20.772
Ghrgrowth hormone receptor0.764
Ptch1patched homolog 10.760
FosFBJ osteosarcoma oncogene0.741
C1qccomplement component 1, q subcomponent, C chain0.729
Ly86lymphocyte antigen 860.726
EvlEna-vasodilator stimulated phosphoprotein0.698
Lyz2lysozyme 20.688
Dok1docking protein 10.687
Plcg2phospholipase C, gamma 20.671
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.663
Tnftumor necrosis factor0.661
Nf1neurofibromatosis 10.659
CblCasitas B-lineage lymphoma0.617
Nr3c1nuclear receptor subfamily 3, group C, member 10.609
Il1binterleukin 1 beta0.603
Axin1axin 10.602
Cdh5cadherin 50.600
Egr1early growth response 10.586
Rassf5Ras association (RalGDS/AF-6) domain family member 50.571
Mapk14mitogen-activated protein kinase 140.562
Casp4caspase 4, apoptosis-related cysteine peptidase0.551
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.550
Ptprcprotein tyrosine phosphatase, receptor type, C0.531
JunJun oncogene0.516
Gsk3bglycogen synthase kinase 3 beta0.515
Tsc1tuberous sclerosis 10.494
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.460
Cd40CD40 antigen0.438
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.423
Grb2growth factor receptor bound protein 20.404
Casp1caspase 10.395
NsfN-ethylmaleimide sensitive fusion protein0.394
Clockcircadian locomotor output cycles kaput0.378
Bmp4bone morphogenetic protein 40.374
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.368
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.362
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.356
Fgfr1fibroblast growth factor receptor 10.331
Aif1allograft inflammatory factor 10.329
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.313
Ppargperoxisome proliferator activated receptor gamma0.312
BrafBraf transforming gene0.309
Itgb1integrin beta 1 (fibronectin receptor beta)0.301
Aim2absent in melanoma 20.300
Irf8interferon regulatory factor 80.298
Enahenabled homolog (Drosophila)0.296
Mdm4transformed mouse 3T3 cell double minute 40.289
Vangl2vang-like 2 (van gogh, Drosophila)0.288
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.285
Prkcbprotein kinase C, beta0.276
BtkBruton agammaglobulinemia tyrosine kinase0.268
Leprleptin receptor0.267
Cd22CD22 antigen0.267
SkilSKI-like0.266
Retret proto-oncogene0.265
Tnfaip3tumor necrosis factor, alpha-induced protein 30.258
Spry2sprouty homolog 2 (Drosophila)0.256
SrcRous sarcoma oncogene0.256
Sirpasignal-regulatory protein alpha0.256
Gbp5guanylate binding protein 50.246
Stk4serine/threonine kinase 40.244
Hsph1heat shock 105kDa/110kDa protein 10.244
Dnajb4DnaJ (Hsp40) homolog, subfamily B, member 40.241
Ptpn6protein tyrosine phosphatase, non-receptor type 60.230
Msh2mutS homolog 2 (E. coli)0.224
Ldb3LIM domain binding 30.217
Relreticuloendotheliosis oncogene0.216
Esr1estrogen receptor 1 (alpha)0.214
Ccnd1cyclin D10.214
Map3k7mitogen-activated protein kinase kinase kinase 70.213
Yap1yes-associated protein 10.212
Irak4interleukin-1 receptor-associated kinase 40.210
Rxraretinoid X receptor alpha0.208
JunbJun-B oncogene0.207
Lrp6low density lipoprotein receptor-related protein 60.205
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.205
Mapk8mitogen-activated protein kinase 80.204
Nr4a1nuclear receptor subfamily 4, group A, member 10.203
E2f1E2F transcription factor 10.198
Grm1glutamate receptor, metabotropic 10.192
TyrobpTYRO protein tyrosine kinase binding protein0.190
Itgb2integrin beta 20.189
Sykbspleen tyrosine kinase0.188
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RLM1Rlm1p0.047
BOI1Boi1p0.034
LHS1Lhs1p0.028
NBP2Nbp2p0.025
MSG5Msg5p0.019
BCK1Bck1p0.012
STE5Ste5p0.012
KSS1Kss1p0.011
PBS2Pbs2p0.011
GAL83Gal83p0.011
STE7Ste7p0.011
GYL1Gyl1p0.010
SSK1Ssk1p0.010