The network for 'positive regulation of nuclease activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of nuclease activity

Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.

NameDescriptionProbabilityFunc Analog Organism
SYVN1synovial apoptosis inhibitor 1, synoviolin0.499
HMGB2high mobility group box 20.189
MDM4Mdm4 p53 binding protein homolog (mouse)0.090
CSNK1A1casein kinase 1, alpha 10.088
CDT1chromatin licensing and DNA replication factor 10.077
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.024
LIG1ligase I, DNA, ATP-dependent0.020
HMGA1high mobility group AT-hook 10.014
VAPAVAMP (vesicle-associated membrane protein)-associated protein A, 33kDa0.014
NUCKS1nuclear casein kinase and cyclin-dependent kinase substrate 10.013
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.012
CDK2cyclin-dependent kinase 20.011
DUTdeoxyuridine triphosphatase0.011
PPP1R14Aprotein phosphatase 1, regulatory (inhibitor) subunit 14A0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
brf-1Protein BRF-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hmgb2bhigh-mobility group box 2b0.405
dhfrdihydrofolate reductase0.149
hmga1ahigh mobility group AT-hook 1a0.140
pcnaproliferating cell nuclear antigen0.132
manfmesencephalic astrocyte-derived neurotrophic factor0.119
h2afvlH2A histone family, member V, like0.113
hmgb2ahigh-mobility group box 2a0.104
hmgb1bhigh-mobility group box 1b0.096
vcpvalosin containing protein0.094
cx43connexin 430.092
dutdUTP pyrophosphatase0.089
ef1aelongation factor 1-alpha0.071
zgc:110540zgc:1105400.059
ranras-related nuclear protein0.054
cdk1cyclin-dependent kinase 10.053
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.051
LOC554173abnormal spindles0.050
hyou1hypoxia up-regulated 10.045
rpa2replication protein A20.044
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.043
tymsthymidylate synthase0.040
ncapd2non-SMC condensin I complex, subunit D20.033
gtf2f2ageneral transcription factor IIF, polypeptide 2a0.033
birc5abaculoviral IAP repeat-containing 5a0.032
nap1l1nucleosome assembly protein 1, like 10.028
mcm4MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)0.027
h3f3aH3 histone, family 3A0.023
fb06f03high-mobility group nucleosome binding domain 1-like0.023
dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.022
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.022
zgc:55461zgc:554610.021
rbmxRNA binding motif protein, X-linked0.020
rfc5replication factor C (activator 1) 50.020
mbnl2muscleblind-like 2 (Drosophila)0.020
snrpbsmall nuclear ribonucleoprotein polypeptides B and B10.019
anp32bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B0.019
prdx2peroxiredoxin 20.017
zgc:123274zgc:1232740.017
prmt1protein arginine methyltransferase 10.016
hspd1heat shock 60kD protein 1 (chaperonin)0.016
zgc:158409zgc:1584090.016
ccng1cyclin G10.015
prim1primase polypeptide 10.015
zgc:64114zgc:641140.015
hmgb1ahigh-mobility group box 1a0.015
rbm8aRNA binding motif protein 8A0.014
gpiaglucose phosphate isomerase a0.014
mifmacrophage migration inhibitory factor0.014
zgc:101761zgc:1017610.014
ranbp1RAN binding protein 10.013
rhoabras homolog gene family, member Ab0.013
prox1prospero-related homeobox gene 10.012
hat1histone acetyltransferase 10.012
rnaseh2aribonuclease H2, subunit A0.012
zgc:109973zgc:1099730.012
hmgb3ahigh-mobility group box 3a0.012
pola2polymerase (DNA directed), alpha 20.012
fen1flap structure-specific endonuclease 10.011
slc39a7solute carrier family 39 (zinc transporter), member 70.011
ssrp1astructure specific recognition protein 1a0.011
pdip5protein disulfide isomerase-related protein (provisional)0.011
wdr76WD repeat domain 760.011
bactin1bactin10.011
zgc:162630zgc:1626300.010
mus81MUS81 endonuclease homolog (yeast)0.010
bhlhe40basic helix-loop-helix family, member e400.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.019
Snrpd1small nuclear ribonucleoprotein D10.019
Hsp90b1heat shock protein 90, beta (Grp94), member 10.019
H2afzH2A histone family, member Z0.018
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
UBI4Ubi4p0.047
FEN1Fen1p0.028
PHO88Pho88p0.028
UTP15Utp15p0.026
RPA12Rpa12p0.019
MNN10Mnn10p0.018
ELP3Elp3p0.018
ELP2Elp2p0.016
BUD20Bud20p0.015
SUR4Sur4p0.014
ENP1Enp1p0.014
RIX1Rix1p0.014
SSB2Ssb2p0.014
DCS1Dcs1p0.014
PSE1Pse1p0.013
UTP21Utp21p0.013
YDL063Chypothetical protein0.013
TRM1Trm1p0.012
RPS0BRps0bp0.012
RLP24Rlp24p0.012
NOP58Nop58p0.012
SSB1Ssb1p0.012
RPS0ARps0ap0.011
RRP6Rrp6p0.011
BUD32Bud32p0.011
KRR1Krr1p0.011
YLR243Whypothetical protein0.011
RPL16BRpl16bp0.011
PRB1Prb1p0.011
NOP2Nop2p0.011
MSC1Msc1p0.010
CIC1Cic1p0.010
RPL35ARpl35ap0.010
RPC40Rpc40p0.010
RPL7ARpl7ap0.010