The network for 'positive regulation of epidermal growth factor receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of epidermal growth factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

NameDescriptionProbabilityFunc Analog Organism
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.430
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.330
CHMP4Bchromatin modifying protein 4B0.214
ARID1BAT rich interactive domain 1B (SWI1-like)0.199
MPDZmultiple PDZ domain protein0.196
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.136
EGFRepidermal growth factor receptor0.130
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.121
DLG1discs, large homolog 1 (Drosophila)0.111
PTPN1protein tyrosine phosphatase, non-receptor type 10.093
PTK2PTK2 protein tyrosine kinase 20.091
AKNAAT-hook transcription factor0.064
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.063
SH3D19SH3 domain containing 190.051
PDCD6IPprogrammed cell death 6 interacting protein0.050
PTPRAprotein tyrosine phosphatase, receptor type, A0.049
MUC1mucin 1, cell surface associated0.043
DNM1dynamin 10.042
ADAM15ADAM metallopeptidase domain 150.042
CCDC6coiled-coil domain containing 60.038
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.035
LRRK2leucine-rich repeat kinase 20.034
MECP2methyl CpG binding protein 2 (Rett syndrome)0.031
EFTUD2elongation factor Tu GTP binding domain containing 20.030
ARID1AAT rich interactive domain 1A (SWI-like)0.028
ADRBK1adrenergic, beta, receptor kinase 10.028
PPP5Cprotein phosphatase 5, catalytic subunit0.027
PRPF6PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)0.027
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.027
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.026
MYLK2myosin light chain kinase 20.025
SNRNP200small nuclear ribonucleoprotein 200kDa (U5)0.024
ARRDC3arrestin domain containing 30.024
ADORA2Aadenosine A2a receptor0.024
PACSIN3protein kinase C and casein kinase substrate in neurons 30.024
SRCIN1SRC kinase signaling inhibitor 10.022
APPamyloid beta (A4) precursor protein0.021
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.021
CAPRIN2caprin family member 20.021
STC2stanniocalcin 20.020
IGFBP3insulin-like growth factor binding protein 30.019
DKK1dickkopf homolog 1 (Xenopus laevis)0.018
PTENphosphatase and tensin homolog0.018
AXIN1axin 10.018
PBRM1polybromo 10.017
ADRB2adrenergic, beta-2-, receptor, surface0.017
SP1Sp1 transcription factor0.017
PTK2BPTK2B protein tyrosine kinase 2 beta0.017
PRPF8PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)0.017
DNAJC1DnaJ (Hsp40) homolog, subfamily C, member 10.016
MBL2mannose-binding lectin (protein C) 2, soluble0.015
PTPN23protein tyrosine phosphatase, non-receptor type 230.015
TBC1D10ATBC1 domain family, member 10A0.015
AHNAKAHNAK nucleoprotein0.014
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.014
SH3GL2SH3-domain GRB2-like 20.014
DDX4DEAD (Asp-Glu-Ala-Asp) box polypeptide 40.014
PSMF1proteasome (prosome, macropain) inhibitor subunit 1 (PI31)0.013
GAB1GRB2-associated binding protein 10.013
METmet proto-oncogene (hepatocyte growth factor receptor)0.012
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.012
SPRR2Asmall proline-rich protein 2A0.012
NOS1APnitric oxide synthase 1 (neuronal) adaptor protein0.012
MAPTmicrotubule-associated protein tau0.011
SIN3ASIN3 homolog A, transcription regulator (yeast)0.011
CCNE1cyclin E10.011
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.011
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.011
APBB2amyloid beta (A4) precursor protein-binding, family B, member 20.011
NCOA2nuclear receptor coactivator 20.011
SH3PXD2ASH3 and PX domains 2A0.011
PTPN21protein tyrosine phosphatase, non-receptor type 210.011
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.011
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.011
GRB10growth factor receptor-bound protein 100.010
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.010
CAV1caveolin 1, caveolae protein, 22kDa0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.821
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.163
Ptenphosphatase and tensin homolog0.132
Nos3nitric oxide synthase 3, endothelial cell0.096
Vdrvitamin D receptor0.072
Ptgs2prostaglandin-endoperoxide synthase 20.069
Egfrepidermal growth factor receptor0.061
Nr3c1nuclear receptor subfamily 3, group C, member 10.059
Nos1nitric oxide synthase 1, neuronal0.058
Smad3MAD homolog 3 (Drosophila)0.053
Il10interleukin 100.049
Arandrogen receptor0.042
Kiss1KiSS-1 metastasis-suppressor0.038
Amhr2anti-Mullerian hormone type 2 receptor0.037
Arid1bAT rich interactive domain 1B (SWI-like)0.035
Fshrfollicle stimulating hormone receptor0.033
Kitkit oncogene0.031
Apoeapolipoprotein E0.030
Stat5asignal transducer and activator of transcription 5A0.029
Kiss1rKISS1 receptor0.028
Lepleptin0.026
Trp53transformation related protein 530.026
Ifnginterferon gamma0.026
Cpeb3cytoplasmic polyadenylation element binding protein 30.026
Apcadenomatosis polyposis coli0.025
Stat3signal transducer and activator of transcription 30.022
Lhcgrluteinizing hormone/choriogonadotropin receptor0.022
Ghrgrowth hormone receptor0.019
Il6stinterleukin 6 signal transducer0.019
Drd2dopamine receptor D20.018
Tgfb1transforming growth factor, beta 10.017
Agtr1aangiotensin II receptor, type 1a0.017
Nos2nitric oxide synthase 2, inducible0.016
Thrathyroid hormone receptor alpha0.015
Ptpn11protein tyrosine phosphatase, non-receptor type 110.014
Cd44CD44 antigen0.014
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.014
Ppargperoxisome proliferator activated receptor gamma0.013
Smarcc2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.013
Klklotho0.013
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.012
Pgrprogesterone receptor0.012
Cdkn1bcyclin-dependent kinase inhibitor 1B0.012
Vegfavascular endothelial growth factor A0.010
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.010
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism