The network for 'convergent extension' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

convergent extension

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.

NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.924
MED28mediator complex subunit 280.596
PTPN1protein tyrosine phosphatase, non-receptor type 10.454
LRRK2leucine-rich repeat kinase 20.413
APCadenomatous polyposis coli0.364
BMPR1Abone morphogenetic protein receptor, type IA0.300
DVL3dishevelled, dsh homolog 3 (Drosophila)0.297
BCAR1breast cancer anti-estrogen resistance 10.254
FNBP1Lformin binding protein 1-like0.211
SMAD1SMAD family member 10.208
CSNK1Ecasein kinase 1, epsilon0.204
MBNL1muscleblind-like (Drosophila)0.178
DSG2desmoglein 20.171
SMURF2SMAD specific E3 ubiquitin protein ligase 20.144
LUMlumican0.139
PTPN12protein tyrosine phosphatase, non-receptor type 120.125
FZD1frizzled homolog 1 (Drosophila)0.105
DVL1dishevelled, dsh homolog 1 (Drosophila)0.103
YAP1Yes-associated protein 10.097
FYNFYN oncogene related to SRC, FGR, YES0.095
TRIP6thyroid hormone receptor interactor 60.094
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.091
BBS2Bardet-Biedl syndrome 20.090
CEP164centrosomal protein 164kDa0.085
BMP1bone morphogenetic protein 10.084
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.083
GSK3Bglycogen synthase kinase 3 beta0.081
BBS1Bardet-Biedl syndrome 10.077
AXIN1axin 10.074
ARandrogen receptor0.073
IFNAR2interferon (alpha, beta and omega) receptor 20.071
PCM1pericentriolar material 10.064
FERMT2fermitin family member 20.064
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.059
STAT2signal transducer and activator of transcription 2, 113kDa0.055
BBS10Bardet-Biedl syndrome 100.055
SKIv-ski sarcoma viral oncogene homolog (avian)0.054
DKK1dickkopf homolog 1 (Xenopus laevis)0.054
BBS9Bardet-Biedl syndrome 90.051
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.051
FSTL1follistatin-like 10.050
COL6A1collagen, type VI, alpha 10.048
CAV1caveolin 1, caveolae protein, 22kDa0.048
CHD4chromodomain helicase DNA binding protein 40.047
SOCS1suppressor of cytokine signaling 10.047
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.045
CFL1cofilin 1 (non-muscle)0.045
KLHL2kelch-like 2, Mayven (Drosophila)0.045
DSTdystonin0.044
ERBB2IPerbb2 interacting protein0.044
SMAD4SMAD family member 40.044
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.043
PTK2PTK2 protein tyrosine kinase 20.043
SOCS3suppressor of cytokine signaling 30.043
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.042
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.042
PPP1CBprotein phosphatase 1, catalytic subunit, beta isozyme0.042
HDAC2histone deacetylase 20.042
CTTNcortactin0.042
IFNGR1interferon gamma receptor 10.042
GJA1gap junction protein, alpha 1, 43kDa0.041
RGS2regulator of G-protein signaling 2, 24kDa0.041
SPTBN1spectrin, beta, non-erythrocytic 10.040
FNBP1formin binding protein 10.040
CAV2caveolin 20.038
PSEN1presenilin 10.038
TIMP2TIMP metallopeptidase inhibitor 20.038
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.037
MCCmutated in colorectal cancers0.036
TTC8tetratricopeptide repeat domain 80.035
NEDD4neural precursor cell expressed, developmentally down-regulated 40.035
FRS2fibroblast growth factor receptor substrate 20.035
UHRF2ubiquitin-like with PHD and ring finger domains 20.035
LRP6low density lipoprotein receptor-related protein 60.034
CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like)0.034
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.033
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.033
CPSF1cleavage and polyadenylation specific factor 1, 160kDa0.033
PTPN14protein tyrosine phosphatase, non-receptor type 140.033
SULF1sulfatase 10.033
HIPK2homeodomain interacting protein kinase 20.033
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.032
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.032
GATA5GATA binding protein 50.032
GLIS2GLIS family zinc finger 20.031
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.031
MPDZmultiple PDZ domain protein0.031
GAB1GRB2-associated binding protein 10.031
SMURF1SMAD specific E3 ubiquitin protein ligase 10.031
TP53BP2tumor protein p53 binding protein, 20.030
TBX5T-box 50.030
CSNK1Dcasein kinase 1, delta0.030
ACSL4acyl-CoA synthetase long-chain family member 40.029
APBA1amyloid beta (A4) precursor protein-binding, family A, member 10.029
HIVEP1human immunodeficiency virus type I enhancer binding protein 10.029
TGFB2transforming growth factor, beta 20.028
ARPC2actin related protein 2/3 complex, subunit 2, 34kDa0.028
PPP1R2protein phosphatase 1, regulatory (inhibitor) subunit 20.028
SH2B1SH2B adaptor protein 10.028
MAGEA2melanoma antigen family A, 20.028
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx16T-box gene 160.958
wnt5bwingless-type MMTV integration site family, member 5b0.923
igf1rbinsulin-like growth factor 1b receptor0.918
nkd1naked cuticle homolog 1 (Drosophila)0.903
smad5MAD homolog 5 (Drosophila)0.901
hnf1baHNF1 homeobox Ba0.893
tbx20T-box 200.888
fn1fibronectin 10.885
pkd2polycystic kidney disease 20.881
col5a2lcollagen, type V, alpha 2-like0.864
flhfloating head0.851
mespamesoderm posterior a0.848
cnn2calponin 20.838
map2k4amitogen-activated protein kinase kinase 4a0.819
wnt9bwingless-type MMTV integration site family, member 9B0.814
smad9MAD homolog 9 (Drosophila)0.792
bmp2abone morphogenetic protein 2a0.786
gna12guanine nucleotide binding protein (G protein) alpha 120.758
sox2SRY-box containing gene 20.754
fzd10frizzled homolog 100.706
lft2lefty20.704
fbln1fibulin 10.703
spns2spinster homolog 2 (Drosophila)0.688
mmp2matrix metalloproteinase 20.685
zeb2azinc finger E-box binding homeobox 2a0.681
lfnglunatic fringe homolog0.679
cc2d2acoiled-coil and C2 domain containing 2A0.675
fzd7afrizzled homolog 7a0.663
chdchordin0.643
fibinfin bud initiation factor0.628
gata5GATA-binding protein 50.626
sox17SRY-box containing gene 170.597
bonbonnie and clyde0.565
fzd7bfrizzled homolog 7b0.557
snai1bsnail homolog 1b (Drosophila)0.548
bmpr1aabone morphogenetic protein receptor, type 1aa0.547
tbx1T-box 10.545
lft1lefty10.544
pcdh8protocadherin 80.537
fzd2frizzled homolog 20.524
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.519
gro1groucho 10.517
ventventral expressed homeobox0.516
smad2MAD homolog 2 (Drosophila)0.509
wnt10awingless-type MMTV integration site family, member 10a0.498
dmbx1adiencephalon/mesencephalon homeobox 1a0.490
ilkintegrin linked kinase0.488
col5a1procollagen, type V, alpha 10.482
gna13aguanine nucleotide binding protein (G protein), alpha 13a0.478
ttnatitin a0.473
aplp2amyloid beta (A4) precursor-like protein 20.470
cdh2cadherin 2, neuronal0.466
snai1asnail homolog 1a (Drosophila)0.451
wnt7bawingless-type MMTV integration site family, member 7Ba0.449
wnt4awingless-type MMTV integration site family, member 4a0.447
irx4biroquois homeobox protein 4b0.446
emx3empty spiracles homeobox 30.442
tpm4tropomyosin 40.436
notum3notum 30.430
fzd8bfrizzled homolog 8b0.430
wnt2bbwingless-type MMTV integration site family, member 2Bb0.423
bmp2bbone morphogenetic protein 2b0.422
osr1odd-skipped related 1 (Drosophila)0.421
lhx1bLIM homeobox 1b0.421
oepone-eyed pinhead0.417
cfl2lcofilin 2, like0.408
wnt11wingless-type MMTV integration site family, member 110.408
ptpraprotein tyrosine phosphatase, receptor type, A0.404
spry4sprouty (Drosophila) homolog 40.399
voxventral homeobox0.397
fgf17fibroblast growth factor 170.392
tp53tumor protein p530.385
ndr2nodal-related 20.382
pmp22aperipheral myelin protein 22a0.379
f2rcoagulation factor II (thrombin) receptor0.376
sp5lSp5 transcription factor-like0.375
fzd5frizzled homolog 50.372
cdh1cadherin 1, epithelial0.369
bocbrother of CDO0.365
wnt10bwingless-type MMTV integration site family, member 10b0.365
foxd5forkhead box D50.357
zeb1zinc finger E-box binding homeobox 10.356
hapln1ahyaluronan and proteoglycan link protein 1a0.356
rnd3aRho family GTPase 3a0.351
dcndecorin0.349
zgc:101761zgc:1017610.346
vangl2vang-like 2 (van gogh, Drosophila)0.344
postnperiostin, osteoblast specific factor0.343
fynaFYN oncogene related to SRC, FGR, YES a0.342
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.339
myf5myogenic factor 50.337
tph1btryptophan hydroxylase 1b0.337
lmo4aLIM domain only 4a0.337
aplnraapelin receptor a0.337
igf1rainsulin-like growth factor 1a receptor0.335
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.332
ephb4beph receptor B4b0.323
ttc21btetratricopeptide repeat domain 21B0.322
tal1T-cell acute lymphocytic leukemia 10.321
sesn1sestrin 10.321
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
roboroundabout0.805
smosmoothened0.802
lealeak0.585
armarmadillo0.540
fzfrizzled0.484
notnon-stop0.401
pod1CG4532 gene product from transcript CG4532-RF0.293
CG14869CG14869 gene product from transcript CG14869-RB0.269
wbwing blister0.257
wgwingless0.248
trctricornered0.240
robo3CG5423 gene product from transcript CG5423-RA0.224
CycECyclin E0.202
drprdraper0.177
Wnt5Wnt oncogene analog 50.175
kirrekin of irre0.167
Klp64DKinesin-like protein at 64D0.159
fjfour-jointed0.146
hephemipterous0.145
ovoCG6824 gene product from transcript CG6824-RE0.145
tutlturtle0.138
Ptp69DProtein tyrosine phosphatase 69D0.136
Wnt4Wnt oncogene analog 40.135
EphrinCG1862 gene product from transcript CG1862-RA0.124
tkvthickveins0.122
panpangolin0.118
dshdishevelled0.117
nkdnaked cuticle0.115
spispitz0.114
Src64BSrc oncogene at 64B0.113
dsdachsous0.106
brkbrinker0.106
bazbazooka0.100
stanstarry night0.099
senssenseless0.095
htshu li tai shao0.094
slislit0.094
bab2CG9102 gene product from transcript CG9102-RA0.090
jumujumeau0.090
Btk29ABtk family kinase at 29A0.084
ctcut0.082
unc-5CG8166 gene product from transcript CG8166-RA0.078
MtlMig-2-like0.077
rokRho-kinase0.076
rempAreduced mechanoreceptor potential A0.076
Mkp3Mitogen-activated protein kinase phosphatase 30.068
uspultraspiracle0.067
cswcorkscrew0.064
mammastermind0.062
MetMethoprene-tolerant0.061
putpunt0.060
exexpanded0.060
arrarrow0.059
SnooSno oncogene0.059
ctaconcertina0.056
VGlutVesicular glutamate transporter0.056
fz2frizzled 20.056
DscamDown syndrome cell adhesion molecule0.054
rinrasputin0.053
MrtfMyocardin-related transcription factor0.053
Akt1CG4006 gene product from transcript CG4006-RA0.053
SoxNSoxNeuro0.052
frufruitless0.052
TlToll0.051
midmidline0.051
mewmultiple edematous wings0.050
Wnt2Wnt oncogene analog 20.050
CG5146CG5146 gene product from transcript CG5146-RA0.050
Fas2Fasciclin 20.050
akirinCG8580 gene product from transcript CG8580-RD0.049
dgodiego0.048
btvbeethoven0.048
sdscalloped0.047
HphHIF prolyl hydroxylase0.047
stumpsCG31317 gene product from transcript CG31317-RC0.047
CSN3COP9 complex homolog subunit 30.045
stwlstonewall0.045
eyeyeless0.044
porporcupine0.043
Hrb87FHeterogeneous nuclear ribonucleoprotein at 87F0.043
CG3194CG3194 gene product from transcript CG3194-RB0.042
binbiniou0.041
CbyChibby0.040
RpLP1Ribosomal protein LP10.040
HopHsp70/Hsp90 organizing protein homolog0.039
CG33960CG33960 gene product from transcript CG33960-RB0.039
plexBplexin B0.039
wtswarts0.039
Lim1CG11354 gene product from transcript CG11354-RA0.039
pygopygopus0.039
kek5kekkon50.038
Sir2CG5216 gene product from transcript CG5216-RA0.037
Eb1CG3265 gene product from transcript CG3265-RF0.037
Sep2Septin-20.037
DDichaete0.037
RpL22Ribosomal protein L220.037
CadNCadherin-N0.036
pkprickle0.036
nubnubbin0.036
ribribbon0.036
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Vangl2vang-like 2 (van gogh, Drosophila)0.999
Dvl2dishevelled 2, dsh homolog (Drosophila)0.998
Gli3GLI-Kruppel family member GLI30.990
Fgfr2fibroblast growth factor receptor 20.952
Wnt3awingless-related MMTV integration site 3A0.948
Dvl3dishevelled 3, dsh homolog (Drosophila)0.902
Pcsk5proprotein convertase subtilisin/kexin type 50.841
Gli2GLI-Kruppel family member GLI20.812
Shhsonic hedgehog0.793
Ptk7PTK7 protein tyrosine kinase 70.785
Fgf8fibroblast growth factor 80.730
FynFyn proto-oncogene0.697
Fzd1frizzled homolog 1 (Drosophila)0.690
Ctnnb1catenin (cadherin associated protein), beta 10.634
Lrp6low density lipoprotein receptor-related protein 60.601
Foxc1forkhead box C10.589
Fgfr1fibroblast growth factor receptor 10.570
Ror2receptor tyrosine kinase-like orphan receptor 20.418
Slit3slit homolog 3 (Drosophila)0.366
Nodalnodal0.366
Hes1hairy and enhancer of split 1 (Drosophila)0.326
Meox2mesenchyme homeobox 20.319
Fzd8frizzled homolog 8 (Drosophila)0.302
Wnt5awingless-related MMTV integration site 5A0.302
Smurf2SMAD specific E3 ubiquitin protein ligase 20.285
Map3k7mitogen-activated protein kinase kinase kinase 70.282
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.282
Tbx3T-box 30.255
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.252
Sfrp2secreted frizzled-related protein 20.250
Dkk1dickkopf homolog 1 (Xenopus laevis)0.242
Sfrp1secreted frizzled-related protein 10.233
Nognoggin0.230
Twist2twist homolog 2 (Drosophila)0.225
Sox9SRY-box containing gene 90.214
Dlg1discs, large homolog 1 (Drosophila)0.210
Pitx2paired-like homeodomain transcription factor 20.202
Bbs2Bardet-Biedl syndrome 2 (human)0.200
Bmp4bone morphogenetic protein 40.199
Fzd7frizzled homolog 7 (Drosophila)0.197
Smad1MAD homolog 1 (Drosophila)0.190
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.188
Egfrepidermal growth factor receptor0.165
Fgfr3fibroblast growth factor receptor 30.164
Smad6MAD homolog 6 (Drosophila)0.151
Msx1homeobox, msh-like 10.149
Vangl1vang-like 1 (van gogh, Drosophila)0.135
Tbx2T-box 20.133
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.126
Acvr1activin A receptor, type 10.125
Prrx1paired related homeobox 10.121
Gata6GATA binding protein 60.117
Smosmoothened homolog (Drosophila)0.112
Bmp7bone morphogenetic protein 70.108
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.106
Wnt4wingless-related MMTV integration site 40.104
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.099
Foxc2forkhead box C20.098
Axin1axin 10.097
Slit1slit homolog 1 (Drosophila)0.095
Efna4ephrin A40.089
Robo2roundabout homolog 2 (Drosophila)0.088
Rbms1RNA binding motif, single stranded interacting protein 10.088
Pax1paired box gene 10.086
Rarbretinoic acid receptor, beta0.081
Hand1heart and neural crest derivatives expressed transcript 10.080
Dlg4discs, large homolog 4 (Drosophila)0.079
Tgfb2transforming growth factor, beta 20.073
Rxraretinoid X receptor alpha0.070
Rararetinoic acid receptor, alpha0.069
Pax3paired box gene 30.068
Gsk3bglycogen synthase kinase 3 beta0.067
Jak2Janus kinase 20.062
Gopcgolgi associated PDZ and coiled-coil motif containing0.062
Amhr2anti-Mullerian hormone type 2 receptor0.059
Tead2TEA domain family member 20.058
Gas1growth arrest specific 10.057
Foxh1forkhead box H10.053
Trp63transformation related protein 630.053
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.049
Lrp5low density lipoprotein receptor-related protein 50.049
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.047
Fgf10fibroblast growth factor 100.046
Gli1GLI-Kruppel family member GLI10.045
Lhx1LIM homeobox protein 10.045
Ptch2patched homolog 20.044
Zfp185zinc finger protein 1850.043
Chrdchordin0.041
Cbx5chromobox homolog 5 (Drosophila HP1a)0.041
Bmpr1abone morphogenetic protein receptor, type 1A0.040
Alx4aristaless-like homeobox 40.040
Fzd2frizzled homolog 2 (Drosophila)0.040
Klf7Kruppel-like factor 7 (ubiquitous)0.037
Wdr1WD repeat domain 10.036
Zfp503zinc finger protein 5030.035
Smad4MAD homolog 4 (Drosophila)0.034
Try10trypsin 100.032
Invsinversin0.032
Fzd10frizzled homolog 10 (Drosophila)0.032
Ptpreprotein tyrosine phosphatase, receptor type, E0.032
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism