The network for 'negative regulation of mitotic sister chromatid separation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of mitotic sister chromatid separation

Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation.

NameDescriptionProbabilityFunc Analog Organism
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.997
CDC27cell division cycle 27 homolog (S. cerevisiae)0.991
CDC20cell division cycle 20 homolog (S. cerevisiae)0.929
ANAPC4anaphase promoting complex subunit 40.893
CCT8chaperonin containing TCP1, subunit 8 (theta)0.613
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.556
CDK2cyclin-dependent kinase 20.523
ANAPC7anaphase promoting complex subunit 70.430
CCNA2cyclin A20.407
CCNB1cyclin B10.364
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.352
ANAPC5anaphase promoting complex subunit 50.244
ANAPC1anaphase promoting complex subunit 10.192
CDC16cell division cycle 16 homolog (S. cerevisiae)0.160
DSN1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)0.148
ANAPC11anaphase promoting complex subunit 110.124
BRCA2breast cancer 2, early onset0.100
CDC23cell division cycle 23 homolog (S. cerevisiae)0.081
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.076
CBX5chromobox homolog 50.069
UHRF2ubiquitin-like with PHD and ring finger domains 20.066
ZWINTZW10 interactor0.065
CASC5cancer susceptibility candidate 50.059
CHAF1Achromatin assembly factor 1, subunit A (p150)0.054
CKS1BCDC28 protein kinase regulatory subunit 1B0.050
CDC6cell division cycle 6 homolog (S. cerevisiae)0.048
OTUB1OTU domain, ubiquitin aldehyde binding 10.046
NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.045
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.041
MYST1MYST histone acetyltransferase 10.039
SKA3spindle and kinetochore associated complex subunit 30.039
SKA1spindle and kinetochore associated complex subunit 10.038
PTTG1pituitary tumor-transforming 10.037
CENPEcentromere protein E, 312kDa0.036
SKA2spindle and kinetochore associated complex subunit 20.034
CDKN3cyclin-dependent kinase inhibitor 30.034
AURKBaurora kinase B0.033
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.033
PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta0.031
CDC26cell division cycle 26 homolog (S. cerevisiae)0.030
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.030
NUF2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.029
ORC2origin recognition complex, subunit 20.026
TINF2TERF1 (TRF1)-interacting nuclear factor 20.025
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.024
ZNF207zinc finger protein 2070.024
PRNPprion protein0.023
TNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase0.023
SKP2S-phase kinase-associated protein 2 (p45)0.022
UHRF1ubiquitin-like with PHD and ring finger domains 10.022
FBXO5F-box protein 50.022
TERF2IPtelomeric repeat binding factor 2, interacting protein0.021
CCDC99coiled-coil domain containing 990.020
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.020
CCNE1cyclin E10.020
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.020
CCNB2cyclin B20.019
C19orf39chromosome 19 open reading frame 390.019
HERC2hect domain and RLD 20.019
NEK2NIMA (never in mitosis gene a)-related kinase 20.018
SMC3structural maintenance of chromosomes 30.018
FXR2fragile X mental retardation, autosomal homolog 20.018
H2AFXH2A histone family, member X0.018
KIF18Akinesin family member 18A0.018
TCP1t-complex 10.018
PTENphosphatase and tensin homolog0.017
CDT1chromatin licensing and DNA replication factor 10.017
KPNA3karyopherin alpha 3 (importin alpha 4)0.017
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.016
ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)0.016
MAD1L1MAD1 mitotic arrest deficient-like 1 (yeast)0.016
HIST1H4Ahistone cluster 1, H4a0.016
SMC4structural maintenance of chromosomes 40.015
UBE2Cubiquitin-conjugating enzyme E2C0.015
ZC3HAV1zinc finger CCCH-type, antiviral 10.015
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.015
ATMINATM interactor0.015
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.015
PPP6R2protein phosphatase 6, regulatory subunit 20.015
RAD52RAD52 homolog (S. cerevisiae)0.015
PPME1protein phosphatase methylesterase 10.015
FANCD2Fanconi anemia, complementation group D20.014
PARP3poly (ADP-ribose) polymerase family, member 30.014
MDC1mediator of DNA-damage checkpoint 10.013
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.013
HIST1H1Ehistone cluster 1, H1e0.013
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.012
USP44ubiquitin specific peptidase 440.012
C13orf34chromosome 13 open reading frame 340.012
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.012
BRCA1breast cancer 1, early onset0.011
TTKTTK protein kinase0.011
EPM2Aepilepsy, progressive myoclonus type 2A, Lafora disease (laforin)0.011
CBX1chromobox homolog 10.011
MAD2L1BPMAD2L1 binding protein0.011
ANKRD52ankyrin repeat domain 520.011
RAD51AP1RAD51 associated protein 10.011
USP49ubiquitin specific peptidase 490.011
TP53BP1tumor protein p53 binding protein 10.011
CCNE2cyclin E20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
BubR1Bub1-related kinase0.601
CycBCyclin B0.555
ncdnon-claret disjunctional0.391
CycB3Cyclin B30.325
IswiImitation SWI0.260
CycACyclin A0.224
Cks30ACyclin-dependent kinase subunit 30A0.201
gwlgreatwall0.174
Rpd3CG7471 gene product from transcript CG7471-RA0.172
pavpavarotti0.172
mei-S332meiotic from via Salaria 3320.166
aslasterless0.146
cmetCENP-meta0.130
poloCG12306 gene product from transcript CG12306-RA0.130
CycECyclin E0.126
SMC2CG10212 gene product from transcript CG10212-RA0.122
Klp61FKinesin-like protein at 61F0.120
Mcm10Sensitized chromosome inheritance modifier 190.108
hayhaywire0.107
dupdouble parked0.085
spn-Dspindle D0.077
flflfalafel0.076
Cap-GCG34438 gene product from transcript CG34438-RF0.074
bambag of marbles0.070
IncenpInner centromere protein0.061
msb1lCG10364 gene product from transcript CG10364-RA0.056
cnncentrosomin0.056
Acf1ATP-dependent chromatin assembly factor large subunit0.054
fzyfizzy0.053
nodno distributive disjunction0.052
tefutelomere fusion0.050
Klp3AKinesin-like protein at 3A0.046
ruxroughex0.046
mad2CG17498 gene product from transcript CG17498-RA0.043
DrefDNA replication-related element factor0.043
aspabnormal spindle0.042
pimpimples0.042
Cdc37CG12019 gene product from transcript CG12019-RA0.038
Mcm5Minichromosome maintenance 50.037
prodproliferation disrupter0.034
cavcaravaggio0.033
thrthree rows0.028
Orc2Origin recognition complex subunit 20.028
Grip75CG6176 gene product from transcript CG6176-RA0.027
nbsCG6754 gene product from transcript CG6754-RC0.027
DNApol-alpha60DNA polymerase alpha 60kD0.027
mus301mutagen-sensitive 3010.026
KP78bCG17216 gene product from transcript CG17216-RB0.026
Mcm7Minichromosome maintenance 70.026
mus209mutagen-sensitive 2090.025
piepineapple eye0.025
alphaTub67Calpha-Tubulin at 67C0.023
Nup153Nucleoporin 1530.022
NiPp1Nuclear inhibitor of Protein phosphatase 10.022
mus312mutagen-sensitive 3120.020
mtrmmatrimony0.020
sleslender lobes0.019
dpadisc proliferation abnormal0.019
marsCG17064 gene product from transcript CG17064-RB0.018
gammaTub23Cgamma-Tubulin at 23C0.018
SAKSak kinase0.018
borrborealin-related0.017
cdc2cCG10498 gene product from transcript CG10498-RC0.017
SseSeparase0.016
zuczucchini0.016
rad50CG6339 gene product from transcript CG6339-RD0.016
blbancal0.016
gemininCG3183 gene product from transcript CG3183-RA0.016
MybMyb oncogene-like0.015
DetDeterin0.015
Bap55Brahma associated protein 55kD0.015
Kmn1kinetochore Mis12-Ndc80 network component 10.014
CG5214CG5214 gene product from transcript CG5214-RA0.014
cdc2CG5363 gene product from transcript CG5363-RA0.013
tra2transformer 20.013
CG8223CG8223 gene product from transcript CG8223-RA0.013
Orc5Origin recognition complex subunit 50.012
Spc105RSpc105-related0.012
cdc16CG6759 gene product from transcript CG6759-RA0.012
CG9776CG9776 gene product from transcript CG9776-RA0.012
ballballchen0.012
nxf2nuclear RNA export factor 20.012
CG14213CG14213 gene product from transcript CG14213-RB0.012
tldtolloid0.012
CG10722CG10722 gene product from transcript CG10722-RA0.012
Cenp-CCG31258 gene product from transcript CG31258-RA0.011
barrbarren0.011
mus101mutagen-sensitive 1010.011
rodrough deal0.011
pngpan gu0.011
Su(var)205Suppressor of variegation 2050.011
SetCG4299 gene product from transcript CG4299-RA0.011
subsubito0.010
AGO2Argonaute 20.010
weeCG4488 gene product from transcript CG4488-RA0.010
Klp10ACG1453 gene product from transcript CG1453-RA0.010
Gem2Gemin20.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.217
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.172
Ccnb1cyclin B10.115
Cdk1cyclin-dependent kinase 10.112
C330027C09RikRIKEN cDNA C330027C09 gene0.102
Brca1breast cancer 10.091
Mki67antigen identified by monoclonal antibody Ki 670.076
Ccna2cyclin A20.063
Birc5baculoviral IAP repeat-containing 50.060
Kif22kinesin family member 220.052
Cenpecentromere protein E0.052
Ooepoocyte expressed protein homolog (dog)0.049
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.044
Kif20akinesin family member 20A0.041
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.040
Brca2breast cancer 20.038
Cdk2cyclin-dependent kinase 20.035
Ccne1cyclin E10.033
Ccnb2cyclin B20.032
Sgol2shugoshin-like 2 (S. pombe)0.032
Prc1protein regulator of cytokinesis 10.031
Hmmrhyaluronan mediated motility receptor (RHAMM)0.031
Spag5sperm associated antigen 50.029
Cdca8cell division cycle associated 80.028
Sgol1shugoshin-like 1 (S. pombe)0.028
Mdm2transformed mouse 3T3 cell double minute 20.027
Aurkaaurora kinase A0.025
Ccnfcyclin F0.024
Kif11kinesin family member 110.023
Kif23kinesin family member 230.019
Chek1checkpoint kinase 1 homolog (S. pombe)0.019
Kif2ckinesin family member 2C0.018
Fbxo5F-box protein 50.017
Cdca5cell division cycle associated 50.016
Plk1polo-like kinase 1 (Drosophila)0.015
Trim59tripartite motif-containing 590.015
Trip13thyroid hormone receptor interactor 130.015
Aurkbaurora kinase B0.015
Kif4kinesin family member 40.015
Gtse1G two S phase expressed protein 10.014
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.014
Ccdc99coiled-coil domain containing 990.014
Wdhd1WD repeat and HMG-box DNA binding protein 10.014
Gsg2germ cell-specific gene 20.014
Ube2cubiquitin-conjugating enzyme E2C0.013
Cenpfcentromere protein F0.013
Dtldenticleless homolog (Drosophila)0.013
Msh2mutS homolog 2 (E. coli)0.013
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.013
Dlgap5discs, large (Drosophila) homolog-associated protein 50.013
Ncapgnon-SMC condensin I complex, subunit G0.012
6720463M24RikRIKEN cDNA 6720463M24 gene0.011
Cep55centrosomal protein 550.011
Ckap2cytoskeleton associated protein 20.011
4632434I11RikRIKEN cDNA 4632434I11 gene0.011
Cdc25ccell division cycle 25 homolog C (S. pombe)0.010
StilScl/Tal1 interrupting locus0.010
Cenpncentromere protein N0.010
Mis18bp1MIS18 binding protein 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PPH21Pph21p0.965
MAD2Mad2p0.941
MTW1Mtw1p0.850
AME1Ame1p0.839
DSN1Dsn1p0.814
NSL1Nsl1p0.809
HHF2Hhf2p0.779
SLK19Slk19p0.766
CDC55Cdc55p0.751
CTF3Ctf3p0.716
CSE4Cse4p0.709
CDC20Cdc20p0.690
PPH22Pph22p0.690
TID3Tid3p0.625
SLI15Sli15p0.612
MAD3Mad3p0.602
CHL4Chl4p0.518
BUB3Bub3p0.498
IML3Iml3p0.492
MCM21Mcm21p0.444
SMC4Smc4p0.391
CTF13Ctf13p0.376
MIF2Mif2p0.338
KIP1Kip1p0.307
SPC105Spc105p0.268
MAD1Mad1p0.249
SPC24Spc24p0.246
BUB1Bub1p0.227
PIG2Pig2p0.201
GIP2Gip2p0.196
MCM22Mcm22p0.180
IPL1Ipl1p0.176
OKP1Okp1p0.168
RTS1Rts1p0.168
YPI1Ypi1p0.147
SDS22Sds22p0.121
DAM1Dam1p0.116
MPS1Mps1p0.113
NUF2Nuf2p0.109
ASE1Ase1p0.102
SGO1Sgo1p0.099
NNF1Nnf1p0.096
YBP2Ybp2p0.079
PPZ1Ppz1p0.070
RAD53Rad53p0.067
HTA1Hta1p0.066
CIN8Cin8p0.063
CBF2Cbf2p0.063
BRN1Brn1p0.051
PDS1Pds1p0.048
CAB3Cab3p0.047
KIC1Kic1p0.047
SPC25Spc25p0.046
PCL10Pcl10p0.045
HHT1Hht1p0.045
SMC5Smc5p0.044
CBF1Cbf1p0.043
PKC1Pkc1p0.043
GLG1Glg1p0.043
SMC6Smc6p0.043
GAC1Gac1p0.039
NBL1Nbl1p0.038
FMP48Fmp48p0.036
CHL1Chl1p0.035
PDR15Pdr15p0.034
ZDS1Zds1p0.033
SPO12Spo12p0.033
BDF2Bdf2p0.032
ECO1Eco1p0.032
VHS3Vhs3p0.031
SMC2Smc2p0.031
SRD1Srd1p0.030
FIN1Fin1p0.029
SPC110Spc110p0.028
SCM3Scm3p0.027
MCM16Mcm16p0.027
PTI1Pti1p0.026
YLR264C-Ahypothetical protein0.025
YLR162Whypothetical protein0.025
PSH1Psh1p0.025
YOL038C-Ahypothetical protein0.025
TIP41Tip41p0.025
NDD1Ndd1p0.025
LEU2Leu2p0.024
PSP1Psp1p0.024
BFA1Bfa1p0.024
IML1Iml1p0.023
YNL144Chypothetical protein0.023
SMC3Smc3p0.023
CRP1Crp1p0.023
HST3Hst3p0.023
RRP15Rrp15p0.023
MER1Mer1p0.022
RRP36Rrp36p0.022
UTP11Utp11p0.022
ARG8Arg8p0.022
RAD61Rad61p0.021
MAM1Mam1p0.021
PRP28Prp28p0.021
GSY1Gsy1p0.021