The network for 'response to hyperoxia' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to hyperoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.

NameDescriptionProbabilityFunc Analog Organism
CAV1caveolin 1, caveolae protein, 22kDa0.996
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.994
CASP8caspase 8, apoptosis-related cysteine peptidase0.975
CASP10caspase 10, apoptosis-related cysteine peptidase0.931
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.916
FADDFas (TNFRSF6)-associated via death domain0.887
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.851
ACTN2actinin, alpha 20.804
ARandrogen receptor0.746
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.726
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.677
PLAUplasminogen activator, urokinase0.623
NOSTRINnitric oxide synthase trafficker0.592
FASFas (TNF receptor superfamily, member 6)0.509
HDAC2histone deacetylase 20.474
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.463
COTL1coactosin-like 1 (Dictyostelium)0.452
PLAURplasminogen activator, urokinase receptor0.443
CFLARCASP8 and FADD-like apoptosis regulator0.421
KAT2BK(lysine) acetyltransferase 2B0.412
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.408
PTPN1protein tyrosine phosphatase, non-receptor type 10.385
CREBBPCREB binding protein0.380
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.363
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.352
CCL5chemokine (C-C motif) ligand 50.346
TRADDTNFRSF1A-associated via death domain0.345
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.344
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.327
UHRF1ubiquitin-like with PHD and ring finger domains 10.326
DNMT1DNA (cytosine-5-)-methyltransferase 10.301
PTENphosphatase and tensin homolog0.293
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.268
PLATplasminogen activator, tissue0.263
NCF4neutrophil cytosolic factor 4, 40kDa0.262
ALDH1A1aldehyde dehydrogenase 1 family, member A10.253
MDM2Mdm2 p53 binding protein homolog (mouse)0.249
NCOA1nuclear receptor coactivator 10.248
TIMP2TIMP metallopeptidase inhibitor 20.197
COL1A2collagen, type I, alpha 20.192
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.178
S100BS100 calcium binding protein B0.172
ESR1estrogen receptor 10.169
THBS1thrombospondin 10.168
PDGFCplatelet derived growth factor C0.161
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.160
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.148
CAV2caveolin 20.139
PDGFAplatelet-derived growth factor alpha polypeptide0.137
COL6A1collagen, type VI, alpha 10.117
NCOA2nuclear receptor coactivator 20.116
NCF1neutrophil cytosolic factor 10.114
BIDBH3 interacting domain death agonist0.112
CXCR4chemokine (C-X-C motif) receptor 40.109
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.105
NCOA6nuclear receptor coactivator 60.103
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.101
COL3A1collagen, type III, alpha 10.100
PTPRFprotein tyrosine phosphatase, receptor type, F0.095
THBS2thrombospondin 20.094
PRDX1peroxiredoxin 10.093
FOXO1forkhead box O10.092
GJA1gap junction protein, alpha 1, 43kDa0.091
COL4A1collagen, type IV, alpha 10.086
FHL2four and a half LIM domains 20.085
F2Rcoagulation factor II (thrombin) receptor0.084
SNAI1snail homolog 1 (Drosophila)0.076
SIRT1sirtuin 10.071
EP300E1A binding protein p3000.071
IGFBP3insulin-like growth factor binding protein 30.070
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.070
ALOX5AParachidonate 5-lipoxygenase-activating protein0.068
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.057
EGR3early growth response 30.056
TGFB1transforming growth factor, beta 10.055
EGFRepidermal growth factor receptor0.055
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.054
DAXXdeath-domain associated protein0.053
EGR2early growth response 20.052
ORM1orosomucoid 10.052
PRKCDBPprotein kinase C, delta binding protein0.051
CYBAcytochrome b-245, alpha polypeptide0.050
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.050
FOXO3forkhead box O30.049
RUNX1runt-related transcription factor 10.047
EZH2enhancer of zeste homolog 2 (Drosophila)0.046
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.044
MYOZ1myozenin 10.044
LOXlysyl oxidase0.043
ADAM12ADAM metallopeptidase domain 120.042
TNFtumor necrosis factor0.041
COL7A1collagen, type VII, alpha 10.040
FGFR1fibroblast growth factor receptor 10.037
CXCR6chemokine (C-X-C motif) receptor 60.037
TAF1DTATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa0.036
SFTPDsurfactant protein D0.035
IL1Binterleukin 1, beta0.035
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG14686CG14686 gene product from transcript CG14686-RA0.054
Gyc-89DbGuanylyl cyclase at 89Db0.048
king-tubbyking tubby0.028
CngCyclic-nucleotide-gated ion channel protein0.028
Pvf2PDGF- and VEGF-related factor 20.026
InRInsulin-like receptor0.026
Gyc-89DaGuanylyl cyclase at 89Da0.025
TpiTriose phosphate isomerase0.024
drddrop dead0.021
reporeversed polarity0.020
ThorCG8846 gene product from transcript CG8846-RA0.018
l(3)82FdCG32464 gene product from transcript CG32464-RR0.017
dnr1defense repressor 10.017
Glut1Glucose transporter 10.016
stumpsCG31317 gene product from transcript CG31317-RC0.015
ImpL2Ecdysone-inducible gene L20.015
dprdefective proboscis extension response0.015
mRpS33mitochondrial ribosomal protein S330.014
l(3)03670lethal (3) 036700.012
GLazGlial Lazarillo0.012
Gr33aGustatory receptor 33a0.011
lbeladybird early0.011
CG14483CG14483 gene product from transcript CG14483-RA0.011
CG3683CG3683 gene product from transcript CG3683-RC0.011
snssticks and stones0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.990
Mmp9matrix metallopeptidase 90.989
Nos3nitric oxide synthase 3, endothelial cell0.962
Trp53transformation related protein 530.951
Apoeapolipoprotein E0.920
Csf1colony stimulating factor 1 (macrophage)0.882
Ptgs2prostaglandin-endoperoxide synthase 20.824
Col1a1collagen, type I, alpha 10.641
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.519
Ptenphosphatase and tensin homolog0.476
Selpselectin, platelet0.444
Fbn1fibrillin 10.417
Ccr2chemokine (C-C motif) receptor 20.371
Lmnalamin A0.369
Lyz2lysozyme 20.354
Tlr4toll-like receptor 40.348
Nos2nitric oxide synthase 2, inducible0.340
Nos1nitric oxide synthase 1, neuronal0.330
Platplasminogen activator, tissue0.305
Ldlrlow density lipoprotein receptor0.298
Vdrvitamin D receptor0.277
Itgb1integrin beta 1 (fibronectin receptor beta)0.271
Vegfavascular endothelial growth factor A0.250
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.239
Tgfbr2transforming growth factor, beta receptor II0.235
Cav1caveolin 1, caveolae protein0.223
Notch2Notch gene homolog 2 (Drosophila)0.155
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.130
Hif1ahypoxia inducible factor 1, alpha subunit0.127
Ccl2chemokine (C-C motif) ligand 20.124
Agtr2angiotensin II receptor, type 20.119
Ppargperoxisome proliferator activated receptor gamma0.115
Pkd1polycystic kidney disease 1 homolog0.113
Foxp3forkhead box P30.093
Tgfb1transforming growth factor, beta 10.085
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.084
Ptgesprostaglandin E synthase0.083
Ifnginterferon gamma0.083
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.081
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.080
Egfrepidermal growth factor receptor0.077
Il6interleukin 60.074
Esr1estrogen receptor 1 (alpha)0.072
Nfe2l2nuclear factor, erythroid derived 2, like 20.071
Alox5aparachidonate 5-lipoxygenase activating protein0.070
FasFas (TNF receptor superfamily member 6)0.070
Loxlysyl oxidase0.063
CrebbpCREB binding protein0.062
Vhlvon Hippel-Lindau tumor suppressor0.061
Il10interleukin 100.058
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.056
Icam1intercellular adhesion molecule 10.053
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.052
Seleselectin, endothelial cell0.049
Mmp2matrix metallopeptidase 20.048
Ppiapeptidylprolyl isomerase A0.047
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.047
Spp1secreted phosphoprotein 10.046
Prkchprotein kinase C, eta0.044
Lpin1lipin 10.043
Nab2Ngfi-A binding protein 20.043
Agtr1aangiotensin II receptor, type 1a0.043
FosFBJ osteosarcoma oncogene0.042
Lrp1low density lipoprotein receptor-related protein 10.041
Cyr61cysteine rich protein 610.041
Arandrogen receptor0.039
Itgb3integrin beta 30.039
Ctnnb1catenin (cadherin associated protein), beta 10.037
Egr2early growth response 20.036
Wdfy2WD repeat and FYVE domain containing 20.036
Ahraryl-hydrocarbon receptor0.035
Col1a2collagen, type I, alpha 20.034
Col4a3collagen, type IV, alpha 30.034
Kitkit oncogene0.033
Ctskcathepsin K0.033
Orai1ORAI calcium release-activated calcium modulator 10.032
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.032
Insrinsulin receptor0.032
Pnpla2patatin-like phospholipase domain containing 20.032
Adrb3adrenergic receptor, beta 30.031
Ltbp3latent transforming growth factor beta binding protein 30.031
Slfn4schlafen 40.031
Adipoqadiponectin, C1Q and collagen domain containing0.031
Cd151CD151 antigen0.031
Timp4tissue inhibitor of metalloproteinase 40.030
Card11caspase recruitment domain family, member 110.030
Tal1T-cell acute lymphocytic leukemia 10.029
Tmprss11etransmembrane protease, serine 11e0.028
Ptpn11protein tyrosine phosphatase, non-receptor type 110.028
Cd44CD44 antigen0.027
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.027
Npc1Niemann Pick type C10.027
Prdx1peroxiredoxin 10.026
Tlr2toll-like receptor 20.026
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.026
Sirt3sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)0.026
Tenc1tensin like C1 domain-containing phosphatase0.026
Rag1recombination activating gene 10.026
Thbs3thrombospondin 30.026
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.837
Col3a1collagen, type III, alpha 10.534
Col1a2collagen, type I, alpha 20.401
Col5a1collagen, type V, alpha 10.390
Egr2early growth response 20.251
ND1NADH dehydrogenase subunit 10.238
COX3cytochrome c oxidase subunit 30.192
Col12a1collagen, type XII, alpha 10.129
COX1cytochrome c oxidase subunit 10.125
Cpa3carboxypeptidase A3, mast cell0.112
Col14a1collagen, type XIV, alpha 10.111
Fndc1fibronectin type III domain containing 10.106
Plauplasminogen activator, urokinase0.103
Selpselectin P0.101
Gna15guanine nucleotide binding protein, alpha 150.092
Col5a2collagen, type V, alpha 20.087
Tpothyroid peroxidase0.085
Col15a1collagen, type XV, alpha 10.081
Chrm1cholinergic receptor, muscarinic 10.076
Ubbubiquitin B0.076
Loxl1lysyl oxidase-like 10.076
RT1-M5RT1 class Ib, locus M50.068
Adra2badrenergic, alpha-2B-, receptor0.067
Plcb2phospholipase C, beta 20.067
Arpp21cAMP-regulated phosphoprotein 210.065
Postnperiostin, osteoblast specific factor0.064
Gpr20G protein-coupled receptor 200.062
Ccl4chemokine (C-C motif) ligand 40.059
FosFBJ osteosarcoma oncogene0.059
ND4NADH dehydrogenase subunit 40.058
S1pr2sphingosine-1-phosphate receptor 20.058
Col10a1collagen, type X, alpha 10.058
Ccl2chemokine (C-C motif) ligand 20.057
Fosl1fos-like antigen 10.056
Adrb1adrenergic, beta-1-, receptor0.054
LOC305103cell surface glycoprotein gp420.053
Adam2ADAM metallopeptidase domain 20.051
Egr1early growth response 10.051
Kcnk13potassium channel, subfamily K, member 130.051
Nr4a3nuclear receptor subfamily 4, group A, member 30.050
Col4a1collagen, type IV, alpha 10.050
Hrh4histamine receptor H40.049
Olr1496olfactory receptor 14960.049
Gckrglucokinase (hexokinase 4) regulator0.048
Tbxa2rthromboxane A2 receptor0.048
Tas2r107taste receptor, type 2, member 1070.048
Serpina5serine (or cysteine) peptidase inhibitor, clade A, member 50.047
Mas1MAS1 oncogene0.047
Il8rbinterleukin 8 receptor, beta0.046
Irx4iroquois homeobox 40.046
Nid2nidogen 20.044
Pcolceprocollagen C-endopeptidase enhancer0.044
Sctrsecretin receptor0.044
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.043
ND2NADH dehydrogenase subunit 20.043
Adam6a disintegrin and metallopeptidase domain 60.042
Sgp158proline-rich glycoprotein (sgp158)0.041
Csf3colony stimulating factor 3 (granulocyte)0.041
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.040
PVRpoliovirus receptor0.040
Ube2iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.039
Aqp8aquaporin 80.039
Rps29ribosomal protein S290.039
Ptgisprostaglandin I2 (prostacyclin) synthase0.039
Gpr182G protein-coupled receptor 1820.039
Il1ainterleukin 1 alpha0.038
Ces2ccarboxylesterase 2C0.038
Ypel5yippee-like 5 (Drosophila)0.038
Ptgdrprostaglandin D receptor0.038
Foxe1forkhead box E1 (thyroid transcription factor 2)0.037
Ccr5chemokine (C-C motif) receptor 50.037
Vcsa2variable coding sequence A20.037
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.037
Nppbnatriuretic peptide precursor B0.037
Lef1lymphoid enhancer binding factor 10.037
Cela1chymotrypsin-like elastase family, member 10.036
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.036
Ncf1neutrophil cytosolic factor 10.036
Ptprhprotein tyrosine phosphatase, receptor type, H0.035
Dbc1deleted in bladder cancer 1 (human)0.035
Cfpcomplement factor properdin0.035
Fapfibroblast activation protein, alpha0.035
CebpeCCAAT/enhancer binding protein (C/EBP), epsilon0.035
Nr4a1nuclear receptor subfamily 4, group A, member 10.033
Dnase1l3deoxyribonuclease 1-like 30.033
Serpina3mserine (or cysteine) proteinase inhibitor, clade A, member 3M0.033
Fgf16fibroblast growth factor 160.033
Icam1intercellular adhesion molecule 10.032
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.032
LOC686539similar to immunoglobulin superfamily containing leucine-rich repeat0.032
Bglapbone gamma-carboxyglutamate (gla) protein0.032
Iappislet amyloid polypeptide0.032
Mmp23matrix metallopeptidase 230.032
Lalbalactalbumin, alpha0.031
Cpxm1carboxypeptidase X (M14 family), member 10.031
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism