The network for 'sterol homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

sterol homeostasis

Any process involved in the maintenance of an internal steady state of sterol within an organism or cell.

NameDescriptionProbabilityFunc Analog Organism
APOA1apolipoprotein A-I0.999
ABCG5ATP-binding cassette, sub-family G (WHITE), member 50.969
NR0B1nuclear receptor subfamily 0, group B, member 10.951
RXRAretinoid X receptor, alpha0.881
FGAfibrinogen alpha chain0.835
CREBBPCREB binding protein0.791
APOEapolipoprotein E0.762
NCOA1nuclear receptor coactivator 10.756
APOA2apolipoprotein A-II0.751
ABCG8ATP-binding cassette, sub-family G (WHITE), member 80.742
RRAGCRas-related GTP binding C0.722
SMAD2SMAD family member 20.646
RPL18Aribosomal protein L18a0.627
APOC1apolipoprotein C-I0.623
LDLRlow density lipoprotein receptor0.600
HNF4Ahepatocyte nuclear factor 4, alpha0.555
RARAretinoic acid receptor, alpha0.538
CRPC-reactive protein, pentraxin-related0.510
PROX1prospero homeobox 10.383
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.380
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.379
LCATlecithin-cholesterol acyltransferase0.344
LRP1low density lipoprotein receptor-related protein 10.332
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.274
APOC2apolipoprotein C-II0.272
SEC24DSEC24 family, member D (S. cerevisiae)0.266
APOBapolipoprotein B (including Ag(x) antigen)0.244
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.215
PTPRFprotein tyrosine phosphatase, receptor type, F0.177
APOC3apolipoprotein C-III0.160
FGBfibrinogen beta chain0.153
ABCF3ATP-binding cassette, sub-family F (GCN20), member 30.152
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.148
NR0B2nuclear receptor subfamily 0, group B, member 20.147
ANKFY1ankyrin repeat and FYVE domain containing 10.102
CAPRIN2caprin family member 20.101
EPS15epidermal growth factor receptor pathway substrate 150.100
KAT2BK(lysine) acetyltransferase 2B0.093
ABCG1ATP-binding cassette, sub-family G (WHITE), member 10.089
CAV2caveolin 20.078
AP2A1adaptor-related protein complex 2, alpha 1 subunit0.077
ARandrogen receptor0.077
EP300E1A binding protein p3000.070
DKK1dickkopf homolog 1 (Xenopus laevis)0.069
TRAF5TNF receptor-associated factor 50.068
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.065
MED25mediator complex subunit 250.057
PPARAperoxisome proliferator-activated receptor alpha0.056
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.054
MASP2mannan-binding lectin serine peptidase 20.053
SEC23ASec23 homolog A (S. cerevisiae)0.052
MTAPmethylthioadenosine phosphorylase0.051
AP2B1adaptor-related protein complex 2, beta 1 subunit0.049
EGFRepidermal growth factor receptor0.048
SREBF2sterol regulatory element binding transcription factor 20.047
PCSK9proprotein convertase subtilisin/kexin type 90.047
SREBF1sterol regulatory element binding transcription factor 10.045
LRRK2leucine-rich repeat kinase 20.045
MBL2mannose-binding lectin (protein C) 2, soluble0.044
EPS8epidermal growth factor receptor pathway substrate 80.044
HIPK2homeodomain interacting protein kinase 20.044
SKILSKI-like oncogene0.042
HRhairless homolog (mouse)0.041
NR2E3nuclear receptor subfamily 2, group E, member 30.039
MAP2K3mitogen-activated protein kinase kinase 30.038
SEC24BSEC24 family, member B (S. cerevisiae)0.037
STON2stonin 20.037
F7coagulation factor VII (serum prothrombin conversion accelerator)0.037
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.037
ESR1estrogen receptor 10.036
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.036
ITGB5integrin, beta 50.035
MDKmidkine (neurite growth-promoting factor 2)0.035
KNG1kininogen 10.035
TXNDC2thioredoxin domain containing 2 (spermatozoa)0.035
APPamyloid beta (A4) precursor protein0.034
NR1I2nuclear receptor subfamily 1, group I, member 20.034
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.033
GSK3Bglycogen synthase kinase 3 beta0.033
AKT2v-akt murine thymoma viral oncogene homolog 20.033
MSTO1misato homolog 1 (Drosophila)0.031
STX12syntaxin 120.031
AMBPalpha-1-microglobulin/bikunin precursor0.031
DHCR77-dehydrocholesterol reductase0.030
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.028
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.026
APBB2amyloid beta (A4) precursor protein-binding, family B, member 20.026
LOXL4lysyl oxidase-like 40.025
RUNX1runt-related transcription factor 10.025
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.025
GPLD1glycosylphosphatidylinositol specific phospholipase D10.024
MICALL1MICAL-like 10.023
APOA4apolipoprotein A-IV0.023
MAT1Amethionine adenosyltransferase I, alpha0.023
NCOA3nuclear receptor coactivator 30.023
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG7916CG7916 gene product from transcript CG7916-RA0.709
CG14837CG14837 gene product from transcript CG14837-RC0.669
Yp1Yolk protein 10.571
CG3880CG3880 gene product from transcript CG3880-RA0.519
Jon25BiiiJonah 25Biii0.357
CG42327CG42327 gene product from transcript CG42327-RE0.319
CG14506CG14506 gene product from transcript CG14506-RA0.305
Amy-dAmylase distal0.273
CG6271CG6271 gene product from transcript CG6271-RA0.273
Met75CbCG18064 gene product from transcript CG18064-RA0.269
CG8997CG8997 gene product from transcript CG8997-RA0.266
lectin-29CaCG17799 gene product from transcript CG17799-RA0.245
ftz-f1ftz transcription factor 10.242
TSG101tumor suppressor protein 1010.214
FatpFatty acid (long chain) transport protein0.212
CG6277CG6277 gene product from transcript CG6277-RA0.212
CG8292CG8292 gene product from transcript CG8292-RA0.210
CG5973CG5973 gene product from transcript CG5973-RA0.195
Spn3Serine protease inhibitor 30.187
Lsd-1Lipid storage droplet-10.186
Cyp4d21CG6730 gene product from transcript CG6730-RA0.186
CG18301CG18301 gene product from transcript CG18301-RA0.185
CG31872CG31872 gene product from transcript CG31872-RA0.166
Acp26AaAccessory gland-specific peptide 26Aa0.166
CG17107CG17107 gene product from transcript CG17107-RA0.166
Spn77BbSerpin 77Bb0.161
stumpsCG31317 gene product from transcript CG31317-RC0.161
MTF-1Metal response element-binding Transcription Factor-10.159
CG17097CG17097 gene product from transcript CG17097-RB0.154
CG7953CG7953 gene product from transcript CG7953-RA0.154
CG9468CG9468 gene product from transcript CG9468-RA0.152
CG17472CG17472 gene product from transcript CG17472-RA0.149
CG11912CG11912 gene product from transcript CG11912-RA0.145
CG14820CG14820 gene product from transcript CG14820-RA0.145
Elo68alphaElongase 68alpha0.144
CG6283CG6283 gene product from transcript CG6283-RA0.143
CG10041CG10041 gene product from transcript CG10041-RA0.143
Spn2Serine protease inhibitor 20.138
LvpHLarval visceral protein H0.137
CG5162CG5162 gene product from transcript CG5162-RA0.136
Acp29ABAccessory gland-specific peptide 29AB0.124
Npc2fNiemann-Pick type C-2f0.116
CG9463CG9463 gene product from transcript CG9463-RA0.114
BG642163CG34102 gene product from transcript CG34102-RA0.112
CG12374CG12374 gene product from transcript CG12374-RA0.110
CG8093CG8093 gene product from transcript CG8093-RA0.109
CG7631CG7631 gene product from transcript CG7631-RA0.109
msopamale-specific opa containing gene0.109
CG13282CG13282 gene product from transcript CG13282-RA0.106
CG31871CG31871 gene product from transcript CG31871-RA0.105
CG7548CG7548 gene product from transcript CG7548-RA0.105
CG12428CG12428 gene product from transcript CG12428-RB0.104
CG8690CG8690 gene product from transcript CG8690-RA0.103
Myo31DFMyosin 31DF0.101
CG18754CG18754 gene product from transcript CG18754-RB0.099
CG7213CG7213 gene product from transcript CG7213-RA0.096
CG11608CG11608 gene product from transcript CG11608-RB0.094
Acp76AAccessory gland-specific peptide 76A0.093
CG12057CG12057 gene product from transcript CG12057-RA0.093
Ptp4EProtein tyrosine phosphatase 4E0.093
Jon99CiJonah 99Ci0.093
Acp26AbAccessory gland-specific peptide 26Ab0.090
CG5267CG5267 gene product from transcript CG5267-RA0.090
CG6409CG6409 gene product from transcript CG6409-RA0.090
CG17265CG17265 gene product from transcript CG17265-RA0.089
CG5326CG5326 gene product from transcript CG5326-RA0.086
Ent1Equilibrative nucleoside transporter 10.086
CG15534CG15534 gene product from transcript CG15534-RA0.084
CG15549CG15549 gene product from transcript CG15549-RA0.083
CG8814CG8814 gene product from transcript CG8814-RA0.082
CG9029CG9029 gene product from transcript CG9029-RA0.079
PH4alphaNE2prolyl-4-hydroxylase-alpha NE20.079
CG5773CG5773 gene product from transcript CG5773-RA0.079
CG14119CG14119 gene product from transcript CG14119-RA0.079
DmsR-2Dromyosuppressin receptor 20.079
SaraSmad anchor for receptor activation0.078
Hr96Hormone receptor-like in 960.078
Vm26AaVitelline membrane 26Aa0.078
Spn77BcSerpin 77Bc0.078
Acp53C14aCG8626 gene product from transcript CG8626-RA0.077
CG6178CG6178 gene product from transcript CG6178-RA0.076
AmyrelCG8221 gene product from transcript CG8221-RA0.076
CG31559CG31559 gene product from transcript CG31559-RA0.075
CG3394CG3394 gene product from transcript CG3394-RA0.074
CG13833CG13833 gene product from transcript CG13833-RA0.073
CG18745CG18745 gene product from transcript CG18745-RA0.073
CG33970CG33970 gene product from transcript CG33970-RA0.073
Jon25BiiJonah 25Bii0.073
Dip-BDipeptidase B0.071
Cp38Chorion protein 380.071
CG31419CG31419 gene product from transcript CG31419-RA0.071
CG31176CG31176 gene product from transcript CG31176-RA0.071
Lip3CG8823 gene product from transcript CG8823-RA0.071
Spn7Serine protease inhibitor 70.070
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Apoeapolipoprotein E1.000
Npc1Niemann Pick type C10.999
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.996
Ghrgrowth hormone receptor0.991
Leprleptin receptor0.951
Lrp1low density lipoprotein receptor-related protein 10.948
Apoa1apolipoprotein A-I0.945
Kiss1KiSS-1 metastasis-suppressor0.865
Rargretinoic acid receptor, gamma0.851
Ldlrlow density lipoprotein receptor0.813
Rxraretinoid X receptor alpha0.805
Vegfavascular endothelial growth factor A0.787
Cd36CD36 antigen0.731
Nr1i2nuclear receptor subfamily 1, group I, member 20.691
Pax8paired box gene 80.677
Ptenphosphatase and tensin homolog0.612
Nr1h3nuclear receptor subfamily 1, group H, member 30.599
Dab1disabled homolog 1 (Drosophila)0.571
Thrathyroid hormone receptor alpha0.556
Cav1caveolin 1, caveolae protein0.543
Ppargperoxisome proliferator activated receptor gamma0.478
Ush1gUsher syndrome 1G homolog (human)0.461
Irs2insulin receptor substrate 20.456
Lhx3LIM homeobox protein 30.446
Abcg5ATP-binding cassette, sub-family G (WHITE), member 50.445
Nr2f2nuclear receptor subfamily 2, group F, member 20.371
Pklrpyruvate kinase liver and red blood cell0.354
Igf1insulin-like growth factor 10.353
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.327
Gpr116G protein-coupled receptor 1160.314
Apobapolipoprotein B0.313
Appamyloid beta (A4) precursor protein0.295
Cideacell death-inducing DNA fragmentation factor, alpha subunit-like effector A0.273
Nos3nitric oxide synthase 3, endothelial cell0.269
Cdkn1bcyclin-dependent kinase inhibitor 1B0.265
Fbp2fructose bisphosphatase 20.263
Nr2f1nuclear receptor subfamily 2, group F, member 10.259
Hnf4ahepatic nuclear factor 4, alpha0.253
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.247
Nr0b2nuclear receptor subfamily 0, group B, member 20.238
Slc12a6solute carrier family 12, member 60.229
Tgfbr2transforming growth factor, beta receptor II0.224
Aqp7aquaporin 70.217
Angptl4angiopoietin-like 40.211
Esr1estrogen receptor 1 (alpha)0.211
Lpin1lipin 10.208
Fabp2fatty acid binding protein 2, intestinal0.203
Dhcr77-dehydrocholesterol reductase0.186
Ptf1apancreas specific transcription factor, 1a0.178
Fgfrl1fibroblast growth factor receptor-like 10.173
Golt1agolgi transport 1 homolog A (S. cerevisiae)0.171
Bcl2B-cell leukemia/lymphoma 20.169
Lpllipoprotein lipase0.167
Sox9SRY-box containing gene 90.161
Prlrprolactin receptor0.158
Pnpla2patatin-like phospholipase domain containing 20.152
Fgf23fibroblast growth factor 230.151
Nr1i3nuclear receptor subfamily 1, group I, member 30.151
Cldn3claudin 30.149
Ptk7PTK7 protein tyrosine kinase 70.149
Clca3chloride channel calcium activated 30.145
Ncoa1nuclear receptor coactivator 10.142
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.139
Duox2dual oxidase 20.132
Ece1endothelin converting enzyme 10.130
Vil1villin 10.128
Fabp4fatty acid binding protein 4, adipocyte0.127
Ednraendothelin receptor type A0.126
Lhx1LIM homeobox protein 10.125
Nr1h4nuclear receptor subfamily 1, group H, member 40.124
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.124
Slc22a1solute carrier family 22 (organic cation transporter), member 10.123
Arandrogen receptor0.121
Ces2ecarboxylesterase 2E0.119
Scd1stearoyl-Coenzyme A desaturase 10.117
Agtr1aangiotensin II receptor, type 1a0.116
Mep1bmeprin 1 beta0.115
Gna11guanine nucleotide binding protein, alpha 110.114
Abcg8ATP-binding cassette, sub-family G (WHITE), member 80.113
Amhr2anti-Mullerian hormone type 2 receptor0.113
Emx2empty spiracles homolog 2 (Drosophila)0.112
Cdh23cadherin 23 (otocadherin)0.110
Fasnfatty acid synthase0.110
Cps1carbamoyl-phosphate synthetase 10.109
Spink3serine peptidase inhibitor, Kazal type 30.109
Cstbcystatin B0.109
Phc2polyhomeotic-like 2 (Drosophila)0.109
Vldlrvery low density lipoprotein receptor0.107
Thrbthyroid hormone receptor beta0.107
Nphs2nephrosis 2 homolog, podocin (human)0.106
Fshrfollicle stimulating hormone receptor0.105
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.104
Psen1presenilin 10.104
Aldobaldolase B, fructose-bisphosphate0.103
Apohapolipoprotein H0.103
Rbp2retinol binding protein 2, cellular0.103
Srfserum response factor0.102
PorP450 (cytochrome) oxidoreductase0.102
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
DbpD site of albumin promoter (albumin D-box) binding protein0.789
Cfdcomplement factor D (adipsin)0.109
Nr2f6nuclear receptor subfamily 2, group F, member 60.087
Hnf4ahepatocyte nuclear factor 4, alpha0.077
Hnf1bHNF1 homeobox B0.077
Apoa5apolipoprotein A-V0.075
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.067
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.065
Pparaperoxisome proliferator activated receptor alpha0.060
A1cfAPOBEC1 complementation factor0.053
Trib1tribbles homolog 1 (Drosophila)0.052
Abcg8ATP-binding cassette, subfamily G (WHITE), member 80.050
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.048
UST4rintegral membrane transport protein UST4r0.047
Acox3acyl-Coenzyme A oxidase 3, pristanoyl0.047
Cyb5r4cytochrome b5 reductase 40.046
Lpllipoprotein lipase0.046
Slc23a1solute carrier family 23 (nucleobase transporters), member 10.045
Cldn3claudin 30.043
Hrghistidine-rich glycoprotein0.041
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.039
Xpnpep2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound0.039
Acot12acyl-CoA thioesterase 120.039
Slc22a7solute carrier family 22 (organic anion transporter), member 70.038
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.036
Slco1b3solute carrier organic anion transporter family, member 1b30.035
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.035
Unc5clunc-5 homolog C (C. elegans)-like0.035
Nr1i2nuclear receptor subfamily 1, group I, member 20.035
Azgp1alpha-2-glycoprotein 1, zinc-binding0.034
Smad6SMAD family member 60.032
A1bgalpha-1-B glycoprotein0.031
Fbp1fructose-1,6-bisphosphatase 10.031
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.030
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.029
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.029
Foxa3forkhead box A30.028
Chukconserved helix-loop-helix ubiquitous kinase0.028
Mettl7bmethyltransferase like 7B0.027
Lsslanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)0.027
Galpgalanin-like peptide0.027
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.027
Sec24dSEC24 family, member D (S. cerevisiae)0.026
Masp2mannan-binding lectin serine peptidase 20.026
Clcn2chloride channel 20.026
Tcf3transcription factor 30.026
Obp1fodorant binding protein I f0.025
Lect2leukocyte cell-derived chemotaxin 20.025
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.025
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.025
Sardhsarcosine dehydrogenase0.025
Gulogulonolactone (L-) oxidase0.024
Slc13a3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 30.024
Hfe2hemochromatosis type 2 (juvenile) homolog (human)0.024
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.024
G6pcglucose-6-phosphatase, catalytic subunit0.023
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.023
Olr1466olfactory receptor 14660.023
Serpinc1serpin peptidase inhibitor, clade C (antithrombin), member 10.023
Tmem82transmembrane protein 820.022
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.021
Phf17PHD finger protein 170.021
Gpr182G protein-coupled receptor 1820.021
Sec14l2SEC14-like 2 (S. cerevisiae)0.021
Serpinf2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.021
Zcchc24zinc finger, CCHC domain containing 240.021
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.021
F10coagulation factor X0.021
Rps6ka1ribosomal protein S6 kinase polypeptide 10.021
Aldh9a1aldehyde dehydrogenase 9 family, member A10.021
Foxa2forkhead box A20.021
Tbc1d15TBC1 domain family, member 150.020
Dmbt1deleted in malignant brain tumors 10.020
Commd10COMM domain containing 100.020
Cps1carbamoyl-phosphate synthetase 10.020
Acsm2acyl-CoA synthetase medium-chain family member 20.020
F2coagulation factor II (thrombin)0.020
Ahraryl hydrocarbon receptor0.020
F12coagulation factor XII (Hageman factor)0.020
Aco1aconitase 1, soluble0.019
Keg1kidney expressed gene 10.019
Fut1fucosyltransferase 10.019
Slc22a23solute carrier family 22, member 230.019
Ammecr1lAMME chromosomal region gene 1-like0.019
Sdr42e1short chain dehydrogenase/reductase family 42E, member 10.019
Fasnfatty acid synthase0.019
Tyw1tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)0.019
Cd36CD36 molecule (thrombospondin receptor)0.018
Inhbcinhibin beta C0.018
Pon3paraoxonase 30.018
Asgr1asialoglycoprotein receptor 10.018
Abcb4ATP-binding cassette, subfamily B (MDR/TAP), member 40.018
Mbl1mannose-binding lectin (protein A) 10.018
Baatbile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)0.018
Cela1chymotrypsin-like elastase family, member 10.018
C8bcomplement component 8, beta polypeptide0.018
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.018
Cdacytidine deaminase0.018
Rab33bRAB33B, member of RAS oncogene family0.018
Nr1d2nuclear receptor subfamily 1, group D, member 20.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YDR307Whypothetical protein0.013
YOL038C-Ahypothetical protein0.011
YLR264C-Ahypothetical protein0.011
YLR162Whypothetical protein0.011