The network for 'negative regulation of protein kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.

NameDescriptionProbabilityFunc Analog Organism
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.998
MAPK1mitogen-activated protein kinase 10.934
RB1retinoblastoma 10.921
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.916
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.874
PRKCZprotein kinase C, zeta0.872
PTPN1protein tyrosine phosphatase, non-receptor type 10.854
ARRB1arrestin, beta 10.852
MAPK14mitogen-activated protein kinase 140.848
EGFRepidermal growth factor receptor0.843
GSK3Bglycogen synthase kinase 3 beta0.786
SHC1SHC (Src homology 2 domain containing) transforming protein 10.765
AKT1v-akt murine thymoma viral oncogene homolog 10.715
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.707
LCKlymphocyte-specific protein tyrosine kinase0.632
GRB2growth factor receptor-bound protein 20.595
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.557
FYNFYN oncogene related to SRC, FGR, YES0.533
ZNF43zinc finger protein 430.521
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.495
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.437
TP53tumor protein p530.401
DUSP1dual specificity phosphatase 10.383
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.366
TRAF6TNF receptor-associated factor 60.347
SRFserum response factor (c-fos serum response element-binding transcription factor)0.324
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.320
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.317
LRRK2leucine-rich repeat kinase 20.317
GHRgrowth hormone receptor0.300
RARAretinoic acid receptor, alpha0.299
GRB10growth factor receptor-bound protein 100.280
METmet proto-oncogene (hepatocyte growth factor receptor)0.274
MAP3K5mitogen-activated protein kinase kinase kinase 50.264
PDCD6IPprogrammed cell death 6 interacting protein0.261
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.256
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.254
PTPN6protein tyrosine phosphatase, non-receptor type 60.248
MAP2K1mitogen-activated protein kinase kinase 10.241
AXIN1axin 10.239
RPTORregulatory associated protein of MTOR, complex 10.236
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.226
SH3KBP1SH3-domain kinase binding protein 10.223
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.222
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.218
ATF2activating transcription factor 20.218
BTKBruton agammaglobulinemia tyrosine kinase0.212
CSNK1Ecasein kinase 1, epsilon0.210
BTRCbeta-transducin repeat containing0.209
MTORmechanistic target of rapamycin (serine/threonine kinase)0.205
DVL3dishevelled, dsh homolog 3 (Drosophila)0.202
CDK6cyclin-dependent kinase 60.200
NCK1NCK adaptor protein 10.193
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.187
SKP1S-phase kinase-associated protein 10.185
PLCG1phospholipase C, gamma 10.185
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.168
CASP8caspase 8, apoptosis-related cysteine peptidase0.166
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.165
CREBBPCREB binding protein0.161
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.161
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.159
FEM1Bfem-1 homolog b (C. elegans)0.152
LAMP1lysosomal-associated membrane protein 10.152
BCAR1breast cancer anti-estrogen resistance 10.151
MED28mediator complex subunit 280.151
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.148
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.147
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.146
BMPR1Abone morphogenetic protein receptor, type IA0.145
SORBS3sorbin and SH3 domain containing 30.143
MAP2K4mitogen-activated protein kinase kinase 40.141
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.141
ZNF253zinc finger protein 2530.140
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.139
CCND3cyclin D30.137
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.137
PTK2PTK2 protein tyrosine kinase 20.135
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.131
JUNjun proto-oncogene0.131
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.130
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.128
PTPN11protein tyrosine phosphatase, non-receptor type 110.127
BAG3BCL2-associated athanogene 30.123
MAPK3mitogen-activated protein kinase 30.123
PTPRJprotein tyrosine phosphatase, receptor type, J0.121
MYD88myeloid differentiation primary response gene (88)0.120
MAPK8mitogen-activated protein kinase 80.119
SYKspleen tyrosine kinase0.119
DUSP6dual specificity phosphatase 60.119
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.115
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.115
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.114
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.114
VAV1vav 1 guanine nucleotide exchange factor0.114
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.107
MAPTmicrotubule-associated protein tau0.104
AKAP1A kinase (PRKA) anchor protein 10.103
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.103
ZNF746zinc finger protein 7460.101
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
egr1early growth response 10.714
efnb2aephrin B2a0.648
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.579
bmp2bbone morphogenetic protein 2b0.489
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.486
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.328
nf1aneurofibromin 1a0.319
dusp6dual specificity phosphatase 60.318
hsp90a.2heat shock protein 90-alpha 20.313
adipoqladiponectin, C1Q and collagen domain containing, like0.295
fzd7bfrizzled homolog 7b0.289
spry2sprouty homolog 20.272
arnt2aryl hydrocarbon receptor nuclear translocator 20.271
odc1ornithine decarboxylase 10.265
sox11aSRY-box containing gene 11a0.231
crhcorticotropin releasing hormone0.226
ip6k2inositol hexaphosphate kinase 20.221
emilin1aelastin microfibril interfacer 1a0.221
fgf3fibroblast growth factor 30.214
snai1asnail homolog 1a (Drosophila)0.211
btg2B-cell translocation gene 20.209
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.209
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.194
tob1atransducer of ERBB2, 1a0.185
wnt1wingless-type MMTV integration site family, member 10.183
dab1adisabled homolog 1a (Drosophila)0.181
mbtps1membrane-bound transcription factor protease, site 10.180
fbln4fibulin 40.177
rcv1recoverin0.177
col7a1lcollagen type VII alpha 1-like0.177
zgc:55259zgc:552590.169
dtngdystrobrevin, gamma and dystrobrevin, gamma-like0.158
copebcore promoter element binding protein0.158
adipoql2adiponectin, C1Q and collagen domain containing, like 20.155
igf1insulin-like growth factor 10.151
tnfatumor necrosis factor a (TNF superfamily, member 2)0.151
fabp11afatty acid binding protein 11a0.150
mapk3mitogen-activated protein kinase 30.148
hs6st1aheparan sulfate 6-O-sulfotransferase 1a0.147
zgc:100919zgc:1009190.146
bocbrother of CDO0.144
egr2bearly growth response 2b0.143
zgc:55813zgc:558130.136
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.136
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.135
thrbthyroid hormone receptor beta0.135
prox2prospero homeobox 20.134
ncf1neutrophil cytosolic factor 10.132
dlcdeltaC0.132
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.131
acvr2aactivin receptor IIa0.128
odz4odd Oz/ten-m homolog 40.128
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.127
bcl2l1bcl2-like 10.127
nr2e3nuclear receptor subfamily 2, group E, member 30.127
ficdFIC domain containing0.126
map4k5mitogen-activated protein kinase kinase kinase kinase 50.126
birc2baculoviral IAP repeat-containing 20.125
foxa3forkhead box A30.123
scn1labsodium channel, voltage-gated, type I like, alpha b0.123
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.123
crxcone-rod homeobox0.123
nr5a2nuclear receptor subfamily 5, group A, member 20.122
wu:fb58e05wu:fb58e050.121
mmp9matrix metalloproteinase 90.119
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.116
actc1bactin, alpha, cardiac muscle 1b0.115
eif4ebp3leukaryotic translation initiation factor 4E binding protein 3, like0.114
hspa4aheat shock protein 4a0.113
hs6st2heparan sulfate 6-O-sulfotransferase 20.111
ikIK cytokine0.110
tp53tumor protein p530.109
adam8aa disintegrin and metalloproteinase domain 8a0.107
pak2ap21 (CDKN1A)-activated kinase 2a0.107
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.106
gmfgglia maturation factor, gamma0.106
ube2i2ubiquitin-conjugating enzyme E2I20.105
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.103
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.103
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.102
pdlim4PDZ and LIM domain 40.101
ntn2netrin 20.100
nrg2aneuregulin 2a0.099
dzip1DAZ interacting protein 10.099
mapk6mitogen-activated protein kinase 60.098
meis1myeloid ecotropic viral integration 10.098
grnagranulin a0.098
prkcqprotein kinase C, theta0.098
brd2abromodomain-containing 2a0.097
sh3gl1bSH3-domain GRB2-like 1b0.097
socs1suppressor of cytokine signaling 10.096
mapk1mitogen-activated protein kinase 10.096
adora2badenosine A2b receptor0.095
mapk14amitogen-activated protein kinase 14a0.095
zgc:153997zgc:1539970.094
ptp4a3protein tyrosine phosphatase type IVA, member 30.094
dctdopachrome tautomerase0.093
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.093
ift57intraflagellar transport protein 570.093
ccng1cyclin G10.093
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.069
InRInsulin-like receptor0.052
rlrolled0.050
Stat92ESignal-transducer and activator of transcription protein at 92E0.047
shnschnurri0.039
shishibire0.027
MadMothers against dpp0.026
Ras85DRas oncogene at 85D0.022
G-oalpha47AG protein oalpha 47A0.021
rutrutabaga0.021
spispitz0.021
rdgBretinal degeneration B0.020
JraJun-related antigen0.019
hephemipterous0.018
CG14614CG14614 gene product from transcript CG14614-RA0.017
Sin3ACG8815 gene product from transcript CG8815-RC0.017
Akt1CG4006 gene product from transcript CG4006-RA0.017
Ras64BRas oncogene at 64B0.017
scbscab0.016
tkvthickveins0.015
rhorhomboid0.015
Src64BSrc oncogene at 64B0.015
Cdc42CG12530 gene product from transcript CG12530-RA0.015
CG13253CG13253 gene product from transcript CG13253-RB0.015
enaenabled0.015
hpohippo0.014
chicoCG5686 gene product from transcript CG5686-RB0.014
hipkhomeodomain interacting protein kinase0.013
phlpole hole0.012
drkdownstream of receptor kinase0.012
Src42ASrc oncogene at 42A0.012
dmdiminutive0.012
dncdunce0.012
CycDCyclin D0.012
rapretina aberrant in pattern0.011
msnmisshapen0.011
jebjelly belly0.011
Pka-C1cAMP-dependent protein kinase 10.011
Dcr-2Dicer-20.011
eghegghead0.010
wtswarts0.010
LLobe0.010
ash2absent, small, or homeotic discs 20.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Junbjun B proto-oncogene0.045
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.044
Sirpasignal-regulatory protein alpha0.036
Cugbp2CUG triplet repeat, RNA binding protein 20.033
Gna12guanine nucleotide binding protein (G protein) alpha 120.031
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.030
Rab1bRAB1B, member RAS oncogene family0.029
Eef2eukaryotic translation elongation factor 20.026
Sgk1serum/glucocorticoid regulated kinase 10.023
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.022
JunJun oncogene0.022
Klf9Kruppel-like factor 90.021
Eif2c2eukaryotic translation initiation factor 2C, 20.020
Nr4a1nuclear receptor subfamily 4, group A, member 10.019
Coq10bcoenzyme Q10 homolog B (S. cerevisiae)0.018
Fmnl1formin-like 10.018
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.018
Epn1Epsin 10.018
Prkcbprotein kinase C, beta0.018
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.017
Dlgap4discs, large homolog-associated protein 4 (Drosophila)0.016
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.016
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.016
Dnm1ldynamin 1-like0.016
Chordc1cysteine and histidine-rich domain (CHORD)-containing 10.016
Gnai1guanine nucleotide binding protein (G protein), alpha inhibiting 10.016
Socs3suppressor of cytokine signaling 30.016
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.016
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.015
Arl5aADP-ribosylation factor-like 5A0.015
Smap2small ArfGAP20.015
Egr1early growth response 10.015
Arpp21cAMP-regulated phosphoprotein 210.014
Cd36CD36 molecule (thrombospondin receptor)0.014
Cx3cl1chemokine (C-X3-C motif) ligand 10.014
Cxcl2chemokine (C-X-C motif) ligand 20.014
Tgoln1trans-golgi network protein0.014
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.014
Hk1hexokinase 10.014
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.014
Slit1slit homolog 1 (Drosophila)0.014
Bcat1branched chain aminotransferase 1, cytosolic0.013
Cntn4contactin 40.013
Cops7aCOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.013
Arl5cADP-ribosylation factor-like 5C0.013
Rpl3ribosomal protein L30.013
Fggfibrinogen gamma chain0.013
Eef1a2eukaryotic translation elongation factor 1 alpha 20.013
Rassf5Ras association (RalGDS/AF-6) domain family member 50.012
FynFYN oncogene related to SRC, FGR, YES0.012
Gria1glutamate receptor, ionotropic, AMPA 10.012
RGD1566085similar to pyridoxal (pyridoxine, vitamin B6) kinase0.012
Hist1h1ahistone cluster 1, H1a0.012
Nrg1neuregulin 10.012
Egfrepidermal growth factor receptor0.012
Dlgap3discs, large (Drosophila) homolog-associated protein 30.012
Jdp2Jun dimerization protein 20.012
Pde10aphosphodiesterase 10A0.011
RGD621098similar to RIKEN cDNA D230025D16Rik0.011
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.011
Akap1A kinase (PRKA) anchor protein 10.011
Arf3ADP-ribosylation factor 30.011
Stxbp5syntaxin binding protein 5 (tomosyn)0.011
Slfn2schlafen 20.011
Vdac1voltage-dependent anion channel 10.011
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.011
Mcf2lMCF.2 cell line derived transforming sequence-like0.011
RGD1305793similar to hypothetical protein FLJ201540.011
Usf2upstream transcription factor 2, c-fos interacting0.011
Hsph1heat shock 105/110 protein 10.011
Foxp1forkhead box P10.010
Il6rinterleukin 6 receptor0.010
Cyfip2cytoplasmic FMR1 interacting protein 20.010
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.010
Fgafibrinogen alpha chain0.010
Kif27kinesin family member 270.010
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.010
Klf6Kruppel-like factor 60.010
Shc1SHC (Src homology 2 domain containing) transforming protein 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PIL1Pil1p0.416
BCK1Bck1p0.253
SSK1Ssk1p0.230
MYO5Myo5p0.183
STE20Ste20p0.145
BOI2Boi2p0.103
MSG5Msg5p0.093
PBS2Pbs2p0.093
RLM1Rlm1p0.088
BOI1Boi1p0.075
CDC37Cdc37p0.062
BCK2Bck2p0.062
PAM1Pam1p0.061
YTA6Yta6p0.055
STE5Ste5p0.055
ROM2Rom2p0.053
PTC2Ptc2p0.047
CAK1Cak1p0.044
PTP3Ptp3p0.043
PTC3Ptc3p0.039
STE7Ste7p0.038
GAL83Gal83p0.037
AIM3Aim3p0.037
SOG2Sog2p0.036
SLT2Slt2p0.033
PAN1Pan1p0.033
SLA2Sla2p0.033
SSK2Ssk2p0.033
GYL1Gyl1p0.033
LSP1Lsp1p0.032
KDX1Kdx1p0.032
TRS65Trs65p0.032
ATM1Atm1p0.031
SIS1Sis1p0.031
PKH1Pkh1p0.031
VMA13Vma13p0.028
YGR205Whypothetical protein0.028
KIC1Kic1p0.027
CDC55Cdc55p0.026
MDM32Mdm32p0.026
SAK1Sak1p0.026
PPH21Pph21p0.025
KSS1Kss1p0.024
PCL9Pcl9p0.024
MKK1Mkk1p0.023
SSK22Ssk22p0.022
YHB1Yhb1p0.022
TAF8Taf8p0.022
YPD1Ypd1p0.020
YCF1Ycf1p0.020
MOB2Mob2p0.020
MKK2Mkk2p0.019
CNE1Cne1p0.019
MCM10Mcm10p0.019
SRO7Sro7p0.019
PAA1Paa1p0.019
SRO77Sro77p0.019
EDE1Ede1p0.017
YLR264C-Ahypothetical protein0.017
SKM1Skm1p0.017
CKB1Ckb1p0.017
SRD1Srd1p0.017
YMR086Whypothetical protein0.017
YIL151Chypothetical protein0.016
CRZ1Crz1p0.016
RRN6Rrn6p0.016
CRP1Crp1p0.016
MPT5Mpt5p0.016
LEU2Leu2p0.015
DIG1Dig1p0.015
YOL038C-Ahypothetical protein0.015
ICS2Ics2p0.015
CHA1Cha1p0.015
YOR111Whypothetical protein0.015
ALD6Ald6p0.014
YLR162Whypothetical protein0.014
MRP8Mrp8p0.014
ARE2Are2p0.014
MER1Mer1p0.013
BMH1Bmh1p0.013
HBT1Hbt1p0.013
RGD1Rgd1p0.013
SPL2Spl2p0.013
VPS13Vps13p0.013
ATP6Atp6p0.013
RRD1Rrd1p0.013
OYE2Oye2p0.013
HXT3Hxt3p0.013
SCP1Scp1p0.013
DUR1,2Dur1,2p0.012
CUP1-1Cup1-1p0.012
ARG8Arg8p0.012
PGS1Pgs1p0.012
SFA1Sfa1p0.012
STT3Stt3p0.012
SAT4Sat4p0.012
YAP7Yap7p0.012
MLP2Mlp2p0.012
UPS3Ups3p0.012
YDR034W-Bhypothetical protein0.012