The network for 'circadian sleep wake cycle sleep' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

circadian sleep wake cycle sleep

The part of the circadian sleep/wake cycle where the organism is asleep.

NameDescriptionProbabilityFunc Analog Organism
DLG4discs, large homolog 4 (Drosophila)0.998
ADORA2Aadenosine A2a receptor0.998
ACTN2actinin, alpha 20.954
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.933
INSRinsulin receptor0.879
NLRC4NLR family, CARD domain containing 40.832
CLOCKclock homolog (mouse)0.782
DRD2dopamine receptor D20.668
CYFIP1cytoplasmic FMR1 interacting protein 10.658
DLGAP1discs, large (Drosophila) homolog-associated protein 10.528
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.469
CYFIP2cytoplasmic FMR1 interacting protein 20.456
GRB10growth factor receptor-bound protein 100.403
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.324
MYOZ1myozenin 10.281
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.272
GAB1GRB2-associated binding protein 10.265
RIPK2receptor-interacting serine-threonine kinase 20.261
IRS1insulin receptor substrate 10.254
AKIP1A kinase (PRKA) interacting protein 10.246
AKAP11A kinase (PRKA) anchor protein 110.243
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.241
LCMT1leucine carboxyl methyltransferase 10.226
IRS2insulin receptor substrate 20.209
RYR2ryanodine receptor 2 (cardiac)0.197
NECAB2N-terminal EF-hand calcium binding protein 20.179
PRKAR2Bprotein kinase, cAMP-dependent, regulatory, type II, beta0.175
CALM1calmodulin 1 (phosphorylase kinase, delta)0.173
HSPH1heat shock 105kDa/110kDa protein 10.169
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.158
ADORA1adenosine A1 receptor0.141
CASP4caspase 4, apoptosis-related cysteine peptidase0.129
STAU1staufen, RNA binding protein, homolog 1 (Drosophila)0.127
FKBP4FK506 binding protein 4, 59kDa0.127
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.126
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.126
AP1M1adaptor-related protein complex 1, mu 1 subunit0.122
LDOC1leucine zipper, down-regulated in cancer 10.117
DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 10.104
NLGN1neuroligin 10.100
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.097
HSPA8heat shock 70kDa protein 80.081
GAB2GRB2-associated binding protein 20.080
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.078
PUM2pumilio homolog 2 (Drosophila)0.062
TBXA2Rthromboxane A2 receptor0.060
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha0.060
CFDcomplement factor D (adipsin)0.058
CHORDC1cysteine and histidine-rich domain (CHORD) containing 10.058
KIAA1377KIAA13770.056
DVL2dishevelled, dsh homolog 2 (Drosophila)0.055
FCGRTFc fragment of IgG, receptor, transporter, alpha0.054
KCTD4potassium channel tetramerisation domain containing 40.052
PYCARDPYD and CARD domain containing0.052
SETD7SET domain containing (lysine methyltransferase) 70.051
CRIPTcysteine-rich PDZ-binding protein0.050
SPRR2Asmall proline-rich protein 2A0.048
DCUN1D4DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)0.046
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 10.044
CDK5RAP2CDK5 regulatory subunit associated protein 20.044
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.044
NAMPTnicotinamide phosphoribosyltransferase0.043
TDRD3tudor domain containing 30.043
KCNA3potassium voltage-gated channel, shaker-related subfamily, member 30.042
HSPA1Aheat shock 70kDa protein 1A0.039
CSNK1Ecasein kinase 1, epsilon0.038
CBScystathionine-beta-synthase0.038
CARD16caspase recruitment domain family, member 160.037
VAPBVAMP (vesicle-associated membrane protein)-associated protein B and C0.036
LIMK1LIM domain kinase 10.036
BMI1BMI1 polycomb ring finger oncogene0.036
MCCmutated in colorectal cancers0.035
EPB41L1erythrocyte membrane protein band 4.1-like 10.035
HES1hairy and enhancer of split 1, (Drosophila)0.033
TSC22D4TSC22 domain family, member 40.032
TBK1TANK-binding kinase 10.031
DISC1disrupted in schizophrenia 10.031
GSK3Bglycogen synthase kinase 3 beta0.031
CNR1cannabinoid receptor 1 (brain)0.028
CCNKcyclin K0.027
TNP2transition protein 2 (during histone to protamine replacement)0.027
EGFRepidermal growth factor receptor0.027
KIF5Ckinesin family member 5C0.027
SERPINB1serpin peptidase inhibitor, clade B (ovalbumin), member 10.027
IGF1Rinsulin-like growth factor 1 receptor0.026
TBKBP1TBK1 binding protein 10.026
CUL4Bcullin 4B0.026
IL18interleukin 18 (interferon-gamma-inducing factor)0.025
PRKAR1Bprotein kinase, cAMP-dependent, regulatory, type I, beta0.025
NELL2NEL-like 2 (chicken)0.025
SIRT1sirtuin 10.024
EGLN1egl nine homolog 1 (C. elegans)0.024
DNAJC13DnaJ (Hsp40) homolog, subfamily C, member 130.024
PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 20.024
PPP5Cprotein phosphatase 5, catalytic subunit0.024
BBS10Bardet-Biedl syndrome 100.024
MTNR1Amelatonin receptor 1A0.023
SORBS3sorbin and SH3 domain containing 30.023
FRS2fibroblast growth factor receptor substrate 20.023
CYTH2cytohesin 20.023
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
drd2ldopamine receptor D2 like0.812
vdravitamin D receptor a0.646
drd2adopamine receptor D2a0.623
ndr1nodal-related 10.609
srfserum response factor0.547
npy8arneuropeptide Y receptor Y8a0.521
unc45bunc-45 homolog B (C. elegans)0.519
mxi1max interacting protein0.494
relnreelin0.481
cebp1CCAAT/enhancer binding protein (C/EBP) 10.467
ntf7neurotrophin 70.413
insrbinsulin receptor b0.393
cry2bcryptochrome 2b0.359
mc4rmelanocortin 4 receptor0.344
dab1adisabled homolog 1a (Drosophila)0.343
tp53bp2tumor protein p53 binding protein, 20.340
tlr21toll-like receptor 210.309
oxtloxytocin-like0.304
adra2aadrenergic, alpha-2A-, receptor0.301
eif3s10eukaryotic translation initiation factor 3, subunit 10 (theta)0.283
gdnfglial cell derived neurotrophic factor0.261
dag1dystroglycan 10.261
ptgdsprostaglandin D2 synthase0.260
vephventricular zone expressed PH domain protein0.253
syce2synaptonemal complex central element protein 20.250
esr1estrogen receptor 10.239
siah2lseven in absentia homolog 2 (Drosophila)-like0.229
smyd1bSET and MYND domain containing 1b0.227
pde10aphosphodiesterase 10A0.207
hcrthypocretin (orexin) neuropeptide precursor0.203
tbx20T-box 200.198
fhlafour and a half LIM domains a0.183
scn1asodium channel, voltage-gated, type I, alpha0.182
gabbr1agamma-aminobutyric acid (GABA) B receptor, 1a0.182
ddcdopa decarboxylase0.172
stac3SH3 and cysteine rich domain 30.165
zgc:101761zgc:1017610.163
insrainsulin receptor a0.156
procprotein C (inactivator of coagulation factors Va and VIIIa)0.155
ncam2neural cell adhesion molecule 20.145
rag2recombination activating gene 20.143
cx55.5connexin 55.50.142
irx4biroquois homeobox protein 4b0.139
arntl1baryl hydrocarbon receptor nuclear translocator-like 1b0.139
tshbthyroid stimulating hormone, beta subunit0.137
dmddystrophin0.136
cx35connexin 350.134
tpmaalpha-tropomyosin0.131
igf2ainsulin-like growth factor 2a0.130
wnt10awingless-type MMTV integration site family, member 10a0.127
ing5inhibitor of growth family, member 5a0.126
cldnkclaudin k0.125
per3period homolog 3 (Drosophila)0.123
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.121
mchr1amelanin-concentrating hormone receptor 1a0.117
slc8a4bsolute carrier family 8 (sodium/calcium exchanger), member 4b0.114
abcb3l1ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 10.113
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.113
pomcaproopiomelanocortin a0.111
lamb2laminin, beta 2 (laminin S)0.110
si:dkeyp-59a8.4si:dkeyp-59a8.40.109
ryr2aryanodine receptor 2a (cardiac)0.108
pou1f1POU domain, class 1, transcription factor 10.108
mpp6bmembrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)0.107
qkquaking0.106
zgc:55582zgc:555820.105
ahr1aaryl hydrocarbon receptor 1a0.104
neurod2neurogenic differentiation 20.104
cx39.9connexin 39.90.100
ttnatitin a0.099
per2period homolog 2 (Drosophila)0.097
or115-10odorant receptor, family F, subfamily 115, member 100.095
cry4cryptochrome 40.093
cry1acryptochrome 1a0.091
zgc:112180zgc:1121800.091
efna5bephrin A5b0.090
gfra1bgdnf family receptor alpha 1b0.088
setd5SET domain containing 50.088
ucn3lurocortin 3, like0.087
gsx1GS homeobox 10.086
esrrbestrogen-related receptor beta0.086
thtyrosine hydroxylase0.083
slc25a27solute carrier family 25, member 270.083
tnnc1btroponin C type 1b (slow)0.081
cry5cryptochrome 50.081
grid2glutamate receptor, ionotropic, delta 20.081
esr2bestrogen receptor 2b0.080
prlprolactin0.080
mtnr1bamelatonin receptor type 1B a0.078
arntl2aryl hydrocarbon receptor nuclear translocator-like 20.078
gnrh2gonadotropin-releasing hormone 20.077
ryr1bryanodine receptor 1b (skeletal)0.076
zbtb4zinc finger and BTB domain containing 40.072
nlgn1neuroligin 10.068
aldh1l1aldehyde dehydrogenase 1 family, member L10.068
vldlrvery low density lipoprotein receptor0.067
tpt1tumor protein, translationally-controlled 10.067
glra1glycine receptor, alpha 10.067
chatcholine acetyltransferase0.065
abca5ATP-binding cassette, sub-family A (ABC1), member 50.064
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Octbeta2RCG33976 gene product from transcript CG33976-RA0.985
DatDopamine N acetyltransferase0.979
CG42629CG42629 gene product from transcript CG42629-RB0.789
ClkClock0.736
crycryptochrome0.598
cyccycle0.509
Dcr-2Dicer-20.414
jebjelly belly0.411
dncdunce0.358
htthuntingtin0.335
OambOctopamine receptor in mushroom bodies0.324
dnr1defense repressor 10.310
CG32810CG32810 gene product from transcript CG32810-RB0.250
timtimeless0.249
IhI[[h]] channel0.233
CG13253CG13253 gene product from transcript CG13253-RB0.228
G-oalpha47AG protein oalpha 47A0.228
Fmr1CG6203 gene product from transcript CG6203-RC0.213
plepale0.212
rho-5rhomboid-50.203
nAcRalpha-7Enicotinic Acetylcholine Receptor alpha 7E0.202
TbhTyramine beta hydroxylase0.195
nAcRalpha-80Bnicotinic Acetylcholine Receptor alpha 80B0.192
cwoclockwork orange0.187
CG34139CG34139 gene product from transcript CG34139-RD0.180
qvrquiver0.168
CrebB-17ACyclic-AMP response element binding protein B at 17A0.163
CanA1Calcineurin A10.152
l(3)82FdCG32464 gene product from transcript CG32464-RR0.143
Or22aOdorant receptor 22a0.137
perperiod0.122
CG4857CG4857 gene product from transcript CG4857-RD0.117
foxoforkhead box, sub-group O0.110
Pvf2PDGF- and VEGF-related factor 20.100
VmatVesicular monoamine transporter0.099
ShawShaker cognate w0.097
Nf1Neurofibromin 10.092
CG16778CG16778 gene product from transcript CG16778-RA0.078
Rab27CG14791 gene product from transcript CG14791-RB0.078
sinusinuous0.076
Glut1Glucose transporter 10.071
Cyp316a1CG8540 gene product from transcript CG8540-RA0.071
homerCG11324 gene product from transcript CG11324-RC0.063
CG34400CG34400 gene product from transcript CG34400-RD0.061
oa2octopamine receptor 20.056
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.055
pdfrPDF receptor0.052
shishibire0.051
fblfumble0.050
Gadd45CG11086 gene product from transcript CG11086-RA0.049
Sema-5cSemaphorin-5c0.048
CanBCalcineurin B0.048
Ef1alpha48DElongation factor 1alpha48D0.046
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.043
Gr28bGustatory receptor 28b0.043
mttmangetout0.043
HmgcrHMG Coenzyme A reductase0.042
NPFR1neuropeptide F receptor0.041
AcerAngiotensin-converting enzyme-related0.040
CG9184CG9184 gene product from transcript CG9184-RB0.039
CG4563CG4563 gene product from transcript CG4563-RA0.036
CG18594CG18594 gene product from transcript CG18594-RA0.036
Socs36ESuppressor of cytokine signaling at 36E0.036
E23Early gene at 230.036
CG1358CG1358 gene product from transcript CG1358-RD0.035
PIP5K59BCG3682 gene product from transcript CG3682-RE0.035
imdimmune deficiency0.034
crccryptocephal0.033
Ork1Open rectifier K[+] channel 10.033
klgklingon0.031
LpR2CG31092 gene product from transcript CG31092-RD0.031
RdlResistant to dieldrin0.031
picoCG11940 gene product from transcript CG11940-RA0.030
beta4GalNAcTACG8536 gene product from transcript CG8536-RA0.030
brpbruchpilot0.030
PdfPigment-dispersing factor0.029
5-HT7Serotonin receptor 70.029
CG18437CG18437 gene product from transcript CG18437-RB0.029
upd2unpaired 20.029
CanA-14FCalcineurin A at 14F0.029
l(3)mbnlethal (3) malignant blood neoplasm0.028
Hr46Hormone receptor-like in 460.028
ShShaker0.027
rutrutabaga0.027
DskDrosulfakinin0.025
CCKLR-17D1CCK-like receptor at 17D10.025
Rya-r44FRyanodine receptor 44F0.025
ActbetaActivin-beta0.025
Ac3CG1506 gene product from transcript CG1506-RA0.025
myoglianinCG1838 gene product from transcript CG1838-RD0.025
DdcDopa decarboxylase0.024
Gad1Glutamic acid decarboxylase 10.022
nonAno on or off transient A0.022
CG31140CG31140 gene product from transcript CG31140-RF0.021
TequilaCG4821 gene product from transcript CG4821-RE0.021
nAcRbeta-64Bnicotinic Acetylcholine Receptor beta 64B0.021
KrnKeren0.021
neuroliginCG13772 gene product from transcript CG13772-RA0.021
CG42574CG42574 gene product from transcript CG42574-RE0.020
CcapCardioacceleratory peptide0.020
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Drd1adopamine receptor D1A0.084
Pdynprodynorphin0.074
Rnf4ring finger protein 40.066
Kcng2potassium voltage-gated channel, subfamily G, member 20.060
Adam10ADAM metallopeptidase domain 100.060
Mapk9mitogen-activated protein kinase 90.052
Gipgastric inhibitory polypeptide0.047
Magmyelin-associated glycoprotein0.045
Adora1adenosine A1 receptor0.044
Ahsgalpha-2-HS-glycoprotein0.043
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.042
Ttrtransthyretin0.041
Casp2caspase 20.041
Apoeapolipoprotein E0.039
Nmuneuromedin U0.038
Calcrlcalcitonin receptor-like0.037
Lim2lens intrinsic membrane protein 20.037
Krt34keratin 340.036
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.035
Olr416olfactory receptor 4160.034
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.034
Fgafibrinogen alpha chain0.033
Vcsa1variable coding sequence A10.031
Cacng5calcium channel, voltage-dependent, gamma subunit 50.030
Prkciprotein kinase C, iota0.030
Adaradenosine deaminase, RNA-specific0.028
OgtO-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)0.028
Crhr1corticotropin releasing hormone receptor 10.028
Toe1target of EGR1, member 1 (nuclear)0.027
Cabp1calcium binding protein 10.027
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.027
Parp14poly (ADP-ribose) polymerase family, member 140.027
Pdzd2PDZ domain containing 20.027
Reg3aregenerating islet-derived 3 alpha0.027
Dhfrdihydrofolate reductase0.026
Tmsb4xthymosin beta 4, X-linked0.026
Agxtalanine-glyoxylate aminotransferase0.026
Aldobaldolase B, fructose-bisphosphate0.026
LOC24906RoBo-10.025
Slc22a13solute carrier family 22 (organic anion transporter), member 130.025
Nrn1lneuritin 1-like0.025
Cdk2cyclin dependent kinase 20.025
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.024
Nudt3nudix (nucleoside diphosphate linked moiety X)-type motif 30.024
RT1-N3RT1 class Ib, locus N30.024
Syt13synaptotagmin XIII0.024
Chrm4cholinergic receptor, muscarinic 40.023
S1pr2sphingosine-1-phosphate receptor 20.023
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive0.022
Spp2secreted phosphoprotein 20.022
Syt11synaptotagmin XI0.022
Uoxurate oxidase0.022
Otud7aOTU domain containing 7A0.022
Cited1Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 10.021
Lin7clin-7 homolog C (C. elegans)0.021
Tpc1808tropic 18080.021
Gjc2gap junction protein, gamma 20.021
Cd48Cd48 molecule0.021
Insrrinsulin receptor-related receptor0.021
Dio3deiodinase, iodothyronine, type III0.021
Gpr6G protein-coupled receptor 60.021
Rgs9regulator of G-protein signaling 90.021
Stk3serine/threonine kinase 3 (STE20 homolog, yeast)0.021
Samsn1SAM domain, SH3 domain and nuclear localization signals, 10.020
RY2G5potential ligand-binding protein0.019
Tlr4toll-like receptor 40.019
LOC100361571keratin associated protein 1-3-like0.019
Bdkrb1bradykinin receptor B10.019
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.018
Pdclphosducin-like0.018
Atxn1ataxin 10.018
Cyp2c7cytochrome P450, family 2, subfamily c, polypeptide 70.018
Ambpalpha-1-microglobulin/bikunin precursor0.018
Trpc4transient receptor potential cation channel, subfamily C, member 40.018
Reg3bregenerating islet-derived 3 beta0.017
Mybphmyosin binding protein H0.017
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.017
Gastgastrin0.017
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.017
Ifnginterferon gamma0.017
Kcnk15potassium channel, subfamily K, member 150.017
Skap2src kinase associated phosphoprotein 20.017
Glp1rglucagon-like peptide 1 receptor0.017
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.016
Accn3amiloride-sensitive cation channel 30.016
Tas2r119taste receptor, type 2, member 1190.016
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.016
Grik1glutamate receptor, ionotropic, kainate 10.016
P2rx5purinergic receptor P2X, ligand-gated ion channel, 50.016
NsfN-ethylmaleimide-sensitive factor0.016
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.016
LOC296235similar to Cystatin S precursor (LM protein)0.016
Hcrtr2hypocretin (orexin) receptor 20.016
Nat1N-acetyltransferase 10.016
Slfn2schlafen 20.015
LOC286987hemiferrin, transferrin-like protein0.015
Giprgastric inhibitory polypeptide receptor0.015
Prlhrprolactin releasing hormone receptor0.015
Crhcorticotropin releasing hormone0.015
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism