The network for 'b cell homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

b cell homeostasis

The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

NameDescriptionProbabilityFunc Analog Organism
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.968
BCL2L1BCL2-like 10.919
APAF1apoptotic peptidase activating factor 10.854
BCL2B-cell CLL/lymphoma 20.656
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.625
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.564
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.405
CXCR4chemokine (C-X-C motif) receptor 40.366
HDAC9histone deacetylase 90.343
RIPK2receptor-interacting serine-threonine kinase 20.279
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.264
MSNmoesin0.243
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.237
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.218
CASP9caspase 9, apoptosis-related cysteine peptidase0.210
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.209
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.192
BAXBCL2-associated X protein0.179
CARD11caspase recruitment domain family, member 110.178
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.139
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.133
BAK1BCL2-antagonist/killer 10.113
HLA-DMBmajor histocompatibility complex, class II, DM beta0.109
XIAPX-linked inhibitor of apoptosis0.104
HLA-DPB1major histocompatibility complex, class II, DP beta 10.101
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.100
ARNTaryl hydrocarbon receptor nuclear translocator0.098
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.092
BIDBH3 interacting domain death agonist0.091
BCL2L11BCL2-like 11 (apoptosis facilitator)0.076
BADBCL2-associated agonist of cell death0.067
C9orf89chromosome 9 open reading frame 890.064
EP300E1A binding protein p3000.062
NCOA6nuclear receptor coactivator 60.057
LATlinker for activation of T cells0.056
TRAF6TNF receptor-associated factor 60.055
HIPK2homeodomain interacting protein kinase 20.053
RNF144Bring finger protein 144B0.053
MAP3K14mitogen-activated protein kinase kinase kinase 140.050
PLCG1phospholipase C, gamma 10.048
CASP7caspase 7, apoptosis-related cysteine peptidase0.047
TNIP2TNFAIP3 interacting protein 20.044
HLA-DRB5major histocompatibility complex, class II, DR beta 50.040
HLA-DRB4major histocompatibility complex, class II, DR beta 40.039
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.037
MAPK12mitogen-activated protein kinase 120.036
TNIP1TNFAIP3 interacting protein 10.036
FGFR1fibroblast growth factor receptor 10.035
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.035
MAPK14mitogen-activated protein kinase 140.034
ZNF282zinc finger protein 2820.032
WASLWiskott-Aldrich syndrome-like0.032
LAPTM5lysosomal protein transmembrane 50.032
BCL10B-cell CLL/lymphoma 100.030
NCOA2nuclear receptor coactivator 20.030
NCOA3nuclear receptor coactivator 30.025
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.025
ABL2v-abl Abelson murine leukemia viral oncogene homolog 20.025
TNFtumor necrosis factor0.025
RNR2l-rRNA0.024
GAB1GRB2-associated binding protein 10.024
BCL2L2BCL2-like 20.023
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.023
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.023
BIRC3baculoviral IAP repeat containing 30.023
IKZF3IKAROS family zinc finger 3 (Aiolos)0.022
CDC37cell division cycle 37 homolog (S. cerevisiae)0.022
EZRezrin0.022
BIKBCL2-interacting killer (apoptosis-inducing)0.021
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.021
CASP6caspase 6, apoptosis-related cysteine peptidase0.021
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.021
DUSP6dual specificity phosphatase 60.021
SPRR2Dsmall proline-rich protein 2D0.020
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.019
KRT17keratin 170.019
MAPK8mitogen-activated protein kinase 80.019
FLNAfilamin A, alpha0.019
BRAPBRCA1 associated protein0.018
KAT2BK(lysine) acetyltransferase 2B0.018
AKT3v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)0.018
EGLN1egl nine homolog 1 (C. elegans)0.018
GAB2GRB2-associated binding protein 20.017
SQSTM1sequestosome 10.016
MEF2Amyocyte enhancer factor 2A0.016
CCDC85Bcoiled-coil domain containing 85B0.016
TCF4transcription factor 40.016
VHLvon Hippel-Lindau tumor suppressor0.016
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.016
AMBRA1autophagy/beclin-1 regulator 10.016
INSRinsulin receptor0.015
PURApurine-rich element binding protein A0.015
CUX1cut-like homeobox 10.015
PYCARDPYD and CARD domain containing0.015
STK17Bserine/threonine kinase 17b0.015
SLC7A11solute carrier family 7, (cationic amino acid transporter, y+ system) member 110.014
CD83CD83 molecule0.014
AHRaryl hydrocarbon receptor0.014
ADAM15ADAM metallopeptidase domain 150.013
FKBP8FK506 binding protein 8, 38kDa0.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ighimmunoglobulin heavy chain complex0.969
CblCasitas B-lineage lymphoma0.939
Map3k7mitogen-activated protein kinase kinase kinase 70.935
Ikzf1IKAROS family zinc finger 10.912
Ikbkginhibitor of kappaB kinase gamma0.813
Grb2growth factor receptor bound protein 20.694
Bcl2B-cell leukemia/lymphoma 20.660
Cd19CD19 antigen0.621
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.608
Ikbkbinhibitor of kappaB kinase beta0.594
Cd40CD40 antigen0.584
Lyz2lysozyme 20.561
BaxBCL2-associated X protein0.557
Ptprcprotein tyrosine phosphatase, receptor type, C0.548
Ptenphosphatase and tensin homolog0.538
Adam17a disintegrin and metallopeptidase domain 170.514
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.492
Ptk2PTK2 protein tyrosine kinase 20.479
TcrdT-cell receptor delta chain0.463
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.446
Tlr4toll-like receptor 40.425
Abi1abl-interactor 10.412
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.369
Smad4MAD homolog 4 (Drosophila)0.353
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.347
Casp1caspase 10.337
Trp53transformation related protein 530.318
WasWiskott-Aldrich syndrome homolog (human)0.312
BlnkB-cell linker0.311
Card11caspase recruitment domain family, member 110.308
Dok1docking protein 10.295
Bcl6B-cell leukemia/lymphoma 60.293
Vhlvon Hippel-Lindau tumor suppressor0.283
TcrbT-cell receptor beta chain0.264
Chukconserved helix-loop-helix ubiquitous kinase0.262
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.258
Prkcdprotein kinase C, delta0.257
Nr3c1nuclear receptor subfamily 3, group C, member 10.246
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.244
BtkBruton agammaglobulinemia tyrosine kinase0.234
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.230
H2-Eb1histocompatibility 2, class II antigen E beta0.224
Plcg2phospholipase C, gamma 20.224
H2-Aahistocompatibility 2, class II antigen A, alpha0.212
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.212
Irf8interferon regulatory factor 80.196
FasFas (TNF receptor superfamily member 6)0.193
Myd88myeloid differentiation primary response gene 880.188
Pou2af1POU domain, class 2, associating factor 10.185
Sykbspleen tyrosine kinase0.181
Ikzf3IKAROS family zinc finger 30.179
Il2interleukin 20.154
Hdac4histone deacetylase 40.152
Arntaryl hydrocarbon receptor nuclear translocator0.151
Lystlysosomal trafficking regulator0.150
Huwe1HECT, UBA and WWE domain containing 10.147
Hif1ahypoxia inducible factor 1, alpha subunit0.137
Casp4caspase 4, apoptosis-related cysteine peptidase0.137
Bak1BCL2-antagonist/killer 10.132
Cd22CD22 antigen0.130
Hdac7histone deacetylase 70.130
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.119
Cd72CD72 antigen0.118
Ttc7tetratricopeptide repeat domain 70.117
H2-DMahistocompatibility 2, class II, locus DMa0.113
Cd79bCD79B antigen0.105
Klf3Kruppel-like factor 3 (basic)0.103
Gbp5guanylate binding protein 50.099
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.096
Hdac5histone deacetylase 50.093
Rc3h1RING CCCH (C3H) domains 10.085
Cybbcytochrome b-245, beta polypeptide0.085
Ptgs2prostaglandin-endoperoxide synthase 20.085
Itsn1intersectin 1 (SH3 domain protein 1A)0.082
Nfe2l2nuclear factor, erythroid derived 2, like 20.081
Wt1Wilms tumor 1 homolog0.079
Stat5bsignal transducer and activator of transcription 5B0.077
Ccr7chemokine (C-C motif) receptor 70.075
Atp11cATPase, class VI, type 11C0.074
Ciitaclass II transactivator0.073
Snap23synaptosomal-associated protein 230.072
Sgpl1sphingosine phosphate lyase 10.067
Nlrp3NLR family, pyrin domain containing 30.066
Rock2Rho-associated coiled-coil containing protein kinase 20.066
Jak3Janus kinase 30.065
9430031J16RikRIKEN cDNA 9430031J16 gene0.065
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.065
Mef2dmyocyte enhancer factor 2D0.065
Jak2Janus kinase 20.064
Icam1intercellular adhesion molecule 10.064
Tgfbr1transforming growth factor, beta receptor I0.063
Il18interleukin 180.062
Tab2TGF-beta activated kinase 1/MAP3K7 binding protein 20.062
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.061
Pxnpaxillin0.060
Smad2MAD homolog 2 (Drosophila)0.059
Birc3baculoviral IAP repeat-containing 30.058
SkilSKI-like0.057
Wdr26WD repeat domain 260.056
Egln1EGL nine homolog 1 (C. elegans)0.055
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism