The network for 'endosome organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.

NameDescriptionProbabilityFunc Analog Organism
SNX9sorting nexin 90.997
DNM2dynamin 20.958
AKTIPAKT interacting protein0.905
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.891
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.830
EEA1early endosome antigen 10.791
ADAM15ADAM metallopeptidase domain 150.774
DNM1dynamin 10.690
ITSN1intersectin 1 (SH3 domain protein)0.678
WASLWiskott-Aldrich syndrome-like0.606
MON1BMON1 homolog B (yeast)0.452
S100A10S100 calcium binding protein A100.442
ANXA1annexin A10.407
APPL2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 20.373
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)0.271
SH3GL2SH3-domain GRB2-like 20.242
ANKRD28ankyrin repeat domain 280.240
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.213
AMPHamphiphysin0.213
TDP2tyrosyl-DNA phosphodiesterase 20.188
RAB7ARAB7A, member RAS oncogene family0.169
SYNJ1synaptojanin 10.158
LRRK2leucine-rich repeat kinase 20.149
BECN1beclin 1, autophagy related0.132
CTTNcortactin0.122
PDCD6IPprogrammed cell death 6 interacting protein0.092
HOOK2hook homolog 2 (Drosophila)0.082
SDCBPsyndecan binding protein (syntenin)0.080
KIAA1377KIAA13770.078
ADAM10ADAM metallopeptidase domain 100.071
MLPHmelanophilin0.068
SNX33sorting nexin 330.068
ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B20.066
ANXA7annexin A70.060
RAB5ARAB5A, member RAS oncogene family0.055
RAB11FIP1RAB11 family interacting protein 1 (class I)0.053
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.053
CHMP1Bchromatin modifying protein 1B0.051
SH3GL1SH3-domain GRB2-like 10.039
RHOAras homolog gene family, member A0.039
PACSIN2protein kinase C and casein kinase substrate in neurons 20.039
ANXA5annexin A50.034
DTX1deltex homolog 1 (Drosophila)0.033
ATG14ATG14 autophagy related 14 homolog (S. cerevisiae)0.033
UVRAGUV radiation resistance associated gene0.030
HOOK3hook homolog 3 (Drosophila)0.030
VAMP4vesicle-associated membrane protein 40.030
CHMP2Bchromatin modifying protein 2B0.029
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.029
TNK2tyrosine kinase, non-receptor, 20.028
VPS24vacuolar protein sorting 24 homolog (S. cerevisiae)0.028
IQGAP1IQ motif containing GTPase activating protein 10.028
ATP6V1DATPase, H+ transporting, lysosomal 34kDa, V1 subunit D0.027
STAMsignal transducing adaptor molecule (SH3 domain and ITAM motif) 10.027
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.027
RABAC1Rab acceptor 1 (prenylated)0.025
CKAP4cytoskeleton-associated protein 40.025
NMT2N-myristoyltransferase 20.024
VIMvimentin0.024
AMBRA1autophagy/beclin-1 regulator 10.023
ANXA2annexin A20.022
ITGB5integrin, beta 50.022
ADAM9ADAM metallopeptidase domain 90.021
ATP6V1C1ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C10.021
SGK3serum/glucocorticoid regulated kinase family, member 30.021
PIK3R4phosphoinositide-3-kinase, regulatory subunit 40.021
ATP6V1E1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E10.020
DEDDdeath effector domain containing0.020
OCRLoculocerebrorenal syndrome of Lowe0.019
MYO5Amyosin VA (heavy chain 12, myoxin)0.019
EXOC8exocyst complex component 80.019
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.019
VPS41vacuolar protein sorting 41 homolog (S. cerevisiae)0.019
TM9SF4transmembrane 9 superfamily protein member 40.019
S100A11S100 calcium binding protein A110.018
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.018
TMSB10thymosin beta 100.018
RAB22ARAB22A, member RAS oncogene family0.017
DYNC2H1dynein, cytoplasmic 2, heavy chain 10.016
SYTL4synaptotagmin-like 40.016
EPB41L3erythrocyte membrane protein band 4.1-like 30.016
NOSTRINnitric oxide synthase trafficker0.015
SNAP25synaptosomal-associated protein, 25kDa0.015
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.015
CLK2CDC-like kinase 20.015
CHIC2cysteine-rich hydrophobic domain 20.015
GPBP1L1GC-rich promoter binding protein 1-like 10.014
CAB39calcium binding protein 390.014
MAP2K4mitogen-activated protein kinase kinase 40.014
PPP6R3protein phosphatase 6, regulatory subunit 30.014
TBL1XR1transducin (beta)-like 1 X-linked receptor 10.014
MYL12Bmyosin, light chain 12B, regulatory0.014
RAB14RAB14, member RAS oncogene family0.014
MED12mediator complex subunit 120.014
EMP3epithelial membrane protein 30.014
KIAA1468KIAA14680.014
RAB11FIP2RAB11 family interacting protein 2 (class I)0.013
REEP6receptor accessory protein 60.013
MEAF6MYST/Esa1-associated factor 60.013
TGFBItransforming growth factor, beta-induced, 68kDa0.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cacna1dacalcium channel, voltage-dependent, L type, alpha 1D subunit, a0.157
zgc:56010zgc:560100.132
atp6v1fATPase, H+ transporting, V1 subunit F0.112
zgc:77849zgc:778490.109
zgc:193699zgc:1936990.065
LOC100005504Gig2-like protein DreL0.065
aqp7aquaporin 70.062
arhgdiaRho GDP dissociation inhibitor (GDI) alpha0.056
rab5aaRAB5A, member RAS oncogene family, a0.055
jak1Janus kinase 10.054
mknk2bMAP kinase-interacting serine/threonine kinase 2b0.054
zgc:55573zgc:555730.053
zgc:55572zgc:555720.052
sec24cSEC24 family, member C (S. cerevisiae)0.050
fcho2FCH domain only 20.049
hsp90b1heat shock protein 90, beta (grp94), member 10.049
pfn2profilin 20.048
LOC100005232Gig2-like protein DreD0.047
nktrnatural killer-tumor recognition sequence0.047
bcl2B-cell leukemia/lymphoma 20.042
capza1acapping protein (actin filament) muscle Z-line, alpha 1a0.042
si:ch211-89p1.1si:ch211-89p1.10.042
pdcd6ipprogrammed cell death 6 interacting protein0.039
zgc:63691zgc:636910.038
zgc:158327zgc:1583270.037
atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.035
aqp8a.2aquaporin 8a, tandem duplicate 20.035
si:ch211-184m19.1si:ch211-184m19.10.035
caprin2caprin family member 20.034
dazap2DAZ associated protein 20.033
zfpm1zinc finger protein, multitype 10.033
si:ch211-260p9.1si:ch211-260p9.10.033
rab5abRAB5A, member RAS oncogene family, b0.032
zgc:92313zgc:923130.032
LOC100005283Gig2-like protein DreE0.031
ubap1ubiquitin associated protein 10.031
atp6v1dATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D0.030
btbd10bBTB (POZ) domain containing 10b0.030
mycl1av-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) a0.030
wu:fi25h02wu:fi25h020.030
dnaja2lDnaJ (Hsp40) homolog, subfamily A, member 2, like0.029
vps26blvacuolar protein sorting 26 homolog B, like0.029
aqp10baquaporin 10b0.028
gfi1.1growth factor independent 1.10.028
rab7RAB7, member RAS oncogene family0.028
slc39a11solute carrier family 39 (metal ion transporter), member 110.028
aqp4aquaporin 40.027
zgc:56049zgc:560490.027
tfr1atransferrin receptor 1a0.026
ube2q2ubiquitin-conjugating enzyme E2Q family member 20.026
pitpnaphosphatidylinositol transfer protein, alpha0.026
arf2ADP-ribosylation factor 20.026
slc26a5solute carrier family 26, member 50.026
cltcaclathrin, heavy polypeptide a (Hc)0.026
slc39a4solute carrier family 39 (zinc transporter), member 40.026
stxbp2syntaxin binding protein 20.025
slc17a8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 80.025
atf4b2activating transcription factor 4b20.025
diaph2diaphanous homolog 2 (Drosophila)0.024
golga1golgin A10.024
nrxn3aneurexin 3a0.024
baxabcl2-associated X protein, a0.024
srsf1bserine/arginine-rich splicing factor 1b0.024
ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.024
abca12ATP-binding cassette, sub-family A (ABC1), member 120.024
frem1aFras1 related extracellular matrix 1a0.024
arf1lADP-ribosylation factor 1 like0.023
lass5LAG1 homolog, ceramide synthase 5 (S. cerevisiae)0.023
tsc22d1TSC22 domain family, member 10.023
LOC566020Gig2-like protein DreO0.023
slc39a9solute carrier family 39 (zinc transporter), member 90.023
zgc:113210zgc:1132100.022
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.022
iqgap1IQ motif containing GTPase activating protein 10.022
uevldUEV and lactate/malate dehyrogenase domains0.022
glb1galactosidase, beta 10.022
pigaphosphatidylinositol glycan anchor biosynthesis, class A0.022
zgc:114108zgc:1141080.022
slc30a9solute carrier family 30 (zinc transporter), member 90.022
aqp10aaquaporin 10a0.022
zgc:112329zgc:1123290.022
si:dkey-204a24.2si:dkey-204a24.20.022
gle1GLE1 RNA export mediator homolog (yeast)0.021
ognosteoglycin0.021
arih2ariadne homolog 2 (Drosophila)0.021
nyxnyctalopin0.021
kdsr3-ketodihydrosphingosine reductase0.021
zgc:162698zgc:1626980.020
casp9caspase 9, apoptosis-related cysteine protease0.020
LOC100151531zinc finger protein Gfi-1b-like0.020
birc2baculoviral IAP repeat-containing 20.020
zgc:113200zgc:1132000.020
tmf1TATA element modulatory factor 10.019
cul1bcullin 1b0.019
scamp2secretory carrier membrane protein 20.019
mtmr12myotubularin related protein 120.019
tbc1d23TBC1 domain family, member 230.019
fgfrl1bfibroblast growth factor receptor-like 1b0.019
atl3atlastin 30.019
cyfip2cytoplasmic FMR1 interacting protein 20.019
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.123
Rab5Rab-protein 50.111
Vha55Vacuolar H[+]-ATPase 55kD B subunit0.068
OsbpOxysterol binding protein0.060
RhebCG1081 gene product from transcript CG1081-RA0.050
CG11347CG11347 gene product from transcript CG11347-RE0.049
ird1immune response deficient 10.039
Syx7Syntaxin 70.037
synjsynaptojanin0.037
prelpreli-like0.029
dosdaughter of sevenless0.028
CG3573CG3573 gene product from transcript CG3573-RA0.027
mopmyopic0.027
StamSignal transducing adaptor molecule0.024
CG9063CG9063 gene product from transcript CG9063-RA0.023
captcapulet0.023
Rab7Rab-protein 70.022
c11.1CG12132 gene product from transcript CG12132-RA0.022
Vps36Vacuolar protein sorting 360.019
Klp68DKinesin-like protein at 68D0.017
ari-2ariadne 20.015
Lis-1Lissencephaly-10.014
desat1CG5887 gene product from transcript CG5887-RA0.013
Pi3K59FPhosphotidylinositol 3 kinase 59F0.013
CG11526CG11526 gene product from transcript CG11526-RB0.013
Vps16AVacuolar protein sorting 16A0.013
lsnlarsen0.012
Atg7Autophagy-specific gene 70.012
DlicDynein light intermediate chain0.011
Traf-likeTNF-receptor-associated factor-like0.011
chinmoChronologically inappropriate morphogenesis0.011
CG6116CG6116 gene product from transcript CG6116-RA0.011
yataCG1973 gene product from transcript CG1973-RA0.011
Vps25Vacuolar protein sorting 250.011
Aut1CG6877 gene product from transcript CG6877-RA0.010
ChcClathrin heavy chain0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lystlysosomal trafficking regulator0.182
Pfn2profilin 20.161
Mlphmelanophilin0.107
Rnf41ring finger protein 410.093
Stx12syntaxin 120.083
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.080
Stam2signal transducing adaptor molecule (SH3 domain and ITAM motif) 20.076
Dync1i2dynein cytoplasmic 1 intermediate chain 20.041
Itsn1intersectin 1 (SH3 domain protein 1A)0.031
Sytl5synaptotagmin-like 50.027
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.026
Prf1perforin 1 (pore forming protein)0.025
Chmp2bchromatin modifying protein 2B0.025
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.021
Stx7syntaxin 70.020
Rnf11ring finger protein 110.019
Ap3b1adaptor-related protein complex 3, beta 1 subunit0.019
Clstn1calsyntenin 10.017
Atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.017
Atp6v0d1ATPase, H+ transporting, lysosomal V0 subunit D10.016
Arf5ADP-ribosylation factor 50.016
Tmem9bTMEM9 domain family, member B0.015
Atp6v1c1ATPase, H+ transporting, lysosomal V1 subunit C10.015
Ndfip1Nedd4 family interacting protein 10.015
Ap2a2adaptor protein complex AP-2, alpha 2 subunit0.014
Chmp5chromatin modifying protein 50.014
Rab5aRAB5A, member RAS oncogene family0.014
Prnpprion protein0.014
RragcRas-related GTP binding C0.014
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.014
anonagouti0.014
Rab11aRAB11a, member RAS oncogene family0.013
Stx11syntaxin 110.013
Wsb2WD repeat and SOCS box-containing 20.013
Tbk1TANK-binding kinase 10.013
Per1period homolog 1 (Drosophila)0.013
Rab2aRAB2A, member RAS oncogene family0.012
Lamtor3late endosomal/lysosomal adaptor, MAPK and MTOR activator 30.012
Stx6syntaxin 60.012
Vps16vacuolar protein sorting 16 (yeast)0.012
Rnf103ring finger protein 1030.011
Grb2growth factor receptor bound protein 20.011
Atp6v1g1ATPase, H+ transporting, lysosomal V1 subunit G10.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.062
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.023
Dync1i2dynein cytoplasmic 1 intermediate chain 20.019
Nfe2l2nuclear factor, erythroid derived 2, like 20.016
Zfp364zinc finger protein 3640.015
Ap3s1adaptor-related protein complex 3, sigma 1 subunit0.014
Zmym4zinc finger, MYM-type 40.014
Brcc3BRCA1/BRCA2-containing complex, subunit 30.014
Bin1bridging integrator 10.012
Gclmglutamate cysteine ligase, modifier subunit0.012
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.012
Ralbp1ralA binding protein 10.011
Arl8bADP-ribosylation factor-like 8B0.011
AktipAKT interacting protein0.011
Klrd1killer cell lectin-like receptor, subfamily D, member 10.011
Trappc6btrafficking protein particle complex 6B0.011
Pdclphosducin-like0.011
Dusp4dual specificity phosphatase 40.011
Ube2d2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.011
Ube2hubiquitin-conjugating enzyme E2H0.010
Chmp1achromatin modifying protein 1A0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
BLI1Bli1p0.982
KXD1Kxd1p0.909
BLS1Bls1p0.858
VAB2Vab2p0.702
SNN1Snn1p0.441
CNL1Cnl1p0.342
YPT1Ypt1p0.236
YPT10Ypt10p0.209
YPT7Ypt7p0.113
YPT52Ypt52p0.103
VAM7Vam7p0.054
VPS27Vps27p0.050
BRO1Bro1p0.049
YPT32Ypt32p0.042
PEP5Pep5p0.037
VPS3Vps3p0.033
YPT6Ypt6p0.031
UGO1Ugo1p0.026
APP1App1p0.023
HAL5Hal5p0.022
SAP1Sap1p0.021
MDM32Mdm32p0.018
NYV1Nyv1p0.018
SRD1Srd1p0.017
CUP1-1Cup1-1p0.016
SOV1Sov1p0.016
ARP10Arp10p0.015
YLR264C-Ahypothetical protein0.015
ARE2Are2p0.015
YOL038C-Ahypothetical protein0.015
LEU2Leu2p0.014
YOR022Chypothetical protein0.014
MER1Mer1p0.013
YLR162Whypothetical protein0.013
YIP3Yip3p0.012
LDB17Ldb17p0.012
YER128Whypothetical protein0.012
SEC4Sec4p0.012
MDS3Mds3p0.012
END3End3p0.012
GDI1Gdi1p0.011
ECM15Ecm15p0.011
YLR042Chypothetical protein0.011
YPL277Chypothetical protein0.011
DSE3Dse3p0.010
HEM14Hem14p0.010
VPS38Vps38p0.010
HXT3Hxt3p0.010
ATP6Atp6p0.010