The network for 'vacuole organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

vacuole organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.

NameDescriptionProbabilityFunc Analog Organism
GABARAPGABA(A) receptor-associated protein1.000
GABARAPL2GABA(A) receptor-associated protein-like 20.998
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.996
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.995
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.992
CTSAcathepsin A0.976
ULK1unc-51-like kinase 1 (C. elegans)0.973
BECN1beclin 1, autophagy related0.972
NBR1neighbor of BRCA1 gene 10.935
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.920
ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)0.897
ATP6V0D1ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d10.876
ATP6V0CATPase, H+ transporting, lysosomal 16kDa, V0 subunit c0.875
AKTIPAKT interacting protein0.859
CFL1cofilin 1 (non-muscle)0.858
SNX6sorting nexin 60.854
GRNgranulin0.835
ATP6V0BATPase, H+ transporting, lysosomal 21kDa, V0 subunit b0.795
PIK3C3phosphoinositide-3-kinase, class 30.795
VPS33Bvacuolar protein sorting 33 homolog B (yeast)0.765
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.761
PSAPprosaposin0.761
ATP6AP1ATPase, H+ transporting, lysosomal accessory protein 10.751
RAB5ARAB5A, member RAS oncogene family0.746
OCRLoculocerebrorenal syndrome of Lowe0.741
LRRK2leucine-rich repeat kinase 20.698
MON1BMON1 homolog B (yeast)0.663
VTI1Bvesicle transport through interaction with t-SNAREs homolog 1B (yeast)0.652
PLD3phospholipase D family, member 30.640
ATG5ATG5 autophagy related 5 homolog (S. cerevisiae)0.621
NEU1sialidase 1 (lysosomal sialidase)0.582
GOLGA2golgin A20.578
ACTBactin, beta0.573
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.566
ITSN1intersectin 1 (SH3 domain protein)0.522
AMBRA1autophagy/beclin-1 regulator 10.491
INSRinsulin receptor0.490
CTSDcathepsin D0.484
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.478
VPS41vacuolar protein sorting 41 homolog (S. cerevisiae)0.471
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.468
ARHGAP1Rho GTPase activating protein 10.456
GABARAPL1GABA(A) receptor-associated protein like 10.448
PTPN23protein tyrosine phosphatase, non-receptor type 230.438
LAMTOR1late endosomal/lysosomal adaptor, MAPK and MTOR activator 10.422
GDI2GDP dissociation inhibitor 20.414
BCL2B-cell CLL/lymphoma 20.412
MTMR12myotubularin related protein 120.390
SQSTM1sequestosome 10.380
STX12syntaxin 120.370
MTM1myotubularin 10.366
RHOAras homolog gene family, member A0.366
ATP6V1DATPase, H+ transporting, lysosomal 34kDa, V1 subunit D0.344
WBP2WW domain binding protein 20.341
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.329
EEA1early endosome antigen 10.326
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.325
LAMP1lysosomal-associated membrane protein 10.318
TPP1tripeptidyl peptidase I0.316
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.309
BCL2L1BCL2-like 10.307
UVRAGUV radiation resistance associated gene0.299
TPM4tropomyosin 40.269
ATG16L1ATG16 autophagy related 16-like 1 (S. cerevisiae)0.267
GRB2growth factor receptor-bound protein 20.249
NCSTNnicastrin0.233
RAB1BRAB1B, member RAS oncogene family0.210
C12orf44chromosome 12 open reading frame 440.203
RAB2ARAB2A, member RAS oncogene family0.185
ATG14ATG14 autophagy related 14 homolog (S. cerevisiae)0.183
TNFAIP1tumor necrosis factor, alpha-induced protein 1 (endothelial)0.177
CREB3cAMP responsive element binding protein 30.174
GLB1galactosidase, beta 10.170
CLTBclathrin, light chain B0.149
MAPK8mitogen-activated protein kinase 80.149
FAM134Afamily with sequence similarity 134, member A0.149
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.149
ATP6V1G1ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G10.147
CHMP2Bchromatin modifying protein 2B0.142
RRAGARas-related GTP binding A0.128
BAK1BCL2-antagonist/killer 10.127
MTMR6myotubularin related protein 60.126
ZFYVE1zinc finger, FYVE domain containing 10.124
MAP3K11mitogen-activated protein kinase kinase kinase 110.124
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.123
PINK1PTEN induced putative kinase 10.122
ATP6V1FATPase, H+ transporting, lysosomal 14kDa, V1 subunit F0.121
COASYCoA synthase0.117
ANKRD27ankyrin repeat domain 27 (VPS9 domain)0.113
ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B20.110
KIAA1377KIAA13770.109
KBTBD7kelch repeat and BTB (POZ) domain containing 70.107
SESN2sestrin 20.101
ARRB2arrestin, beta 20.101
CFL2cofilin 2 (muscle)0.101
OS9osteosarcoma amplified 9, endoplasmic reticulum lectin0.100
SPTLC1serine palmitoyltransferase, long chain base subunit 10.100
C5orf54chromosome 5 open reading frame 540.099
NSFN-ethylmaleimide-sensitive factor0.095
TUBA1Ctubulin, alpha 1c0.094
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
skn-1Protein SKN-10.014
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.143
atp6v1hATPase, H+ transporting, lysosomal, V1 subunit H0.118
atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.103
cltcaclathrin, heavy polypeptide a (Hc)0.080
arf2ADP-ribosylation factor 20.062
zgc:110239zgc:1102390.061
arf5ADP-ribosylation factor 50.061
rab13RAB13, member RAS oncogene family0.059
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.059
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.058
atp6v1fATPase, H+ transporting, V1 subunit F0.058
ctsdcathepsin D0.050
cnn2calponin 20.047
snx4sorting nexin 40.043
ctszcathepsin Z0.038
slc45a2solute carrier family 45, member 20.035
elovl1belongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b0.035
apg3lAPG3 autophagy 3-like0.035
zgc:77849zgc:778490.033
mxd4MAX dimerization protein 40.033
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.033
pfn2profilin 20.033
ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.031
sept2septin 20.030
zgc:110815zgc:1108150.030
atp6v1e1bATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b0.030
bc2putative breast adenocarcinoma marker0.029
atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.028
cpvlcarboxypeptidase, vitellogenic-like0.027
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.027
atp6v1dATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D0.024
rab5aaRAB5A, member RAS oncogene family, a0.024
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.022
vps18vacuolar protein sorting protein 180.022
ctsfcathepsin F0.022
ccm2cerebral cavernous malformation 20.021
stxbp2syntaxin binding protein 20.021
map1lc3amicrotubule-associated protein 1 light chain 3 alpha0.021
zgc:152830zgc:1528300.020
zgc:92765zgc:927650.019
clcn7chloride channel 70.018
gabarapaGABA(A) receptor-associated protein a0.018
msnamoesin a0.018
rab5cRAB5C, member RAS oncogene family0.018
zgc:55813zgc:558130.017
ck2bcasein kinase 2 beta0.017
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.016
si:dkey-222f8.3si:dkey-222f8.30.016
ctbschitobiase, di-N-acetyl-0.015
cd63Cd63 antigen0.015
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.015
eno1enolase 1, (alpha)0.014
gle1GLE1 RNA export mediator homolog (yeast)0.014
tax1bp1bTax1 (human T-cell leukemia virus type I) binding protein 1b0.014
wdr45WD repeat domain 450.014
dnaja2lDnaJ (Hsp40) homolog, subfamily A, member 2, like0.014
zgc:123177zgc:1231770.014
grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.014
zgc:91910zgc:919100.013
mxi1max interacting protein0.013
pkm2apyruvate kinase, muscle, a0.013
nebnebulin0.012
atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.012
med7mediator complex subunit 70.012
pgk1phosphoglycerate kinase 10.012
atp6v1g1ATPase, H+ transporting, V1 subunit G isoform 10.012
rer1RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)0.012
zgc:100919zgc:1009190.012
hn1lhematological and neurological expressed 1-like0.012
map1lc3bmicrotubule-associated protein 1 light chain 3 beta0.011
zgc:63831zgc:638310.011
tm9sf2transmembrane 9 superfamily member 20.011
sypl2bsynaptophysin-like 2b0.011
si:ch211-146l10.2si:ch211-146l10.20.011
tp53tumor protein p530.011
midnmidnolin0.010
zgc:77517zgc:775170.010
zgc:56530zgc:565300.010
map2k7mitogen-activated protein kinase kinase 70.010
npc2Niemann-Pick disease, type C20.010
psenenpresenilin enhancer 2 homolog0.010
mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.010
tmem50atransmembrane protein 50A0.010
wipi2WD repeat domain, phosphoinositide interacting 20.010
tmem9bTMEM9 domain family, member B0.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rab7Rab-protein 70.379
RhebCG1081 gene product from transcript CG1081-RA0.204
Akt1CG4006 gene product from transcript CG4006-RA0.135
Atg1Autophagy-specific gene 10.120
Pi3K59FPhosphotidylinositol 3 kinase 59F0.070
Rab2Rab-protein 20.057
Atg18Autophagy-specific gene 180.042
CG1599CG1599 gene product from transcript CG1599-RA0.034
Atg8aAutophagy-specific gene 8a0.030
Rab6Rab-protein 60.026
Atg2Autophagy-specific gene 20.026
Syx7Syntaxin 70.025
Syx17Syntaxin 170.024
SnapSoluble NSF attachment protein0.024
Gos28CG7700 gene product from transcript CG7700-RA0.023
CG7220CG7220 gene product from transcript CG7220-RD0.023
gammaSnapgamma-soluble NSF attachment protein0.022
ClC-bChloride channel-b0.022
keykenny0.021
drprdraper0.019
StamSignal transducing adaptor molecule0.019
SybSynaptobrevin0.018
Atg9Autophagy-specific gene 90.017
Atg6Autophagy-specific gene 60.016
Pi3K92ECG4141 gene product from transcript CG4141-RB0.015
RalaRas-related protein0.012
CG10904CG10904 gene product from transcript CG10904-RA0.012
Vti1CG3279 gene product from transcript CG3279-RA0.012
S6kRPS6-p70-protein kinase0.011
Rac2CG8556 gene product from transcript CG8556-RA0.011
CG12004CG12004 gene product from transcript CG12004-RC0.011
prelpreli-like0.011
mtsmicrotubule star0.011
CG11975CG11975 gene product from transcript CG11975-RA0.010
CG7611CG7611 gene product from transcript CG7611-RJ0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Atg12autophagy-related 12 (yeast)0.996
Rac1RAS-related C3 botulinum substrate 10.995
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.987
Dpp7dipeptidylpeptidase 70.958
Hexahexosaminidase A0.914
Hexbhexosaminidase B0.819
Psapprosaposin0.745
Lamp1lysosomal-associated membrane protein 10.711
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.707
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.697
0610031J06RikRIKEN cDNA 0610031J06 gene0.650
Ulk1Unc-51 like kinase 1 (C. elegans)0.631
Ctsbcathepsin B0.606
Mitfmicrophthalmia-associated transcription factor0.600
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.540
Rab11aRAB11a, member RAS oncogene family0.532
Atg13ATG13 autophagy related 13 homolog (S. cerevisiae)0.525
Lrrk2leucine-rich repeat kinase 20.513
Mtormechanistic target of rapamycin (serine/threonine kinase)0.499
Mfsd1major facilitator superfamily domain containing 10.492
Actr3ARP3 actin-related protein 3 homolog (yeast)0.485
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.481
Gnsglucosamine (N-acetyl)-6-sulfatase0.447
Ncstnnicastrin0.441
RragcRas-related GTP binding C0.438
Lrp1low density lipoprotein receptor-related protein 10.430
Atg3autophagy-related 3 (yeast)0.427
Npc1Niemann Pick type C10.416
Igf2rinsulin-like growth factor 2 receptor0.415
Sgpl1sphingosine phosphate lyase 10.415
Sqstm1sequestosome 10.383
Aph1aanterior pharynx defective 1a homolog (C. elegans)0.374
Grb10growth factor receptor bound protein 100.355
Stx7syntaxin 70.352
Wdr81WD repeat domain 810.345
Gaaglucosidase, alpha, acid0.331
Lpin1lipin 10.331
Eef1a1eukaryotic translation elongation factor 1 alpha 10.316
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.315
Ndfip1Nedd4 family interacting protein 10.315
Ctsacathepsin A0.312
Renbprenin binding protein0.304
Snx2sorting nexin 20.303
Grngranulin0.300
Actg1actin, gamma, cytoplasmic 10.287
Atp6v0bATPase, H+ transporting, lysosomal V0 subunit B0.277
Apoeapolipoprotein E0.268
Atg5autophagy-related 5 (yeast)0.268
Snap23synaptosomal-associated protein 230.253
Rab1RAB1, member RAS oncogene family0.250
Sept7septin 70.248
Ctsdcathepsin D0.241
Atp6v0eATPase, H+ transporting, lysosomal V0 subunit E0.237
Cltcclathrin, heavy polypeptide (Hc)0.222
NagaN-acetyl galactosaminidase, alpha0.212
Ctszcathepsin Z0.211
Rab27aRAB27A, member RAS oncogene family0.207
Notch2Notch gene homolog 2 (Drosophila)0.205
Mapk9mitogen-activated protein kinase 90.197
Tpp1tripeptidyl peptidase I0.196
Itgb5integrin beta 50.192
Mapre3microtubule-associated protein, RP/EB family, member 30.192
Rap1bRAS related protein 1b0.188
Asah1N-acylsphingosine amidohydrolase 10.181
Man2b1mannosidase 2, alpha B10.179
Pld3phospholipase D family, member 30.177
Plbd2phospholipase B domain containing 20.173
Lamtor3late endosomal/lysosomal adaptor, MAPK and MTOR activator 30.170
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.170
Clcn7chloride channel 70.169
Arl1ADP-ribosylation factor-like 10.161
Capza2capping protein (actin filament) muscle Z-line, alpha 20.161
Iduaiduronidase, alpha-L-0.156
Trp53inp2transformation related protein 53 inducible nuclear protein 20.153
Sdcbpsyndecan binding protein0.152
Arf1ADP-ribosylation factor 10.151
Copb1coatomer protein complex, subunit beta 10.150
Gdi2guanosine diphosphate (GDP) dissociation inhibitor 20.147
anonagouti0.147
Calm1calmodulin 10.146
Gopcgolgi associated PDZ and coiled-coil motif containing0.143
Rab18RAB18, member RAS oncogene family0.141
Vps35vacuolar protein sorting 350.141
Npc2Niemann Pick type C20.139
Ssr3signal sequence receptor, gamma0.138
Gusbglucuronidase, beta0.137
Lgmnlegumain0.136
Arl8bADP-ribosylation factor-like 8B0.134
Atg2aATG2 autophagy related 2 homolog A (S. cerevisiae)0.134
Igf2insulin-like growth factor 20.133
Twf1twinfilin, actin-binding protein, homolog 1 (Drosophila)0.131
Atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.130
Tcn2transcobalamin 20.130
Naglualpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)0.128
Pi4kbphosphatidylinositol 4-kinase, catalytic, beta polypeptide0.123
Ikbkbinhibitor of kappaB kinase beta0.120
Lipalysosomal acid lipase A0.119
Tbc1d17TBC1 domain family, member 170.117
Pik3c3phosphoinositide-3-kinase, class 30.116
Pldnpallidin0.116
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Arf1ADP-ribosylation factor 10.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
VTI1Vti1p0.968
PEP12Pep12p0.934
YKT6Ykt6p0.930
VPS45Vps45p0.899
VPS21Vps21p0.885
VAM6Vam6p0.807
VAM7Vam7p0.753
VPS41Vps41p0.742
VTC1Vtc1p0.714
PEP3Pep3p0.714
VPS16Vps16p0.614
VPS33Vps33p0.604
VPS15Vps15p0.593
SEC4Sec4p0.519
VAM3Vam3p0.358
SEC17Sec17p0.347
SYS1Sys1p0.316
VTC4Vtc4p0.309
PEP5Pep5p0.308
ATG20Atg20p0.298
VTC3Vtc3p0.291
CDC42Cdc42p0.279
TLG2Tlg2p0.255
CNB1Cnb1p0.255
ATG9Atg9p0.250
VPS60Vps60p0.247
ATG8Atg8p0.243
CTR9Ctr9p0.238
SSO1Sso1p0.229
ATG3Atg3p0.228
TOM1Tom1p0.228
FAB1Fab1p0.215
VPS8Vps8p0.186
SCP1Scp1p0.175
ATG4Atg4p0.168
MLC1Mlc1p0.167
AHP1Ahp1p0.166
ATG14Atg14p0.165
RCY1Rcy1p0.160
PAF1Paf1p0.158
ERR3Err3p0.157
YPT1Ypt1p0.150
GPA2Gpa2p0.148
YPT52Ypt52p0.146
VTC2Vtc2p0.143
DRS2Drs2p0.139
PHO81Pho81p0.138
ATG29Atg29p0.136
HSV2Hsv2p0.135
RHO4Rho4p0.135
ATG18Atg18p0.130
RHO1Rho1p0.125
KEX1Kex1p0.125
YPT7Ypt7p0.121
CIS1Cis1p0.121
VPS51Vps51p0.118
TLG1Tlg1p0.115
LRG1Lrg1p0.111
NBP2Nbp2p0.108
LCB2Lcb2p0.106
ATG13Atg13p0.106
VPS3Vps3p0.105
ATG11Atg11p0.103
ATG23Atg23p0.101
STF1Stf1p0.100
TPI1Tpi1p0.100
LEM3Lem3p0.098
CDC55Cdc55p0.091
PHO84Pho84p0.091
DOP1Dop1p0.091
COX13Cox13p0.090
MUK1Muk1p0.090
SYN8Syn8p0.088
PTC1Ptc1p0.086
SHE2She2p0.086
ARP2Arp2p0.086
SPO7Spo7p0.086
GDI1Gdi1p0.086
VPS17Vps17p0.080
GPI1Gpi1p0.078
ATG16Atg16p0.078
PHM6Phm6p0.077
BEM4Bem4p0.076
VMA6Vma6p0.075
ARV1Arv1p0.074
ATG7Atg7p0.073
CAP1Cap1p0.072
ARE2Are2p0.071
SHE3She3p0.071
ARC18Arc18p0.071
GCS1Gcs1p0.070
MSB3Msb3p0.070
COT1Cot1p0.070
NPR2Npr2p0.070
ATG1Atg1p0.070
AKR1Akr1p0.069
NYV1Nyv1p0.069
PHO11Pho11p0.068
SRL1Srl1p0.068
GPR1Gpr1p0.068