The network for 'regulation of cartilage development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cartilage development

Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

NameDescriptionProbabilityFunc Analog Organism
SMAD7SMAD family member 70.967
LTBP2latent transforming growth factor beta binding protein 20.886
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.827
ELNelastin0.769
SMAD2SMAD family member 20.767
FBLN1fibulin 10.638
SMAD4SMAD family member 40.605
SMAD1SMAD family member 10.555
SMAD5SMAD family member 50.551
BMPR1Abone morphogenetic protein receptor, type IA0.504
WWP2WW domain containing E3 ubiquitin protein ligase 20.489
ATN1atrophin 10.486
CTGFconnective tissue growth factor0.469
FSTL1follistatin-like 10.459
POU3F2POU class 3 homeobox 20.456
COL1A1collagen, type I, alpha 10.352
COL6A1collagen, type VI, alpha 10.342
LOXL1lysyl oxidase-like 10.337
SMAD3SMAD family member 30.321
PAX3paired box 30.320
LOXlysyl oxidase0.255
FN1fibronectin 10.246
FBN1fibrillin 10.227
TGFB1transforming growth factor, beta 10.221
CHRDchordin0.200
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.199
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.168
COL6A2collagen, type VI, alpha 20.167
FBLN5fibulin 50.152
RXRAretinoid X receptor, alpha0.138
TGFB3transforming growth factor, beta 30.132
SKIv-ski sarcoma viral oncogene homolog (avian)0.114
NCOA1nuclear receptor coactivator 10.111
BMPR1Bbone morphogenetic protein receptor, type IB0.107
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.096
BMP7bone morphogenetic protein 70.095
COL5A1collagen, type V, alpha 10.090
BGNbiglycan0.090
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.090
MEOX2mesenchyme homeobox 20.088
ENGendoglin0.088
ZFYVE9zinc finger, FYVE domain containing 90.086
BMP2bone morphogenetic protein 20.083
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.078
MMP14matrix metallopeptidase 14 (membrane-inserted)0.078
CYR61cysteine-rich, angiogenic inducer, 610.078
EGR1early growth response 10.074
MED25mediator complex subunit 250.074
BTRCbeta-transducin repeat containing0.072
THBS1thrombospondin 10.060
SMURF2SMAD specific E3 ubiquitin protein ligase 20.059
TGFBR1transforming growth factor, beta receptor 10.058
PCOLCEprocollagen C-endopeptidase enhancer0.057
PMLpromyelocytic leukemia0.056
COL1A2collagen, type I, alpha 20.055
HSPG2heparan sulfate proteoglycan 20.051
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.048
SMAD6SMAD family member 60.045
TNCtenascin C0.045
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.041
COL3A1collagen, type III, alpha 10.035
DCNdecorin0.034
COL18A1collagen, type XVIII, alpha 10.033
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.033
MRC2mannose receptor, C type 20.032
SUFUsuppressor of fused homolog (Drosophila)0.031
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.031
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.030
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.030
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.030
COL2A1collagen, type II, alpha 10.028
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 20.027
CALD1caldesmon 10.027
MFAP2microfibrillar-associated protein 20.027
CTBP2C-terminal binding protein 20.025
AXIN1axin 10.025
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.025
WISP1WNT1 inducible signaling pathway protein 10.023
CREBBPCREB binding protein0.023
SOX11SRY (sex determining region Y)-box 110.023
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.023
BMP1bone morphogenetic protein 10.022
FZD1frizzled homolog 1 (Drosophila)0.022
MMP11matrix metallopeptidase 11 (stromelysin 3)0.022
LAMB2laminin, beta 2 (laminin S)0.021
IGFBP5insulin-like growth factor binding protein 50.021
LTBP4latent transforming growth factor beta binding protein 40.021
CHAC1ChaC, cation transport regulator homolog 1 (E. coli)0.021
COMPcartilage oligomeric matrix protein0.020
TGFB2transforming growth factor, beta 20.020
AMOTL2angiomotin like 20.020
NRP2neuropilin 20.020
MDM2Mdm2 p53 binding protein homolog (mouse)0.020
HOXA10homeobox A100.019
MAFBv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)0.019
MMP16matrix metallopeptidase 16 (membrane-inserted)0.019
CD248CD248 molecule, endosialin0.019
MXRA8matrix-remodelling associated 80.018
SMURF1SMAD specific E3 ubiquitin protein ligase 10.018
PRKD2protein kinase D20.018
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.755
bmp2bbone morphogenetic protein 2b0.476
runx2brunt-related transcription factor 2b0.441
rargaretinoic acid receptor gamma a0.386
hapln1ahyaluronan and proteoglycan link protein 1a0.211
fgf3fibroblast growth factor 30.204
tbx16T-box gene 160.182
fgf10afibroblast growth factor 10a0.173
runx2arunt-related transcription factor 2a0.135
twist3twist30.132
gpr126G protein-coupled receptor 1260.124
col2a1acollagen type II, alpha-1a0.124
flhfloating head0.121
sox9aSRY-box containing gene 9a0.117
bmperBMP binding endothelial regulator0.105
shhasonic hedgehog a0.102
tgfbitransforming growth factor, beta-induced0.098
rarabretinoic acid receptor, alpha b0.096
s1pr2sphingosine-1-phosphate receptor 20.092
ndr2nodal-related 20.090
prdm1aPR domain containing 1a, with ZNF domain0.086
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.084
fgfrl1bfibroblast growth factor receptor-like 1b0.084
chdchordin0.082
fgfr1afibroblast growth factor receptor 1a0.079
cx30.3connexin 30.30.076
hand2heart and neural crest derivatives expressed transcript 20.070
gscgoosecoid0.070
hoxa13bhomeo box A13b0.069
lft1lefty10.068
osr1odd-skipped related 1 (Drosophila)0.065
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.064
gli2aGLI-Kruppel family member GLI2a0.061
dlx4adistal-less homeobox gene 4a0.056
snai1bsnail homolog 1b (Drosophila)0.053
prrx1apaired related homeobox 1a0.053
bmp2abone morphogenetic protein 2a0.051
twist1atwist1a0.050
wu:fv91b12wu:fv91b120.050
sox2SRY-box containing gene 20.049
rxrbbretinoid x receptor, beta b0.049
col10a1collagen, type X, alpha 10.049
gdf6agrowth differentiation factor 6a0.048
dlx2adistal-less homeobox gene 2a0.046
hoxa11bhomeo box A11b0.045
msxcmuscle segment homeobox C0.045
hoxd10ahomeo box D10a0.044
hoxd12ahomeo box D12a0.043
si:ch211-173b8.2si:ch211-173b8.20.043
hoxa9bhomeo box A9b0.041
hoxd13ahomeo box D13a0.041
foxa3forkhead box A30.041
jag1bjagged 1b0.040
fgf4fibroblast growth factor 40.038
sec24dSEC24 family, member D (S. cerevisiae)0.037
pax9paired box gene 90.037
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.035
wnt5bwingless-type MMTV integration site family, member 5b0.034
spry2sprouty homolog 20.034
sall4sal-like 4 (Drosophila)0.034
hoxa10bhomeo box A10b0.034
ptch1patched 10.033
col1a1acollagen, type I, alpha 1a0.033
foxi1forkhead box I10.033
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.030
dlx5adistal-less homeobox gene 5a0.030
spns2spinster homolog 2 (Drosophila)0.029
loxl3blysyl oxidase-like 3b0.029
ctgfconnective tissue growth factor0.029
znf703zinc finger protein 7030.028
fn1fibronectin 10.028
sparcsecreted acidic cysteine rich glycoprotein0.028
tcf12transcription factor 120.027
fgfr2fibroblast growth factor receptor 20.027
kitakit receptor a0.027
hsp47heat shock protein 470.027
ptch2patched 20.026
zic1zic family member 1 (odd-paired homolog, Drosophila)0.026
loxl2blysyl oxidase-like 2b0.026
twist2twist20.025
efnb1ephrin B10.025
shhbsonic hedgehog b0.025
ldb2aLIM-domain binding factor 2a0.024
bocbrother of CDO0.024
pcdh18aprotocadherin 18a0.023
dlx3bdistal-less homeobox gene 3b0.023
spon2aspondin 2a, extracellular matrix protein0.022
mab21l2mab-21-like 20.021
hoxa11ahomeo box A11a0.021
prrx1bpaired related homeobox 1b0.021
frem3Fras1 related extracellular matrix 30.021
barx1BarH-like homeobox 10.020
srfserum response factor0.020
rxraaretinoid X receptor, alpha a0.020
sh3gl1bSH3-domain GRB2-like 1b0.020
bmp4bone morphogenetic protein 40.020
hoxb5ahomeo box B5a0.020
sp7Sp7 transcription factor0.019
dkk1bdickkopf 1b0.019
admpanti-dorsalizing morphogenic protein0.019
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Gli2GLI-Kruppel family member GLI21.000
Fgfr2fibroblast growth factor receptor 21.000
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.999
Gli3GLI-Kruppel family member GLI30.999
Prrx1paired related homeobox 10.996
Sox9SRY-box containing gene 90.994
Prrx2paired related homeobox 20.993
Ror2receptor tyrosine kinase-like orphan receptor 20.983
Fgfr3fibroblast growth factor receptor 30.976
Bmp4bone morphogenetic protein 40.973
Bmp7bone morphogenetic protein 70.972
Isl1ISL1 transcription factor, LIM/homeodomain0.962
Smad3MAD homolog 3 (Drosophila)0.954
Hoxd11homeobox D110.950
Twist2twist homolog 2 (Drosophila)0.947
Fzd8frizzled homolog 8 (Drosophila)0.944
Tgfb2transforming growth factor, beta 20.943
Nognoggin0.942
Acvr1activin A receptor, type 10.940
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.939
Hoxa10homeobox A100.934
Smad6MAD homolog 6 (Drosophila)0.932
Pax6paired box gene 60.928
Rargretinoic acid receptor, gamma0.926
Hoxd13homeobox D130.925
Wnt5awingless-related MMTV integration site 5A0.916
En1engrailed 10.890
Tcfap2atranscription factor AP-2, alpha0.886
Gas1growth arrest specific 10.884
Ascl1achaete-scute complex homolog 1 (Drosophila)0.879
Fgf8fibroblast growth factor 80.878
Nodalnodal0.875
Gata4GATA binding protein 40.872
Fgf10fibroblast growth factor 100.859
Snai1snail homolog 1 (Drosophila)0.854
Hoxa13homeobox A130.851
Pthlhparathyroid hormone-like peptide0.850
Rspo2R-spondin 2 homolog (Xenopus laevis)0.840
Pax3paired box gene 30.825
Msx1homeobox, msh-like 10.823
Wnt3awingless-related MMTV integration site 3A0.818
Hand1heart and neural crest derivatives expressed transcript 10.794
Foxc1forkhead box C10.794
Pax2paired box gene 20.791
Neurod1neurogenic differentiation 10.783
Tbx15T-box 150.775
Tgfbr2transforming growth factor, beta receptor II0.768
Pbx1pre B-cell leukemia transcription factor 10.766
Hspg2perlecan (heparan sulfate proteoglycan 2)0.745
Bmpr1abone morphogenetic protein receptor, type 1A0.727
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.715
Pax8paired box gene 80.710
Fbn1fibrillin 10.708
Col5a1collagen, type V, alpha 10.706
Dlx5distal-less homeobox 50.697
Smad7MAD homolog 7 (Drosophila)0.685
Chrdchordin0.681
Smosmoothened homolog (Drosophila)0.673
Meox2mesenchyme homeobox 20.667
Eya1eyes absent 1 homolog (Drosophila)0.663
Gata6GATA binding protein 60.656
Fgf18fibroblast growth factor 180.650
Nr5a1nuclear receptor subfamily 5, group A, member 10.636
Lhx1LIM homeobox protein 10.617
Hoxa11homeobox A110.608
Runx2runt related transcription factor 20.591
Otx2orthodenticle homolog 2 (Drosophila)0.582
Tbx3T-box 30.569
Dkk1dickkopf homolog 1 (Xenopus laevis)0.550
Emx2empty spiracles homolog 2 (Drosophila)0.545
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.542
Twist1twist homolog 1 (Drosophila)0.542
Rarbretinoic acid receptor, beta0.541
Fgfr1fibroblast growth factor receptor 10.538
Mrc2mannose receptor, C type 20.535
Fzd1frizzled homolog 1 (Drosophila)0.524
Alx4aristaless-like homeobox 40.523
Pax9paired box gene 90.501
Hand2heart and neural crest derivatives expressed transcript 20.497
Sox11SRY-box containing gene 110.489
Col2a1collagen, type II, alpha 10.482
Alx3aristaless-like homeobox 30.476
Lmx1aLIM homeobox transcription factor 1 alpha0.470
Ptf1apancreas specific transcription factor, 1a0.462
Foxf1aforkhead box F1a0.461
Pitx1paired-like homeodomain transcription factor 10.451
Ntf3neurotrophin 30.450
Tbx2T-box 20.435
Apcadenomatosis polyposis coli0.427
Hoxa1homeobox A10.426
Retret proto-oncogene0.424
Tcf21transcription factor 210.422
Msx2homeobox, msh-like 20.405
Kiss1KiSS-1 metastasis-suppressor0.405
Rararetinoic acid receptor, alpha0.402
Col1a1collagen, type I, alpha 10.401
Fgf9fibroblast growth factor 90.394
Neurog3neurogenin 30.394
Fstfollistatin0.393
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism