The network for 'positive regulation of peptidyl tyrosine phosphorylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of peptidyl tyrosine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
BCAR1breast cancer anti-estrogen resistance 10.999
TRAF1TNF receptor-associated factor 10.998
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.996
PTPN1protein tyrosine phosphatase, non-receptor type 10.996
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.995
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.989
FGF1fibroblast growth factor 1 (acidic)0.987
FHL2four and a half LIM domains 20.984
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.972
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.967
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.965
FGFR2fibroblast growth factor receptor 20.964
FN1fibronectin 10.962
PTPRCprotein tyrosine phosphatase, receptor type, C0.960
PTK2PTK2 protein tyrosine kinase 20.953
TEKTEK tyrosine kinase, endothelial0.946
VEGFAvascular endothelial growth factor A0.942
SHC1SHC (Src homology 2 domain containing) transforming protein 10.933
SOCS3suppressor of cytokine signaling 30.933
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.929
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.928
PDIA3protein disulfide isomerase family A, member 30.911
CCR5chemokine (C-C motif) receptor 50.885
JAK2Janus kinase 20.876
PLCG1phospholipase C, gamma 10.874
METmet proto-oncogene (hepatocyte growth factor receptor)0.871
SPRR2Asmall proline-rich protein 2A0.827
SH2D1ASH2 domain containing 1A0.808
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.806
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.793
SH2D4ASH2 domain containing 4A0.761
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.759
IL6interleukin 6 (interferon, beta 2)0.716
VCAM1vascular cell adhesion molecule 10.704
BIRC3baculoviral IAP repeat containing 30.698
NRP1neuropilin 10.685
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.679
WIPF1WAS/WASL interacting protein family, member 10.679
CCL2chemokine (C-C motif) ligand 20.676
AXLAXL receptor tyrosine kinase0.669
MMP14matrix metallopeptidase 14 (membrane-inserted)0.667
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.664
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.658
THBS1thrombospondin 10.624
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.611
EPHA2EPH receptor A20.607
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.606
ICAM1intercellular adhesion molecule 10.603
FLNAfilamin A, alpha0.592
ADAM15ADAM metallopeptidase domain 150.548
GRB2growth factor receptor-bound protein 20.547
EPORerythropoietin receptor0.532
TNFtumor necrosis factor0.528
TAL1T-cell acute lymphocytic leukemia 10.528
TRAF5TNF receptor-associated factor 50.513
MPDZmultiple PDZ domain protein0.507
SYKspleen tyrosine kinase0.502
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.502
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.493
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.484
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.481
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.469
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.467
ESR1estrogen receptor 10.446
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.441
SOCS1suppressor of cytokine signaling 10.437
IL8interleukin 80.423
TNFRSF9tumor necrosis factor receptor superfamily, member 90.422
GDF9growth differentiation factor 90.420
CD247CD247 molecule0.414
IGF1Rinsulin-like growth factor 1 receptor0.410
LATlinker for activation of T cells0.403
ARRB1arrestin, beta 10.393
IL4Rinterleukin 4 receptor0.386
GH1growth hormone 10.384
FGAfibrinogen alpha chain0.380
CXCL9chemokine (C-X-C motif) ligand 90.373
MUC1mucin 1, cell surface associated0.371
PTPN6protein tyrosine phosphatase, non-receptor type 60.370
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.369
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.363
CCL4chemokine (C-C motif) ligand 40.363
TLN1talin 10.361
MTORmechanistic target of rapamycin (serine/threonine kinase)0.359
SOS1son of sevenless homolog 1 (Drosophila)0.337
TRAF3TNF receptor-associated factor 30.329
MAGEA11melanoma antigen family A, 110.329
CCL7chemokine (C-C motif) ligand 70.327
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.322
IL6Rinterleukin 6 receptor0.321
PRKCAprotein kinase C, alpha0.320
TRADDTNFRSF1A-associated via death domain0.320
CASP8caspase 8, apoptosis-related cysteine peptidase0.309
TBX5T-box 50.309
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.307
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.306
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cmybtranscription factor cmyb0.454
trpm7transient receptor potential cation channel, subfamily M, member 70.329
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.309
cdh6cadherin 60.296
nrp2aneuropilin 2a0.236
nrp2bneuropilin 2b0.232
itgb1aintegrin, beta 1a0.204
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.202
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.179
sox10SRY-box containing gene 100.174
hgfbhepatocyte growth factor b0.168
ltkleukocyte tyrosine kinase0.145
pax7bpaired box gene 7b0.137
LOC557072caspase recruitment domain-containing protein 11-like0.130
terttelomerase reverse transcriptase0.117
nod1nucleotide-binding oligomerization domain containing 10.112
sox7SRY-box containing gene 70.112
tal1T-cell acute lymphocytic leukemia 10.110
mesp2mesoderm posterior 2 homolog (mouse)0.104
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.103
ighz2immunoglobulin heavy constant zeta20.101
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.096
ptk6aPTK6 protein tyrosine kinase 6a0.093
tfectranscription factor EC0.091
ptk2.1protein tyrosine kinase 2a0.091
cdkn1acyclin-dependent kinase inhibitor 1A0.090
igf2binsulin-like growth factor 2b0.089
mnx1motor neuron and pancreas homeobox 10.089
LOC555739serine/threonine-protein kinase LMTK1-like0.089
mpxmyeloid-specific peroxidase0.088
wt1bwilms tumor 1b0.088
wnt3awingless-type MMTV integration site family, member 3A0.083
dccdeleted in colorectal carcinoma0.082
alkanaplastic lymphoma kinase (Ki-1)0.077
epha4aeph receptor A4a0.077
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.073
ccbe1collagen and calcium binding EGF domains 10.073
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.073
ntn2netrin 20.072
angptl2angiopoietin-like 20.071
mibmind bomb0.070
il6stinterleukin 6 signal transducer0.069
npy8brneuropeptide Y receptor Y8b0.067
prox1prospero-related homeobox gene 10.067
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.066
adora2badenosine A2b receptor0.065
pomt1protein-O-mannosyltransferase 10.064
spon1bspondin 1b0.064
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.063
card9caspase recruitment domain family, member 90.061
fbln4fibulin 40.059
wtipWilms tumor 1 interacting protein0.059
metmet proto-oncogene (hepatocyte growth factor receptor)0.057
rykreceptor-like tyrosine kinase0.057
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.057
il7rinterleukin 7 receptor0.056
plxna3plexin A30.056
adra2badrenergic, alpha-2B-, receptor0.055
itgb1bintegrin, beta 1b0.055
egr2bearly growth response 2b0.054
fn1fibronectin 10.054
dkk3ldickkopf homolog 3 like (Xenopus laevis)0.053
mapk6mitogen-activated protein kinase 60.053
LOC567405novel protein similar to vertebrate megakaryocyte-associated tyrosine kinase (MATK)0.053
olig1oligodendrocyte lineage transcription factor 10.053
abl1c-abl oncogene 1, non-receptor tyrosine kinase0.053
ror2receptor tyrosine kinase-like orphan receptor 20.052
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.052
st8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.051
lrp2low density lipoprotein-related protein 20.051
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.051
mitfamicrophthalmia-associated transcription factor a0.050
mfn2mitofusin 20.050
neurodneurogenic differentiation0.049
ahcyl2S-adenosylhomocysteine hydrolase-like 20.049
ddr2bdiscoidin domain receptor family, member 2b0.048
bnc2basonuclin 20.048
rtn4areticulon 4a0.048
dnm2dynamin 20.048
hoxb1ahomeo box B1a0.047
cdx4caudal type homeo box transcription factor 40.047
stat5.2signal transducer and activator of transcription 5.20.046
ikzf1IKAROS family zinc finger 1 (Ikaros)0.046
kbpkif1-binding protein0.046
smtnbsmoothelin b0.046
dyrk1bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.046
pomt2protein-O-mannosyltransferase 20.046
fesfeline sarcoma oncogene0.045
tpst1tyrosylprotein sulfotransferase 10.045
tgfb3transforming growth factor, beta 30.045
traf4atnf receptor-associated factor 4a0.044
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
HLHm7E(spl) region transcript m70.648
HLHmgammaE(spl) region transcript mgamma0.634
HLHmdeltaE(spl) region transcript mdelta0.502
E(spl)Enhancer of split0.407
HLHm3E(spl) region transcript m30.394
HLHmbetaE(spl) region transcript mbeta0.329
mbcmyoblast city0.243
HLHm5E(spl) region transcript m50.177
SaraSmad anchor for receptor activation0.168
par-1CG8201 gene product from transcript CG8201-RA0.135
malphaE(spl) region transcript malpha0.121
m2E(spl) region transcript m20.116
TomTwin of m40.115
NFATNFAT homolog0.115
reporeversed polarity0.103
Pk61CProtein kinase 61C0.102
zfh1Zn finger homeodomain 10.101
dec-1defective chorion 10.101
inaDinactivation no afterpotential D0.095
RASSF8CG5053 gene product from transcript CG5053-RA0.090
RalaRas-related protein0.088
DadDaughters against dpp0.087
Dhc64CDynein heavy chain 64C0.085
eyaeyes absent0.079
TBPHCG10327 gene product from transcript CG10327-RC0.069
GripGlutamate receptor binding protein0.064
fs(1)Yafemale sterile (1) Young arrest0.061
Tm1Tropomyosin 10.060
Src42ASrc oncogene at 42A0.055
aopanterior open0.051
slp1sloppy paired 10.050
rolsrolling pebbles0.050
l(2)k16918lethal (2) k169180.046
nocno ocelli0.046
mewmultiple edematous wings0.045
emsempty spiracles0.044
PvrPDGF- and VEGF-receptor related0.043
p120ctnAdherens junction protein p1200.043
numbCG3779 gene product from transcript CG3779-RB0.043
taptarget of Poxn0.042
wbwing blister0.042
Nrx-IVNeurexin IV0.042
LanB2Laminin B20.042
CG12424CG12424 gene product from transcript CG12424-RC0.042
Pvf1PDGF- and VEGF-related factor 10.041
LanALaminin A0.040
ninaBneither inactivation nor afterpotential B0.038
slboslow border cells0.037
fs(1)M3female sterile (1) M30.037
argosCG4531 gene product from transcript CG4531-RA0.037
bibbig brain0.036
Cnx99ACalnexin 99A0.036
HcfHost cell factor0.035
Adf1Adh transcription factor 10.035
weeCG4488 gene product from transcript CG4488-RA0.035
Akt1CG4006 gene product from transcript CG4006-RA0.035
Vrp1Verprolin 10.034
ari-2ariadne 20.034
betaInt-nubeta[nu] integrin0.034
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Il6stinterleukin 6 signal transducer0.995
Dab1disabled homolog 1 (Drosophila)0.989
Inpp5dinositol polyphosphate-5-phosphatase D0.984
Kitkit oncogene0.969
Emx2empty spiracles homolog 2 (Drosophila)0.942
Lyz2lysozyme 20.938
Esr1estrogen receptor 1 (alpha)0.930
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.919
Cd44CD44 antigen0.914
Stat3signal transducer and activator of transcription 30.904
Emx1empty spiracles homolog 1 (Drosophila)0.902
FynFyn proto-oncogene0.891
Plcg1phospholipase C, gamma 10.848
Nos2nitric oxide synthase 2, inducible0.827
Ctnnb1catenin (cadherin associated protein), beta 10.827
Apoeapolipoprotein E0.821
Lhx3LIM homeobox protein 30.817
Gata4GATA binding protein 40.798
Ptenphosphatase and tensin homolog0.796
Hes5hairy and enhancer of split 5 (Drosophila)0.782
Trp53transformation related protein 530.780
Pax2paired box gene 20.780
Fgf8fibroblast growth factor 80.777
Itgb1integrin beta 1 (fibronectin receptor beta)0.765
Cd28CD28 antigen0.741
Tnftumor necrosis factor0.735
Ptpn11protein tyrosine phosphatase, non-receptor type 110.729
Prf1perforin 1 (pore forming protein)0.722
SrcRous sarcoma oncogene0.703
Ephb2Eph receptor B20.698
Cd19CD19 antigen0.680
Drd2dopamine receptor D20.676
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.670
Otx2orthodenticle homolog 2 (Drosophila)0.668
Gli3GLI-Kruppel family member GLI30.650
Meox2mesenchyme homeobox 20.648
Flt4FMS-like tyrosine kinase 40.647
Pax8paired box gene 80.640
Cdkn1bcyclin-dependent kinase inhibitor 1B0.628
Slamf1signaling lymphocytic activation molecule family member 10.616
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.605
Grb2growth factor receptor bound protein 20.604
Ptk2PTK2 protein tyrosine kinase 20.602
Flt1FMS-like tyrosine kinase 10.575
Ikzf1IKAROS family zinc finger 10.572
Dvl2dishevelled 2, dsh homolog (Drosophila)0.570
CblCasitas B-lineage lymphoma0.564
Ccl2chemokine (C-C motif) ligand 20.556
Plxna1plexin A10.535
Adrb1adrenergic receptor, beta 10.520
Fgfr1fibroblast growth factor receptor 10.519
Mtormechanistic target of rapamycin (serine/threonine kinase)0.505
Latlinker for activation of T cells0.499
Il4interleukin 40.493
Cd40CD40 antigen0.482
Leprleptin receptor0.479
Dvl3dishevelled 3, dsh homolog (Drosophila)0.477
Rag1recombination activating gene 10.476
Ptprcprotein tyrosine phosphatase, receptor type, C0.458
Cdkn2acyclin-dependent kinase inhibitor 2A0.446
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.442
Lcklymphocyte protein tyrosine kinase0.416
Csf1colony stimulating factor 1 (macrophage)0.413
Efnb2ephrin B20.412
Foxf1aforkhead box F1a0.394
Pax3paired box gene 30.380
Tbx3T-box 30.375
S1pr2sphingosine-1-phosphate receptor 20.372
Adam17a disintegrin and metallopeptidase domain 170.367
Ins2insulin II0.364
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.360
Tal1T-cell acute lymphocytic leukemia 10.359
Hes1hairy and enhancer of split 1 (Drosophila)0.350
Sox10SRY-box containing gene 100.341
Smad3MAD homolog 3 (Drosophila)0.334
Wnt3awingless-related MMTV integration site 3A0.331
Pgrprogesterone receptor0.330
Ntf3neurotrophin 30.316
Ighimmunoglobulin heavy chain complex0.315
Rxraretinoid X receptor alpha0.314
Icosinducible T-cell co-stimulator0.298
Smad4MAD homolog 4 (Drosophila)0.296
Sox7SRY-box containing gene 70.289
Psen1presenilin 10.288
Smad6MAD homolog 6 (Drosophila)0.286
Ifnginterferon gamma0.283
Fgd1FYVE, RhoGEF and PH domain containing 10.282
Foxc2forkhead box C20.282
Mmp9matrix metallopeptidase 90.278
Pitx2paired-like homeodomain transcription factor 20.273
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.272
Hckhemopoietic cell kinase0.272
Il6interleukin 60.271
Chrm1cholinergic receptor, muscarinic 1, CNS0.267
Il1r1interleukin 1 receptor, type I0.260
Foxn1forkhead box N10.260
Acvrl1activin A receptor, type II-like 10.260
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ptafrplatelet-activating factor receptor0.012
Pld4phospholipase D family, member 40.011
Fgfr2fibroblast growth factor receptor 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism