The network for 'negative regulation of sequence specific dna binding transcription factor activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of sequence specific dna binding transcription factor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

NameDescriptionProbabilityFunc Analog Organism
CREBBPCREB binding protein1.000
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)1.000
SMAD3SMAD family member 31.000
IRAK2interleukin-1 receptor-associated kinase 20.999
TP53tumor protein p530.999
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.999
HDAC1histone deacetylase 10.999
MDM2Mdm2 p53 binding protein homolog (mouse)0.998
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.997
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.997
EP300E1A binding protein p3000.996
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.994
TRAF6TNF receptor-associated factor 60.992
IRAK1interleukin-1 receptor-associated kinase 10.989
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.986
RNF11ring finger protein 110.984
ESR1estrogen receptor 10.983
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.982
ZNF43zinc finger protein 430.972
HNF4Ahepatocyte nuclear factor 4, alpha0.971
SMURF2SMAD specific E3 ubiquitin protein ligase 20.970
SMAD1SMAD family member 10.962
RB1retinoblastoma 10.961
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.952
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.951
SP1Sp1 transcription factor0.941
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.938
COMMD1copper metabolism (Murr1) domain containing 10.921
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.913
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.910
ARandrogen receptor0.910
SIN3ASIN3 homolog A, transcription regulator (yeast)0.910
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.909
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.902
SMN1survival of motor neuron 1, telomeric0.898
UBCubiquitin C0.894
SMAD2SMAD family member 20.893
MYD88myeloid differentiation primary response gene (88)0.879
MAP3K5mitogen-activated protein kinase kinase kinase 50.878
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.858
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.841
NR0B2nuclear receptor subfamily 0, group B, member 20.815
ZNF273zinc finger protein 2730.815
DAXXdeath-domain associated protein0.805
TCEAL4transcription elongation factor A (SII)-like 40.801
IL1R1interleukin 1 receptor, type I0.791
POU5F1POU class 5 homeobox 10.784
SOCS1suppressor of cytokine signaling 10.762
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.757
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.740
ZNF253zinc finger protein 2530.737
NCOR1nuclear receptor corepressor 10.703
PMLpromyelocytic leukemia0.672
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.663
SMAD7SMAD family member 70.662
SMURF1SMAD specific E3 ubiquitin protein ligase 10.640
MAP3K3mitogen-activated protein kinase kinase kinase 30.635
IL1Binterleukin 1, beta0.631
KLF4Kruppel-like factor 4 (gut)0.626
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.613
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.606
JUNjun proto-oncogene0.601
CCR5chemokine (C-C motif) receptor 50.599
TNFAIP3tumor necrosis factor, alpha-induced protein 30.598
ZNF675zinc finger protein 6750.571
TCEAL1transcription elongation factor A (SII)-like 10.548
DTX3Ldeltex 3-like (Drosophila)0.541
TNIP2TNFAIP3 interacting protein 20.526
MAP3K8mitogen-activated protein kinase kinase kinase 80.523
HIPK2homeodomain interacting protein kinase 20.515
GSK3Bglycogen synthase kinase 3 beta0.502
NCOR2nuclear receptor corepressor 20.501
MDM4Mdm4 p53 binding protein homolog (mouse)0.494
NR4A2nuclear receptor subfamily 4, group A, member 20.492
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.470
TRAF1TNF receptor-associated factor 10.452
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.451
SETD8SET domain containing (lysine methyltransferase) 80.449
KLF6Kruppel-like factor 60.436
SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein)0.434
BTRCbeta-transducin repeat containing0.432
TRIM21tripartite motif containing 210.430
ING2inhibitor of growth family, member 20.429
JUNBjun B proto-oncogene0.426
RBBP4retinoblastoma binding protein 40.410
MTA1metastasis associated 10.401
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.400
PRKD2protein kinase D20.397
SKILSKI-like oncogene0.397
SP100SP100 nuclear antigen0.397
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.387
CCL4chemokine (C-C motif) ligand 40.385
RXRAretinoid X receptor, alpha0.383
TNFRSF9tumor necrosis factor receptor superfamily, member 90.380
MED15mediator complex subunit 150.373
S100A10S100 calcium binding protein A100.372
RNF31ring finger protein 310.370
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.369
RORARAR-related orphan receptor A0.366
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nod1nucleotide-binding oligomerization domain containing 10.707
gata6GATA-binding protein 60.677
mtpmicrosomal triglyceride transfer protein0.605
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.561
hhexhematopoietically expressed homeobox0.552
LOC557072caspase recruitment domain-containing protein 11-like0.526
evx1even-skipped homeobox 10.447
alcamaactivated leukocyte cell adhesion molecule a0.410
sox9bSRY-box containing gene 9b0.375
arl4abADP-ribosylation factor-like 4ab0.363
ripk2receptor-interacting serine-threonine kinase 20.320
card9caspase recruitment domain family, member 90.301
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.299
foxa3forkhead box A30.285
crip2cysteine-rich protein 20.266
igf1insulin-like growth factor 10.258
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.254
sox3SRY-box containing gene 30.252
nod2nucleotide-binding oligomerization domain containing 20.232
shhasonic hedgehog a0.228
igf2ainsulin-like growth factor 2a0.228
eporerythropoietin receptor0.223
prox1prospero-related homeobox gene 10.220
nkx2.2aNK2 transcription factor related 2a0.220
dtngdystrobrevin, gamma and dystrobrevin, gamma-like0.217
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.210
runx1runt-related transcription factor 10.204
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.194
dab1adisabled homolog 1a (Drosophila)0.193
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.179
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.179
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.178
tmem88atransmembrane protein 88 a0.176
mapk3mitogen-activated protein kinase 30.175
arandrogen receptor0.169
her6hairy-related 60.167
cpoxcoproporphyrinogen oxidase0.165
sox9aSRY-box containing gene 9a0.165
hnf1baHNF1 homeobox Ba0.165
card14caspase recruitment domain family, member 140.164
igf2binsulin-like growth factor 2b0.160
wnt2bbwingless-type MMTV integration site family, member 2Bb0.159
rtn1areticulon 1a0.157
tal1T-cell acute lymphocytic leukemia 10.156
nog1noggin 10.156
trpm7transient receptor potential cation channel, subfamily M, member 70.155
hist2h2lhistone 2, H2, like0.148
esr2bestrogen receptor 2b0.142
irx4airoquois homeobox protein 4a0.142
gfergrowth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)0.138
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.137
gata3GATA-binding protein 30.135
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.135
klf2aKruppel-like factor 2a0.134
foxo3bforkhead box O3b0.133
aldh1a2aldehyde dehydrogenase 1 family, member A20.127
uxs1UDP-glucuronic acid decarboxylase 10.126
edn1endothelin 10.123
zfand5azinc finger, AN1-type domain 5a0.122
tbx5bT-box 5b0.122
bmp4bone morphogenetic protein 40.121
gata2aGATA-binding protein 2a0.117
nr5a1bnuclear receptor subfamily 5, group A, member 1b0.116
eif2ak1eukaryotic translation initiation factor 2-alpha kinase 10.110
gsnagelsolin a0.110
hoxb2ahomeo box B2a0.108
wnt10awingless-type MMTV integration site family, member 10a0.108
klf4Kruppel-like factor 40.107
klf2bKruppel-like factor 2b0.106
atp6v0d1ATPase, H+ transporting, V0 subunit D isoform 10.104
ahcyS-adenosylhomocysteine hydrolase0.103
rargaretinoic acid receptor gamma a0.103
etv2ets variant gene 20.102
lndc1ly6/neurotoxin domain containing 10.102
chrna2acholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)0.101
hand2heart and neural crest derivatives expressed transcript 20.100
dhrs3adehydrogenase/reductase (SDR family) member 3a0.099
efnb2aephrin B2a0.098
sumo2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.098
tsc22d3TSC22 domain family, member 30.094
fgf8afibroblast growth factor 8 a0.091
rasl11bRAS-like, family 11, member B0.091
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.090
ftr82finTRIM family, member 820.089
barx1BarH-like homeobox 10.089
ankra2ankyrin repeat, family A (RFXANK-like), 20.089
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.089
bmp2bbone morphogenetic protein 2b0.088
ddcdopa decarboxylase0.087
st8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.086
egr2bearly growth response 2b0.086
thrbthyroid hormone receptor beta0.086
pbx2pre-B-cell leukemia transcription factor 20.085
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.153
Mes2CG11100 gene product from transcript CG11100-RB0.119
snssticks and stones0.093
Stat92ESignal-transducer and activator of transcription protein at 92E0.085
PvrPDGF- and VEGF-receptor related0.080
mxcmulti sex combs0.079
HLH54FCG5005 gene product from transcript CG5005-RA0.077
phlpole hole0.066
slmbsupernumerary limbs0.058
cindrCIN85 and CD2AP orthologue0.056
Top1Topoisomerase 10.050
Tab2TAK1-associated binding protein 20.049
nkdnaked cuticle0.047
Trxr-1Thioredoxin reductase-10.047
l(3)82FdCG32464 gene product from transcript CG32464-RR0.041
Ras85DRas oncogene at 85D0.040
Pka-C1cAMP-dependent protein kinase 10.038
HsfHeat shock factor0.038
Pros26.4Proteasome 26S subunit subunit 4 ATPase0.037
rolsrolling pebbles0.036
ash2absent, small, or homeotic discs 20.035
p38bCG7393 gene product from transcript CG7393-RA0.032
Rpn9CG10230 gene product from transcript CG10230-RB0.031
ewgerect wing0.031
Pros35Proteasome 35kD subunit0.030
pr-set7CG3307 gene product from transcript CG3307-RC0.030
SmoxSmad on X0.029
oddodd skipped0.029
gcmglial cells missing0.029
Su(z)2Suppressor of zeste 20.029
Rac1CG2248 gene product from transcript CG2248-RA0.028
Rpt3CG16916 gene product from transcript CG16916-RA0.028
Btk29ABtk family kinase at 29A0.027
Hnf4Hepatocyte nuclear factor 40.027
AblAbl tyrosine kinase0.027
CG1021CG1021 gene product from transcript CG1021-RE0.026
fasfaint sausage0.025
Pvf2PDGF- and VEGF-related factor 20.025
GLazGlial Lazarillo0.024
Rpt4CG3455 gene product from transcript CG3455-RA0.024
Pka-R2cAMP-dependent protein kinase R20.024
Lim3CG10699 gene product from transcript CG10699-RB0.024
SaraSmad anchor for receptor activation0.023
srpk79Dserine-arginine protein kinase at 79D0.023
bratbrain tumor0.023
C15CG7937 gene product from transcript CG7937-RA0.023
grimCG4345 gene product from transcript CG4345-RA0.023
Myo31DFMyosin 31DF0.023
EgfrEpidermal growth factor receptor0.023
mbcmyoblast city0.022
kibrakibra ortholog0.022
MrtfMyocardin-related transcription factor0.022
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.022
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.997
Pitx2paired-like homeodomain transcription factor 20.992
Hand2heart and neural crest derivatives expressed transcript 20.991
Neurod1neurogenic differentiation 10.986
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.984
Foxc1forkhead box C10.982
Shhsonic hedgehog0.982
Traf6TNF receptor-associated factor 60.963
Gata4GATA binding protein 40.951
Pax6paired box gene 60.948
Foxa2forkhead box A20.938
Isl1ISL1 transcription factor, LIM/homeodomain0.910
Otx2orthodenticle homolog 2 (Drosophila)0.896
Pax2paired box gene 20.896
Bmp4bone morphogenetic protein 40.894
Tgfb2transforming growth factor, beta 20.872
Tbx1T-box 10.851
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.835
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.826
Rargretinoic acid receptor, gamma0.824
Gli3GLI-Kruppel family member GLI30.804
Tcf3transcription factor 30.804
Smad6MAD homolog 6 (Drosophila)0.792
Tnfaip3tumor necrosis factor, alpha-induced protein 30.777
Ascl1achaete-scute complex homolog 1 (Drosophila)0.760
Pax3paired box gene 30.756
Arrb1arrestin, beta 10.747
Id3inhibitor of DNA binding 30.745
Insm1insulinoma-associated 10.733
Ighimmunoglobulin heavy chain complex0.732
Nr5a1nuclear receptor subfamily 5, group A, member 10.703
Gli2GLI-Kruppel family member GLI20.696
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.661
Msx1homeobox, msh-like 10.658
Sox2SRY-box containing gene 20.625
Fgf8fibroblast growth factor 80.618
Fgfr2fibroblast growth factor receptor 20.614
Sox9SRY-box containing gene 90.570
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.569
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.550
Lmx1bLIM homeobox transcription factor 1 beta0.546
Hand1heart and neural crest derivatives expressed transcript 10.536
Eya1eyes absent 1 homolog (Drosophila)0.524
Trp53transformation related protein 530.520
Gata6GATA binding protein 60.518
Dlx5distal-less homeobox 50.518
Kiss1KiSS-1 metastasis-suppressor0.516
Neurog2neurogenin 20.508
Gscgoosecoid homeobox0.486
Ncoa3nuclear receptor coactivator 30.483
Grb10growth factor receptor bound protein 100.481
Pbx1pre B-cell leukemia transcription factor 10.470
Mef2dmyocyte enhancer factor 2D0.464
Hdac1histone deacetylase 10.453
Runx2runt related transcription factor 20.443
Vegfavascular endothelial growth factor A0.431
Id1inhibitor of DNA binding 10.424
Lhx3LIM homeobox protein 30.398
Onecut1one cut domain, family member 10.393
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.391
Fgfr1fibroblast growth factor receptor 10.367
Lhx1LIM homeobox protein 10.356
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.355
Jag1jagged 10.354
Ghrgrowth hormone receptor0.351
Rb1retinoblastoma 10.350
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.348
Nkx2-1NK2 homeobox 10.341
Dab1disabled homolog 1 (Drosophila)0.336
Irs2insulin receptor substrate 20.331
Ptpn11protein tyrosine phosphatase, non-receptor type 110.326
Socs1suppressor of cytokine signaling 10.324
Pax8paired box gene 80.321
Insrinsulin receptor0.316
En1engrailed 10.309
Pitx1paired-like homeodomain transcription factor 10.297
Hoxd13homeobox D130.295
Msx2homeobox, msh-like 20.292
Fgf10fibroblast growth factor 100.284
Pdx1pancreatic and duodenal homeobox 10.275
Gbx2gastrulation brain homeobox 20.269
Zic3zinc finger protein of the cerebellum 30.267
Zeb1zinc finger E-box binding homeobox 10.265
Alx4aristaless-like homeobox 40.264
Foxh1forkhead box H10.263
SharpinSHANK-associated RH domain interacting protein0.259
Nkx3-2NK3 homeobox 20.257
Atoh1atonal homolog 1 (Drosophila)0.255
Rxraretinoid X receptor alpha0.253
Smad7MAD homolog 7 (Drosophila)0.247
Ror2receptor tyrosine kinase-like orphan receptor 20.242
Foxc2forkhead box C20.242
Mavsmitochondrial antiviral signaling protein0.241
Sin3atranscriptional regulator, SIN3A (yeast)0.239
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.236
Tnftumor necrosis factor0.235
Arid1aAT rich interactive domain 1A (SWI-like)0.233
Twist2twist homolog 2 (Drosophila)0.231
Egr2early growth response 20.228
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dusp1dual specificity phosphatase 10.424
Junbjun B proto-oncogene0.202
Zfp36zinc finger protein 360.179
Btg2BTG family, member 20.177
Nr4a1nuclear receptor subfamily 4, group A, member 10.175
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.134
FosFBJ osteosarcoma oncogene0.129
Id1inhibitor of DNA binding 10.094
JunJun oncogene0.074
Errfi1ERBB receptor feedback inhibitor 10.059
Ier2immediate early response 20.047
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.045
Egr1early growth response 10.037
Atf4activating transcription factor 4 (tax-responsive enhancer element B67)0.032
Cyb5r1cytochrome b5 reductase 10.026
Scarb1scavenger receptor class B, member 10.025
DbpD site of albumin promoter (albumin D-box) binding protein0.025
Sgk1serum/glucocorticoid regulated kinase 10.025
Csrnp1cysteine-serine-rich nuclear protein 10.023
Rararetinoic acid receptor, alpha0.022
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.021
Hand2heart and neural crest derivatives expressed 20.020
Klf2Kruppel-like factor 2 (lung)0.020
Hoxa1homeo box A10.019
Ier3immediate early response 30.019
Sorbs3sorbin and SH3 domain containing 30.019
Gpha2glycoprotein hormone alpha 20.019
Atf3activating transcription factor 30.019
Vegfavascular endothelial growth factor A0.019
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.018
Scnn1bsodium channel, nonvoltage-gated 1, beta0.018
Id3inhibitor of DNA binding 30.015
Ddr1discoidin domain receptor tyrosine kinase 10.015
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.014
Ddit4DNA-damage-inducible transcript 40.014
Map3k3mitogen activated protein kinase kinase kinase 30.012
Klf4Kruppel-like factor 4 (gut)0.012
Klf6Kruppel-like factor 60.012
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.012
Tcf3transcription factor 30.011
Ralgdsral guanine nucleotide dissociation stimulator0.011
Crip2cysteine-rich protein 20.011
Dusp6dual specificity phosphatase 60.011
Ccnl1cyclin L10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism