The network for 'negative regulation of megakaryocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of megakaryocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.

NameDescriptionProbabilityFunc Analog Organism
HIST1H3Dhistone cluster 1, H3d1.000
HIST1H2AEhistone cluster 1, H2ae1.000
HIST1H2BGhistone cluster 1, H2bg1.000
HIST1H2AMhistone cluster 1, H2am0.999
HIST1H2AJhistone cluster 1, H2aj0.999
HIST2H2BEhistone cluster 2, H2be0.998
HIST1H2AIhistone cluster 1, H2ai0.998
HIST1H4Bhistone cluster 1, H4b0.998
HIST1H1Chistone cluster 1, H1c0.997
HIST1H4Hhistone cluster 1, H4h0.997
HIST1H4Dhistone cluster 1, H4d0.996
HIST1H2ABhistone cluster 1, H2ab0.995
HIST1H2ALhistone cluster 1, H2al0.994
HIST1H3Ahistone cluster 1, H3a0.988
CXCL2chemokine (C-X-C motif) ligand 20.988
HIST1H2BJhistone cluster 1, H2bj0.980
HIST1H4Ahistone cluster 1, H4a0.967
HIST1H4Ehistone cluster 1, H4e0.965
HIST1H3Bhistone cluster 1, H3b0.929
HIST1H2BChistone cluster 1, H2bc0.911
HIST1H2BMhistone cluster 1, H2bm0.872
HIST1H4Jhistone cluster 1, H4j0.860
HIST2H2AChistone cluster 2, H2ac0.856
HIST1H2AKhistone cluster 1, H2ak0.817
HIST1H2BBhistone cluster 1, H2bb0.810
PSEN2presenilin 2 (Alzheimer disease 4)0.780
HIST1H2AGhistone cluster 1, H2ag0.778
HIST1H3Hhistone cluster 1, H3h0.746
HIST1H3Ghistone cluster 1, H3g0.742
HIST2H4Ahistone cluster 2, H4a0.631
HIST1H1Ehistone cluster 1, H1e0.559
HIST1H2BNhistone cluster 1, H2bn0.557
HIST2H2AA3histone cluster 2, H2aa30.530
HIST1H4Fhistone cluster 1, H4f0.517
SP3Sp3 transcription factor0.469
HIST1H2BOhistone cluster 1, H2bo0.458
HIST2H4Bhistone cluster 2, H4b0.433
IL8interleukin 80.432
TP53BP1tumor protein p53 binding protein 10.417
HIST1H4Ihistone cluster 1, H4i0.405
HIST1H2AChistone cluster 1, H2ac0.377
HIST1H4Lhistone cluster 1, H4l0.365
DPP4dipeptidyl-peptidase 40.343
HIST1H1Dhistone cluster 1, H1d0.326
CXCL5chemokine (C-X-C motif) ligand 50.301
HIST1H4Chistone cluster 1, H4c0.292
WASLWiskott-Aldrich syndrome-like0.279
CCL20chemokine (C-C motif) ligand 200.275
MDC1mediator of DNA-damage checkpoint 10.234
HIST1H2BIhistone cluster 1, H2bi0.229
HIST1H3Fhistone cluster 1, H3f0.166
CXCL3chemokine (C-X-C motif) ligand 30.150
CCL8chemokine (C-C motif) ligand 80.102
HIST2H2AA4histone cluster 2, H2aa40.096
HIST1H3Ihistone cluster 1, H3i0.092
HIST1H1Bhistone cluster 1, H1b0.085
HIST1H2AHhistone cluster 1, H2ah0.081
HIST1H2BDhistone cluster 1, H2bd0.080
IL6interleukin 6 (interferon, beta 2)0.078
HIST1H3Chistone cluster 1, H3c0.073
HIST1H2BFhistone cluster 1, H2bf0.072
HIST1H2BLhistone cluster 1, H2bl0.071
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.069
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.064
HIST1H3Ehistone cluster 1, H3e0.059
KDM4Alysine (K)-specific demethylase 4A0.054
PPBPpro-platelet basic protein (chemokine (C-X-C motif) ligand 7)0.051
HIST1H3Jhistone cluster 1, H3j0.046
HIST3H3histone cluster 3, H30.043
HIST3H2Ahistone cluster 3, H2a0.034
UBDubiquitin D0.033
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.031
PHF20PHD finger protein 200.030
EIF4A3eukaryotic translation initiation factor 4A30.029
HBA2hemoglobin, alpha 20.025
CXCL9chemokine (C-X-C motif) ligand 90.019
H3F3AH3 histone, family 3A0.018
RAD52RAD52 homolog (S. cerevisiae)0.016
HIST1H2BEhistone cluster 1, H2be0.015
HIST4H4histone cluster 4, H40.014
L3MBTL1l(3)mbt-like 1 (Drosophila)0.013
CXCL10chemokine (C-X-C motif) ligand 100.013
CTTNcortactin0.013
SPSB2splA/ryanodine receptor domain and SOCS box containing 20.013
SNX9sorting nexin 90.013
CXCL11chemokine (C-X-C motif) ligand 110.012
IL1Binterleukin 1, beta0.011
RAD51L1RAD51-like 1 (S. cerevisiae)0.011
BCL2A1BCL2-related protein A10.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism