The network for 'macrophage activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

macrophage activation

A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

NameDescriptionProbabilityFunc Analog Organism
MYD88myeloid differentiation primary response gene (88)0.282
NLRC4NLR family, CARD domain containing 40.212
TICAM2toll-like receptor adaptor molecule 20.124
UBASH3Bubiquitin associated and SH3 domain containing B0.073
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.051
LY96lymphocyte antigen 960.038
TNIP1TNFAIP3 interacting protein 10.037
DOCK7dedicator of cytokinesis 70.032
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.030
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.028
TNFAIP3tumor necrosis factor, alpha-induced protein 30.027
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.026
IL4interleukin 40.023
TLR1toll-like receptor 10.023
ZCCHC17zinc finger, CCHC domain containing 170.021
FOSFBJ murine osteosarcoma viral oncogene homolog0.019
MPOmyeloperoxidase0.019
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.018
FZD1frizzled homolog 1 (Drosophila)0.017
TLR2toll-like receptor 20.016
U2AF1U2 small nuclear RNA auxiliary factor 10.016
TLR4toll-like receptor 40.015
ELANEelastase, neutrophil expressed0.013
IRAK2interleukin-1 receptor-associated kinase 20.013
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.012
DUSP1dual specificity phosphatase 10.012
RIPK2receptor-interacting serine-threonine kinase 20.012
MYO9Bmyosin IXB0.012
SNCAIPsynuclein, alpha interacting protein0.012
BCL2L1BCL2-like 10.011
TGFB1transforming growth factor, beta 10.011
SH3KBP1SH3-domain kinase binding protein 10.011
AZU1azurocidin 10.010
CYR61cysteine-rich, angiogenic inducer, 610.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tlr4toll-like receptor 40.996
Ccr2chemokine (C-C motif) receptor 20.931
Cd44CD44 antigen0.850
FosFBJ osteosarcoma oncogene0.793
Il1r1interleukin 1 receptor, type I0.700
Stat3signal transducer and activator of transcription 30.675
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.631
Cd14CD14 antigen0.601
Ccl2chemokine (C-C motif) ligand 20.561
Stat6signal transducer and activator of transcription 60.490
Casp4caspase 4, apoptosis-related cysteine peptidase0.480
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.410
Myd88myeloid differentiation primary response gene 880.404
Lyz2lysozyme 20.376
Il1binterleukin 1 beta0.360
Klrk1killer cell lectin-like receptor subfamily K, member 10.338
Csf1colony stimulating factor 1 (macrophage)0.316
Ifnginterferon gamma0.299
Il1rl1interleukin 1 receptor-like 10.277
Ldb3LIM domain binding 30.212
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.204
Mmp9matrix metallopeptidase 90.181
Slc30a3solute carrier family 30 (zinc transporter), member 30.178
Ccr6chemokine (C-C motif) receptor 60.177
Apoeapolipoprotein E0.168
Cxcr2chemokine (C-X-C motif) receptor 20.159
Zfp36zinc finger protein 360.159
Prdm1PR domain containing 1, with ZNF domain0.144
Cd7CD7 antigen0.127
S1pr4sphingosine-1-phosphate receptor 40.125
Map3k8mitogen-activated protein kinase kinase kinase 80.109
Il13interleukin 130.106
FaslFas ligand (TNF superfamily, member 6)0.105
ItkIL2-inducible T-cell kinase0.099
FasFas (TNF receptor superfamily member 6)0.092
Selpselectin, platelet0.092
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.089
Dusp1dual specificity phosphatase 10.085
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.085
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.084
Icosinducible T-cell co-stimulator0.083
Mbmyoglobin0.079
Il4rainterleukin 4 receptor, alpha0.079
Egr1early growth response 10.079
C1qacomplement component 1, q subcomponent, alpha polypeptide0.077
Cd247CD247 antigen0.075
Csf1rcolony stimulating factor 1 receptor0.074
Gbp5guanylate binding protein 50.069
Itgamintegrin alpha M0.069
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.069
Atf3activating transcription factor 30.068
Adora3adenosine A3 receptor0.065
H2-Obhistocompatibility 2, O region beta locus0.064
Adam8a disintegrin and metallopeptidase domain 80.064
Btg2B-cell translocation gene 2, anti-proliferative0.062
Klrd1killer cell lectin-like receptor, subfamily D, member 10.062
Spp1secreted phosphoprotein 10.062
AF251705cDNA sequence AF2517050.062
MefvMediterranean fever0.061
Sftpdsurfactant associated protein D0.061
Ccl3chemokine (C-C motif) ligand 30.061
Hbb-b1hemoglobin, beta adult major chain0.060
Mapk8mitogen-activated protein kinase 80.059
Prnpprion protein0.059
Fpr-rs3formyl peptide receptor, related sequence 30.056
Klrg1killer cell lectin-like receptor subfamily G, member 10.054
Hspa9heat shock protein 90.053
Cxcr3chemokine (C-X-C motif) receptor 30.053
Mdm2transformed mouse 3T3 cell double minute 20.052
Muc13mucin 13, epithelial transmembrane0.051
PycardPYD and CARD domain containing0.051
Lair1leukocyte-associated Ig-like receptor 10.051
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.050
Cd22CD22 antigen0.050
Ticam1toll-like receptor adaptor molecule 10.049
Ier2immediate early response 20.049
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.049
Tfrctransferrin receptor0.049
Ccr4chemokine (C-C motif) receptor 40.049
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.048
Nr4a1nuclear receptor subfamily 4, group A, member 10.048
Exoc6exocyst complex component 60.048
C1qccomplement component 1, q subcomponent, C chain0.047
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.046
Efna1ephrin A10.046
Bdkrb1bradykinin receptor, beta 10.045
U46068cDNA sequence U460680.045
Il18interleukin 180.045
Il6interleukin 60.045
Actn2actinin alpha 20.044
Nlrp3NLR family, pyrin domain containing 30.043
Mapk1mitogen-activated protein kinase 10.043
C1qbcomplement component 1, q subcomponent, beta polypeptide0.043
SrcRous sarcoma oncogene0.043
C3ar1complement component 3a receptor 10.043
Soat2sterol O-acyltransferase 20.042
Fcer2aFc receptor, IgE, low affinity II, alpha polypeptide0.041
Seleselectin, endothelial cell0.041
C5ar1complement component 5a receptor 10.040
Irf4interferon regulatory factor 40.039
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tlr4toll-like receptor 40.051
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.036
Igsf6immunoglobulin superfamily, member 60.029
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.028
Casp1caspase 10.024
Adam17ADAM metallopeptidase domain 170.023
Ccl22chemokine (C-C motif) ligand 220.022
Arl11ADP-ribosylation factor-like 110.022
Eregepiregulin0.018
Cpceruloplasmin0.018
Junbjun B proto-oncogene0.017
Glipr1GLI pathogenesis-related 10.017
Slco2b1solute carrier organic anion transporter family, member 2b10.016
Serpinb7serpin peptidase inhibitor, clade B (ovalbumin), member 70.015
Edn1endothelin 10.014
Ptprcprotein tyrosine phosphatase, receptor type, C0.014
Cd38CD38 molecule0.014
Ctsccathepsin C0.013
Cnr2cannabinoid receptor 2 (macrophage)0.013
Nat1N-acetyltransferase 10.013
C3ar1complement component 3a receptor 10.013
Trpm8transient receptor potential cation channel, subfamily M, member 80.013
Ifi204interferon activated gene 2040.013
Cdk11bcyclin-dependent kinase 11B0.012
Fam38bfamily with sequence similarity 38, member B0.012
Rab32RAB32, member RAS oncogene family0.012
Itpr2inositol 1,4,5-triphosphate receptor, type 20.012
Bcl3B-cell CLL/lymphoma 30.012
Myl7myosin, light chain 7, regulatory0.011
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.011
Cd86CD86 molecule0.011
Klrc2killer cell lectin-like receptor subfamily C, member 20.011
Tas2r118taste receptor, type 2, member 1180.011
FosFBJ osteosarcoma oncogene0.011
Casp8caspase 80.010
Slasrc-like adaptor0.010
Hsph1heat shock 105/110 protein 10.010
Smad1SMAD family member 10.010
Capza3capping protein (actin filament) muscle Z-line, alpha 30.010
Zfp36zinc finger protein 360.010
Vom1r102vomeronasal 1 receptor 1020.010
Gcnt1glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)0.010
Chi3l1chitinase 3-like 10.010
Tas2r107taste receptor, type 2, member 1070.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism