The network for 'negative regulation of jun kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of jun kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.

NameDescriptionProbabilityFunc Analog Organism
MAPK8mitogen-activated protein kinase 81.000
ZNF43zinc finger protein 430.999
ZNF253zinc finger protein 2530.991
ZNF273zinc finger protein 2730.982
ZNF675zinc finger protein 6750.981
MAP2K4mitogen-activated protein kinase kinase 40.978
ARRB1arrestin, beta 10.945
MAP2K7mitogen-activated protein kinase kinase 70.895
JUNjun proto-oncogene0.872
ZNF430zinc finger protein 4300.830
ZNF680zinc finger protein 6800.802
ZNF254zinc finger protein 2540.767
ZNF91zinc finger protein 910.709
ZNF117zinc finger protein 1170.697
ZNF93zinc finger protein 930.649
ZNF708zinc finger protein 7080.636
WWOXWW domain containing oxidoreductase0.585
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.578
MAP3K1mitogen-activated protein kinase kinase kinase 10.497
ZNF85zinc finger protein 850.468
ATF2activating transcription factor 20.408
ZNF107zinc finger protein 1070.397
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.303
TOX4TOX high mobility group box family member 40.270
LIMD1LIM domains containing 10.248
ZNF92zinc finger protein 920.233
MAP3K7mitogen-activated protein kinase kinase kinase 70.232
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.213
ZNF682zinc finger protein 6820.182
AXIN1axin 10.180
ARRB2arrestin, beta 20.175
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.108
SGK3serum/glucocorticoid regulated kinase family, member 30.092
ATXN3ataxin 30.091
RECQL5RecQ protein-like 50.086
ATF3activating transcription factor 30.084
ZNF136zinc finger protein 1360.075
GSK3Bglycogen synthase kinase 3 beta0.075
APPamyloid beta (A4) precursor protein0.073
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.071
DTX1deltex homolog 1 (Drosophila)0.070
LIMK2LIM domain kinase 20.068
CMTM6CKLF-like MARVEL transmembrane domain containing 60.062
ZNF506zinc finger protein 5060.057
MAPK14mitogen-activated protein kinase 140.057
ZNF100zinc finger protein 1000.055
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.055
XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble0.054
ZNF493zinc finger protein 4930.054
MBD6methyl-CpG binding domain protein 60.053
MDFIMyoD family inhibitor0.051
ZNF138zinc finger protein 1380.049
CREB1cAMP responsive element binding protein 10.048
DOCK7dedicator of cytokinesis 70.047
ZNF567zinc finger protein 5670.047
NINninein (GSK3B interacting protein)0.047
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.046
ZNF12zinc finger protein 120.045
ANXA7annexin A70.045
C12orf41chromosome 12 open reading frame 410.045
GORASP1golgi reassembly stacking protein 1, 65kDa0.044
ILKintegrin-linked kinase0.044
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.043
CHORDC1cysteine and histidine-rich domain (CHORD) containing 10.043
YAP1Yes-associated protein 10.041
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.041
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.041
TRAF6TNF receptor-associated factor 60.039
HSPH1heat shock 105kDa/110kDa protein 10.038
SNCAsynuclein, alpha (non A4 component of amyloid precursor)0.038
LRP6low density lipoprotein receptor-related protein 60.038
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.037
MTMR4myotubularin related protein 40.037
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.036
ZNF665zinc finger protein 6650.035
TP63tumor protein p630.034
MAPK1mitogen-activated protein kinase 10.034
PINX1PIN2/TERF1 interacting, telomerase inhibitor 10.034
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.034
SIAH2seven in absentia homolog 2 (Drosophila)0.034
FOSFBJ murine osteosarcoma viral oncogene homolog0.034
MAPK9mitogen-activated protein kinase 90.033
DUSP4dual specificity phosphatase 40.033
BICD1bicaudal D homolog 1 (Drosophila)0.032
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.032
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.032
ZNF480zinc finger protein 4800.031
ZNF492zinc finger protein 4920.030
AICDAactivation-induced cytidine deaminase0.030
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.030
ZNF700zinc finger protein 7000.029
DEFA1defensin, alpha 10.029
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif, 100.028
HSPA1Bheat shock 70kDa protein 1B0.028
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.028
CBLCCas-Br-M (murine) ecotropic retroviral transforming sequence c0.028
ZBTB25zinc finger and BTB domain containing 250.027
XPO7exportin 70.027
DUSP1dual specificity phosphatase 10.027
FLNBfilamin B, beta0.026
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wnt4awingless-type MMTV integration site family, member 4a0.039
fgf3fibroblast growth factor 30.034
wnt3awingless-type MMTV integration site family, member 3A0.022
fzd7bfrizzled homolog 7b0.021
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.017
frem3Fras1 related extracellular matrix 30.016
ntn1bnetrin 1b0.015
efnb2aephrin B2a0.015
wnt1wingless-type MMTV integration site family, member 10.015
wnt8bwingless-type MMTV integration site family, member 8b0.013
mapk1mitogen-activated protein kinase 10.013
mapk4mitogen-activated protein kinase 40.013
mapk3mitogen-activated protein kinase 30.012
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.012
col7a1lcollagen type VII alpha 1-like0.012
bocbrother of CDO0.011
mapk12mitogen-activated protein kinase 120.010
hspa12bheat shock protein 12B0.010
sox2SRY-box containing gene 20.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 11.000
JunJun oncogene0.999
Apcadenomatosis polyposis coli0.998
Trp53transformation related protein 530.990
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.950
Sfrp2secreted frizzled-related protein 20.948
Ptenphosphatase and tensin homolog0.930
Mapk14mitogen-activated protein kinase 140.914
FosFBJ osteosarcoma oncogene0.857
Axin1axin 10.772
Mdm2transformed mouse 3T3 cell double minute 20.701
Trp63transformation related protein 630.698
Sfrp1secreted frizzled-related protein 10.664
Nr4a1nuclear receptor subfamily 4, group A, member 10.658
Mapk9mitogen-activated protein kinase 90.600
Klc1kinesin light chain 10.527
Mapk8mitogen-activated protein kinase 80.477
Emx1empty spiracles homolog 1 (Drosophila)0.451
Mapk1mitogen-activated protein kinase 10.397
Gsk3bglycogen synthase kinase 3 beta0.337
Smad3MAD homolog 3 (Drosophila)0.296
Lrp6low density lipoprotein receptor-related protein 60.230
Prkceprotein kinase C, epsilon0.230
Trp73transformation related protein 730.218
Psen1presenilin 10.192
Gsta4glutathione S-transferase, alpha 40.190
Vangl2vang-like 2 (van gogh, Drosophila)0.185
Rhobras homolog gene family, member B0.139
Tab1TGF-beta activated kinase 1/MAP3K7 binding protein 10.127
Hspa1bheat shock protein 1B0.112
Mdm4transformed mouse 3T3 cell double minute 40.112
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.106
Gm3776predicted gene 37760.093
Hspa8heat shock protein 80.091
Rac1RAS-related C3 botulinum substrate 10.086
Ccnd1cyclin D10.075
Rassf5Ras association (RalGDS/AF-6) domain family member 50.075
Hsph1heat shock 105kDa/110kDa protein 10.066
Klf6Kruppel-like factor 60.065
Appamyloid beta (A4) precursor protein0.060
Ier2immediate early response 20.056
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.054
Atf3activating transcription factor 30.051
Spag9sperm associated antigen 90.049
Dnajb4DnaJ (Hsp40) homolog, subfamily B, member 40.048
Kif1bkinesin family member 1B0.045
Ces1dcarboxylesterase 1D0.044
Ahsa2AHA1, activator of heat shock protein ATPase homolog 2 (yeast)0.043
Gstm1glutathione S-transferase, mu 10.041
Klf7Kruppel-like factor 7 (ubiquitous)0.041
Vhlvon Hippel-Lindau tumor suppressor0.039
Gli3GLI-Kruppel family member GLI30.038
Lef1lymphoid enhancer binding factor 10.032
Zfp36zinc finger protein 360.032
Homer1homer homolog 1 (Drosophila)0.031
Ikbkginhibitor of kappaB kinase gamma0.030
Mtmr1myotubularin related protein 10.028
Dnajc5DnaJ (Hsp40) homolog, subfamily C, member 50.028
Gli2GLI-Kruppel family member GLI20.027
Irf6interferon regulatory factor 60.025
Map3k12mitogen-activated protein kinase kinase kinase 120.025
Egr1early growth response 10.024
Wnt5awingless-related MMTV integration site 5A0.024
Errfi1ERBB receptor feedback inhibitor 10.024
Gsta3glutathione S-transferase, alpha 30.023
NsfN-ethylmaleimide sensitive fusion protein0.023
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.023
Bmpr1abone morphogenetic protein receptor, type 1A0.023
Smad7MAD homolog 7 (Drosophila)0.023
Klc2kinesin light chain 20.022
Klf4Kruppel-like factor 4 (gut)0.021
Runx1runt related transcription factor 10.021
Thbs1thrombospondin 10.021
Adh7alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide0.020
Aff1AF4/FMR2 family, member 10.020
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.020
Ptpn11protein tyrosine phosphatase, non-receptor type 110.019
Il6stinterleukin 6 signal transducer0.019
Atf2activating transcription factor 20.019
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.019
Usp25ubiquitin specific peptidase 250.018
Pbx1pre B-cell leukemia transcription factor 10.018
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.017
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.017
Csnk1ecasein kinase 1, epsilon0.017
Map2k4mitogen-activated protein kinase kinase 40.017
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.017
Hhathedgehog acyltransferase0.016
Mapk11mitogen-activated protein kinase 110.016
Efnb2ephrin B20.015
Numbnumb gene homolog (Drosophila)0.015
BrafBraf transforming gene0.015
Prdx6peroxiredoxin 60.015
Fscn1fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)0.015
Bhlhe40basic helix-loop-helix family, member e400.015
Lrrk2leucine-rich repeat kinase 20.014
Gstt1glutathione S-transferase, theta 10.014
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism