The network for 'negative regulation of cellular amino acid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular amino acid metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid.

NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.987
PTPN1protein tyrosine phosphatase, non-receptor type 10.948
BTKBruton agammaglobulinemia tyrosine kinase0.943
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.920
LCKlymphocyte-specific protein tyrosine kinase0.909
FYNFYN oncogene related to SRC, FGR, YES0.888
SMAD3SMAD family member 30.881
SIN3ASIN3 homolog A, transcription regulator (yeast)0.868
SH3KBP1SH3-domain kinase binding protein 10.792
VAV1vav 1 guanine nucleotide exchange factor0.783
ESR1estrogen receptor 10.736
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.708
CD44CD44 molecule (Indian blood group)0.706
EGFRepidermal growth factor receptor0.688
NCK1NCK adaptor protein 10.663
NCF1neutrophil cytosolic factor 10.642
GRB2growth factor receptor-bound protein 20.632
SMAD2SMAD family member 20.631
GHRgrowth hormone receptor0.616
DTNAdystrobrevin, alpha0.589
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.579
CAV1caveolin 1, caveolae protein, 22kDa0.569
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.527
SMURF2SMAD specific E3 ubiquitin protein ligase 20.493
SOCS1suppressor of cytokine signaling 10.491
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.490
BLNKB-cell linker0.486
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.477
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.471
PTPRCprotein tyrosine phosphatase, receptor type, C0.460
TBC1D10ATBC1 domain family, member 10A0.442
FEM1Bfem-1 homolog b (C. elegans)0.423
BAK1BCL2-antagonist/killer 10.397
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.387
SMAD1SMAD family member 10.383
SPTBN1spectrin, beta, non-erythrocytic 10.357
KLF4Kruppel-like factor 4 (gut)0.356
MAPK12mitogen-activated protein kinase 120.350
PRKCBprotein kinase C, beta0.348
VAC14Vac14 homolog (S. cerevisiae)0.342
CTBP1C-terminal binding protein 10.341
PRKCAprotein kinase C, alpha0.341
SCHIP1schwannomin interacting protein 10.338
SHC1SHC (Src homology 2 domain containing) transforming protein 10.335
SETD8SET domain containing (lysine methyltransferase) 80.334
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.318
KLF6Kruppel-like factor 60.313
HIPK2homeodomain interacting protein kinase 20.307
SH3BP2SH3-domain binding protein 20.302
SPRR2Asmall proline-rich protein 2A0.302
SPRY2sprouty homolog 2 (Drosophila)0.298
SMAD7SMAD family member 70.297
PTPN6protein tyrosine phosphatase, non-receptor type 60.295
ACTBactin, beta0.295
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.286
BADBCL2-associated agonist of cell death0.284
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.281
TP53BP2tumor protein p53 binding protein, 20.277
PROX1prospero homeobox 10.266
LRP6low density lipoprotein receptor-related protein 60.263
NCF4neutrophil cytosolic factor 4, 40kDa0.261
CREBBPCREB binding protein0.259
TNS4tensin 40.257
SOCS2suppressor of cytokine signaling 20.255
NOXA1NADPH oxidase activator 10.253
HDAC1histone deacetylase 10.252
BCL2L1BCL2-like 10.252
PTPN11protein tyrosine phosphatase, non-receptor type 110.250
TESK1testis-specific kinase 10.247
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.240
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.230
NTRK1neurotrophic tyrosine kinase, receptor, type 10.227
SKIv-ski sarcoma viral oncogene homolog (avian)0.225
PTENphosphatase and tensin homolog0.223
SH2D1ASH2 domain containing 1A0.217
NRIP1nuclear receptor interacting protein 10.214
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.213
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.212
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.211
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.205
TRAF4TNF receptor-associated factor 40.199
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.198
SLAMF1signaling lymphocytic activation molecule family member 10.195
CD28CD28 molecule0.191
TSC22D1TSC22 domain family, member 10.190
FLNBfilamin B, beta0.190
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.189
ACTN1actinin, alpha 10.187
TFF1trefoil factor 10.185
SCN5Asodium channel, voltage-gated, type V, alpha subunit0.179
SP1Sp1 transcription factor0.176
PTPN3protein tyrosine phosphatase, non-receptor type 30.175
F11RF11 receptor0.174
KAT2BK(lysine) acetyltransferase 2B0.173
MAPTmicrotubule-associated protein tau0.170
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.167
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
drkdownstream of receptor kinase0.012
trpmltransient receptor potential mucolipin0.010
EDTPEgg-derived tyrosine phosphatase0.010
Atg1Autophagy-specific gene 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptpn11protein tyrosine phosphatase, non-receptor type 110.999
Leprleptin receptor0.997
Ptenphosphatase and tensin homolog0.997
Trp53transformation related protein 530.994
FynFyn proto-oncogene0.993
Egfrepidermal growth factor receptor0.993
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.988
Slamf1signaling lymphocytic activation molecule family member 10.982
CblCasitas B-lineage lymphoma0.982
Grb2growth factor receptor bound protein 20.981
Smad3MAD homolog 3 (Drosophila)0.978
Neurod1neurogenic differentiation 10.975
Axin1axin 10.973
Bcl2B-cell leukemia/lymphoma 20.973
Apcadenomatosis polyposis coli0.971
Nos3nitric oxide synthase 3, endothelial cell0.956
Dusp1dual specificity phosphatase 10.948
Sfrp2secreted frizzled-related protein 20.932
Smad1MAD homolog 1 (Drosophila)0.928
Gab2growth factor receptor bound protein 2-associated protein 20.922
Gab1growth factor receptor bound protein 2-associated protein 10.910
Ascl1achaete-scute complex homolog 1 (Drosophila)0.907
Gsk3bglycogen synthase kinase 3 beta0.893
Eporerythropoietin receptor0.884
Shc1src homology 2 domain-containing transforming protein C10.879
Arrb2arrestin, beta 20.871
Gata1GATA binding protein 10.848
Spry4sprouty homolog 4 (Drosophila)0.847
Ldb3LIM domain binding 30.830
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.826
Neurod4neurogenic differentiation 40.811
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.786
TcrdT-cell receptor delta chain0.786
Sos1son of sevenless homolog 1 (Drosophila)0.785
TcrbT-cell receptor beta chain0.784
Cd28CD28 antigen0.781
Vhlvon Hippel-Lindau tumor suppressor0.781
Klf4Kruppel-like factor 4 (gut)0.771
Zeb1zinc finger E-box binding homeobox 10.765
Arrb1arrestin, beta 10.757
Stat3signal transducer and activator of transcription 30.746
Vaspvasodilator-stimulated phosphoprotein0.741
Egr1early growth response 10.738
JunJun oncogene0.736
Jak2Janus kinase 20.734
Ptpn12protein tyrosine phosphatase, non-receptor type 120.729
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.715
Ptk2PTK2 protein tyrosine kinase 20.711
Inpp5dinositol polyphosphate-5-phosphatase D0.701
Atmataxia telangiectasia mutated homolog (human)0.669
Dmddystrophin, muscular dystrophy0.657
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.652
Rhobras homolog gene family, member B0.630
FosFBJ osteosarcoma oncogene0.626
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.624
Ptf1apancreas specific transcription factor, 1a0.618
Socs2suppressor of cytokine signaling 20.610
Hand2heart and neural crest derivatives expressed transcript 20.610
Mdm2transformed mouse 3T3 cell double minute 20.603
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.592
Prkcbprotein kinase C, beta0.591
MecomMDS1 and EVI1 complex locus0.589
Vav1vav 1 oncogene0.587
Cishcytokine inducible SH2-containing protein0.572
Mapk8mitogen-activated protein kinase 80.572
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.571
Gpsm3G-protein signalling modulator 3 (AGS3-like, C. elegans)0.571
Sfrp1secreted frizzled-related protein 10.553
Insrinsulin receptor0.553
Cd19CD19 antigen0.551
Zfp36zinc finger protein 360.550
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.547
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.537
Ank1ankyrin 1, erythroid0.531
EvlEna-vasodilator stimulated phosphoprotein0.531
Sh3kbp1SH3-domain kinase binding protein 10.529
Plcg2phospholipase C, gamma 20.516
Slc4a1solute carrier family 4 (anion exchanger), member 10.512
En1engrailed 10.508
Ikzf1IKAROS family zinc finger 10.502
Ren1renin 1 structural0.501
BrafBraf transforming gene0.497
Otx2orthodenticle homolog 2 (Drosophila)0.495
Mdm4transformed mouse 3T3 cell double minute 40.493
Ikzf3IKAROS family zinc finger 30.491
Jak1Janus kinase 10.488
Tcf15transcription factor 150.486
Wt1Wilms tumor 1 homolog0.483
Drd2dopamine receptor D20.475
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.468
Icosinducible T-cell co-stimulator0.467
Neurog2neurogenin 20.466
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.463
Cacng2calcium channel, voltage-dependent, gamma subunit 20.463
Smad4MAD homolog 4 (Drosophila)0.460
Enahenabled homolog (Drosophila)0.446
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.446
Btg2B-cell translocation gene 2, anti-proliferative0.444
Klf2Kruppel-like factor 2 (lung)0.443
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Mx1myxovirus (influenza virus) resistance 10.025
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.021
Sgk1serum/glucocorticoid regulated kinase 10.019
Isg15ISG15 ubiquitin-like modifier0.018
RT1-S3RT1 class Ib, locus S30.017
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.016
Hckhemopoietic cell kinase0.016
Stat6signal transducer and activator of transcription 60.015
Rsad2radical S-adenosyl methionine domain containing 20.015
Ptpn6protein tyrosine phosphatase, non-receptor type 60.014
Clcn5chloride channel 50.014
Tgfbr2transforming growth factor, beta receptor II0.014
Tsc22d3TSC22 domain family, member 30.013
Bcl2B-cell CLL/lymphoma 20.013
Efnb1ephrin B10.013
Klf9Kruppel-like factor 90.013
Nek9NIMA (never in mitosis gene a)- related kinase 90.013
Gbp2guanylate binding protein 20.013
Usf2upstream transcription factor 2, c-fos interacting0.013
Nos3nitric oxide synthase 3, endothelial cell0.013
Ptch1patched homolog 1 (Drosophila)0.013
Rabac1Rab acceptor 1 (prenylated)0.013
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.012
Cxcr4chemokine (C-X-C motif) receptor 40.012
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.012
Gja5gap junction protein, alpha 50.012
Fn3kfructosamine 3 kinase0.012
Gna11guanine nucleotide binding protein, alpha 110.012
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.012
Slfn2schlafen 20.012
Adhfe1alcohol dehydrogenase, iron containing, 10.012
C3ar1complement component 3a receptor 10.012
Pink1PTEN induced putative kinase 10.012
Arrb1arrestin, beta 10.012
Oas1a2'-5' oligoadenylate synthetase 1A0.012
Purbpurine rich element binding protein B0.012
RGD1564865similar to 20-alpha-hydroxysteroid dehydrogenase0.012
Qarsglutaminyl-tRNA synthetase0.012
Dctn1dynactin 10.012
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.012
Fgfr4fibroblast growth factor receptor 40.011
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.011
Npr1natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)0.011
Myo10myosin X0.011
Aif1allograft inflammatory factor 10.011
Dusp1dual specificity phosphatase 10.011
Fgfr2fibroblast growth factor receptor 20.011
RestRE1-silencing transcription factor0.011
Il6rinterleukin 6 receptor0.011
Acacbacetyl-Coenzyme A carboxylase beta0.011
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.011
Nr1i2nuclear receptor subfamily 1, group I, member 20.011
Foxi2forkhead box I20.011
TapbpTAP binding protein0.011
Map3k8mitogen-activated protein kinase kinase kinase 80.011
Irs1insulin receptor substrate 10.011
St3gal3ST3 beta-galactoside alpha-2,3-sialyltransferase 30.011
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.011
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.011
Arnt2aryl hydrocarbon receptor nuclear translocator 20.011
Rps8ribosomal protein S80.011
Zfp36zinc finger protein 360.011
Rararetinoic acid receptor, alpha0.011
Zfc3h1zinc finger, C3H1-type containing0.011
Fabp1fatty acid binding protein 1, liver0.011
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.011
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.011
Apobapolipoprotein B0.011
Cldn2claudin 20.011
Foxa3forkhead box A30.011
Rin1Ras and Rab interactor 10.011
Csnk1g2casein kinase 1, gamma 20.011
FosFBJ osteosarcoma oncogene0.011
Tmprss2transmembrane protease, serine 20.011
Foxp1forkhead box P10.011
Mug1murinoglobulin 10.011
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.011
Smad7SMAD family member 70.011
Rab15RAB15, member RAS oncogene family0.011
Fnbp1formin binding protein 10.011
Vav1vav 1 guanine nucleotide exchange factor0.011
Tbxa2rthromboxane A2 receptor0.011
Ass1argininosuccinate synthetase 10.011
Ahraryl hydrocarbon receptor0.011
Creb1cAMP responsive element binding protein 10.011
Hnf4ahepatocyte nuclear factor 4, alpha0.011
Ss18l1synovial sarcoma translocation gene on chromosome 18-like 10.011
Bin2bridging integrator 20.011
Nrp2neuropilin 20.011
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.011
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.011
Litaflipopolysaccharide-induced TNF factor0.011
Ikzf1IKAROS family zinc finger 10.011
Pdk2pyruvate dehydrogenase kinase, isozyme 20.011
Map2k5mitogen activated protein kinase kinase 50.011
Vipr1vasoactive intestinal peptide receptor 10.011
Tcf21transcription factor 210.011
Galnt10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)0.011
Dbndd2dysbindin (dystrobrevin binding protein 1) domain containing 20.011
Ehfets homologous factor0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism