The network for 'midbrain development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

midbrain development

The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).

NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.999
ZNF43zinc finger protein 430.974
XIAPX-linked inhibitor of apoptosis0.893
CASP3caspase 3, apoptosis-related cysteine peptidase0.888
FGFR2fibroblast growth factor receptor 20.859
S100BS100 calcium binding protein B0.829
ZNF273zinc finger protein 2730.820
ZNF253zinc finger protein 2530.739
MDM2Mdm2 p53 binding protein homolog (mouse)0.719
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.680
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.659
S100A1S100 calcium binding protein A10.642
S100A6S100 calcium binding protein A60.583
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.576
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.551
FGFR1fibroblast growth factor receptor 10.496
ZNF675zinc finger protein 6750.494
FGF1fibroblast growth factor 1 (acidic)0.470
S100A16S100 calcium binding protein A160.442
ANXA2annexin A20.433
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.409
DTNAdystrobrevin, alpha0.375
CFL1cofilin 1 (non-muscle)0.345
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.325
HIST1H2BFhistone cluster 1, H2bf0.320
RHOAras homolog gene family, member A0.317
ZNF85zinc finger protein 850.305
S100A11S100 calcium binding protein A110.296
AKT1v-akt murine thymoma viral oncogene homolog 10.288
ZNF117zinc finger protein 1170.287
ZNF708zinc finger protein 7080.282
ZNF91zinc finger protein 910.244
HIST1H2BHhistone cluster 1, H2bh0.243
ZNF254zinc finger protein 2540.220
PKM2pyruvate kinase, muscle0.207
CAPNS1calpain, small subunit 10.206
ZNF93zinc finger protein 930.197
ZNF430zinc finger protein 4300.194
APAF1apoptotic peptidase activating factor 10.193
PFN1profilin 10.189
MDH1malate dehydrogenase 1, NAD (soluble)0.185
S100A4S100 calcium binding protein A40.185
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.181
ZNF680zinc finger protein 6800.175
MDFIMyoD family inhibitor0.159
FGF10fibroblast growth factor 100.146
MTORmechanistic target of rapamycin (serine/threonine kinase)0.146
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.141
CASP9caspase 9, apoptosis-related cysteine peptidase0.126
TRRAPtransformation/transcription domain-associated protein0.123
HUS1HUS1 checkpoint homolog (S. pombe)0.122
NDUFA3NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa0.120
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.116
SMAD5SMAD family member 50.114
LDHAlactate dehydrogenase A0.106
TAF4TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa0.105
PTPN6protein tyrosine phosphatase, non-receptor type 60.102
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.096
S100A8S100 calcium binding protein A80.093
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.093
ACTG1actin, gamma 10.093
TMSB4Xthymosin beta 4, X-linked0.092
FGF2fibroblast growth factor 2 (basic)0.083
FASFas (TNF receptor superfamily, member 6)0.083
NDRG1N-myc downstream regulated 10.080
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.079
VDAC3voltage-dependent anion channel 30.076
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.076
RIPK2receptor-interacting serine-threonine kinase 20.071
S100A9S100 calcium binding protein A90.071
RIPK3receptor-interacting serine-threonine kinase 30.071
ATP5OATP synthase, H+ transporting, mitochondrial F1 complex, O subunit0.070
ARHGAP1Rho GTPase activating protein 10.070
ATP5BATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.069
BCORBCL6 corepressor0.069
ANXA7annexin A70.067
RHOGras homolog gene family, member G (rho G)0.067
MYO10myosin X0.067
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.066
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.062
MYH11myosin, heavy chain 11, smooth muscle0.061
PILRApaired immunoglobin-like type 2 receptor alpha0.061
MSH3mutS homolog 3 (E. coli)0.060
TNFAIP1tumor necrosis factor, alpha-induced protein 1 (endothelial)0.060
ZNF682zinc finger protein 6820.057
FADDFas (TNFRSF6)-associated via death domain0.055
CFL2cofilin 2 (muscle)0.055
CRYABcrystallin, alpha B0.055
DKK1dickkopf homolog 1 (Xenopus laevis)0.054
ATP5LATP synthase, H+ transporting, mitochondrial Fo complex, subunit G0.054
ZNF136zinc finger protein 1360.053
S100PS100 calcium binding protein P0.052
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.051
NOTCH1notch 10.050
ZNF92zinc finger protein 920.050
BCL2B-cell CLL/lymphoma 20.047
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ascl1aachaete-scute complex-like 1a (Drosophila)0.982
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.817
eya1eyes absent homolog 10.773
fgf3fibroblast growth factor 30.718
gbx2gastrulation brain homeo box 20.718
eng1aengrailed 1a0.697
pax2apaired box gene 2a0.659
wnt8bwingless-type MMTV integration site family, member 8b0.658
gata3GATA-binding protein 30.650
gpiaglucose phosphate isomerase a0.643
pax8paired box gene 80.597
otx1borthodenticle homolog 1b0.568
dbx1adeveloping brain homeobox 1a0.564
lmx1b.1LIM homeobox transcription factor 1, beta 10.531
phox2apaired-like homeobox 2a0.527
bhlhe22basic helix-loop-helix family, member e220.519
nova2neuro-oncological ventral antigen 20.509
otpborthopedia homolog b0.476
fgf4fibroblast growth factor 40.463
notch3notch homolog 30.443
irx7iroquois homeobox protein 70.442
dmbx1adiencephalon/mesencephalon homeobox 1a0.414
vcanaversican a0.401
lmx1b.2LIM homeobox transcription factor 1, beta 20.386
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.383
scube2signal peptide, CUB domain, EGF-like 20.382
foxd3forkhead box D30.369
zic5zic family member 5 (odd-paired homolog, Drosophila)0.366
nkx2.2aNK2 transcription factor related 2a0.362
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.355
pea3ETS-domain transcription factor pea30.349
her5hairy-related 50.347
mab21l2mab-21-like 20.322
grhl2bgrainyhead-like 2b (Drosophila)0.322
olig2oligodendrocyte lineage transcription factor 20.316
zic4zic family member 40.313
gpr126G protein-coupled receptor 1260.296
axin2axin 2 (conductin, axil)0.291
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.270
fgf8bfibroblast growth factor 8 b0.267
zic1zic family member 1 (odd-paired homolog, Drosophila)0.262
eng2bengrailed 2b0.259
neurodneurogenic differentiation0.247
ptch2patched 20.246
spry4sprouty (Drosophila) homolog 40.242
sox2SRY-box containing gene 20.237
bmp2bbone morphogenetic protein 2b0.237
hoxb1bhomeo box B1b0.226
coblcordon-bleu homolog (mouse)0.225
il17rdinterleukin 17 receptor D0.224
nr2f1anuclear receptor subfamily 2, group F, member 1a0.202
tbx1T-box 10.199
meis2.1myeloid ecotropic viral integration site 2.10.196
wnt11wingless-type MMTV integration site family, member 110.195
sall1asal-like 1a (Drosophila)0.193
rx3retinal homeobox gene 30.192
tfap2atranscription factor AP-2 alpha0.190
epb41l5erythrocyte membrane protein band 4.1 like 50.188
phox2bpaired-like homeobox 2b0.185
eng2aengrailed 2a0.180
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.175
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.174
apcadenomatosis polyposis coli0.168
pax6bpaired box gene 6b0.156
hand2heart and neural crest derivatives expressed transcript 20.154
egr2bearly growth response 2b0.152
foxo3bforkhead box O3b0.149
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.149
lhx6LIM homeobox 60.148
pax2bpaired box gene 2b0.147
crabp2acellular retinoic acid binding protein 2, a0.146
sox3SRY-box containing gene 30.145
mapk3mitogen-activated protein kinase 30.139
otx5orthodenticle homolog 50.138
fgf10afibroblast growth factor 10a0.133
wlswntless homolog (Drosophila)0.131
ywhaqatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a0.126
hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.125
foxi1forkhead box I10.123
appaamyloid beta (A4) precursor protein a0.123
eng1bengrailed 1b0.120
rdh10aretinol dehydrogenase 10a0.118
oc90otoconin 900.117
tfap2btranscription factor AP-2 beta0.115
zfp36l1azinc finger protein 36, C3H type-like 1a0.115
cldnkclaudin k0.112
sp5lSp5 transcription factor-like0.109
hes6hairy and enhancer of split 6 (Drosophila)0.108
cdh6cadherin 60.107
mbpmyelin basic protein0.107
sox1aSRY-box containing gene 1a0.106
dusp6dual specificity phosphatase 60.106
nr2f2nuclear receptor subfamily 2, group F, member 20.105
irx1biroquois homeobox protein 1, b0.105
nadl1.1neural adhesion molecule L1.10.101
rx2retinal homeobox gene 20.096
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Otx2orthodenticle homolog 2 (Drosophila)1.000
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Pax2paired box gene 20.999
En1engrailed 10.984
Pax6paired box gene 60.980
Emx1empty spiracles homolog 1 (Drosophila)0.979
Pax3paired box gene 30.966
Fgfr1fibroblast growth factor receptor 10.966
Foxc1forkhead box C10.936
Emx2empty spiracles homolog 2 (Drosophila)0.919
Msx1homeobox, msh-like 10.905
Gbx2gastrulation brain homeobox 20.905
Fgfr2fibroblast growth factor receptor 20.900
Gli2GLI-Kruppel family member GLI20.886
Tbx3T-box 30.879
Lmx1aLIM homeobox transcription factor 1 alpha0.878
Appamyloid beta (A4) precursor protein0.874
Hoxa13homeobox A130.868
Hoxa11homeobox A110.857
Lhx5LIM homeobox protein 50.854
Nr5a1nuclear receptor subfamily 5, group A, member 10.848
Fgf8fibroblast growth factor 80.830
Lhx1LIM homeobox protein 10.824
Pitx2paired-like homeodomain transcription factor 20.812
Isl1ISL1 transcription factor, LIM/homeodomain0.803
Prrx2paired related homeobox 20.799
Hes1hairy and enhancer of split 1 (Drosophila)0.794
Ascl1achaete-scute complex homolog 1 (Drosophila)0.782
Msx2homeobox, msh-like 20.776
Dkk1dickkopf homolog 1 (Xenopus laevis)0.773
Foxg1forkhead box G10.746
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.737
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.736
Rargretinoic acid receptor, gamma0.721
Smad3MAD homolog 3 (Drosophila)0.712
Retret proto-oncogene0.692
Eya1eyes absent 1 homolog (Drosophila)0.673
Neurod1neurogenic differentiation 10.652
Ror2receptor tyrosine kinase-like orphan receptor 20.648
Efna2ephrin A20.632
Hoxa1homeobox A10.587
Smad6MAD homolog 6 (Drosophila)0.586
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.578
Lhx3LIM homeobox protein 30.570
Prnpprion protein0.565
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.560
Rac1RAS-related C3 botulinum substrate 10.530
Bmp4bone morphogenetic protein 40.528
Sox2SRY-box containing gene 20.525
Hoxd13homeobox D130.521
Phox2apaired-like homeobox 2a0.514
Hoxd11homeobox D110.505
Fgf10fibroblast growth factor 100.501
Phox2bpaired-like homeobox 2b0.496
Hand2heart and neural crest derivatives expressed transcript 20.493
Pitx1paired-like homeodomain transcription factor 10.488
Sox11SRY-box containing gene 110.481
Ctnnb1catenin (cadherin associated protein), beta 10.480
Tcfap2atranscription factor AP-2, alpha0.462
Fgfr3fibroblast growth factor receptor 30.448
Pbx1pre B-cell leukemia transcription factor 10.434
Tcf21transcription factor 210.428
Gdnfglial cell line derived neurotrophic factor0.425
Neurog2neurogenin 20.409
Dab1disabled homolog 1 (Drosophila)0.399
Pax8paired box gene 80.398
Lef1lymphoid enhancer binding factor 10.381
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.376
Snai1snail homolog 1 (Drosophila)0.366
Col2a1collagen, type II, alpha 10.362
Gscgoosecoid homeobox0.361
Pou3f3POU domain, class 3, transcription factor 30.360
Wnt1wingless-related MMTV integration site 10.358
Chd7chromodomain helicase DNA binding protein 70.356
Hoxa2homeobox A20.353
Dlx5distal-less homeobox 50.349
Smosmoothened homolog (Drosophila)0.344
Tbx15T-box 150.342
Gdf5growth differentiation factor 50.340
Sox9SRY-box containing gene 90.340
Bmpr1abone morphogenetic protein receptor, type 1A0.335
Vax1ventral anterior homeobox containing gene 10.325
Vangl2vang-like 2 (van gogh, Drosophila)0.323
Hes5hairy and enhancer of split 5 (Drosophila)0.315
Fzd7frizzled homolog 7 (Drosophila)0.315
Otx1orthodenticle homolog 1 (Drosophila)0.312
Hoxa10homeobox A100.311
Bdnfbrain derived neurotrophic factor0.295
Drd2dopamine receptor D20.288
Foxb1forkhead box B10.288
Gas1growth arrest specific 10.287
Tbx1T-box 10.282
Lrp2low density lipoprotein receptor-related protein 20.282
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.279
Foxc2forkhead box C20.276
Myod1myogenic differentiation 10.276
Insm1insulinoma-associated 10.271
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism