The network for 'dendritic spine organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dendritic spine organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.

NameDescriptionProbabilityFunc Analog Organism
ACTG1actin, gamma 10.375
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.234
ACTBactin, beta0.211
FHL2four and a half LIM domains 20.183
USPL1ubiquitin specific peptidase like 10.139
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.137
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.116
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.089
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.067
HPhaptoglobin0.063
WBP11WW domain binding protein 110.056
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.052
PELP1proline, glutamate and leucine rich protein 10.047
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.043
WASLWiskott-Aldrich syndrome-like0.037
APOC1apolipoprotein C-I0.036
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.036
CFL2cofilin 2 (muscle)0.036
SNX9sorting nexin 90.035
BCAR1breast cancer anti-estrogen resistance 10.035
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.034
RIN1Ras and Rab interactor 10.031
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.028
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.028
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.026
GRB7growth factor receptor-bound protein 70.026
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.026
ITGB4integrin, beta 40.025
PRKCGprotein kinase C, gamma0.024
UBA2ubiquitin-like modifier activating enzyme 20.024
APOC3apolipoprotein C-III0.024
ANAPC7anaphase promoting complex subunit 70.024
CYTH2cytohesin 20.024
SPRR2Asmall proline-rich protein 2A0.023
SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.023
SENP1SUMO1/sentrin specific peptidase 10.023
NEDD4neural precursor cell expressed, developmentally down-regulated 40.023
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.023
IQGAP1IQ motif containing GTPase activating protein 10.022
TEX10testis expressed 100.022
CABLES1Cdk5 and Abl enzyme substrate 10.022
LCATlecithin-cholesterol acyltransferase0.020
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.020
TMSB4Xthymosin beta 4, X-linked0.019
PRLHRprolactin releasing hormone receptor0.019
PACSIN2protein kinase C and casein kinase substrate in neurons 20.019
RANGAP1Ran GTPase activating protein 10.019
APOA2apolipoprotein A-II0.019
ANAPC4anaphase promoting complex subunit 40.018
LRP6low density lipoprotein receptor-related protein 60.018
BAI2brain-specific angiogenesis inhibitor 20.018
ACCN2amiloride-sensitive cation channel 2, neuronal0.018
ITSN1intersectin 1 (SH3 domain protein)0.018
DLGAP1discs, large (Drosophila) homolog-associated protein 10.018
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.017
ALAS1aminolevulinate, delta-, synthase 10.017
PIAS4protein inhibitor of activated STAT, 40.017
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.017
NTRK3neurotrophic tyrosine kinase, receptor, type 30.016
CDC37cell division cycle 37 homolog (S. cerevisiae)0.016
LRP5low density lipoprotein receptor-related protein 50.016
G3BP1GTPase activating protein (SH3 domain) binding protein 10.016
TNK2tyrosine kinase, non-receptor, 20.016
C4orf14chromosome 4 open reading frame 140.016
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.016
MAPKAPK3mitogen-activated protein kinase-activated protein kinase 30.016
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.015
PFDN1prefoldin subunit 10.015
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.015
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.014
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.014
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.014
APOEapolipoprotein E0.014
WIPF1WAS/WASL interacting protein family, member 10.014
ADRB2adrenergic, beta-2-, receptor, surface0.014
DLG2discs, large homolog 2 (Drosophila)0.014
ALBalbumin0.014
CAV2caveolin 20.013
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.013
MAP2K6mitogen-activated protein kinase kinase 60.013
PALLDpalladin, cytoskeletal associated protein0.013
PCBP1poly(rC) binding protein 10.013
BAIAP2BAI1-associated protein 20.013
FIBPfibroblast growth factor (acidic) intracellular binding protein0.013
CAV1caveolin 1, caveolae protein, 22kDa0.013
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.012
SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.012
ANAPC5anaphase promoting complex subunit 50.012
HSF2heat shock transcription factor 20.012
FHL3four and a half LIM domains 30.012
SNCAsynuclein, alpha (non A4 component of amyloid precursor)0.012
CDC16cell division cycle 16 homolog (S. cerevisiae)0.012
GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 10.012
UBE2Mubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)0.012
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.012
NLGN1neuroligin 10.012
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homolog0.012
MAP1Bmicrotubule-associated protein 1B0.012
RAB5BRAB5B, member RAS oncogene family0.012
PAK7p21 protein (Cdc42/Rac)-activated kinase 70.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ephb2Eph receptor B21.000
Efnb2ephrin B20.997
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.997
Dab1disabled homolog 1 (Drosophila)0.990
Dlg4discs, large homolog 4 (Drosophila)0.989
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.969
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.939
Epha4Eph receptor A40.908
Ctnnb1catenin (cadherin associated protein), beta 10.902
Wdr1WD repeat domain 10.848
Itgb1integrin beta 1 (fibronectin receptor beta)0.830
Dlgap1discs, large (Drosophila) homolog-associated protein 10.812
Arpc4actin related protein 2/3 complex, subunit 40.787
Dock1dedicator of cytokinesis 10.740
Itga3integrin alpha 30.713
Grip1glutamate receptor interacting protein 10.676
Armcx3armadillo repeat containing, X-linked 30.621
Ephb3Eph receptor B30.611
Hey2hairy/enhancer-of-split related with YRPW motif 20.550
Capzbcapping protein (actin filament) muscle Z-line, beta0.521
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.479
Cttncortactin0.458
Fgd1FYVE, RhoGEF and PH domain containing 10.441
SrcRous sarcoma oncogene0.439
Citcitron0.414
Dlg3discs, large homolog 3 (Drosophila)0.410
Mtap2microtubule-associated protein 20.383
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.352
Inainternexin neuronal intermediate filament protein, alpha0.351
BrafBraf transforming gene0.344
F11rF11 receptor0.333
Dlg1discs, large homolog 1 (Drosophila)0.291
Pfn1profilin 10.286
Nrcamneuron-glia-CAM-related cell adhesion molecule0.266
Dnm1dynamin 10.260
NsfN-ethylmaleimide sensitive fusion protein0.257
Nf1neurofibromatosis 10.244
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.239
Arcactivity regulated cytoskeletal-associated protein0.237
Tnks1bp1tankyrase 1 binding protein 10.220
Leprleptin receptor0.218
Fzd1frizzled homolog 1 (Drosophila)0.218
Adam17a disintegrin and metallopeptidase domain 170.216
Bmp1bone morphogenetic protein 10.210
Nck2non-catalytic region of tyrosine kinase adaptor protein 20.205
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.188
Psen1presenilin 10.184
Plcg1phospholipase C, gamma 10.182
Shank2SH3/ankyrin domain gene 20.178
Nos3nitric oxide synthase 3, endothelial cell0.176
Tceal1transcription elongation factor A (SII)-like 10.160
Grik5glutamate receptor, ionotropic, kainate 5 (gamma 2)0.156
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.154
Prkceprotein kinase C, epsilon0.151
Lrp8low density lipoprotein receptor-related protein 8, apolipoprotein e receptor0.150
Arhgef40Rho guanine nucleotide exchange factor (GEF) 400.149
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.149
Dlg2discs, large homolog 2 (Drosophila)0.145
Efnb1ephrin B10.143
Kalrnkalirin, RhoGEF kinase0.143
Itgb3integrin beta 30.143
Lama5laminin, alpha 50.137
Lrp5low density lipoprotein receptor-related protein 50.137
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.136
NynrinNYN domain and retroviral integrase containing0.131
Flt1FMS-like tyrosine kinase 10.130
Itgb2integrin beta 20.126
Shc1src homology 2 domain-containing transforming protein C10.126
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.122
Armcx1armadillo repeat containing, X-linked 10.120
Armcx2armadillo repeat containing, X-linked 20.118
RoraRAR-related orphan receptor alpha0.112
Retret proto-oncogene0.107
Actg1actin, gamma, cytoplasmic 10.106
Gata5GATA binding protein 50.105
Fgfr2fibroblast growth factor receptor 20.103
Epha7Eph receptor A70.095
Fam171a1family with sequence similarity 171, member A10.092
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.086
Hnrnpfheterogeneous nuclear ribonucleoprotein F0.086
Lcklymphocyte protein tyrosine kinase0.086
Myh10myosin, heavy polypeptide 10, non-muscle0.085
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.082
Hs1bp3HCLS1 binding protein 30.080
Relnreelin0.080
Bai1brain-specific angiogenesis inhibitor 10.080
Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)0.079
Dsg1adesmoglein 1 alpha0.078
BC018242cDNA sequence BC0182420.077
Vclvinculin0.077
Cdk5r2cyclin-dependent kinase 5, regulatory subunit 2 (p39)0.076
Edarectodysplasin-A receptor0.076
Kif3akinesin family member 3A0.075
Grm1glutamate receptor, metabotropic 10.075
Fzd7frizzled homolog 7 (Drosophila)0.075
Irs1insulin receptor substrate 10.073
Sox18SRY-box containing gene 180.072
Mdm2transformed mouse 3T3 cell double minute 20.069
Myo1fmyosin IF0.068
Pvrl1poliovirus receptor-related 10.067
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gria2glutamate receptor, ionotropic, AMPA 20.490
Gria1glutamate receptor, ionotropic, AMPA 10.456
Dlgap1discs, large (Drosophila) homolog-associated protein 10.360
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.260
Pfn1profilin 10.223
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.152
Sec23aSec23 homolog A (S. cerevisiae)0.147
Grip1glutamate receptor interacting protein 10.138
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.136
Nlgn2neuroligin 20.132
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.130
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.126
Cttncortactin0.106
Lin7blin-7 homolog b (C. elegans)0.088
Homer1homer homolog 1 (Drosophila)0.084
Cnksr2connector enhancer of kinase suppressor of Ras 20.081
Prkceprotein kinase C, epsilon0.074
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.064
Csrp3cysteine and glycine-rich protein 30.051
NsfN-ethylmaleimide-sensitive factor0.050
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.048
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.045
Wdr1WD repeat domain 10.042
Prkcaprotein kinase C, alpha0.040
Dlg2discs, large homolog 2 (Drosophila)0.039
Efhd2EF-hand domain family, member D20.039
Tspyl1TSPY-like 10.032
Efnb2ephrin B20.029
Sh3gl2SH3-domain GRB2-like 20.029
Baiap2BAI1-associated protein 20.028
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.028
Ate1arginyltransferase 10.027
Copb1coatomer protein complex, subunit beta 10.026
Map2microtubule-associated protein 20.026
Prelid1PRELI domain containing 10.026
Gosr1golgi SNAP receptor complex member 10.026
Dlg3discs, large homolog 3 (Drosophila)0.025
Gabra5gamma-aminobutyric acid (GABA) A receptor, alpha 50.025
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.025
Atp6v0cATPase, H+ transporting, lysosomal V0 subunit C0.024
Rab15RAB15, member RAS oncogene family0.024
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.023
Vamp2vesicle-associated membrane protein 20.022
Gria3glutamate receptor, ionotrophic, AMPA 30.021
Rab6aRAB6A, member RAS oncogene family0.021
Dlg4discs, large homolog 4 (Drosophila)0.021
Fkbp1aFK506 binding protein 1a0.020
Tagln2transgelin 20.020
Npdc1neural proliferation, differentiation and control, 10.020
Ryr2ryanodine receptor 2, cardiac0.020
Litaflipopolysaccharide-induced TNF factor0.020
Atf2activating transcription factor 20.020
Ippintracisternal A particle-promoted polypeptide0.019
Rabac1Rab acceptor 1 (prenylated)0.019
Sdk2sidekick homolog 2 (chicken)0.018
Apcadenomatous polyposis coli0.018
Rab4bRAB4B, member RAS oncogene family0.017
Serinc1serine incorporator 10.017
Mink1misshapen-like kinase 1 (zebrafish)0.017
Clcn2chloride channel 20.016
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.016
Pds5aPDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)0.016
Calrcalreticulin0.016
Fam45afamily with sequence similarity 45, member A0.015
Arcn1archain 10.015
Fkbp1bFK506 binding protein 1b0.015
Epha7Eph receptor A70.014
Adam10ADAM metallopeptidase domain 100.014
RGD1311122similar to RIKEN cDNA 1110003E010.014
Ntmneurotrimin0.013
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.013
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.013
Pafah1b2platelet-activating factor acetylhydrolase, isoform 1b, subunit 20.012
Mapk10mitogen activated protein kinase 100.012
Slc35b1solute carrier family 35, member B10.012
Top1topoisomerase (DNA) I0.012
Rdh2retinol dehydrogenase 20.012
Nlgn1neuroligin 10.012
RGD1311493similar to CG13379-PA0.012
Kctd3potassium channel tetramerisation domain containing 30.012
Eif2c2eukaryotic translation initiation factor 2C, 20.012
Ppp2r4protein phosphatase 2A activator, regulatory subunit 40.011
Gpr155G protein-coupled receptor 1550.011
Dctn4dynactin 40.011
Pou3f3POU class 3 homeobox 30.011
MaddMAP-kinase activating death domain0.011
Bsnbassoon0.011
Kcnn2potassium intermediate/small conductance calcium-activated channel, subfamily N, member 20.011
Prkcbprotein kinase C, beta0.011
PVRpoliovirus receptor0.011
Ehd4EH-domain containing 40.011
Lrch4leucine-rich repeats and calponin homology (CH) domain containing 40.011
Atp2b3ATPase, Ca++ transporting, plasma membrane 30.011
Shank2SH3 and multiple ankyrin repeat domains 20.011
Ntf4neurotrophin 40.011
Stx6syntaxin 60.011
Csnk1g3casein kinase 1, gamma 30.011
Ap1s1adaptor-related protein complex 1, sigma 1 subunit0.010
Lrfn2leucine rich repeat and fibronectin type III domain containing 20.010
Dgkidiacylglycerol kinase, iota0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism