The network for 'response to thyroid hormone' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to thyroid hormone

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.

NameDescriptionProbabilityFunc Analog Organism
TAL1T-cell acute lymphocytic leukemia 10.996
HNF4Ahepatocyte nuclear factor 4, alpha0.697
NPC2Niemann-Pick disease, type C20.635
LDB1LIM domain binding 10.393
ESRRGestrogen-related receptor gamma0.321
PRDX1peroxiredoxin 10.305
CTSBcathepsin B0.270
PPARGperoxisome proliferator-activated receptor gamma0.268
FTLferritin, light polypeptide0.229
CD63CD63 molecule0.215
HEXBhexosaminidase B (beta polypeptide)0.159
RGS2regulator of G-protein signaling 2, 24kDa0.150
CSTAcystatin A (stefin A)0.138
MED10mediator complex subunit 100.102
INCENPinner centromere protein antigens 135/155kDa0.094
COL1A1collagen, type I, alpha 10.085
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.082
COL3A1collagen, type III, alpha 10.076
GATA2GATA binding protein 20.075
STAT1signal transducer and activator of transcription 1, 91kDa0.071
TBX5T-box 50.061
KITLGKIT ligand0.060
IFI30interferon, gamma-inducible protein 300.052
CTSL1cathepsin L10.052
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.052
DYNLT1dynein, light chain, Tctex-type 10.052
NFE2L2nuclear factor (erythroid-derived 2)-like 20.050
MED29mediator complex subunit 290.046
ANXA2annexin A20.043
LAMP1lysosomal-associated membrane protein 10.042
HLA-Bmajor histocompatibility complex, class I, B0.041
GPNMBglycoprotein (transmembrane) nmb0.041
SEC24DSEC24 family, member D (S. cerevisiae)0.039
FTH1ferritin, heavy polypeptide 10.038
TIMP1TIMP metallopeptidase inhibitor 10.037
SAT1spermidine/spermine N1-acetyltransferase 10.037
TPP1tripeptidyl peptidase I0.035
S100A4S100 calcium binding protein A40.032
CDK19cyclin-dependent kinase 190.031
S100A10S100 calcium binding protein A100.031
AMBPalpha-1-microglobulin/bikunin precursor0.031
MED14mediator complex subunit 140.030
RUNX1runt-related transcription factor 10.030
AURKBaurora kinase B0.028
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.028
ZFPM1zinc finger protein, multitype 10.027
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.025
NFE2L1nuclear factor (erythroid-derived 2)-like 10.024
GSTO1glutathione S-transferase omega 10.023
CTSDcathepsin D0.023
CSTBcystatin B (stefin B)0.023
LDB2LIM domain binding 20.022
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.021
IFNGR1interferon gamma receptor 10.020
IL10RBinterleukin 10 receptor, beta0.020
TGS1trimethylguanosine synthase 10.020
CDK8cyclin-dependent kinase 80.018
NR0B2nuclear receptor subfamily 0, group B, member 20.018
ANXA5annexin A50.018
DAZAP2DAZ associated protein 20.018
CTSAcathepsin A0.018
RXRAretinoid X receptor, alpha0.018
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.018
LMO2LIM domain only 2 (rhombotin-like 1)0.018
MAPRE2microtubule-associated protein, RP/EB family, member 20.017
SDCBPsyndecan binding protein (syntenin)0.016
MED13mediator complex subunit 130.016
TCF21transcription factor 210.016
LOXlysyl oxidase0.016
GNSglucosamine (N-acetyl)-6-sulfatase0.015
LY96lymphocyte antigen 960.014
HLA-Cmajor histocompatibility complex, class I, C0.014
SOD2superoxide dismutase 2, mitochondrial0.014
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.014
SQRDLsulfide quinone reductase-like (yeast)0.013
SOCS1suppressor of cytokine signaling 10.012
CTSHcathepsin H0.012
DPP3dipeptidyl-peptidase 30.012
HLA-Amajor histocompatibility complex, class I, A0.012
LGALS3lectin, galactoside-binding, soluble, 30.011
CREG1cellular repressor of E1A-stimulated genes 10.011
S100A6S100 calcium binding protein A60.011
TGFBItransforming growth factor, beta-induced, 68kDa0.011
THRAthyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)0.011
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.011
TSC22D3TSC22 domain family, member 30.011
GATA4GATA binding protein 40.011
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.011
KLF13Kruppel-like factor 130.011
HMOX1heme oxygenase (decycling) 10.011
PRDX4peroxiredoxin 40.011
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.011
KIF20Akinesin family member 20A0.010
TMSB4Xthymosin beta 4, X-linked0.010
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
TyrobpTYRO protein tyrosine kinase binding protein0.879
Nos3nitric oxide synthase 3, endothelial cell0.877
Vegfavascular endothelial growth factor A0.609
Kdrkinase insert domain protein receptor0.571
Col1a1collagen, type I, alpha 10.484
Tgfb2transforming growth factor, beta 20.370
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.231
Leprleptin receptor0.200
Fgfr2fibroblast growth factor receptor 20.199
Foxc2forkhead box C20.198
Meox2mesenchyme homeobox 20.196
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.171
Ptenphosphatase and tensin homolog0.167
Tal1T-cell acute lymphocytic leukemia 10.155
Kitlkit ligand0.153
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.150
Vegfcvascular endothelial growth factor C0.143
C1qccomplement component 1, q subcomponent, C chain0.136
C1qbcomplement component 1, q subcomponent, beta polypeptide0.129
Cdh5cadherin 50.121
C1qacomplement component 1, q subcomponent, alpha polypeptide0.115
Ly86lymphocyte antigen 860.105
Ptpn11protein tyrosine phosphatase, non-receptor type 110.101
Ednrbendothelin receptor type B0.100
Ctnnb1catenin (cadherin associated protein), beta 10.093
Runx2runt related transcription factor 20.091
Plcg1phospholipase C, gamma 10.086
Csf1colony stimulating factor 1 (macrophage)0.083
Ren1renin 1 structural0.080
Hand1heart and neural crest derivatives expressed transcript 10.072
Tekendothelial-specific receptor tyrosine kinase0.066
Ptprbprotein tyrosine phosphatase, receptor type, B0.065
Tgfbr2transforming growth factor, beta receptor II0.061
Prrx1paired related homeobox 10.061
Col3a1collagen, type III, alpha 10.059
Flt4FMS-like tyrosine kinase 40.056
Mmp2matrix metallopeptidase 20.056
Bmp2bone morphogenetic protein 20.056
Mitfmicrophthalmia-associated transcription factor0.055
Agtr1aangiotensin II receptor, type 1a0.055
Ptch1patched homolog 10.055
Fgfr3fibroblast growth factor receptor 30.055
Cxcl12chemokine (C-X-C motif) ligand 120.053
Itgb1integrin beta 1 (fibronectin receptor beta)0.052
Ldlrlow density lipoprotein receptor0.050
Agtr2angiotensin II receptor, type 20.048
Ppargperoxisome proliferator activated receptor gamma0.047
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.047
Lyz1lysozyme 10.046
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.046
Fcgr2bFc receptor, IgG, low affinity IIb0.046
Mrc1mannose receptor, C type 10.045
Dab2disabled homolog 2 (Drosophila)0.044
Zeb1zinc finger E-box binding homeobox 10.044
Sox9SRY-box containing gene 90.044
Ctslcathepsin L0.043
Lamp2lysosomal-associated membrane protein 20.043
Gja1gap junction protein, alpha 10.041
Bmp7bone morphogenetic protein 70.040
Foxc1forkhead box C10.040
Lrp1low density lipoprotein receptor-related protein 10.040
Ctsdcathepsin D0.039
Cav1caveolin 1, caveolae protein0.039
Lamp1lysosomal-associated membrane protein 10.038
Ms4a6bmembrane-spanning 4-domains, subfamily A, member 6B0.037
Ednraendothelin receptor type A0.037
Col5a2collagen, type V, alpha 20.036
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.036
Tmem204transmembrane protein 2040.036
Lyz2lysozyme 20.036
Msx1homeobox, msh-like 10.034
Alx1ALX homeobox 10.033
Tcfap2atranscription factor AP-2, alpha0.033
Col6a1collagen, type VI, alpha 10.033
Fbln1fibulin 10.032
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.032
Fzd4frizzled homolog 4 (Drosophila)0.032
CblCasitas B-lineage lymphoma0.032
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.032
Arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.031
Nid1nidogen 10.030
Ppargc1bperoxisome proliferative activated receptor, gamma, coactivator 1 beta0.030
Mpeg1macrophage expressed gene 10.030
Fcgr3Fc receptor, IgG, low affinity III0.029
Plvapplasmalemma vesicle associated protein0.029
Smosmoothened homolog (Drosophila)0.029
Gucy1b3guanylate cyclase 1, soluble, beta 30.028
Fgfr1fibroblast growth factor receptor 10.028
Cyp4v3cytochrome P450, family 4, subfamily v, polypeptide 30.027
Flt1FMS-like tyrosine kinase 10.027
Pax3paired box gene 30.027
Gata6GATA binding protein 60.026
Il18interleukin 180.026
Tgfb1transforming growth factor, beta 10.026
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col3a1collagen, type III, alpha 10.172
Col1a1collagen, type I, alpha 10.132
Col1a2collagen, type I, alpha 20.131
Col5a2collagen, type V, alpha 20.042
Postnperiostin, osteoblast specific factor0.035
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.020
C3complement component 30.019
Col5a1collagen, type V, alpha 10.018
C1rcomplement component 1, r subcomponent0.015
Fbn1fibrillin 10.014
Col12a1collagen, type XII, alpha 10.014
Pcolceprocollagen C-endopeptidase enhancer0.013
Oaz1ornithine decarboxylase antizyme 10.011
Loxlysyl oxidase0.011
Sdf4stromal cell derived factor 40.011
Fn1fibronectin 10.011
Fuca1fucosidase, alpha-L- 1, tissue0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism