The network for 'negative regulation of lipid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of lipid metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.

NameDescriptionProbabilityFunc Analog Organism
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)1.000
APOA1apolipoprotein A-I0.995
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.982
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.974
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.962
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.958
IL1R1interleukin 1 receptor, type I0.949
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.948
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.941
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.939
APOEapolipoprotein E0.853
VEGFAvascular endothelial growth factor A0.802
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.743
BMPR1Abone morphogenetic protein receptor, type IA0.742
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.718
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.714
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.650
NOXA1NADPH oxidase activator 10.644
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.620
BCL3B-cell CLL/lymphoma 30.614
MPDZmultiple PDZ domain protein0.593
IER3immediate early response 30.586
LDLRlow density lipoprotein receptor0.573
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.554
NCOR2nuclear receptor corepressor 20.544
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.527
HNF4Ahepatocyte nuclear factor 4, alpha0.516
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.513
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.494
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.433
ACACAacetyl-CoA carboxylase alpha0.411
APOC1apolipoprotein C-I0.402
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.382
ITGB1BP3integrin beta 1 binding protein 30.375
IL1RAPinterleukin 1 receptor accessory protein0.301
CDCP1CUB domain containing protein 10.278
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.269
APOC3apolipoprotein C-III0.257
ESR1estrogen receptor 10.246
AKT1v-akt murine thymoma viral oncogene homolog 10.239
RXRAretinoid X receptor, alpha0.231
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.220
PICK1protein interacting with PRKCA 10.219
MAP3K5mitogen-activated protein kinase kinase kinase 50.217
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.203
NCF1neutrophil cytosolic factor 10.191
CREB1cAMP responsive element binding protein 10.180
HRhairless homolog (mouse)0.179
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.172
APOC2apolipoprotein C-II0.162
CREBBPCREB binding protein0.161
PGFplacental growth factor0.161
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 10.159
APOA2apolipoprotein A-II0.154
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.151
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.149
RARAretinoic acid receptor, alpha0.146
KLBklotho beta0.143
JUBjub, ajuba homolog (Xenopus laevis)0.138
TRADDTNFRSF1A-associated via death domain0.135
PPP2R5Eprotein phosphatase 2, regulatory subunit B', epsilon isoform0.133
CCDC6coiled-coil domain containing 60.128
BCL2B-cell CLL/lymphoma 20.128
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.126
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.126
SESN2sestrin 20.124
ATF5activating transcription factor 50.115
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.099
APOBapolipoprotein B (including Ag(x) antigen)0.091
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)0.091
PPFIA1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 10.091
CSNK1A1casein kinase 1, alpha 10.090
FGAfibrinogen alpha chain0.089
IL1R2interleukin 1 receptor, type II0.088
IDI1isopentenyl-diphosphate delta isomerase 10.088
PTPRBprotein tyrosine phosphatase, receptor type, B0.083
IL1Binterleukin 1, beta0.078
COL2A1collagen, type II, alpha 10.074
MAP3K8mitogen-activated protein kinase kinase kinase 80.073
PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta0.072
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.072
EP300E1A binding protein p3000.071
ADORA2Aadenosine A2a receptor0.070
FGF18fibroblast growth factor 180.068
CHUKconserved helix-loop-helix ubiquitous kinase0.066
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 10.065
ARRDC3arrestin domain containing 30.065
LCATlecithin-cholesterol acyltransferase0.064
BAG3BCL2-associated athanogene 30.061
PDK1pyruvate dehydrogenase kinase, isozyme 10.061
TNIP2TNFAIP3 interacting protein 20.057
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.056
BMP4bone morphogenetic protein 40.056
WNT11wingless-type MMTV integration site family, member 110.056
NRP1neuropilin 10.055
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Drep-2DNA fragmentation factor-related protein 20.020
Mef2Myocyte enhancer factor 20.017
foxoforkhead box, sub-group O0.014
eveeven skipped0.011
InRInsulin-like receptor0.011
TpiTriose phosphate isomerase0.011
EgfrEpidermal growth factor receptor0.010
yip2yippee interacting protein 20.010
chicoCG5686 gene product from transcript CG5686-RB0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ppargperoxisome proliferator activated receptor gamma0.995
Cideccell death-inducing DFFA-like effector c0.987
Pnpla2patatin-like phospholipase domain containing 20.986
Leprleptin receptor0.840
Mup10major urinary protein 100.827
LOC100048884novel member of the major urinary protein (Mup) gene family0.764
Mup19major urinary protein 190.744
Ptenphosphatase and tensin homolog0.698
Sox9SRY-box containing gene 90.652
Nos3nitric oxide synthase 3, endothelial cell0.613
Trp53transformation related protein 530.611
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.542
Insrinsulin receptor0.535
Esr1estrogen receptor 1 (alpha)0.522
Fgfr1fibroblast growth factor receptor 10.490
Ghrgrowth hormone receptor0.486
Wnt3awingless-related MMTV integration site 3A0.419
Mup12major urinary protein 120.405
Ctnnb1catenin (cadherin associated protein), beta 10.400
Rxraretinoid X receptor alpha0.400
Bmp7bone morphogenetic protein 70.384
Cav1caveolin 1, caveolae protein0.379
Nr1h4nuclear receptor subfamily 1, group H, member 40.379
Atf4activating transcription factor 40.374
Il1ainterleukin 1 alpha0.372
Mup4major urinary protein 40.367
Plin1perilipin 10.358
Mup1major urinary protein 10.336
Tbx1T-box 10.333
Casrcalcium-sensing receptor0.331
Mup9major urinary protein 90.331
Mup14major urinary protein 140.319
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.317
Akr1c6aldo-keto reductase family 1, member C60.298
Abhd5abhydrolase domain containing 50.297
Acvr1activin A receptor, type 10.293
Lipelipase, hormone sensitive0.293
Mup7major urinary protein 70.274
Itih1inter-alpha trypsin inhibitor, heavy chain 10.268
Arandrogen receptor0.266
Mup8major urinary protein 80.259
Mup5major urinary protein 50.257
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.256
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.250
Shhsonic hedgehog0.247
Rararetinoic acid receptor, alpha0.245
Notch2Notch gene homolog 2 (Drosophila)0.239
LOC100048885major urinary protein LOC1000488850.233
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.232
Prlrprolactin receptor0.232
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.230
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.225
Lrp6low density lipoprotein receptor-related protein 60.224
Dlx6distal-less homeobox 60.223
Mup13major urinary protein 130.218
Serpina3cserine (or cysteine) peptidase inhibitor, clade A, member 3C0.218
Pou3f1POU domain, class 3, transcription factor 10.211
Mup17major urinary protein 170.210
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.199
Mup2major urinary protein 20.197
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.193
Adipor2adiponectin receptor 20.192
Bscl2Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)0.192
Uoxurate oxidase0.189
Mup15major urinary protein 150.188
Serpina1bserine (or cysteine) preptidase inhibitor, clade A, member 1B0.184
Adrb3adrenergic receptor, beta 30.182
Lhx1LIM homeobox protein 10.180
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.177
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.171
F13bcoagulation factor XIII, beta subunit0.169
Mup11major urinary protein 110.165
Irs2insulin receptor substrate 20.165
Ror2receptor tyrosine kinase-like orphan receptor 20.164
Dkk1dickkopf homolog 1 (Xenopus laevis)0.161
Mup3major urinary protein 30.157
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.153
Fgfr2fibroblast growth factor receptor 20.152
Tgfb1transforming growth factor, beta 10.148
Plin4perilipin 40.143
Kitkit oncogene0.141
Hbb-b1hemoglobin, beta adult major chain0.137
Porcnporcupine homolog (Drosophila)0.135
Egfrepidermal growth factor receptor0.129
Agpat21-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)0.126
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.125
Fgf8fibroblast growth factor 80.122
SrcRous sarcoma oncogene0.121
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.121
Serpina12serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 120.120
Epn1epsin 10.118
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.116
Inhbeinhibin beta E0.115
Rargretinoic acid receptor, gamma0.114
Lpin1lipin 10.110
Vamp2vesicle-associated membrane protein 20.109
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism