The network for 'regulation of translational initiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of translational initiation

Any process that modulates the frequency, rate or extent of translational initiation.

NameDescriptionProbabilityFunc Analog Organism
PABPC1poly(A) binding protein, cytoplasmic 11.000
EIF4G1eukaryotic translation initiation factor 4 gamma, 10.916
EIF4A1eukaryotic translation initiation factor 4A10.763
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.761
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.714
TNRC6Atrinucleotide repeat containing 6A0.626
EIF4G2eukaryotic translation initiation factor 4 gamma, 20.582
HNRNPA1heterogeneous nuclear ribonucleoprotein A10.528
EIF2C2eukaryotic translation initiation factor 2C, 20.391
MAPK14mitogen-activated protein kinase 140.343
YBX1Y box binding protein 10.314
HNRNPKheterogeneous nuclear ribonucleoprotein K0.232
CUL3cullin 30.206
EIF3Aeukaryotic translation initiation factor 3, subunit A0.181
EIF3Beukaryotic translation initiation factor 3, subunit B0.181
RPTORregulatory associated protein of MTOR, complex 10.176
EIF2C1eukaryotic translation initiation factor 2C, 10.176
EIF2C4eukaryotic translation initiation factor 2C, 40.172
RXRAretinoid X receptor, alpha0.160
EIF3Heukaryotic translation initiation factor 3, subunit H0.144
EIF3Deukaryotic translation initiation factor 3, subunit D0.135
EIF3Ieukaryotic translation initiation factor 3, subunit I0.121
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.120
MED25mediator complex subunit 250.116
EIF4Eeukaryotic translation initiation factor 4E0.111
EIF2S1eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa0.079
PAN3PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)0.079
HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)0.075
PCBP2poly(rC) binding protein 20.071
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.071
TNRC6Ctrinucleotide repeat containing 6C0.070
EIF2S2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa0.069
KLHL12kelch-like 12 (Drosophila)0.067
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.066
G3BP1GTPase activating protein (SH3 domain) binding protein 10.066
EIF2B5eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa0.063
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.063
COASYCoA synthase0.062
RICTORRPTOR independent companion of MTOR, complex 20.053
EIF4A2eukaryotic translation initiation factor 4A20.052
TOP1topoisomerase (DNA) I0.049
MAPK1mitogen-activated protein kinase 10.048
DAZ1deleted in azoospermia 10.047
SRPK2SRSF protein kinase 20.046
WNK4WNK lysine deficient protein kinase 40.046
DAPK1death-associated protein kinase 10.044
EIF2C3eukaryotic translation initiation factor 2C, 30.043
EIF3Ceukaryotic translation initiation factor 3, subunit C0.042
EIF3Feukaryotic translation initiation factor 3, subunit F0.041
MKNK1MAP kinase interacting serine/threonine kinase 10.041
STAU1staufen, RNA binding protein, homolog 1 (Drosophila)0.040
EIF3Geukaryotic translation initiation factor 3, subunit G0.040
SF1splicing factor 10.039
MAP3K7mitogen-activated protein kinase kinase kinase 70.038
EIF2B2eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa0.037
CSNK2A1casein kinase 2, alpha 1 polypeptide0.037
LNX1ligand of numb-protein X 10.035
PRMT1protein arginine methyltransferase 10.035
EIF4Beukaryotic translation initiation factor 4B0.035
EIF4EBP3eukaryotic translation initiation factor 4E binding protein 30.034
EIF4G3eukaryotic translation initiation factor 4 gamma, 30.034
MAPK3mitogen-activated protein kinase 30.033
ESF1ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)0.033
EIF4ENIF1eukaryotic translation initiation factor 4E nuclear import factor 10.033
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.032
SMC5structural maintenance of chromosomes 50.032
KLHL2kelch-like 2, Mayven (Drosophila)0.032
PCBP1poly(rC) binding protein 10.031
PRRC2Cproline-rich coiled-coil 2C0.030
FBXO33F-box protein 330.029
GSK3Bglycogen synthase kinase 3 beta0.028
USP46ubiquitin specific peptidase 460.028
EIF1AYeukaryotic translation initiation factor 1A, Y-linked0.027
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.027
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.027
DDAH2dimethylarginine dimethylaminohydrolase 20.024
C17orf85chromosome 17 open reading frame 850.023
PARNpoly(A)-specific ribonuclease (deadenylation nuclease)0.023
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.022
EEF2Keukaryotic elongation factor-2 kinase0.021
NFE2L2nuclear factor (erythroid-derived 2)-like 20.021
SYNCRIPsynaptotagmin binding, cytoplasmic RNA interacting protein0.020
GSPT1G1 to S phase transition 10.019
HNRNPMheterogeneous nuclear ribonucleoprotein M0.018
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.018
KHDRBS3KH domain containing, RNA binding, signal transduction associated 30.017
CYFIP2cytoplasmic FMR1 interacting protein 20.017
TARDBPTAR DNA binding protein0.017
IPO8importin 80.016
RXRBretinoid X receptor, beta0.016
DDX1DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.016
STAG2stromal antigen 20.015
RPS6KB1ribosomal protein S6 kinase, 70kDa, polypeptide 10.015
MTORmechanistic target of rapamycin (serine/threonine kinase)0.015
THOC2THO complex 20.015
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.014
MPP1membrane protein, palmitoylated 1, 55kDa0.014
CCAR1cell division cycle and apoptosis regulator 10.014
UPF3BUPF3 regulator of nonsense transcripts homolog B (yeast)0.014
HNRNPA0heterogeneous nuclear ribonucleoprotein A00.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
F59G1.4Protein F59G1.40.016
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hbae3hemoglobin alpha embryonic-30.911
ef1aelongation factor 1-alpha0.660
hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.634
alas2aminolevulinate, delta-, synthetase 20.583
eef2beukaryotic translation elongation factor 2b0.560
etf1eukaryotic translation termination factor 10.447
hbae1hemoglobin alpha embryonic-10.423
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.292
rpl4ribosomal protein L40.276
rplp0ribosomal protein, large, P00.233
zgc:112425zgc:1124250.221
eif4a1aeukaryotic translation initiation factor 4A, isoform 1A0.220
ola1Obg-like ATPase 10.211
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.207
si:ch211-254d18.3si:ch211-254d18.30.195
eif3s10eukaryotic translation initiation factor 3, subunit 10 (theta)0.166
sptbspectrin, beta, erythrocytic0.150
ssbSjogren syndrome antigen B (autoantigen La)0.145
etv5bets variant 5b0.142
chd7chromodomain helicase DNA binding protein 70.138
gspt1lG1 to S phase transition 1, like0.117
cpsf6cleavage and polyadenylation specific factor 60.116
rxrgaretinoid x receptor, gamma a0.116
rpl5bribosomal protein L5b0.114
slc4a1asolute carrier family 4, anion exchanger, member 1a0.113
ikzf1IKAROS family zinc finger 1 (Ikaros)0.104
karslysyl-tRNA synthetase0.103
syncriplsynaptotagmin binding, cytoplasmic RNA interacting protein, like0.102
mpxmyeloid-specific peroxidase0.100
mapkapk2amitogen-activated protein kinase-activated protein kinase 2a0.097
klfdKruppel-like factor d0.096
hsp90ab1heat shock protein 90, alpha (cytosolic), class B member 10.096
cct6achaperonin containing TCP1, subunit 6A (zeta 1)0.092
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.089
ppp2cbprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform0.088
pnrc2proline-rich nuclear receptor coactivator 20.086
khdrbs1bKH domain containing, RNA binding, signal transduction associated 1b0.083
usp10ubiquitin specific peptidase 100.083
brd2abromodomain-containing 2a0.082
rpl5aribosomal protein L5a0.082
hmga1ahigh mobility group AT-hook 1a0.081
znf330zinc finger protein 3300.080
eif4bbeukaryotic translation initiation factor 4Bb0.080
zbtb16azinc finger and BTB domain containing 16a0.078
ywhaqatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a0.076
zgc:109736zgc:1097360.076
polr2apolymerase (RNA) II (DNA directed) polypeptide A0.076
pfdn5prefoldin 50.071
rb1retinoblastoma 10.071
wu:fb17g07wu:fb17g070.071
ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.071
rbm4.3RNA binding motif protein 4.30.067
acvr2bactivin receptor IIb0.065
hnrnpa0lheterogeneous nuclear ribonucleoprotein A0, like0.064
wu:fi04f09wu:fi04f090.064
mycamyelocytomatosis oncogene a0.061
cdk8cyclin-dependent kinase 80.061
abcf1ATP-binding cassette, sub-family F (GCN20), member 10.061
npm1nucleophosmin 10.060
rarabretinoic acid receptor, alpha b0.058
rbbp9retinoblastoma binding protein 90.057
eef1geukaryotic translation elongation factor 1 gamma0.057
dnmt3DNA (cytosine-5-)-methyltransferase 30.056
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.056
eif2s2eukaryotic translation initiation factor 2, subunit 2 beta0.055
mphosph6M-phase phosphoprotein 60.055
hbbe2hemoglobin beta embryonic-20.054
eif3haeukaryotic translation initiation factor 3, subunit H, a0.054
gata1aGATA binding protein 1a0.054
nrp2bneuropilin 2b0.053
zgc:110460zgc:1104600.053
obfc2aaoligonucleotide/oligosaccharide-binding fold containing 2Aa0.053
ybx1Y box binding protein 10.053
gcn1l1GCN1 general control of amino-acid synthesis 1-like 1 (yeast)0.052
rpl3ribosomal protein L30.052
fgfrl1afibroblast growth factor receptor-like 1a0.050
raraaretinoic acid receptor, alpha a0.050
ube4bubiquitination factor E4B, UFD2 homolog (S. cerevisiae)0.050
npm4nucleophosmin/nucleoplasmin, 40.050
hdrhematopoietic death receptor0.049
hnrnpa1heterogeneous nuclear ribonucleoprotein A10.049
mychmyelocytomatosis oncogene homolog0.048
dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.048
ndnl2necdin-like 20.048
slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.048
aarsalanyl-tRNA synthetase0.048
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.047
abcf2ATP-binding cassette, sub-family F (GCN20), member 20.046
cd2bp2CD2 antigen (cytoplasmic tail) binding protein 20.045
cct7chaperonin containing TCP1, subunit 7 (eta)0.045
zgc:103688zgc:1036880.045
pax3apaired box gene 3a0.045
lsm12LSM12 homolog (S. cerevisiae)0.045
nt5c2l15'-nucleotidase, cytosolic II, like 10.044
ppp4caprotein phosphatase 4 (formerly X), catalytic subunit a0.044
st8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.043
rpn1ribophorin I0.043
eif3s6ipeukaryotic translation initiation factor 3, subunit 6 interacting protein0.042
top1ltopoisomerase (DNA) I, like0.042
si:ch211-59d15.5si:ch211-59d15.50.041
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Map3k14mitogen-activated protein kinase kinase kinase 140.987
Rargretinoic acid receptor, gamma0.945
Pax2paired box gene 20.889
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.814
Eif3aeukaryotic translation initiation factor 3, subunit A0.754
Ikzf1IKAROS family zinc finger 10.723
Ifnginterferon gamma0.711
Eif4g1eukaryotic translation initiation factor 4, gamma 10.618
Il7interleukin 70.591
Pax8paired box gene 80.550
Ltalymphotoxin A0.475
Il2interleukin 20.408
Ltblymphotoxin B0.355
Ece1endothelin converting enzyme 10.339
Rxraretinoid X receptor alpha0.298
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.289
Shhsonic hedgehog0.269
Rararetinoic acid receptor, alpha0.260
Eif2c2eukaryotic translation initiation factor 2C, 20.257
Ptpn11protein tyrosine phosphatase, non-receptor type 110.255
Cxcr5chemokine (C-X-C motif) receptor 50.250
Ptenphosphatase and tensin homolog0.249
Fgfr2fibroblast growth factor receptor 20.243
Slc4a1solute carrier family 4 (anion exchanger), member 10.239
Il4interleukin 40.210
Toxthymocyte selection-associated high mobility group box0.198
Eif4eeukaryotic translation initiation factor 4E0.158
Tnftumor necrosis factor0.157
Il10interleukin 100.152
Cxcl13chemokine (C-X-C motif) ligand 130.149
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.149
Eif3beukaryotic translation initiation factor 3, subunit B0.143
Pklrpyruvate kinase liver and red blood cell0.125
Eif4a1eukaryotic translation initiation factor 4A10.114
Pitx2paired-like homeodomain transcription factor 20.111
Nclnucleolin0.107
Ghrgrowth hormone receptor0.105
Sox4SRY-box containing gene 40.101
Fxr1fragile X mental retardation gene 1, autosomal homolog0.097
Exoc6exocyst complex component 60.096
Ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.096
Cd19CD19 antigen0.090
Bmp4bone morphogenetic protein 40.081
Fmr1fragile X mental retardation syndrome 1 homolog0.078
Spna1spectrin alpha 10.076
Csde1cold shock domain containing E1, RNA binding0.071
Eya1eyes absent 1 homolog (Drosophila)0.070
Emx2empty spiracles homolog 2 (Drosophila)0.069
Paip2bpoly(A) binding protein interacting protein 2B0.067
Pabpc1poly(A) binding protein, cytoplasmic 10.065
Gata5GATA binding protein 50.063
Tefthyrotroph embryonic factor0.063
Tcf3transcription factor 30.060
FasFas (TNF receptor superfamily member 6)0.059
Rarbretinoic acid receptor, beta0.056
Fgfrl1fibroblast growth factor receptor-like 10.055
Phf17PHD finger protein 170.055
TcraT-cell receptor alpha chain0.053
Lhx1LIM homeobox protein 10.053
Prdm16PR domain containing 160.051
Psmd3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.050
Hbb-b2hemoglobin, beta adult minor chain0.049
Il2rginterleukin 2 receptor, gamma chain0.049
Cd28CD28 antigen0.047
Wnt9bwingless-type MMTV integration site 9B0.046
Esr1estrogen receptor 1 (alpha)0.045
Mknk2MAP kinase-interacting serine/threonine kinase 20.044
Notch2Notch gene homolog 2 (Drosophila)0.043
Foxc1forkhead box C10.042
Cd247CD247 antigen0.042
Rspo2R-spondin 2 homolog (Xenopus laevis)0.042
Rxrbretinoid X receptor beta0.041
Spry2sprouty homolog 2 (Drosophila)0.036
Traf4TNF receptor associated factor 40.035
Mapk11mitogen-activated protein kinase 110.033
Cetn2centrin 20.032
FynFyn proto-oncogene0.032
Atg2aATG2 autophagy related 2 homolog A (S. cerevisiae)0.031
Trp63transformation related protein 630.031
ORF61open reading frame 610.031
Sox9SRY-box containing gene 90.031
Ppardperoxisome proliferator activator receptor delta0.031
Fgf8fibroblast growth factor 80.030
Eif2s3xeukaryotic translation initiation factor 2, subunit 3, structural gene X-linked0.029
Med25mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)0.029
Nr0b1nuclear receptor subfamily 0, group B, member 10.029
Rag1recombination activating gene 10.028
Eif2ak1eukaryotic translation initiation factor 2 alpha kinase 10.027
Slc25a25solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 250.027
Nr1i3nuclear receptor subfamily 1, group I, member 30.027
BmperBMP-binding endothelial regulator0.027
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.026
Otx2orthodenticle homolog 2 (Drosophila)0.026
Ighimmunoglobulin heavy chain complex0.025
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.025
Vegfavascular endothelial growth factor A0.025
Latlinker for activation of T cells0.025
Cd40CD40 antigen0.024
Ulk1Unc-51 like kinase 1 (C. elegans)0.024
Chd7chromodomain helicase DNA binding protein 70.024
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC100134871beta globin minor gene0.573
LOC689064beta-globin0.254
Hbb-b1hemoglobin, beta adult major chain0.124
Hba-a2hemoglobin alpha, adult chain 20.049
Alas2aminolevulinate, delta-, synthase 20.042
LOC287167globin, alpha0.035
Eif3deukaryotic translation initiation factor 3, subunit D0.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PUB1Pub1p0.568
SUI3Sui3p0.308
SUI2Sui2p0.289
STO1Sto1p0.172
GCD1Gcd1p0.144
RPG1Rpg1p0.130
DCP2Dcp2p0.100
GCD11Gcd11p0.089
DED1Ded1p0.076
CAF40Caf40p0.069
PSP2Psp2p0.066
DHH1Dhh1p0.063
GCD6Gcd6p0.055
NIP1Nip1p0.052
HCR1Hcr1p0.050
TIF4632Tif4632p0.044
RPB3Rpb3p0.043
CBP1Cbp1p0.040
TIF5Tif5p0.037
HMO1Hmo1p0.036
MPT5Mpt5p0.034
TIF35Tif35p0.033
FUN12Fun12p0.030
SKI3Ski3p0.027
IST1Ist1p0.027
PRT1Prt1p0.027
RPB11Rpb11p0.026
NUP82Nup82p0.026
GCD2Gcd2p0.026
ANB1Anb1p0.025
PUF4Puf4p0.025
KEM1Kem1p0.023
SRO9Sro9p0.023
HEM3Hem3p0.023
GCD7Gcd7p0.023
DSS1Dss1p0.021
TFG2Tfg2p0.021
YPL199Chypothetical protein0.021
DBP5Dbp5p0.021
LSM3Lsm3p0.021
UTP22Utp22p0.021
GFD1Gfd1p0.020
YLR162Whypothetical protein0.020
RPA135Rpa135p0.020
RIO2Rio2p0.019
SRD1Srd1p0.019
YLR264C-Ahypothetical protein0.018
RPP2BRpp2bp0.018
RPM2Rpm2p0.018
LSM4Lsm4p0.018
RPL13ARpl13ap0.018
LEU2Leu2p0.017
YER186Chypothetical protein0.017
NUP49Nup49p0.016
URA6Ura6p0.016
YOL038C-Ahypothetical protein0.016
SWM2Swm2p0.016
HXT3Hxt3p0.016
YKR041Whypothetical protein0.016
SUP35Sup35p0.015
UPS3Ups3p0.015
MER1Mer1p0.015
LSM2Lsm2p0.015
RPS22ARps22ap0.015
ARP10Arp10p0.015
SSP1Ssp1p0.015
URA3Ura3p0.015
RPS22BRps22bp0.015
ZPS1Zps1p0.015
FMT1Fmt1p0.014
IML1Iml1p0.014
SUI1Sui1p0.014
FKH1Fkh1p0.014
SPL2Spl2p0.014
MTC7Mtc7p0.014
YLR042Chypothetical protein0.014
YER039C-Ahypothetical protein0.014
TOM7Tom7p0.014
YPR157Whypothetical protein0.014
CUP1-1Cup1-1p0.014
PRS2Prs2p0.014
SFT1Sft1p0.013
CDD1Cdd1p0.013
ARG8Arg8p0.013
YIR035Chypothetical protein0.013
TCP1Tcp1p0.013
ICS2Ics2p0.013
YBR013Chypothetical protein0.013
YAR068Whypothetical protein0.013
DPB2Dpb2p0.013
GLN1Gln1p0.013
ATP6Atp6p0.013
DEF1Def1p0.013
UBP1Ubp1p0.013
SCM4Scm4p0.013
HPF1Hpf1p0.013
BSC1Bsc1p0.012
MF(ALPHA)2Mf(alpha)2p0.012
AUA1Aua1p0.012
CPD1Cpd1p0.012