The network for 'cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell fate commitment

The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.

NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p531.000
CREBBPCREB binding protein0.993
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.991
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.963
SMAD2SMAD family member 20.956
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.943
FGFR2fibroblast growth factor receptor 20.922
TAL1T-cell acute lymphocytic leukemia 10.869
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.865
STK11serine/threonine kinase 110.835
SMAD4SMAD family member 40.833
GRB2growth factor receptor-bound protein 20.817
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.796
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.786
SFNstratifin0.737
NOTCH1notch 10.690
PRKCZprotein kinase C, zeta0.643
JAG1jagged 10.623
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.621
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.606
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.568
ARID1AAT rich interactive domain 1A (SWI-like)0.545
ARandrogen receptor0.531
SMAD1SMAD family member 10.507
PMLpromyelocytic leukemia0.506
SMAD7SMAD family member 70.502
SMAD3SMAD family member 30.482
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.475
HDAC1histone deacetylase 10.475
HDAC4histone deacetylase 40.443
MYOD1myogenic differentiation 10.386
FOXA2forkhead box A20.373
CDC25Acell division cycle 25 homolog A (S. pombe)0.372
RARAretinoic acid receptor, alpha0.372
NCOR1nuclear receptor corepressor 10.370
NR4A1nuclear receptor subfamily 4, group A, member 10.368
SP1Sp1 transcription factor0.358
CDK2cyclin-dependent kinase 20.352
POU3F2POU class 3 homeobox 20.348
RB1retinoblastoma 10.345
FGFR1fibroblast growth factor receptor 10.344
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.299
WDR5WD repeat domain 50.293
IL4Rinterleukin 4 receptor0.265
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.260
PBX1pre-B-cell leukemia homeobox 10.249
RBPMSRNA binding protein with multiple splicing0.243
RUNX1runt-related transcription factor 10.243
CDC25Bcell division cycle 25 homolog B (S. pombe)0.241
FGF1fibroblast growth factor 1 (acidic)0.239
FOXD3forkhead box D30.227
HTThuntingtin0.224
CDK1cyclin-dependent kinase 10.220
PBKPDZ binding kinase0.219
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.218
CCNB2cyclin B20.211
BMPR1Abone morphogenetic protein receptor, type IA0.204
ATXN1ataxin 10.199
CSNK1Ecasein kinase 1, epsilon0.195
DAXXdeath-domain associated protein0.185
RAXretina and anterior neural fold homeobox0.176
MDFIMyoD family inhibitor0.174
BTBD2BTB (POZ) domain containing 20.173
PAX3paired box 30.170
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.168
SMURF2SMAD specific E3 ubiquitin protein ligase 20.164
BBS10Bardet-Biedl syndrome 100.154
SOX2SRY (sex determining region Y)-box 20.154
MSX1msh homeobox 10.154
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.153
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.151
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.150
SMAD9SMAD family member 90.148
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.148
APCadenomatous polyposis coli0.147
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.145
CCT8chaperonin containing TCP1, subunit 8 (theta)0.142
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.142
SH3KBP1SH3-domain kinase binding protein 10.138
NUP62nucleoporin 62kDa0.137
PRKCIprotein kinase C, iota0.133
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.133
EGFRepidermal growth factor receptor0.132
EP300E1A binding protein p3000.132
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.130
GATA4GATA binding protein 40.126
CALM1calmodulin 1 (phosphorylase kinase, delta)0.125
RACGAP1Rac GTPase activating protein 10.122
BMP7bone morphogenetic protein 70.122
SHC1SHC (Src homology 2 domain containing) transforming protein 10.119
CCNA2cyclin A20.119
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.118
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.118
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.116
WNT3Awingless-type MMTV integration site family, member 3A0.115
SIRT1sirtuin 10.113
BRCA1breast cancer 1, early onset0.106
RFC3replication factor C (activator 1) 3, 38kDa0.106
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.104
TCF4transcription factor 40.104
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pha-4Protein PHA-41.000
egl-18Protein EGL-181.000
lag-1Protein LAG-10.999
pop-1Protein POP-10.997
hlh-2Protein HLH-20.996
cam-1Protein CAM-10.994
nhr-67Protein NHR-670.993
mab-5Protein MAB-50.992
elt-6Protein ELT-60.990
inx-3Protein INX-30.989
lin-12Protein LIN-120.986
hlh-1Protein HLH-10.986
unc-42Protein UNC-420.983
fkh-2Protein FKH-20.933
egl-46Protein EGL-460.931
atn-1Protein ATN-10.925
nhr-25Protein NHR-250.922
eya-1Protein EYA-10.920
let-60Protein LET-600.920
zip-7Protein ZIP-70.883
unc-73Protein UNC-730.871
egl-27Protein EGL-270.869
sdz-28Protein SDZ-280.862
sel-10Protein SEL-100.862
mom-2Protein MOM-20.859
egl-13Protein EGL-130.855
lsy-2Protein LSY-20.849
nhr-2Protein NHR-20.843
pry-1Protein PRY-10.837
mex-5Protein MEX-50.829
ten-1Protein TEN-10.821
F39B2.1Protein F39B2.10.814
cnd-1Protein CND-10.801
mls-2Protein MLS-20.800
cye-1Protein CYE-10.784
hbl-1Protein HBL-10.768
cki-1Protein CKI-10.733
daf-3Protein DAF-30.728
lin-36Protein LIN-360.720
unc-62Protein UNC-620.712
flh-1Protein FLH-10.695
psa-3Protein PSA-30.679
lin-17Protein LIN-170.662
rig-5Protein RIG-50.661
lin-11Protein LIN-110.661
ceh-20Protein CEH-200.641
hnd-1Protein HND-10.630
sel-8Protein SEL-80.610
CELE_F54D5.5Protein F54D5.50.608
efn-2Protein EFN-20.608
sem-5Protein SEM-50.591
dpy-22Protein DPY-220.581
trim-9Protein TRIM-90.563
mes-4Protein MES-40.563
tbx-8Protein TBX-80.557
pes-1Protein PES-10.556
ztf-2Protein ZTF-20.554
vab-3Protein VAB-30.546
lin-29Protein LIN-290.539
hcp-3Protein HCP-30.537
ain-1Protein AIN-10.527
odd-2Protein ODD-20.519
zyg-8Protein ZYG-80.517
pos-1Protein POS-10.499
egl-5Protein EGL-50.498
bar-1Protein BAR-10.498
cdc-25.1Protein CDC-25.10.496
sys-1Protein SYS-10.492
mig-5Protein MIG-50.489
mat-3Protein MAT-30.489
ceh-27Protein CEH-270.485
eor-1Protein EOR-10.484
mbk-2Protein MBK-20.484
sos-1Protein SOS-10.476
ceh-32Protein CEH-320.475
lin-15AProtein LIN-15A0.466
vab-1Protein VAB-10.431
syx-4Protein SYX-40.416
pal-1Protein PAL-10.409
sup-17Protein SUP-170.401
glp-1Protein GLP-10.396
dsh-2Protein DSH-20.395
hlh-3Protein HLH-30.394
tbx-33Protein TBX-330.392
F13C5.2Protein F13C5.20.390
ceh-16Protein CEH-160.363
sox-2Protein SOX-20.362
lex-1Protein LEX-10.358
T28F4.1Protein T28F4.10.351
sur-2Protein SUR-20.347
lin-40Protein LIN-400.345
K10C3.4Protein K10C3.40.343
zen-4Protein ZEN-40.339
lin-1Protein LIN-10.339
rnr-1Protein RNR-10.337
ceh-38Protein CEH-380.333
tbx-9Protein TBX-90.323
mig-38Protein MIG-380.312
gsp-2Protein GSP-20.308
eef-1A.1Protein EEF-1A.10.304
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin1.000
notch1anotch homolog 1a0.998
jag2jagged 20.987
gdf6agrowth differentiation factor 6a0.985
tbx1T-box 10.984
ntlano tail a0.982
kdrlkinase insert domain receptor like0.982
tbx16T-box gene 160.979
fgf3fibroblast growth factor 30.977
raraaretinoic acid receptor, alpha a0.964
ndr2nodal-related 20.961
gli1GLI-Kruppel family member 10.961
rx3retinal homeobox gene 30.956
hey1hairy/enhancer-of-split related with YRPW motif 10.951
rereaarginine-glutamic acid dipeptide (RE) repeats a0.948
lef1lymphocyte enhancer binding factor 10.944
gata3GATA-binding protein 30.941
dkk1bdickkopf 1b0.940
mibmind bomb0.937
otpborthopedia homolog b0.932
neurod4neurogenic differentiation 40.932
rarabretinoic acid receptor, alpha b0.926
hoxb1bhomeo box B1b0.920
mab21l2mab-21-like 20.920
zic4zic family member 40.918
flhfloating head0.918
ascl1aachaete-scute complex-like 1a (Drosophila)0.917
wnt11wingless-type MMTV integration site family, member 110.915
hoxd4ahomeo box D4a0.912
hoxb3ahomeo box B3a0.904
gata6GATA-binding protein 60.904
tbx2bT-box 2b0.903
gbx2gastrulation brain homeo box 20.895
six3bsine oculis homeobox homolog 3b0.890
cdx4caudal type homeo box transcription factor 40.888
pax6apaired box gene 6a0.885
bocbrother of CDO0.872
bmp2bbone morphogenetic protein 2b0.871
otx2orthodenticle homolog 20.871
alcambactivated leukocyte cell adhesion molecule b0.856
gli2aGLI-Kruppel family member GLI2a0.846
hoxc6ahomeo box C6a0.846
her3hairy-related 30.843
snai1bsnail homolog 1b (Drosophila)0.836
col2a1acollagen type II, alpha-1a0.835
pcdh8protocadherin 80.825
lhx2bLIM homeobox 2b0.822
sox19aSRY-box containing gene 19a0.820
msxcmuscle segment homeobox C0.819
fezf2FEZ family zinc finger 20.799
inka1ainduced in neural crest by AP2, 1a0.798
wnt5bwingless-type MMTV integration site family, member 5b0.793
jag1bjagged 1b0.790
dharmadharma0.789
eya1eyes absent homolog 10.789
pax6bpaired box gene 6b0.785
ephb4beph receptor B4b0.774
hoxa4ahomeo box A4a0.770
hoxa2bhomeo box A2b0.758
fibinfin bud initiation factor0.755
hoxd11ahomeo box D11a0.755
pdlim7PDZ and LIM domain 70.743
emx3empty spiracles homeobox 30.743
hoxb5ahomeo box B5a0.741
hoxb5bhomeo box B5b0.736
cdh1cadherin 1, epithelial0.734
irx3airoquois homeobox protein 3a0.728
dlcdeltaC0.722
pou3f3aPOU class 3 homeobox 3a0.721
sox1aSRY-box containing gene 1a0.710
etv5bets variant 5b0.710
dlx5adistal-less homeobox gene 5a0.698
eng2aengrailed 2a0.697
six4asine oculis homeobox homolog 4a0.696
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.688
dmbx1adiencephalon/mesencephalon homeobox 1a0.683
dzip1DAZ interacting protein 10.673
igfbp3insulin-like growth factor binding protein 30.663
nr2f1anuclear receptor subfamily 2, group F, member 1a0.656
six4bsine oculis homeobox homolog 4b0.654
hoxb8ahomeo box B8a0.650
phox2apaired-like homeobox 2a0.645
rx2retinal homeobox gene 20.641
bhlhe22basic helix-loop-helix family, member e220.638
dlddeltaD0.634
dbx1adeveloping brain homeobox 1a0.631
spawsouthpaw0.627
dlx4adistal-less homeobox gene 4a0.621
hoxb2ahomeo box B2a0.617
lhx1aLIM homeobox 1a0.617
tfap2atranscription factor AP-2 alpha0.616
dlbdeltaB0.615
hoxd13ahomeo box D13a0.606
thsd7athrombospondin, type I, domain containing 7A0.605
wnt2bbwingless-type MMTV integration site family, member 2Bb0.597
gata1aGATA binding protein 1a0.592
dlx3bdistal-less homeobox gene 3b0.592
pitx2paired-like homeodomain transcription factor 20.590
sox2SRY-box containing gene 20.579
foxd3forkhead box D30.576
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Pax6paired box gene 61.000
Ptenphosphatase and tensin homolog1.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Sox2SRY-box containing gene 21.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Foxc1forkhead box C11.000
Gli3GLI-Kruppel family member GLI31.000
Emx1empty spiracles homolog 1 (Drosophila)1.000
Fgfr2fibroblast growth factor receptor 21.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Pax3paired box gene 31.000
Pax2paired box gene 21.000
Hoxd13homeobox D130.999
Pitx2paired-like homeodomain transcription factor 20.999
Hand1heart and neural crest derivatives expressed transcript 10.999
Fgf8fibroblast growth factor 80.999
Vangl2vang-like 2 (van gogh, Drosophila)0.998
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.998
Gli2GLI-Kruppel family member GLI20.998
Lhx3LIM homeobox protein 30.998
Foxg1forkhead box G10.997
Emx2empty spiracles homolog 2 (Drosophila)0.997
Alx4aristaless-like homeobox 40.996
Tbx1T-box 10.996
Lef1lymphoid enhancer binding factor 10.996
Ikzf1IKAROS family zinc finger 10.996
Bdnfbrain derived neurotrophic factor0.996
Gata4GATA binding protein 40.996
Pou5f1POU domain, class 5, transcription factor 10.995
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.995
Trp53transformation related protein 530.995
Tcfap2atranscription factor AP-2, alpha0.994
Hoxa13homeobox A130.994
Csf1colony stimulating factor 1 (macrophage)0.994
Fgfr1fibroblast growth factor receptor 10.992
Isl1ISL1 transcription factor, LIM/homeodomain0.992
Tbx3T-box 30.992
Hoxa1homeobox A10.991
Kitkit oncogene0.991
Apcadenomatosis polyposis coli0.989
Chd7chromodomain helicase DNA binding protein 70.989
Tgfbr2transforming growth factor, beta receptor II0.988
Insm1insulinoma-associated 10.988
Foxp3forkhead box P30.987
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.986
Dlx5distal-less homeobox 50.985
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.984
Sall4sal-like 4 (Drosophila)0.983
Smad3MAD homolog 3 (Drosophila)0.982
Hes1hairy and enhancer of split 1 (Drosophila)0.980
Ror2receptor tyrosine kinase-like orphan receptor 20.980
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.975
Hoxa11homeobox A110.975
Ptk7PTK7 protein tyrosine kinase 70.974
Zeb1zinc finger E-box binding homeobox 10.974
Ptf1apancreas specific transcription factor, 1a0.971
Otx1orthodenticle homolog 1 (Drosophila)0.970
Ntf3neurotrophin 30.970
Msx2homeobox, msh-like 20.970
Foxc2forkhead box C20.969
Zic3zinc finger protein of the cerebellum 30.969
Rargretinoic acid receptor, gamma0.968
Chrdchordin0.968
Onecut1one cut domain, family member 10.967
Ascl1achaete-scute complex homolog 1 (Drosophila)0.967
Zic2zinc finger protein of the cerebellum 20.964
Tbx15T-box 150.963
Nognoggin0.961
Rb1retinoblastoma 10.960
Tcf4transcription factor 40.958
Fgf3fibroblast growth factor 30.958
Runx1runt related transcription factor 10.957
Eya1eyes absent 1 homolog (Drosophila)0.957
Hoxa2homeobox A20.957
Arandrogen receptor0.957
Dll1delta-like 1 (Drosophila)0.956
Tbx2T-box 20.955
Prf1perforin 1 (pore forming protein)0.952
Hoxd11homeobox D110.946
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.945
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.943
Neurod1neurogenic differentiation 10.942
Tnftumor necrosis factor0.940
Nr2f1nuclear receptor subfamily 2, group F, member 10.940
Msx1homeobox, msh-like 10.937
Wnt6wingless-related MMTV integration site 60.936
Inpp5dinositol polyphosphate-5-phosphatase D0.935
Bmp4bone morphogenetic protein 40.934
Atoh1atonal homolog 1 (Drosophila)0.934
Pitx3paired-like homeodomain transcription factor 30.931
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.931
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.930
Gdf5growth differentiation factor 50.928
Psen1presenilin 10.924
Kitlkit ligand0.923
UncxUNC homeobox0.921
Jag1jagged 10.919
Il10interleukin 100.919
Arid1aAT rich interactive domain 1A (SWI-like)0.917
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
MYO4Myo4p0.782
FKH1Fkh1p0.461
ISW1Isw1p0.459
CDC45Cdc45p0.403
MLC1Mlc1p0.313
CKA2Cka2p0.294
CTF4Ctf4p0.271
RAD10Rad10p0.268
RLM1Rlm1p0.261
SWI1Swi1p0.230
HMLALPHA2Hmlalpha2p0.221
HHO1Hho1p0.212
CKA1Cka1p0.210
MEC1Mec1p0.205
RIM101Rim101p0.179
MLH1Mlh1p0.178
MIG2Mig2p0.177
CSR2Csr2p0.175
RAD1Rad1p0.175
TBF1Tbf1p0.160
NTO1Nto1p0.159
HAL5Hal5p0.146
RTG3Rtg3p0.137
RTT106Rtt106p0.114
PSF2Psf2p0.113
SNF5Snf5p0.111
IXR1Ixr1p0.105
MIG1Mig1p0.105
TOM1Tom1p0.105
MRS6Mrs6p0.104
CKB1Ckb1p0.102
PHB2Phb2p0.100
NDD1Ndd1p0.100
MCM5Mcm5p0.097
LYS5Lys5p0.096
YPT1Ypt1p0.096
SLX4Slx4p0.093
SSK2Ssk2p0.091
MCM3Mcm3p0.090
MSA2Msa2p0.089
CLN1Cln1p0.084
MET4Met4p0.081
SLD5Sld5p0.081
HXT3Hxt3p0.080
HMRA1Hmra1p0.080
HMO1Hmo1p0.079
VPS27Vps27p0.078
YKR075Chypothetical protein0.076
HDA2Hda2p0.076
PNC1Pnc1p0.073
YPL014Whypothetical protein0.073
YCL042Whypothetical protein0.070
MIG3Mig3p0.069
PGM2Pgm2p0.067
POL2Pol2p0.066
CHD1Chd1p0.066
ABF1Abf1p0.066
GAT2Gat2p0.065
HIR2Hir2p0.064
MYO1Myo1p0.064
KAP95Kap95p0.063
MOB2Mob2p0.060
IFH1Ifh1p0.058
YLR297Whypothetical protein0.058
OLE1Ole1p0.058
MSH6Msh6p0.058
XRS2Xrs2p0.058
RGS2Rgs2p0.057
MKS1Mks1p0.056
ROX1Rox1p0.055
IOC4Ioc4p0.052
YOL036Whypothetical protein0.052
PSF1Psf1p0.051
HRK1Hrk1p0.051
DNA2Dna2p0.050
HSF1Hsf1p0.050
VAC7Vac7p0.050
SDC1Sdc1p0.050
PPH3Pph3p0.050
VAC17Vac17p0.049
HXK1Hxk1p0.049
YPR157Whypothetical protein0.048
SIN3Sin3p0.048
MRE11Mre11p0.046
MYO5Myo5p0.046
RFC4Rfc4p0.046
BEM3Bem3p0.046
HOHop0.045
MSH3Msh3p0.045
POL12Pol12p0.045
DNM1Dnm1p0.043
RSC4Rsc4p0.043
YER130Chypothetical protein0.043
IML1Iml1p0.042
SMP1Smp1p0.042
GBP2Gbp2p0.042
MF(ALPHA)2Mf(alpha)2p0.042
ORC2Orc2p0.041
REB1Reb1p0.041
POL30Pol30p0.039