The network for 'negative regulation of cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.

NameDescriptionProbabilityFunc Analog Organism
JUNjun proto-oncogene1.000
SMAD4SMAD family member 41.000
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa1.000
SMAD3SMAD family member 30.999
CREBBPCREB binding protein0.998
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.998
PTPN1protein tyrosine phosphatase, non-receptor type 10.997
ARandrogen receptor0.997
EGFRepidermal growth factor receptor0.992
TAL1T-cell acute lymphocytic leukemia 10.989
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.986
SMAD1SMAD family member 10.985
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.982
NCOR2nuclear receptor corepressor 20.977
IL4Rinterleukin 4 receptor0.972
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.972
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.964
FOSFBJ murine osteosarcoma viral oncogene homolog0.960
ZNF43zinc finger protein 430.957
SMAD7SMAD family member 70.957
SMAD2SMAD family member 20.954
CAV1caveolin 1, caveolae protein, 22kDa0.952
ESR1estrogen receptor 10.951
ATF2activating transcription factor 20.938
ATF3activating transcription factor 30.924
YAP1Yes-associated protein 10.919
PTPN6protein tyrosine phosphatase, non-receptor type 60.916
NCOA1nuclear receptor coactivator 10.908
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.905
ZNF273zinc finger protein 2730.883
FN1fibronectin 10.881
JAG1jagged 10.881
HNRPDLheterogeneous nuclear ribonucleoprotein D-like0.877
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.874
C1QAcomplement component 1, q subcomponent, A chain0.864
JUNBjun B proto-oncogene0.859
MED15mediator complex subunit 150.851
HLA-Bmajor histocompatibility complex, class I, B0.850
PDX1pancreatic and duodenal homeobox 10.848
CCT8chaperonin containing TCP1, subunit 8 (theta)0.844
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.838
AXIN1axin 10.837
B2Mbeta-2-microglobulin0.836
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.826
SP1Sp1 transcription factor0.824
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.822
HOXB5homeobox B50.821
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.818
BCAR1breast cancer anti-estrogen resistance 10.814
FHL2four and a half LIM domains 20.802
CXCL2chemokine (C-X-C motif) ligand 20.799
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.797
TP73tumor protein p730.796
DDIT3DNA-damage-inducible transcript 30.795
SMN1survival of motor neuron 1, telomeric0.793
DICER1dicer 1, ribonuclease type III0.792
SFRP1secreted frizzled-related protein 10.784
MED10mediator complex subunit 100.769
LTBP2latent transforming growth factor beta binding protein 20.765
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.755
BMP2bone morphogenetic protein 20.746
ATN1atrophin 10.744
IL8interleukin 80.740
GSK3Bglycogen synthase kinase 3 beta0.734
NOTCH1notch 10.733
RAD21RAD21 homolog (S. pombe)0.730
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.728
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.721
CCND1cyclin D10.718
HMGA1high mobility group AT-hook 10.712
GATA2GATA binding protein 20.712
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.704
NCOR1nuclear receptor corepressor 10.702
FGF1fibroblast growth factor 1 (acidic)0.701
TP53tumor protein p530.700
DUSP1dual specificity phosphatase 10.697
RBBP4retinoblastoma binding protein 40.693
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.684
SETDB1SET domain, bifurcated 10.684
SMURF2SMAD specific E3 ubiquitin protein ligase 20.682
FBLN1fibulin 10.680
CDK8cyclin-dependent kinase 80.672
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.665
HNF4Ahepatocyte nuclear factor 4, alpha0.661
COL1A1collagen, type I, alpha 10.660
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.659
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.659
SOX2SRY (sex determining region Y)-box 20.655
TMSB4Xthymosin beta 4, X-linked0.647
APPamyloid beta (A4) precursor protein0.646
PAX3paired box 30.646
SOX11SRY (sex determining region Y)-box 110.641
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.640
SRFserum response factor (c-fos serum response element-binding transcription factor)0.635
PSG9pregnancy specific beta-1-glycoprotein 90.634
ENGendoglin0.627
SMAD6SMAD family member 60.621
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.611
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.609
MED6mediator complex subunit 60.602
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.049
bar-1Protein BAR-10.012
nhr-67Protein NHR-670.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin0.923
tal1T-cell acute lymphocytic leukemia 10.789
tbx16T-box gene 160.721
dlcdeltaC0.655
ascl1aachaete-scute complex-like 1a (Drosophila)0.633
ndr2nodal-related 20.605
foxa2forkhead box A20.553
wnt5bwingless-type MMTV integration site family, member 5b0.540
foxi1forkhead box I10.530
hmx3homeo box (H6 family) 30.511
gata1aGATA binding protein 1a0.479
twist3twist30.467
fgf8afibroblast growth factor 8 a0.427
pcdh8protocadherin 80.403
notch1anotch homolog 1a0.390
six4bsine oculis homeobox homolog 4b0.389
fn1fibronectin 10.377
tbx2bT-box 2b0.375
bmp2bbone morphogenetic protein 2b0.358
gli1GLI-Kruppel family member 10.353
sox1aSRY-box containing gene 1a0.352
myod1myogenic differentiation 10.349
cxcr4bchemokine (C-X-C motif), receptor 4b0.348
pax7apaired box gene 7a0.344
cdh1cadherin 1, epithelial0.339
dlx4bdistal-less homeobox gene 4b0.338
bmp2abone morphogenetic protein 2a0.337
sox7SRY-box containing gene 70.336
nog1noggin 10.335
fzd8afrizzled homolog 8a0.326
mecomMDS1 and EVI1 complex locus0.317
fzd7afrizzled homolog 7a0.315
wnt11rwingless-type MMTV integration site family, member 11, related0.287
nr2e1nuclear receptor subfamily 2, group E, member 10.284
alcamaactivated leukocyte cell adhesion molecule a0.278
wnt4awingless-type MMTV integration site family, member 4a0.277
atoh8atonal homolog 80.270
sox2SRY-box containing gene 20.267
hlxb9lahomeo box HB9 like a0.267
gdf6agrowth differentiation factor 6a0.264
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.263
hey1hairy/enhancer-of-split related with YRPW motif 10.260
sox17SRY-box containing gene 170.260
pax6apaired box gene 6a0.260
isl1islet10.259
rdh10aretinol dehydrogenase 10a0.258
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.253
jag2jagged 20.253
tp53tumor protein p530.248
dhrs3adehydrogenase/reductase (SDR family) member 3a0.248
sox19aSRY-box containing gene 19a0.247
spry4sprouty (Drosophila) homolog 40.246
nkx2.2aNK2 transcription factor related 2a0.245
dkk1bdickkopf 1b0.238
foxd3forkhead box D30.229
foxd5forkhead box D50.213
fgfr3fibroblast growth factor receptor 30.212
her7hairy and enhancer of split related-70.209
hoxb3ahomeo box B3a0.207
tbx6T-box gene 60.203
foxa3forkhead box A30.203
whsc1Wolf-Hirschhorn syndrome candidate 10.201
neurod4neurogenic differentiation 40.198
her12hairy-related 120.193
cdx4caudal type homeo box transcription factor 40.192
fzd10frizzled homolog 100.192
lhx1aLIM homeobox 1a0.191
dlx2adistal-less homeobox gene 2a0.187
lfnglunatic fringe homolog0.187
robo2roundabout homolog 20.182
egr2bearly growth response 2b0.180
flhfloating head0.179
her6hairy-related 60.178
mespamesoderm posterior a0.173
nkx2.2bNK2 transcription factor related 2b0.171
cxcr4achemokine (C-X-C motif) receptor 4a0.169
hoxa2bhomeo box A2b0.163
wnt2bbwingless-type MMTV integration site family, member 2Bb0.162
sox3SRY-box containing gene 30.161
phox2apaired-like homeobox 2a0.158
lef1lymphocyte enhancer binding factor 10.158
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.158
cdoncell adhesion molecule-related/down-regulated by oncogenes0.154
tia1cytotoxic granule-associated RNA binding protein 10.152
etv2ets variant gene 20.152
rarabretinoic acid receptor, alpha b0.150
foxj1bforkhead box J1b0.146
pkd2polycystic kidney disease 20.145
atoh1aatonal homolog 1a0.144
sox9bSRY-box containing gene 9b0.144
hoxb1bhomeo box B1b0.144
itgb1aintegrin, beta 1a0.142
gsnagelsolin a0.141
slit3slit (Drosophila) homolog 30.141
barhl2BarH-like 20.141
otpborthopedia homolog b0.140
cntn2contactin 20.139
ccnd1cyclin D10.137
notch3notch homolog 30.136
vsx2visual system homeobox 20.134
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.996
sosine oculis0.995
dapdacapo0.992
Ras85DRas oncogene at 85D0.991
DlDelta0.985
MadMothers against dpp0.979
bratbrain tumor0.975
emcextra macrochaetae0.972
enengrailed0.966
NNotch0.964
EgfrEpidermal growth factor receptor0.940
sdscalloped0.920
Stat92ESignal-transducer and activator of transcription protein at 92E0.920
E(spl)Enhancer of split0.917
tkvthickveins0.916
Su(H)Suppressor of Hairless0.916
hhhedgehog0.916
bskbasket0.915
Gap1GTPase-activating protein 10.890
effeffete0.881
atoatonal0.846
ph-ppolyhomeotic proximal0.822
rlrolled0.812
eyaeyes absent0.808
MED4Mediator complex subunit 40.786
hephemipterous0.777
ykiyorkie0.764
nkdnaked cuticle0.762
slp1sloppy paired 10.747
saxsaxophone0.739
shnschnurri0.725
Wnt4Wnt oncogene analog 40.721
grogroucho0.706
armarmadillo0.705
shishibire0.703
dadaughterless0.699
Tao-1CG14217 gene product from transcript CG14217-RF0.683
CkIIalphaCasein kinase II alpha subunit0.683
Akt1CG4006 gene product from transcript CG4006-RA0.677
smosmoothened0.660
stwlstonewall0.659
uspultraspiracle0.656
G-oalpha47AG protein oalpha 47A0.654
slmbsupernumerary limbs0.653
ovoCG6824 gene product from transcript CG6824-RE0.644
NetBNetrin-B0.640
apapterous0.637
MoeMoesin0.600
tuptailup0.594
wgwingless0.593
dmdiminutive0.581
spensplit ends0.581
MED11Mediator complex subunit 110.580
rinrasputin0.575
exexpanded0.570
SerSerrate0.570
HLHm7E(spl) region transcript m70.568
dallydivision abnormally delayed0.566
CtBPC-terminal Binding Protein0.562
twstwins0.551
nubnubbin0.548
MED6Mediator complex subunit 60.539
knknot0.527
MED27Mediator complex subunit 270.523
elavembryonic lethal abnormal vision0.517
rhorhomboid0.513
slp2sloppy paired 20.510
Su(z)12CG8013 gene product from transcript CG8013-RA0.510
tintinman0.509
G-salpha60AG protein salpha 60A0.503
nmonemo0.503
giggigas0.500
Gp150CG5820 gene product from transcript CG5820-RA0.498
UbqnUbiquilin0.492
lblladybird late0.491
MED31Mediator complex subunit 310.486
acachaete0.483
dpndeadpan0.482
dsdachsous0.480
BicDBicaudal D0.477
gsbgooseberry0.470
pydpolychaetoid0.466
osoutstretched0.449
CG5794CG5794 gene product from transcript CG5794-RB0.448
pnrpannier0.448
DadDaughters against dpp0.444
rapretina aberrant in pattern0.441
bowlbrother of odd with entrails limited0.431
CdsACDP diglyceride synthetase0.428
SnooSno oncogene0.419
UbxUltrabithorax0.415
Ptp69DProtein tyrosine phosphatase 69D0.406
drprdraper0.406
fngfringe0.405
PakPAK-kinase0.403
chicoCG5686 gene product from transcript CG5686-RB0.402
snostrawberry notch0.396
Ten-aTenascin accessory0.392
LamLamin0.390
ababrupt0.390
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
S100a6S100 calcium binding protein A60.693
Fgfr2fibroblast growth factor receptor 20.624
Rararetinoic acid receptor, alpha0.459
Cd9CD9 molecule0.420
S100a9S100 calcium binding protein A90.375
Otx1orthodenticle homeobox 10.371
S100a8S100 calcium binding protein A80.354
Anxa2annexin A20.319
Foxq1forkhead box Q10.307
Ascl1achaete-scute complex homolog 1 (Drosophila)0.295
Jak1Janus kinase 10.288
S100a10S100 calcium binding protein A100.278
Lgals5lectin, galactose binding, soluble 50.274
Itpr2inositol 1,4,5-triphosphate receptor, type 20.269
Gna15guanine nucleotide binding protein, alpha 150.247
Marcksmyristoylated alanine rich protein kinase C substrate0.244
Ageradvanced glycosylation end product-specific receptor0.243
Egr1early growth response 10.242
Aqp4aquaporin 40.240
Calcrlcalcitonin receptor-like0.233
Acvr1activin A receptor, type I0.220
Tcfe2atranscription factor E2a0.216
Ednrbendothelin receptor type B0.209
Igfbp5insulin-like growth factor binding protein 50.205
Nptnneuroplastin0.203
Sorbs3sorbin and SH3 domain containing 30.196
Galr3galanin receptor 30.188
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.186
Cd4Cd4 molecule0.178
Gata3GATA binding protein 30.172
Tnftumor necrosis factor (TNF superfamily, member 2)0.169
S100a4S100 calcium-binding protein A40.167
Ifitm3interferon induced transmembrane protein 30.163
Ptprdprotein tyrosine phosphatase, receptor type, D0.162
Gata6GATA binding protein 60.156
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.150
Twist2twist homolog 2 (Drosophila)0.148
Anxa5annexin A50.144
NrarpNotch-regulated ankyrin repeat protein0.144
Irs1insulin receptor substrate 10.143
Lgals3lectin, galactoside-binding, soluble, 30.143
AhnakAHNAK nucleoprotein0.142
Foxs1forkhead box S10.141
Rxraretinoid X receptor alpha0.140
Adcy6adenylate cyclase 60.140
Foxe1forkhead box E1 (thyroid transcription factor 2)0.139
Cd5Cd5 molecule0.138
Zfp36zinc finger protein 360.138
Nek9NIMA (never in mitosis gene a)- related kinase 90.137
S100a11S100 calcium binding protein A11 (calizzarin)0.135
Anxa1annexin A10.135
Mybpc2myosin binding protein C, fast-type0.133
RestRE1-silencing transcription factor0.131
Relnreelin0.130
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.130
Il12binterleukin 12B0.129
Ralgdsral guanine nucleotide dissociation stimulator0.126
Oxtroxytocin receptor0.125
Pld1phospholipase D10.125
Myo1cmyosin IC0.124
Gja1gap junction protein, alpha 10.121
Scarb1scavenger receptor class B, member 10.120
Phox2apaired-like homeobox 2a0.120
Hes1hairy and enhancer of split 1 (Drosophila)0.119
Sf1splicing factor 10.118
Mgpmatrix Gla protein0.117
Mtpnmyotrophin0.115
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.114
Rps6ka1ribosomal protein S6 kinase polypeptide 10.113
Cdk2cyclin dependent kinase 20.111
Fut2fucosyltransferase 2 (secretor status included)0.111
Capn2calpain 20.110
Prkcdprotein kinase C, delta0.110
Nedd4neural precursor cell expressed, developmentally down-regulated 40.108
TriobpTRIO and F-actin binding protein0.108
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.108
Klf4Kruppel-like factor 4 (gut)0.108
Notch1Notch homolog 1, translocation-associated (Drosophila)0.102
Gpx3glutathione peroxidase 30.102
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.102
Slco2a1solute carrier organic anion transporter family, member 2a10.101
Ece1endothelin converting enzyme 10.100
Gja6gap junction protein, alpha 60.100
Syt6synaptotagmin VI0.098
RGD1310262hypothetical LOC3046500.098
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.096
Cripcysteine-rich intestinal protein0.095
Myh9myosin, heavy chain 9, non-muscle0.095
Ddr1discoidin domain receptor tyrosine kinase 10.094
Dll1delta-like 1 (Drosophila)0.094
Stat6signal transducer and activator of transcription 60.094
Ccnd1cyclin D10.094
Ifitm1interferon induced transmembrane protein 10.094
Pls3plastin 3 (T-isoform)0.093
Pld2phospholipase D20.093
Gpc1glypican 10.093
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.093
Nos2nitric oxide synthase 2, inducible0.093
Prss22protease, serine, 220.091
Notch3Notch homolog 3 (Drosophila)0.091
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
IRA1Ira1p0.017
RAS2Ras2p0.016
PSD2Psd2p0.015
PIR1Pir1p0.015
PCL9Pcl9p0.013
KDX1Kdx1p0.012
PTM1Ptm1p0.012
MSG5Msg5p0.011
FUS3Fus3p0.011
CDC25Cdc25p0.010
CYR1Cyr1p0.010