The network for 'positive regulation of nf kappab transcription factor activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of nf kappab transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

NameDescriptionProbabilityFunc Analog Organism
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma1.000
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)1.000
BIRC3baculoviral IAP repeat containing 30.998
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.996
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.996
CASP8caspase 8, apoptosis-related cysteine peptidase0.992
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.991
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.991
NCF1neutrophil cytosolic factor 10.991
RIPK2receptor-interacting serine-threonine kinase 20.983
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.980
SQSTM1sequestosome 10.977
TRAF2TNF receptor-associated factor 20.972
BIRC2baculoviral IAP repeat containing 20.968
TRAF1TNF receptor-associated factor 10.967
MYD88myeloid differentiation primary response gene (88)0.951
MAP3K7mitogen-activated protein kinase kinase kinase 70.914
TRAF3TNF receptor-associated factor 30.907
PRKCAprotein kinase C, alpha0.903
TNFAIP3tumor necrosis factor, alpha-induced protein 30.889
PMLpromyelocytic leukemia0.887
MAP3K14mitogen-activated protein kinase kinase kinase 140.881
IRAK2interleukin-1 receptor-associated kinase 20.873
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.852
SMAD3SMAD family member 30.844
TRAF6TNF receptor-associated factor 60.842
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.840
MTORmechanistic target of rapamycin (serine/threonine kinase)0.792
NLRC4NLR family, CARD domain containing 40.789
IRAK1interleukin-1 receptor-associated kinase 10.782
TRIM21tripartite motif containing 210.663
IL1R1interleukin 1 receptor, type I0.653
PYCARDPYD and CARD domain containing0.641
TICAM2toll-like receptor adaptor molecule 20.630
BCL3B-cell CLL/lymphoma 30.606
CREBBPCREB binding protein0.588
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.545
BCL10B-cell CLL/lymphoma 100.516
TXNthioredoxin0.498
PRKCZprotein kinase C, zeta0.498
TTNtitin0.496
CARD11caspase recruitment domain family, member 110.482
RNF31ring finger protein 310.444
TNIP2TNFAIP3 interacting protein 20.442
TNFtumor necrosis factor0.422
TRIM63tripartite motif containing 630.413
INADLInaD-like (Drosophila)0.409
UBE2Uubiquitin-conjugating enzyme E2U (putative)0.405
ESR1estrogen receptor 10.392
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.389
TRIM41tripartite motif containing 410.362
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.361
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.352
PSEN2presenilin 2 (Alzheimer disease 4)0.350
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.347
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.338
IRAK3interleukin-1 receptor-associated kinase 30.319
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.287
ZMYND11zinc finger, MYND-type containing 110.286
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.281
SPRR2Asmall proline-rich protein 2A0.276
TRIM5tripartite motif containing 50.270
GSK3Bglycogen synthase kinase 3 beta0.265
NCF4neutrophil cytosolic factor 4, 40kDa0.251
NMIN-myc (and STAT) interactor0.246
PRKCBprotein kinase C, beta0.244
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.244
AKT1v-akt murine thymoma viral oncogene homolog 10.239
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.230
TRAF5TNF receptor-associated factor 50.230
SP110SP110 nuclear body protein0.211
IRF7interferon regulatory factor 70.206
TNIP1TNFAIP3 interacting protein 10.198
NOXA1NADPH oxidase activator 10.198
NCOA1nuclear receptor coactivator 10.192
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.188
ZC3H12Azinc finger CCCH-type containing 12A0.188
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.187
NCOA3nuclear receptor coactivator 30.186
ZNRF1zinc and ring finger 10.186
TRIM22tripartite motif containing 220.185
TSC22D1TSC22 domain family, member 10.185
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.183
CASP4caspase 4, apoptosis-related cysteine peptidase0.177
CDC37cell division cycle 37 homolog (S. cerevisiae)0.175
NCLnucleolin0.168
PRDX4peroxiredoxin 40.164
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.160
EFCAB4BEF-hand calcium binding domain 4B0.156
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.156
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.153
MAP2K1mitogen-activated protein kinase kinase 10.151
DHX58DEXH (Asp-Glu-X-His) box polypeptide 580.146
ARIH2ariadne homolog 2 (Drosophila)0.146
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.145
PDPK13-phosphoinositide dependent protein kinase-10.144
ZNF746zinc finger protein 7460.143
MED15mediator complex subunit 150.143
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.142
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.139
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Myd88myeloid differentiation primary response gene 880.997
Traf6TNF receptor-associated factor 60.997
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.977
Tnftumor necrosis factor0.953
Tlr4toll-like receptor 40.948
Cd44CD44 antigen0.926
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.885
Tnfaip3tumor necrosis factor, alpha-induced protein 30.852
Ldb3LIM domain binding 30.766
Map3k7mitogen-activated protein kinase kinase kinase 70.761
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.735
Il10interleukin 100.718
Cd40CD40 antigen0.638
Ikbkginhibitor of kappaB kinase gamma0.501
Acvrl1activin A receptor, type II-like 10.466
Casp1caspase 10.463
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.433
Prkccprotein kinase C, gamma0.377
Map3k8mitogen-activated protein kinase kinase kinase 80.351
Arntlaryl hydrocarbon receptor nuclear translocator-like0.265
Casp4caspase 4, apoptosis-related cysteine peptidase0.265
Tlr2toll-like receptor 20.255
Il1r1interleukin 1 receptor, type I0.252
Actn2actinin alpha 20.252
Rargretinoic acid receptor, gamma0.249
Mmp9matrix metallopeptidase 90.248
Nos2nitric oxide synthase 2, inducible0.235
Csf1colony stimulating factor 1 (macrophage)0.234
Map3k14mitogen-activated protein kinase kinase kinase 140.222
FasFas (TNF receptor superfamily member 6)0.222
Mavsmitochondrial antiviral signaling protein0.206
Irak4interleukin-1 receptor-associated kinase 40.203
Ikbkbinhibitor of kappaB kinase beta0.191
Vdrvitamin D receptor0.180
Ighimmunoglobulin heavy chain complex0.178
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.177
Birc3baculoviral IAP repeat-containing 30.162
Leprleptin receptor0.162
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.149
Trp53transformation related protein 530.149
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.141
PycardPYD and CARD domain containing0.137
Smad3MAD homolog 3 (Drosophila)0.132
Adam17a disintegrin and metallopeptidase domain 170.127
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.125
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.122
Bcl3B-cell leukemia/lymphoma 30.122
Adam15a disintegrin and metallopeptidase domain 15 (metargidin)0.119
Itchitchy, E3 ubiquitin protein ligase0.116
Clockcircadian locomotor output cycles kaput0.115
Il6stinterleukin 6 signal transducer0.115
Casp8caspase 80.115
BtkBruton agammaglobulinemia tyrosine kinase0.107
Plxna1plexin A10.100
Ccl2chemokine (C-C motif) ligand 20.097
Ptenphosphatase and tensin homolog0.097
Stat3signal transducer and activator of transcription 30.093
Ptgs2prostaglandin-endoperoxide synthase 20.093
Akt1thymoma viral proto-oncogene 10.091
Irak3interleukin-1 receptor-associated kinase 30.082
Ppargperoxisome proliferator activated receptor gamma0.082
Prkcdprotein kinase C, delta0.078
Ccr2chemokine (C-C motif) receptor 20.077
Cyldcylindromatosis (turban tumor syndrome)0.075
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.073
Ltbrlymphotoxin B receptor0.071
Hif1ahypoxia inducible factor 1, alpha subunit0.069
Prkceprotein kinase C, epsilon0.068
Il4interleukin 40.068
Il4rainterleukin 4 receptor, alpha0.063
Hdac7histone deacetylase 70.056
Nlrp3NLR family, pyrin domain containing 30.055
Fzd1frizzled homolog 1 (Drosophila)0.053
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.049
Myo1cmyosin IC0.049
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.047
Ksr1kinase suppressor of ras 10.047
Ltalymphotoxin A0.046
Il6interleukin 60.045
Vhlvon Hippel-Lindau tumor suppressor0.045
2010106G01RikRIKEN cDNA 2010106G01 gene0.045
Arhgef1Rho guanine nucleotide exchange factor (GEF) 10.044
Sfnstratifin0.044
Inhainhibin alpha0.044
Dlg4discs, large homolog 4 (Drosophila)0.044
Ifi44interferon-induced protein 440.043
Lyz2lysozyme 20.042
Eif2c1eukaryotic translation initiation factor 2C, 10.042
Foxf1aforkhead box F1a0.041
Traf3ip2TRAF3 interacting protein 20.041
Irf9interferon regulatory factor 90.041
Prnpprion protein0.040
Runx1runt related transcription factor 10.040
Klf3Kruppel-like factor 3 (basic)0.040
Ticam1toll-like receptor adaptor molecule 10.040
Rnf31ring finger protein 310.039
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.039
Epb4.1l2erythrocyte protein band 4.1-like 20.035
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.034
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.034
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.046
Zyxzyxin0.020
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.012
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.011
Stat3signal transducer and activator of transcription 30.011
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism