The network for 'regulation of binding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of binding

Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.

NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.984
FHL2four and a half LIM domains 20.914
TGFB1transforming growth factor, beta 10.899
ZNF43zinc finger protein 430.877
SKILSKI-like oncogene0.830
NCOR2nuclear receptor corepressor 20.753
SMAD3SMAD family member 30.739
APPamyloid beta (A4) precursor protein0.715
STAT1signal transducer and activator of transcription 1, 91kDa0.706
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.701
SIN3ASIN3 homolog A, transcription regulator (yeast)0.680
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.654
BCL2L1BCL2-like 10.649
ZNF253zinc finger protein 2530.642
CREBBPCREB binding protein0.596
CDK9cyclin-dependent kinase 90.586
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.577
ENGendoglin0.564
HDAC4histone deacetylase 40.558
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.556
IFIT1interferon-induced protein with tetratricopeptide repeats 10.556
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.553
TGFBR1transforming growth factor, beta receptor 10.537
JUNjun proto-oncogene0.475
RB1retinoblastoma 10.471
CSNK1Ecasein kinase 1, epsilon0.456
ZMYND11zinc finger, MYND-type containing 110.445
ZNF273zinc finger protein 2730.439
ZNF260zinc finger protein 2600.432
ZNF567zinc finger protein 5670.430
CDK2cyclin-dependent kinase 20.426
SMAD4SMAD family member 40.422
IFIT3interferon-induced protein with tetratricopeptide repeats 30.413
PSEN2presenilin 2 (Alzheimer disease 4)0.410
GSK3Bglycogen synthase kinase 3 beta0.410
RXRAretinoid X receptor, alpha0.402
SPTBspectrin, beta, erythrocytic0.381
ZNF512Bzinc finger protein 512B0.376
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.366
ANXA1annexin A10.364
RBBP4retinoblastoma binding protein 40.342
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.340
SMAD2SMAD family member 20.339
ZNF675zinc finger protein 6750.339
ARRB1arrestin, beta 10.339
HMGA1high mobility group AT-hook 10.320
ZNF91zinc finger protein 910.316
E2F1E2F transcription factor 10.314
PTENphosphatase and tensin homolog0.312
IGF2Rinsulin-like growth factor 2 receptor0.301
IFIT5interferon-induced protein with tetratricopeptide repeats 50.299
TP53tumor protein p530.294
ZNF84zinc finger protein 840.291
CDC20cell division cycle 20 homolog (S. cerevisiae)0.290
HEXIM1hexamethylene bis-acetamide inducible 10.289
ATF3activating transcription factor 30.281
DVL3dishevelled, dsh homolog 3 (Drosophila)0.277
PDIA3protein disulfide isomerase family A, member 30.276
BCL2L11BCL2-like 11 (apoptosis facilitator)0.275
MYOD1myogenic differentiation 10.274
EGFRepidermal growth factor receptor0.268
C1QAcomplement component 1, q subcomponent, A chain0.266
HSPA4heat shock 70kDa protein 40.257
FN1fibronectin 10.246
CSNK2Bcasein kinase 2, beta polypeptide0.237
NCOR1nuclear receptor corepressor 10.224
CCR5chemokine (C-C motif) receptor 50.223
IFI44interferon-induced protein 440.221
DVL1dishevelled, dsh homolog 1 (Drosophila)0.213
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.210
MEF2Cmyocyte enhancer factor 2C0.210
TK1thymidine kinase 1, soluble0.209
PMLpromyelocytic leukemia0.209
PINK1PTEN induced putative kinase 10.205
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.199
FLNAfilamin A, alpha0.195
FOSFBJ murine osteosarcoma viral oncogene homolog0.194
PRKD2protein kinase D20.193
CAV1caveolin 1, caveolae protein, 22kDa0.192
LMO2LIM domain only 2 (rhombotin-like 1)0.190
FAF1Fas (TNFRSF6) associated factor 10.190
ATF2activating transcription factor 20.190
RCC1regulator of chromosome condensation 10.189
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.189
ZNF430zinc finger protein 4300.188
SOCS3suppressor of cytokine signaling 30.186
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.184
HTThuntingtin0.183
ZNF85zinc finger protein 850.177
HIF1ANhypoxia inducible factor 1, alpha subunit inhibitor0.174
CXCL9chemokine (C-X-C motif) ligand 90.165
CCL4chemokine (C-C motif) ligand 40.164
PTPRCprotein tyrosine phosphatase, receptor type, C0.163
LRP6low density lipoprotein receptor-related protein 60.162
NUDT3nudix (nucleoside diphosphate linked moiety X)-type motif 30.162
ARandrogen receptor0.161
TPM1tropomyosin 1 (alpha)0.159
SETD7SET domain containing (lysine methyltransferase) 70.159
ZNF93zinc finger protein 930.159
ZNF680zinc finger protein 6800.157
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.616
robo3roundabout homolog 30.598
hmgb1bhigh-mobility group box 1b0.546
dladeltaA0.494
cdh2cadherin 2, neuronal0.458
bmp4bone morphogenetic protein 40.438
tal1T-cell acute lymphocytic leukemia 10.419
mef2camyocyte enhancer factor 2ca0.364
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.347
alcamaactivated leukocyte cell adhesion molecule a0.344
hsp90a.2heat shock protein 90-alpha 20.339
hmgb1ahigh-mobility group box 1a0.337
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.315
nkx2.5NK2 transcription factor related 50.292
egr2bearly growth response 2b0.289
efnb2aephrin B2a0.283
klf4Kruppel-like factor 40.278
ptmaaprothymosin, alpha a0.270
bmp2bbone morphogenetic protein 2b0.265
crabp2acellular retinoic acid binding protein 2, a0.264
lef1lymphocyte enhancer binding factor 10.262
hmgb3ahigh-mobility group box 3a0.260
ef1aelongation factor 1-alpha0.259
hoxd4ahomeo box D4a0.258
plcg1phospholipase C, gamma 10.227
mapk1mitogen-activated protein kinase 10.226
slc4a1asolute carrier family 4, anion exchanger, member 1a0.222
eif5a2eukaryotic translation initiation factor 5A20.219
tnnt2atroponin T2a, cardiac0.218
ccna2cyclin A20.211
svilsupervillin0.208
wnt11rwingless-type MMTV integration site family, member 11, related0.206
smyhc1slow myosin heavy chain 10.205
tbx2bT-box 2b0.203
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.196
aldh1a2aldehyde dehydrogenase 1 family, member A20.192
extl3exostoses (multiple)-like 30.192
foxd3forkhead box D30.187
tbx5aT-box 5a0.176
tlr3toll-like receptor 30.173
crip2cysteine-rich protein 20.173
notch3notch homolog 30.166
flot1bflotillin 1b0.163
sall1asal-like 1a (Drosophila)0.162
smad3bMAD, mothers against decapentaplegic homolog 3b (Drosophila)0.162
icnictacalcin0.156
nrg2aneuregulin 2a0.153
socs3asuppressor of cytokine signaling 3a0.149
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.147
dlx5adistal-less homeobox gene 5a0.147
hspb1heat shock protein, alpha-crystallin-related, 10.145
gata2aGATA-binding protein 2a0.145
lama5laminin, alpha 50.145
zgc:92027zgc:920270.143
sh3gl1bSH3-domain GRB2-like 1b0.142
ndrg4N-myc downstream regulated gene 40.142
actc1bactin, alpha, cardiac muscle 1b0.140
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.139
tfe3atranscription factor binding to IGHM enhancer 3a0.136
aplp2amyloid beta (A4) precursor-like protein 20.136
cxcr4bchemokine (C-X-C motif), receptor 4b0.134
appaamyloid beta (A4) precursor protein a0.133
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.133
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.131
cx43connexin 430.131
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.131
hmx4H6 family homeobox 40.130
trpv6transient receptor potential cation channel, subfamily V, member 60.127
angptl7angiopoietin-like 70.127
ahctf1AT hook containing transcription factor 10.126
rbpms2RNA binding protein with multiple splicing 20.125
ptgs2aprostaglandin-endoperoxide synthase 2a0.123
emx3empty spiracles homeobox 30.121
phlda2pleckstrin homology-like domain, family A, member 20.120
scg3secretogranin III0.118
gdf6agrowth differentiation factor 6a0.117
eng1aengrailed 1a0.117
her6hairy-related 60.115
brd4bromodomain containing 40.114
gcgaglucagon a and glucagon a-like0.114
pollpolymerase (DNA directed), lambda0.113
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.112
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.112
fabp7afatty acid binding protein 7, brain, a0.112
mapk4mitogen-activated protein kinase 40.111
lft1lefty10.109
hs3st3b1aheparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a0.109
hdac4histone deacetylase 40.109
mapk6mitogen-activated protein kinase 60.107
tm4sf4transmembrane 4 L six family member 40.105
wnt5bwingless-type MMTV integration site family, member 5b0.105
rnf2ring finger protein 20.104
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.103
bmpr1aabone morphogenetic protein receptor, type 1aa0.103
ntn1anetrin 1a0.103
col1a1acollagen, type I, alpha 1a0.103
hhexhematopoietically expressed homeobox0.102
dlx2adistal-less homeobox gene 2a0.102
mfn2mitofusin 20.102
tcf12transcription factor 120.101
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
DrefDNA replication-related element factor0.067
dapdacapo0.057
nejnejire0.044
enaenabled0.043
Ptp69DProtein tyrosine phosphatase 69D0.039
MadMothers against dpp0.038
NrgNeuroglian0.033
GugGrunge0.022
dcodiscs overgrown0.021
coracoracle0.021
mei-41meiotic 410.020
Su(H)Suppressor of Hairless0.019
aspabnormal spindle0.017
saxsaxophone0.016
ninaEneither inactivation nor afterpotential E0.016
shnschnurri0.016
phlpole hole0.016
SoxNSoxNeuro0.016
wupAwings up A0.015
hthhomothorax0.015
CaMKIICalcium/calmodulin-dependent protein kinase II0.014
armarmadillo0.013
Adf1Adh transcription factor 10.013
kaykayak0.013
PICK1CG6167 gene product from transcript CG6167-RA0.013
opaodd paired0.013
dpndeadpan0.012
Pi3K92ECG4141 gene product from transcript CG4141-RB0.012
nufnuclear fallout0.012
NrtNeurotactin0.012
aopanterior open0.012
timtimeless0.012
mib1mind bomb 10.011
hydhyperplastic discs0.011
prdpaired0.011
Uba1Ubiquitin activating enzyme 10.011
fasfaint sausage0.011
discodisconnected0.011
trxtrithorax0.011
tortorso0.011
hrghiiragi0.010
crbcrumbs0.010
zpgzero population growth0.010
Pka-C1cAMP-dependent protein kinase 10.010
perperiod0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.998
Trp53transformation related protein 530.998
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.972
Otx2orthodenticle homolog 2 (Drosophila)0.966
Ctnnb1catenin (cadherin associated protein), beta 10.965
Pax3paired box gene 30.962
Gata4GATA binding protein 40.962
Csf1colony stimulating factor 1 (macrophage)0.950
Appamyloid beta (A4) precursor protein0.939
Axin1axin 10.938
Pax6paired box gene 60.936
Fgfr1fibroblast growth factor receptor 10.926
Notch1Notch gene homolog 1 (Drosophila)0.924
Pax2paired box gene 20.924
Psen1presenilin 10.920
Jag1jagged 10.920
Ikzf1IKAROS family zinc finger 10.918
En1engrailed 10.918
Tgfbr2transforming growth factor, beta receptor II0.892
Gsk3bglycogen synthase kinase 3 beta0.881
Tbx3T-box 30.878
Tcf4transcription factor 40.865
Smad4MAD homolog 4 (Drosophila)0.863
Arid1aAT rich interactive domain 1A (SWI-like)0.862
Pitx2paired-like homeodomain transcription factor 20.858
Rxraretinoid X receptor alpha0.855
Mapk8mitogen-activated protein kinase 80.850
Emx1empty spiracles homolog 1 (Drosophila)0.850
Tgfb2transforming growth factor, beta 20.849
Smad3MAD homolog 3 (Drosophila)0.838
Fgf8fibroblast growth factor 80.819
Rararetinoic acid receptor, alpha0.795
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.786
Apcadenomatosis polyposis coli0.786
Shhsonic hedgehog0.779
Rargretinoic acid receptor, gamma0.769
Meox2mesenchyme homeobox 20.763
Gli3GLI-Kruppel family member GLI30.757
Foxc1forkhead box C10.732
Ascl1achaete-scute complex homolog 1 (Drosophila)0.718
S100a8S100 calcium binding protein A8 (calgranulin A)0.716
Gbx2gastrulation brain homeobox 20.716
Rb1retinoblastoma 10.713
Fgfr2fibroblast growth factor receptor 20.702
Lyz2lysozyme 20.698
Ncoa3nuclear receptor coactivator 30.696
Emx2empty spiracles homolog 2 (Drosophila)0.693
Bcl2B-cell leukemia/lymphoma 20.686
Hes1hairy and enhancer of split 1 (Drosophila)0.684
Id1inhibitor of DNA binding 10.675
Klc1kinesin light chain 10.672
Foxg1forkhead box G10.643
Sox11SRY-box containing gene 110.638
Mstnmyostatin0.636
Tcf3transcription factor 30.628
Itgb1integrin beta 1 (fibronectin receptor beta)0.621
Lgals3lectin, galactose binding, soluble 30.620
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.618
Hes5hairy and enhancer of split 5 (Drosophila)0.617
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.614
Leprleptin receptor0.614
S100a6S100 calcium binding protein A6 (calcyclin)0.614
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.612
Sox4SRY-box containing gene 40.580
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.579
Foxf1aforkhead box F1a0.557
Cd19CD19 antigen0.550
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.548
Pitx1paired-like homeodomain transcription factor 10.540
Tbx1T-box 10.532
Arrb1arrestin, beta 10.531
Bmpr1abone morphogenetic protein receptor, type 1A0.522
Smad1MAD homolog 1 (Drosophila)0.521
Thrathyroid hormone receptor alpha0.519
Lmx1aLIM homeobox transcription factor 1 alpha0.518
Zeb1zinc finger E-box binding homeobox 10.514
Myod1myogenic differentiation 10.513
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.511
Tlr4toll-like receptor 40.502
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.499
Nognoggin0.495
Hand2heart and neural crest derivatives expressed transcript 20.494
MecomMDS1 and EVI1 complex locus0.491
Neurod1neurogenic differentiation 10.487
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.486
Nrp1neuropilin 10.481
Vegfavascular endothelial growth factor A0.463
Fstfollistatin0.462
Foxn1forkhead box N10.461
Rac1RAS-related C3 botulinum substrate 10.459
Ptf1apancreas specific transcription factor, 1a0.448
Lhx3LIM homeobox protein 30.443
Lhx9LIM homeobox protein 90.443
Ifnar1interferon (alpha and beta) receptor 10.442
Csnk1ecasein kinase 1, epsilon0.442
Gpc3glypican 30.438
Neurog3neurogenin 30.430
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.429
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.426
Gata5GATA binding protein 50.422
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CKS1Cks1p0.011
CLB2Clb2p0.010