The network for 'regulation of jnk cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of jnk cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.

NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
EGFRepidermal growth factor receptor1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.999
MAP3K7mitogen-activated protein kinase kinase kinase 70.997
RIPK2receptor-interacting serine-threonine kinase 20.994
GSK3Bglycogen synthase kinase 3 beta0.993
CSNK1Ecasein kinase 1, epsilon0.989
SMAD2SMAD family member 20.975
TRAF1TNF receptor-associated factor 10.975
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.968
MAPK14mitogen-activated protein kinase 140.965
ZNF43zinc finger protein 430.964
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.963
BCAR1breast cancer anti-estrogen resistance 10.953
BIRC3baculoviral IAP repeat containing 30.945
BBS10Bardet-Biedl syndrome 100.941
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.935
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.918
TRAF6TNF receptor-associated factor 60.915
IL1R1interleukin 1 receptor, type I0.883
TRAF5TNF receptor-associated factor 50.878
ARRB1arrestin, beta 10.875
MYD88myeloid differentiation primary response gene (88)0.874
LATlinker for activation of T cells0.873
MAPK1mitogen-activated protein kinase 10.864
GRB2growth factor receptor-bound protein 20.856
AKT1v-akt murine thymoma viral oncogene homolog 10.847
TRAF2TNF receptor-associated factor 20.840
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.840
SH3KBP1SH3-domain kinase binding protein 10.826
CALM1calmodulin 1 (phosphorylase kinase, delta)0.826
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.825
RASSF5Ras association (RalGDS/AF-6) domain family member 50.817
ZNF253zinc finger protein 2530.815
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.809
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.809
MAPK8mitogen-activated protein kinase 80.786
LRRK2leucine-rich repeat kinase 20.778
STK4serine/threonine kinase 40.751
MAP2K7mitogen-activated protein kinase kinase 70.723
MAP3K5mitogen-activated protein kinase kinase kinase 50.710
ZNF273zinc finger protein 2730.706
ILKintegrin-linked kinase0.700
PTK2PTK2 protein tyrosine kinase 20.700
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.696
CCR5chemokine (C-C motif) receptor 50.688
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.682
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.661
SOS1son of sevenless homolog 1 (Drosophila)0.658
MAP3K11mitogen-activated protein kinase kinase kinase 110.587
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.581
GAB1GRB2-associated binding protein 10.576
SMURF2SMAD specific E3 ubiquitin protein ligase 20.570
FYNFYN oncogene related to SRC, FGR, YES0.546
ZNF746zinc finger protein 7460.544
ABI1abl-interactor 10.540
DUSP1dual specificity phosphatase 10.539
AXIN1axin 10.518
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.514
ZNF675zinc finger protein 6750.503
TNFtumor necrosis factor0.495
DVL3dishevelled, dsh homolog 3 (Drosophila)0.477
CTGFconnective tissue growth factor0.460
IRS1insulin receptor substrate 10.450
HSPB1heat shock 27kDa protein 10.443
SKILSKI-like oncogene0.439
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.435
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.419
CAV1caveolin 1, caveolae protein, 22kDa0.417
SH3BP2SH3-domain binding protein 20.411
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.410
PDCD6IPprogrammed cell death 6 interacting protein0.405
MAPK3mitogen-activated protein kinase 30.403
CD40CD40 molecule, TNF receptor superfamily member 50.402
SOCS1suppressor of cytokine signaling 10.392
RASA1RAS p21 protein activator (GTPase activating protein) 10.384
ZNF91zinc finger protein 910.370
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.366
TRADDTNFRSF1A-associated via death domain0.356
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.355
ZMYND11zinc finger, MYND-type containing 110.355
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.348
PTENphosphatase and tensin homolog0.342
BLNKB-cell linker0.337
C7orf36chromosome 7 open reading frame 360.327
CHUKconserved helix-loop-helix ubiquitous kinase0.325
ZNF85zinc finger protein 850.324
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.323
CAPZA2capping protein (actin filament) muscle Z-line, alpha 20.321
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.314
SMN1survival of motor neuron 1, telomeric0.312
SMAD3SMAD family member 30.302
ZNF512Bzinc finger protein 512B0.300
ZNF117zinc finger protein 1170.291
IRAK2interleukin-1 receptor-associated kinase 20.290
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.282
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.281
DVL1dishevelled, dsh homolog 1 (Drosophila)0.281
SOS2son of sevenless homolog 2 (Drosophila)0.280
NLRC4NLR family, CARD domain containing 40.277
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cst-1Protein CST-10.052
F21A10.2Protein F21A10.20.031
unc-129Protein UNC-1290.019
mig-15Protein MIG-150.015
dpy-22Protein DPY-220.015
sel-2Protein SEL-20.014
nipi-3Protein NIPI-30.014
eor-2Protein EOR-20.013
lat-1Protein LAT-10.013
tir-1Protein TIR-10.013
bar-1Protein BAR-10.012
nhr-6Protein NHR-60.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dkk1bdickkopf 1b0.038
nod1nucleotide-binding oligomerization domain containing 10.026
pias4aprotein inhibitor of activated STAT, 4a0.018
LOC557072caspase recruitment domain-containing protein 11-like0.017
dvl2dishevelled, dsh homolog 2 (Drosophila)0.016
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.016
fzd5frizzled homolog 50.016
notch3notch homolog 30.015
ripk2receptor-interacting serine-threonine kinase 20.015
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.014
fzd9bfrizzled homolog 9b0.014
fgf3fibroblast growth factor 30.011
wnt4awingless-type MMTV integration site family, member 4a0.011
st8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.010
jag2jagged 20.010
atp1b3aATPase, Na+/K+ transporting, beta 3a polypeptide0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.667
skpACG16983 gene product from transcript CG16983-RD0.396
PknProtein kinase related to protein kinase N0.350
p38bCG7393 gene product from transcript CG7393-RA0.332
Rho1CG8416 gene product from transcript CG8416-RB0.269
Akt1CG4006 gene product from transcript CG4006-RA0.240
par-1CG8201 gene product from transcript CG8201-RA0.232
POSHPlenty of SH3s0.199
chicoCG5686 gene product from transcript CG5686-RB0.174
Mpk2CG5475 gene product from transcript CG5475-RB0.168
Gap1GTPase-activating protein 10.164
Cip4CG15015 gene product from transcript CG15015-RA0.158
Sra-1specifically Rac1-associated protein 10.125
p120ctnAdherens junction protein p1200.121
RalaRas-related protein0.119
SosSon of sevenless0.116
Sir2CG5216 gene product from transcript CG5216-RA0.112
Cdc42CG12530 gene product from transcript CG12530-RA0.110
CG5794CG5794 gene product from transcript CG5794-RB0.108
JraJun-related antigen0.097
X11LCG5675 gene product from transcript CG5675-RB0.081
CG10743CG10743 gene product from transcript CG10743-RB0.074
dcodiscs overgrown0.073
SmoxSmad on X0.073
RhebCG1081 gene product from transcript CG1081-RA0.072
Rab5Rab-protein 50.071
p53CG33336 gene product from transcript CG33336-RB0.071
PGRP-SAPeptidoglycan recognition protein SA0.071
Myo31DFMyosin 31DF0.068
Toll-7CG8595 gene product from transcript CG8595-RA0.066
gekgenghis khan0.058
Klp64DKinesin-like protein at 64D0.057
PP2A-B'CG7913 gene product from transcript CG7913-RK0.056
Atg1Autophagy-specific gene 10.055
Tak1TGF-beta activated kinase 10.055
stcksteamer duck0.054
Rab7Rab-protein 70.053
PGRP-LFPeptidoglycan recognition protein LF0.052
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.052
debcldeath executioner Bcl-2 homologue0.052
PGRP-SDCG7496 gene product from transcript CG7496-RA0.051
piepineapple eye0.050
RYBPRing and YY1 Binding Protein0.049
HphHIF prolyl hydroxylase0.048
PGRP-LCPeptidoglycan recognition protein LC0.045
ShcSHC-adaptor protein0.044
CG32185CG32185 gene product from transcript CG32185-RA0.044
AblAbl tyrosine kinase0.043
WnkCG7177 gene product from transcript CG7177-RA0.043
Adf1Adh transcription factor 10.042
maskmultiple ankyrin repeats single KH domain0.041
Top1Topoisomerase 10.041
Pink1PTEN-induced putative kinase 10.040
shotshort stop0.039
CG18594CG18594 gene product from transcript CG18594-RA0.039
upd2unpaired 20.038
ThorCG8846 gene product from transcript CG8846-RA0.038
CG16718CG16718 gene product from transcript CG16718-RA0.038
Sema-1aCG18405 gene product from transcript CG18405-RD0.037
pirkpoor Imd response upon knock-in0.036
dlg1discs large 10.035
phlpole hole0.035
S6kRPS6-p70-protein kinase0.035
Sin3ACG8815 gene product from transcript CG8815-RC0.035
mib1mind bomb 10.035
Pk61CProtein kinase 61C0.035
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Traf6TNF receptor-associated factor 60.999
Mapk8mitogen-activated protein kinase 80.994
Dvl2dishevelled 2, dsh homolog (Drosophila)0.993
Tnftumor necrosis factor0.990
Cd40CD40 antigen0.985
Map3k7mitogen-activated protein kinase kinase kinase 70.976
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.968
Axin1axin 10.964
Myd88myeloid differentiation primary response gene 880.959
Mapk14mitogen-activated protein kinase 140.951
Tnfaip3tumor necrosis factor, alpha-induced protein 30.901
Casp4caspase 4, apoptosis-related cysteine peptidase0.876
Map3k14mitogen-activated protein kinase kinase kinase 140.861
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.848
Ctnnb1catenin (cadherin associated protein), beta 10.847
Vangl2vang-like 2 (van gogh, Drosophila)0.814
Plcg1phospholipase C, gamma 10.810
Ptenphosphatase and tensin homolog0.767
Klc1kinesin light chain 10.758
Prkceprotein kinase C, epsilon0.757
Rac1RAS-related C3 botulinum substrate 10.753
Apcadenomatosis polyposis coli0.722
Wnt3awingless-related MMTV integration site 3A0.694
Grb10growth factor receptor bound protein 100.688
Smad6MAD homolog 6 (Drosophila)0.669
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.665
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.645
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.644
Sfrp2secreted frizzled-related protein 20.614
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.608
Fzd8frizzled homolog 8 (Drosophila)0.604
Msr1macrophage scavenger receptor 10.586
Cxcl13chemokine (C-X-C motif) ligand 130.576
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.567
Ccl2chemokine (C-C motif) ligand 20.559
C3ar1complement component 3a receptor 10.552
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.536
Il1binterleukin 1 beta0.524
Wnt5awingless-related MMTV integration site 5A0.509
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.500
Cd44CD44 antigen0.496
FosFBJ osteosarcoma oncogene0.489
Metmet proto-oncogene0.449
Sfrp1secreted frizzled-related protein 10.440
Fgf18fibroblast growth factor 180.422
Gsk3bglycogen synthase kinase 3 beta0.418
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.411
Per2period homolog 2 (Drosophila)0.399
Efnb2ephrin B20.398
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.397
Smad7MAD homolog 7 (Drosophila)0.380
Ccr1chemokine (C-C motif) receptor 10.380
Dvl3dishevelled 3, dsh homolog (Drosophila)0.367
Clec4nC-type lectin domain family 4, member n0.365
Thbs1thrombospondin 10.363
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.360
Socs1suppressor of cytokine signaling 10.345
Irak4interleukin-1 receptor-associated kinase 40.340
Gopcgolgi associated PDZ and coiled-coil motif containing0.334
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.332
Cd86CD86 antigen0.331
Atf2activating transcription factor 20.328
SrcRous sarcoma oncogene0.323
Ltblymphotoxin B0.322
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.314
Cdx2caudal type homeobox 20.311
Epha4Eph receptor A40.307
Cd22CD22 antigen0.300
Ephb2Eph receptor B20.299
Cry2cryptochrome 2 (photolyase-like)0.296
Grap2GRB2-related adaptor protein 20.294
Cyldcylindromatosis (turban tumor syndrome)0.284
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.270
Fzd1frizzled homolog 1 (Drosophila)0.269
Ndel1nuclear distribution gene E-like homolog 1 (A. nidulans)0.269
Ikbkginhibitor of kappaB kinase gamma0.265
Ighimmunoglobulin heavy chain complex0.263
Dab1disabled homolog 1 (Drosophila)0.257
Parvaparvin, alpha0.256
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.255
Wnt7bwingless-related MMTV integration site 7B0.248
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.248
Gli2GLI-Kruppel family member GLI20.246
Mef2amyocyte enhancer factor 2A0.244
Ltalymphotoxin A0.243
Cd14CD14 antigen0.241
Ccl3chemokine (C-C motif) ligand 30.231
Cd19CD19 antigen0.229
Mecp2methyl CpG binding protein 20.225
Ikzf1IKAROS family zinc finger 10.223
Il4interleukin 40.220
Ptk7PTK7 protein tyrosine kinase 70.217
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.213
Cxcr5chemokine (C-X-C motif) receptor 50.210
Mapk9mitogen-activated protein kinase 90.205
Ephb3Eph receptor B30.204
Ccl4chemokine (C-C motif) ligand 40.200
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.195
Mdm2transformed mouse 3T3 cell double minute 20.187
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Grip1glutamate receptor interacting protein 10.535
Fkbp1aFK506 binding protein 1a0.370
Usf2upstream transcription factor 2, c-fos interacting0.296
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.283
Jtbjumping translocation breakpoint0.267
Mapk1mitogen activated protein kinase 10.244
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.218
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.204
Ube2bubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)0.190
Atp1b3ATPase, Na+/K+ transporting, beta 3 polypeptide0.156
Fgfr1Fibroblast growth factor receptor 10.135
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.122
Sh3bp1SH3-domain binding protein 10.115
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.113
Hsph1heat shock 105/110 protein 10.111
Ccl4chemokine (C-C motif) ligand 40.107
Grm7glutamate receptor, metabotropic 70.105
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.093
Zhx1zinc fingers and homeoboxes 10.087
Gria2glutamate receptor, ionotropic, AMPA 20.087
Mca32mast cell antigen 320.085
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.084
Sf1splicing factor 10.080
Cltcclathrin, heavy chain (Hc)0.078
Map2microtubule-associated protein 20.076
Arl5aADP-ribosylation factor-like 5A0.076
Ptp4a2protein tyrosine phosphatase 4a20.075
Gria1glutamate receptor, ionotropic, AMPA 10.074
Bcl2l2Bcl2-like 20.071
Zfp36zinc finger protein 360.067
Ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.067
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.063
Mapk8mitogen-activated protein kinase 80.061
Myd88myeloid differentiation primary response gene 880.058
Itgamintegrin, alpha M0.058
Jak1Janus kinase 10.056
Map3k1mitogen activated protein kinase kinase kinase 10.056
Nudt3nudix (nucleoside diphosphate linked moiety X)-type motif 30.055
Atf2activating transcription factor 20.054
Col5a2collagen, type V, alpha 20.054
Eef2eukaryotic translation elongation factor 20.053
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.053
Elf1E74-like factor 10.052
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.051
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.049
St13suppression of tumorigenicity 130.048
Ptgs2prostaglandin-endoperoxide synthase 20.047
Kcnk1potassium channel, subfamily K, member 10.047
Prkcbprotein kinase C, beta0.046
Rab10RAB10, member RAS oncogene family0.045
Gnrhrgonadotropin releasing hormone receptor0.044
Gltpglycolipid transfer protein0.043
Homer1homer homolog 1 (Drosophila)0.043
Itpr1inositol 1,4,5-triphosphate receptor, type 10.043
Nek9NIMA (never in mitosis gene a)- related kinase 90.042
Ccnl1cyclin L10.041
Cttnbp2cortactin binding protein 20.041
Fkbp4FK506 binding protein 40.040
Il1binterleukin 1 beta0.038
Socs3suppressor of cytokine signaling 30.038
Chordc1cysteine and histidine-rich domain (CHORD)-containing 10.037
Dpp9dipeptidyl peptidase 90.037
Tfebtranscription factor EB0.036
Gatad1GATA zinc finger domain containing 10.036
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.035
Cry2cryptochrome 2 (photolyase-like)0.035
Pdp1pyruvate dehyrogenase phosphatase catalytic subunit 10.034
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.034
Rps6ka1ribosomal protein S6 kinase polypeptide 10.034
Tgfb2transforming growth factor, beta 20.034
Gna12guanine nucleotide binding protein (G protein) alpha 120.033
LOC286960preprotrypsinogen IV0.032
Adora2aadenosine A2a receptor0.032
Zfp706zinc finger protein 7060.032
Vegfavascular endothelial growth factor A0.032
Il1r1interleukin 1 receptor, type I0.031
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.031
Mapk9mitogen-activated protein kinase 90.031
Gria3glutamate receptor, ionotrophic, AMPA 30.030
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.030
Bap1BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)0.029
Stat3signal transducer and activator of transcription 30.029
Hist1h1ahistone cluster 1, H1a0.028
SnrkSNF related kinase0.028
Eif5beukaryotic translation initiation factor 5B0.028
RGD1305793similar to hypothetical protein FLJ201540.028
Hspd1heat shock protein 1 (chaperonin)0.028
Plac8placenta-specific 80.028
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.028
Abcb4ATP-binding cassette, subfamily B (MDR/TAP), member 40.028
March5membrane-associated ring finger (C3HC4) 50.027
Oaz2ornithine decarboxylase antizyme 20.027
Vat1vesicle amine transport protein 1 homolog (T californica)0.027
Plscr3phospholipid scramblase 30.026
Akr1b7aldo-keto reductase family 1, member B70.026
Ifit1interferon-induced protein with tetratricopeptide repeats 10.026
RybpRING1 and YY1 binding protein0.026
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism