The network for 'leukocyte chemotaxis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

NameDescriptionProbabilityFunc Analog Organism
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.995
CCR5chemokine (C-C motif) receptor 50.994
LATlinker for activation of T cells0.990
S100A6S100 calcium binding protein A60.990
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.987
SYKspleen tyrosine kinase0.984
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.952
VEGFAvascular endothelial growth factor A0.933
IL8interleukin 80.913
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.909
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.879
CXCL9chemokine (C-X-C motif) ligand 90.876
S100A11S100 calcium binding protein A110.855
CCL5chemokine (C-C motif) ligand 50.841
LCKlymphocyte-specific protein tyrosine kinase0.831
S100A9S100 calcium binding protein A90.830
CXCL2chemokine (C-X-C motif) ligand 20.809
TIMP1TIMP metallopeptidase inhibitor 10.801
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.680
MPZL2myelin protein zero-like 20.677
CCL22chemokine (C-C motif) ligand 220.657
CCR7chemokine (C-C motif) receptor 70.642
CXCL3chemokine (C-X-C motif) ligand 30.633
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.605
S100A8S100 calcium binding protein A80.601
NCF2neutrophil cytosolic factor 20.600
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.580
CCL2chemokine (C-C motif) ligand 20.572
S100A16S100 calcium binding protein A160.565
PLAURplasminogen activator, urokinase receptor0.565
MDM2Mdm2 p53 binding protein homolog (mouse)0.560
DPP4dipeptidyl-peptidase 40.560
MPZL3myelin protein zero-like 30.523
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.514
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.494
CCL20chemokine (C-C motif) ligand 200.492
IL6interleukin 6 (interferon, beta 2)0.486
NRP1neuropilin 10.485
AXLAXL receptor tyrosine kinase0.470
PDIA3protein disulfide isomerase family A, member 30.469
IFNGinterferon, gamma0.438
ANXA2annexin A20.434
LST1leukocyte specific transcript 10.421
CD28CD28 molecule0.412
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.400
CCL19chemokine (C-C motif) ligand 190.394
CCL8chemokine (C-C motif) ligand 80.390
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.383
CAV1caveolin 1, caveolae protein, 22kDa0.376
PTPN1protein tyrosine phosphatase, non-receptor type 10.373
S100A14S100 calcium binding protein A140.372
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.369
CXCR4chemokine (C-X-C motif) receptor 40.349
CXCL5chemokine (C-X-C motif) ligand 50.335
CCL7chemokine (C-C motif) ligand 70.322
GAS7growth arrest-specific 70.320
GRB2growth factor receptor-bound protein 20.318
SLASrc-like-adaptor0.317
CCL13chemokine (C-C motif) ligand 130.310
CXCL13chemokine (C-X-C motif) ligand 130.309
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.307
BAXBCL2-associated X protein0.302
JAK1Janus kinase 10.299
LAIR1leukocyte-associated immunoglobulin-like receptor 10.298
CXCL10chemokine (C-X-C motif) ligand 100.291
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.275
PTPRCprotein tyrosine phosphatase, receptor type, C0.271
IL1Binterleukin 1, beta0.269
ABI2abl-interactor 20.242
IL10interleukin 100.238
EGFRepidermal growth factor receptor0.236
CCL11chemokine (C-C motif) ligand 110.215
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.212
PLATplasminogen activator, tissue0.212
MMP12matrix metallopeptidase 12 (macrophage elastase)0.207
CCR1chemokine (C-C motif) receptor 10.201
AREGamphiregulin0.199
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.199
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.194
TMSB10thymosin beta 100.194
VIMvimentin0.191
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.187
ALOX5arachidonate 5-lipoxygenase0.187
GAB1GRB2-associated binding protein 10.186
MTORmechanistic target of rapamycin (serine/threonine kinase)0.186
VCAM1vascular cell adhesion molecule 10.184
PLEKpleckstrin0.181
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.179
IL2RGinterleukin 2 receptor, gamma0.177
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.175
RICTORRPTOR independent companion of MTOR, complex 20.174
PLCG1phospholipase C, gamma 10.173
PPBPpro-platelet basic protein (chemokine (C-X-C motif) ligand 7)0.172
CDH5cadherin 5, type 2 (vascular endothelium)0.169
S100A12S100 calcium binding protein A120.167
CXCL11chemokine (C-X-C motif) ligand 110.167
COL4A1collagen, type IV, alpha 10.165
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.163
APOEapolipoprotein E0.162
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.161
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mmp9matrix metalloproteinase 90.736
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.326
csf3rcolony stimulating factor 3 receptor (granulocyte)0.220
nod1nucleotide-binding oligomerization domain containing 10.197
csf1racolony stimulating factor 1 receptor, a0.153
cdh5cadherin 50.141
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.116
btkBruton agammaglobulinemia tyrosine kinase0.109
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.097
si:dkey-12o15.1si:dkey-12o15.10.092
st14asuppression of tumorigenicity 14 (colon carcinoma) a0.090
mpxmyeloid-specific peroxidase0.088
lyzlysozyme0.085
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.078
mmp13amatrix metalloproteinase 13a0.072
kdrlkinase insert domain receptor like0.068
ptpn6protein tyrosine phosphatase, non-receptor type 60.061
LOC553366hypothetical protein LOC5533660.059
myhz2myosin, heavy polypeptide 2, fast muscle specific0.058
vegfcvascular endothelial growth factor c0.054
si:ch211-212m21.5si:ch211-212m21.50.051
sulf1sulfatase 10.051
zgc:101614zgc:1016140.049
spns2spinster homolog 2 (Drosophila)0.047
kirrel3lkin of IRRE like 3 like0.046
jam2ajunctional adhesion molecule 2a0.045
tie2endothelium-specific receptor tyrosine kinase 20.043
fabp11afatty acid binding protein 11a0.042
cdh1cadherin 1, epithelial0.041
myf5myogenic factor 50.039
zgc:110010zgc:1100100.037
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.037
lta4hleukotriene A4 hydrolase0.037
epas1bendothelial PAS domain protein 1b0.035
vegfaavascular endothelial growth factor Aa0.034
tie1endothelium-specific receptor tyrosine kinase 10.033
f11rF11 receptor0.033
col4a5collagen, type IV, alpha 5 (Alport syndrome)0.032
esrp2epithelial splicing regulatory protein 20.031
fli1afriend leukemia integration 1a0.030
ptprcprotein tyrosine phosphatase, receptor type, C0.030
hspa12bheat shock protein 12B0.030
col12a1collagen, type XII, alpha 10.030
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.029
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.029
ncf1neutrophil cytosolic factor 10.029
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.028
sox7SRY-box containing gene 70.027
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.026
tjp2atight junction protein 2a (zona occludens 2)0.026
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.026
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.025
im:7154036im:71540360.025
angptl7angiopoietin-like 70.025
snrk1SNF related kinase 10.024
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.024
plxnd1plexin D10.023
ntn1anetrin 1a0.023
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.023
dll4delta-like 4 (Drosophila)0.023
sheSrc homology 2 domain containing E0.023
lrrc33leucine rich repeat containing 330.022
nr1h5nuclear receptor subfamily 1, group H, member 50.022
il8interleukin 80.022
LOC100151531zinc finger protein Gfi-1b-like0.021
tm4sf4transmembrane 4 L six family member 40.021
pax7bpaired box gene 7b0.020
si:ch211-284e13.2si:ch211-284e13.20.020
metap2methionyl aminopeptidase 20.019
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.018
eng1aengrailed 1a0.018
mapk15mitogen-activated protein kinase 150.018
irf8interferon regulatory factor 80.018
il1binterleukin 1, beta and interleukin 1, beta0.017
dlcdeltaC0.017
stc1lstanniocalcin 1, like0.017
myd88myeloid differentiation primary response gene (88)0.017
tnfatumor necrosis factor a (TNF superfamily, member 2)0.017
spint1bserine peptidase inhibitor, Kunitz type 1 b0.016
pcsk5aproprotein convertase subtilisin/kexin type 5a0.016
spon2aspondin 2a, extracellular matrix protein0.016
adora2badenosine A2b receptor0.016
slco2b1solute carrier organic anion transporter family, member 2B10.016
wtipWilms tumor 1 interacting protein0.016
mrc1amannose receptor, C type 1a0.016
fli1bfriend leukemia integration 1b0.015
f2rcoagulation factor II (thrombin) receptor0.015
ca15acarbonic anhydrase XV a0.015
LOC557072caspase recruitment domain-containing protein 11-like0.015
lrrc6leucine rich repeat containing 60.015
adora2aaadenosine A2a receptor a0.015
fevFEV (ETS oncogene family)0.015
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.015
sb:cb930sb:cb9300.015
ptch2patched 20.015
igfbp1binsulin-like growth factor binding protein 1b0.015
rhagRhesus blood group-associated glycoprotein0.015
gmfgglia maturation factor, gamma0.015
plce1phospholipase C, epsilon 10.015
vtg7vitellogenin 70.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Selpselectin, platelet0.956
Ccr2chemokine (C-C motif) receptor 20.942
Clec4dC-type lectin domain family 4, member d0.936
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.910
Itgaxintegrin alpha X0.909
Cd44CD44 antigen0.898
Mmp9matrix metallopeptidase 90.898
Il1binterleukin 1 beta0.892
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.877
S100a8S100 calcium binding protein A8 (calgranulin A)0.867
C5ar1complement component 5a receptor 10.855
Ccl3chemokine (C-C motif) ligand 30.845
C3ar1complement component 3a receptor 10.806
Csf1colony stimulating factor 1 (macrophage)0.780
Il1rninterleukin 1 receptor antagonist0.762
Ccr1chemokine (C-C motif) receptor 10.745
Cxcl13chemokine (C-X-C motif) ligand 130.728
Ltblymphotoxin B0.727
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.712
Fcgr1Fc receptor, IgG, high affinity I0.709
Cxcr2chemokine (C-X-C motif) receptor 20.685
Ccl2chemokine (C-C motif) ligand 20.668
Apoeapolipoprotein E0.666
Cd40CD40 antigen0.628
Slfn1schlafen 10.596
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.590
AF251705cDNA sequence AF2517050.589
Msr1macrophage scavenger receptor 10.584
Sirpasignal-regulatory protein alpha0.578
Itgb1integrin beta 1 (fibronectin receptor beta)0.577
Mmp8matrix metallopeptidase 80.570
Kitlkit ligand0.551
Cx3cr1chemokine (C-X3-C) receptor 10.535
Cd3eCD3 antigen, epsilon polypeptide0.521
Il7rinterleukin 7 receptor0.518
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.517
Sellselectin, lymphocyte0.515
Cxcl2chemokine (C-X-C motif) ligand 20.478
S100a4S100 calcium binding protein A40.467
Itgb3integrin beta 30.465
Slit3slit homolog 3 (Drosophila)0.432
Il1ainterleukin 1 alpha0.424
Mitfmicrophthalmia-associated transcription factor0.417
Itgamintegrin alpha M0.415
Map3k14mitogen-activated protein kinase kinase kinase 140.415
Flt1FMS-like tyrosine kinase 10.414
Ccl7chemokine (C-C motif) ligand 70.411
Gzmbgranzyme B0.405
Mmp12matrix metallopeptidase 120.402
Ccl12chemokine (C-C motif) ligand 120.395
S100a9S100 calcium binding protein A9 (calgranulin B)0.393
Ifnginterferon gamma0.389
TyrobpTYRO protein tyrosine kinase binding protein0.388
Selplgselectin, platelet (p-selectin) ligand0.386
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.381
Cxcl1chemokine (C-X-C motif) ligand 10.379
Rab3il1RAB3A interacting protein (rabin3)-like 10.371
Sfpi1SFFV proviral integration 10.370
Vav1vav 1 oncogene0.370
Prrx1paired related homeobox 10.367
Itgb2integrin beta 20.360
Lyz2lysozyme 20.360
Tgfb1transforming growth factor, beta 10.360
Seleselectin, endothelial cell0.359
Cd22CD22 antigen0.352
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.349
Klrg1killer cell lectin-like receptor subfamily G, member 10.348
Acvrl1activin A receptor, type II-like 10.348
Cybbcytochrome b-245, beta polypeptide0.341
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.336
Dlg1discs, large homolog 1 (Drosophila)0.336
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.335
Gm14548predicted gene 145480.326
Tgfb2transforming growth factor, beta 20.316
S100a6S100 calcium binding protein A6 (calcyclin)0.310
Fpr2formyl peptide receptor 20.298
Mmp3matrix metallopeptidase 30.296
Efnb2ephrin B20.296
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.294
Irf1interferon regulatory factor 10.293
Hckhemopoietic cell kinase0.287
Has1hyaluronan synthase10.286
Ltbp2latent transforming growth factor beta binding protein 20.285
Ccl17chemokine (C-C motif) ligand 170.282
Cxcl5chemokine (C-X-C motif) ligand 50.280
Tgfbr2transforming growth factor, beta receptor II0.280
Klrk1killer cell lectin-like receptor subfamily K, member 10.277
Cdh5cadherin 50.274
Anxa2annexin A20.273
Il18rapinterleukin 18 receptor accessory protein0.271
Ctnnb1catenin (cadherin associated protein), beta 10.268
H2-DMahistocompatibility 2, class II, locus DMa0.268
Il16interleukin 160.265
Ncf1neutrophil cytosolic factor 10.262
Myo1fmyosin IF0.255
Rspo2R-spondin 2 homolog (Xenopus laevis)0.255
H2-Eb1histocompatibility 2, class II antigen E beta0.253
Aoahacyloxyacyl hydrolase0.251
Ednrbendothelin receptor type B0.247
Pcdh12protocadherin 120.244
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ccl4chemokine (C-C motif) ligand 40.889
Cd14CD14 molecule0.809
Il1binterleukin 1 beta0.770
Ccl2chemokine (C-C motif) ligand 20.722
Ccl3chemokine (C-C motif) ligand 30.669
S100a9S100 calcium binding protein A90.647
Cxcl2chemokine (C-X-C motif) ligand 20.637
Cxcl10chemokine (C-X-C motif) ligand 100.617
S100a8S100 calcium binding protein A80.523
Il1ainterleukin 1 alpha0.458
Il6interleukin 60.430
Cd83CD83 molecule0.424
Hckhemopoietic cell kinase0.368
TcrbT-cell receptor beta chain0.265
Tnftumor necrosis factor (TNF superfamily, member 2)0.256
Cd53Cd53 molecule0.239
Ccl7chemokine (C-C motif) ligand 70.210
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.199
Laptm5lysosomal protein transmembrane 50.187
Ctsscathepsin S0.182
Cd37CD37 molecule0.170
S100a4S100 calcium-binding protein A40.164
Cd68Cd68 molecule0.162
Sellselectin L0.158
Il8rbinterleukin 8 receptor, beta0.157
Arpc1bactin related protein 2/3 complex, subunit 1B0.157
Ptprcprotein tyrosine phosphatase, receptor type, C0.137
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.135
Hpgdshematopoietic prostaglandin D synthase0.126
Rac2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.122
Plekpleckstrin0.116
Neurl3neuralized homolog 3 (Drosophila)0.114
Seleselectin E0.114
F2rl1coagulation factor II (thrombin) receptor-like 10.104
Anxa1annexin A10.090
Ripk3receptor-interacting serine-threonine kinase 30.082
Igsf6immunoglobulin superfamily, member 60.078
Calcrlcalcitonin receptor-like0.073
Adam2ADAM metallopeptidase domain 20.071
Cd3gCD3 molecule, gamma0.071
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.069
Utrnutrophin0.066
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.061
Cd86CD86 molecule0.061
Fgfr2fibroblast growth factor receptor 20.060
Ccr5chemokine (C-C motif) receptor 50.060
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.059
Nkg7natural killer cell group 7 sequence0.058
Nek9NIMA (never in mitosis gene a)- related kinase 90.057
Clec2dC-type lectin domain family 2, member d0.056
Thbdthrombomodulin0.056
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.055
Pfn1profilin 10.055
Mmp12matrix metallopeptidase 120.050
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.050
Col12a1collagen, type XII, alpha 10.049
Ly86lymphocyte antigen 860.048
Mapk1mitogen activated protein kinase 10.047
Pla1aphospholipase A1 member A0.046
Cd69Cd69 molecule0.045
Klrd1killer cell lectin-like receptor, subfamily D, member 10.045
S100a10S100 calcium binding protein A100.044
Gzmkgranzyme K0.044
ArhgdibRho, GDP dissociation inhibitor (GDI) beta0.043
Ptgs2prostaglandin-endoperoxide synthase 20.043
Gzmcgranzyme C0.043
Vcanversican0.042
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.042
Iappislet amyloid polypeptide0.041
Slco2b1solute carrier organic anion transporter family, member 2b10.041
Ccl20chemokine (C-C motif) ligand 200.039
Timp1TIMP metallopeptidase inhibitor 10.038
Reg3gregenerating islet-derived 3 gamma0.037
Olr1500olfactory receptor 15000.037
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.036
Cxcl3chemokine (C-X-C motif) ligand 30.036
Ptafrplatelet-activating factor receptor0.036
Reg3bregenerating islet-derived 3 beta0.036
Syn1synapsin I0.035
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.034
Tgm1transglutaminase 1, K polypeptide0.034
Cnp2',3'-cyclic nucleotide 3' phosphodiesterase0.034
Plauplasminogen activator, urokinase0.034
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.034
Ccr2chemokine (C-C motif) receptor 20.033
F2rl2coagulation factor II (thrombin) receptor-like 20.033
Cstbcystatin B (stefin B)0.031
Fut2fucosyltransferase 2 (secretor status included)0.031
Ptger4prostaglandin E receptor 4 (subtype EP4)0.031
Elk3ELK3, ETS-domain protein0.030
GperG protein-coupled estrogen receptor 10.029
Edn1endothelin 10.029
Socs3suppressor of cytokine signaling 30.029
Stx11syntaxin 110.029
Rab10RAB10, member RAS oncogene family0.028
RT1-BaRT1 class II, locus Ba0.027
Rab20RAB20, member RAS oncogene family0.027
Cd5Cd5 molecule0.027
Ivlinvolucrin0.027
Rnf4ring finger protein 40.027
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism