The network for 'response to alcohol' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to alcohol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor0.994
ESR1estrogen receptor 10.992
RARAretinoic acid receptor, alpha0.919
IL8interleukin 80.849
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.845
RXRAretinoid X receptor, alpha0.814
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.773
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.773
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.766
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.755
PTPN1protein tyrosine phosphatase, non-receptor type 10.746
SMAD2SMAD family member 20.741
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.727
ARandrogen receptor0.672
IL2RBinterleukin 2 receptor, beta0.668
CCL5chemokine (C-C motif) ligand 50.637
DLG4discs, large homolog 4 (Drosophila)0.629
FGFR2fibroblast growth factor receptor 20.594
CCR5chemokine (C-C motif) receptor 50.540
NR4A1nuclear receptor subfamily 4, group A, member 10.494
NCOA1nuclear receptor coactivator 10.474
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.472
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.470
BCL2B-cell CLL/lymphoma 20.469
IL6interleukin 6 (interferon, beta 2)0.466
THBS1thrombospondin 10.451
EGR1early growth response 10.434
FN1fibronectin 10.426
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.423
CAV1caveolin 1, caveolae protein, 22kDa0.416
CREBBPCREB binding protein0.413
GSK3Bglycogen synthase kinase 3 beta0.409
SMAD1SMAD family member 10.398
MDM2Mdm2 p53 binding protein homolog (mouse)0.392
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.391
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.380
NRP1neuropilin 10.380
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.368
NCF1neutrophil cytosolic factor 10.347
EPORerythropoietin receptor0.345
CCL2chemokine (C-C motif) ligand 20.326
CCL4chemokine (C-C motif) ligand 40.305
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.301
CRHR1corticotropin releasing hormone receptor 10.300
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.298
HDAC1histone deacetylase 10.294
DAXXdeath-domain associated protein0.288
SLMAPsarcolemma associated protein0.273
PPARAperoxisome proliferator-activated receptor alpha0.263
SMAD7SMAD family member 70.263
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.262
NCOR1nuclear receptor corepressor 10.262
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.253
CCL22chemokine (C-C motif) ligand 220.247
HNF4Ahepatocyte nuclear factor 4, alpha0.243
CXCL9chemokine (C-X-C motif) ligand 90.239
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.230
ACACAacetyl-CoA carboxylase alpha0.227
HSPB1heat shock 27kDa protein 10.224
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.222
NR0B1nuclear receptor subfamily 0, group B, member 10.220
IL4Rinterleukin 4 receptor0.219
BMP2bone morphogenetic protein 20.211
TP53tumor protein p530.210
FSTL1follistatin-like 10.208
SIRT1sirtuin 10.208
TGFB1transforming growth factor, beta 10.202
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.200
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.198
SHC1SHC (Src homology 2 domain containing) transforming protein 10.196
BRCA1breast cancer 1, early onset0.192
XIAPX-linked inhibitor of apoptosis0.192
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.188
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.179
IFNGinterferon, gamma0.176
VCAM1vascular cell adhesion molecule 10.174
CCND1cyclin D10.169
JAK2Janus kinase 20.167
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.166
TBX5T-box 50.165
MAP3K11mitogen-activated protein kinase kinase kinase 110.165
TNFtumor necrosis factor0.159
PAX8paired box 80.157
NRIP1nuclear receptor interacting protein 10.156
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.149
ARRB1arrestin, beta 10.148
ADNPactivity-dependent neuroprotector homeobox0.148
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.146
MAPK14mitogen-activated protein kinase 140.143
MAPK8mitogen-activated protein kinase 80.140
JAK1Janus kinase 10.139
BAXBCL2-associated X protein0.134
ATF2activating transcription factor 20.133
JUNjun proto-oncogene0.133
MAPK3mitogen-activated protein kinase 30.129
APAF1apoptotic peptidase activating factor 10.126
SRFserum response factor (c-fos serum response element-binding transcription factor)0.126
SOCS5suppressor of cytokine signaling 50.125
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.124
PLAUplasminogen activator, urokinase0.121
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
apoebapolipoprotein Eb0.481
shhasonic hedgehog a0.413
inhbaainhibin, beta Aa0.389
socs3asuppressor of cytokine signaling 3a0.375
nrp2bneuropilin 2b0.313
sox11aSRY-box containing gene 11a0.199
ptgs2aprostaglandin-endoperoxide synthase 2a0.178
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.143
col1a1acollagen, type I, alpha 1a0.142
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.136
ptprfprotein tyrosine phosphatase, receptor type, F0.089
otx2orthodenticle homolog 20.089
dag1dystroglycan 10.081
gpr126G protein-coupled receptor 1260.075
acvr2aactivin receptor IIa0.073
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.072
esrrgaestrogen-related receptor gamma a0.070
uts1urotensin 10.070
esr1estrogen receptor 10.068
per2period homolog 2 (Drosophila)0.066
ca2carbonic anhydrase II0.061
evx1even-skipped homeobox 10.061
alcamaactivated leukocyte cell adhesion molecule a0.057
igf3insulin-like growth factor 30.055
gdf11growth differentiation factor 110.054
cbr1lcarbonyl reductase 1-like0.053
cyp3a65cytochrome P450, family 3, subfamily A, polypeptide 650.052
itgb1aintegrin, beta 1a0.050
robo2roundabout homolog 20.050
pcnaproliferating cell nuclear antigen0.049
gcm2glial cells missing homolog 2 (Drosophila)0.048
ctsbacathepsin B, a0.048
maomonoamine oxidase0.045
dab1adisabled homolog 1a (Drosophila)0.045
ca8carbonic anhydrase VIII0.045
ppargc1alperoxisome proliferator-activated receptor gamma, coactivator 1 alpha like0.044
fzd7afrizzled homolog 7a0.044
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.041
pdia4protein disulfide isomerase associated 40.040
rc3rabconnectin 30.040
igf2binsulin-like growth factor 2b0.039
paqr7bprogestin and adipoQ receptor family member VII, b0.038
pcp4aPurkinje cell protein 4a0.038
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.038
ripk2receptor-interacting serine-threonine kinase 20.037
cry1acryptochrome 1a0.037
spry4sprouty (Drosophila) homolog 40.037
inhainhibin, alpha0.037
cadm1bcell adhesion molecule 1b0.037
cry3cryptochrome 30.037
trpm7transient receptor potential cation channel, subfamily M, member 70.036
chrm2acholinergic receptor, muscarinic 2a0.035
fgf3fibroblast growth factor 30.035
bcl2B-cell leukemia/lymphoma 20.034
sept9aseptin 9a0.034
tgfbr2transforming growth factor, beta receptor II0.033
hsp90a.1heat shock protein 90-alpha 10.033
mmp9matrix metalloproteinase 90.032
gdf9growth differentiation factor 90.032
bcl2l1bcl2-like 10.031
foxi1forkhead box I10.031
mmp2matrix metalloproteinase 20.031
gfra1agdnf family receptor alpha 1a0.031
mycamyelocytomatosis oncogene a0.030
nr2f1bnuclear receptor subfamily 2, group F, member 1b0.030
th2tyrosine hydroxylase 20.030
mapk1mitogen-activated protein kinase 10.030
epas1bendothelial PAS domain protein 1b0.029
ahi1Abelson helper integration site 10.029
nrg1neuregulin 10.028
robo3roundabout homolog 30.028
calrcalreticulin and calreticulin0.028
thtyrosine hydroxylase0.027
ctszcathepsin Z0.027
glud1aglutamate dehydrogenase 1a0.027
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.027
nr1d1nuclear receptor subfamily 1, group d, member 10.027
mef2dmyocyte enhancer factor 2d0.026
junbjun B proto-oncogene0.025
fzd8bfrizzled homolog 8b0.025
avplarginine vasopressin-like0.025
wnt10awingless-type MMTV integration site family, member 10a0.025
kif5ckinesin family member 5C0.025
ptgs1prostaglandin-endoperoxide synthase 10.025
slit3slit (Drosophila) homolog 30.025
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.025
bhmtbetaine-homocysteine methyltransferase0.025
tfap2atranscription factor AP-2 alpha0.025
lhx3LIM homeobox 30.024
chrna4cholinergic receptor, nicotinic, alpha 40.024
fgfr4fibroblast growth factor receptor 40.024
zbtb10zinc finger and BTB domain containing 100.024
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.024
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.024
dbhdopamine beta hydroxylase0.023
wif1wnt inhibitory factor 10.023
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
TBPHCG10327 gene product from transcript CG10327-RC0.971
Fas2Fasciclin 20.826
EcREcdysone receptor0.825
mewmultiple edematous wings0.805
Ras85DRas oncogene at 85D0.780
EgfrEpidermal growth factor receptor0.712
argosCG4531 gene product from transcript CG4531-RA0.613
Ced-12CG5336 gene product from transcript CG5336-RA0.603
CG7998CG7998 gene product from transcript CG7998-RA0.526
bvesCG32513 gene product from transcript CG32513-RA0.493
InRInsulin-like receptor0.473
S6kRPS6-p70-protein kinase0.453
Sir2CG5216 gene product from transcript CG5216-RA0.423
ph-ppolyhomeotic proximal0.422
JheJuvenile hormone esterase0.373
CG17734CG17734 gene product from transcript CG17734-RA0.343
DscamDown syndrome cell adhesion molecule0.318
drkdownstream of receptor kinase0.312
eveeven skipped0.310
Pkc98EProtein C kinase 98E0.295
Nmdar1NMDA receptor 10.292
NPFR1neuropeptide F receptor0.286
easeasily shocked0.263
gcmglial cells missing0.258
BRWD3CG31132 gene product from transcript CG31132-RA0.253
CG13253CG13253 gene product from transcript CG13253-RB0.238
gfAgiant fibre A0.234
tauCG31057 gene product from transcript CG31057-RA0.233
Pi3K92ECG4141 gene product from transcript CG4141-RB0.224
yuCG3249 gene product from transcript CG3249-RA0.216
Spn27ASerpin 27A0.214
mbmmushroom body miniature0.206
Rac1CG2248 gene product from transcript CG2248-RA0.204
CG3011CG3011 gene product from transcript CG3011-RA0.202
TbhTyramine beta hydroxylase0.183
Akap200A kinase anchor protein 2000.177
Tao-1CG14217 gene product from transcript CG14217-RF0.175
2mitCG42573 gene product from transcript CG42573-RA0.171
TrhTryptophan hydroxylase0.169
AcCoASAcetyl Coenzyme A synthase0.169
Patr-1Protein associated with topo II related - 10.168
CG8773CG8773 gene product from transcript CG8773-RB0.164
rictorrapamycin-insensitive companion of Tor0.164
Or83bOdorant receptor 83b0.162
MtpMicrosomal triacylglycerol transfer protein0.151
Nf-YCNuclear factor Y-box C0.150
CG34168CG34168 gene product from transcript CG34168-RA0.150
HopHsp70/Hsp90 organizing protein homolog0.149
vvlventral veins lacking0.143
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.999
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.999
Nos3nitric oxide synthase 3, endothelial cell0.998
Drd2dopamine receptor D20.994
Apcadenomatosis polyposis coli0.985
Esr1estrogen receptor 1 (alpha)0.983
Ptenphosphatase and tensin homolog0.967
Arandrogen receptor0.965
Fshrfollicle stimulating hormone receptor0.952
Tgfb1transforming growth factor, beta 10.950
Stat3signal transducer and activator of transcription 30.934
Ptgs2prostaglandin-endoperoxide synthase 20.906
Ptpn11protein tyrosine phosphatase, non-receptor type 110.883
Nos1nitric oxide synthase 1, neuronal0.850
Csf1colony stimulating factor 1 (macrophage)0.815
Ccl2chemokine (C-C motif) ligand 20.812
Bglapbone gamma carboxyglutamate protein0.737
Prlrprolactin receptor0.733
Robo1roundabout homolog 1 (Drosophila)0.697
Agtr1aangiotensin II receptor, type 1a0.689
Pgrprogesterone receptor0.658
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.608
Slc12a1solute carrier family 12, member 10.604
Nr3c1nuclear receptor subfamily 3, group C, member 10.587
Prkceprotein kinase C, epsilon0.580
Smad3MAD homolog 3 (Drosophila)0.575
Fgfr2fibroblast growth factor receptor 20.566
Cdk4cyclin-dependent kinase 40.552
Amhr2anti-Mullerian hormone type 2 receptor0.551
Ren1renin 1 structural0.550
Cdkn1bcyclin-dependent kinase inhibitor 1B0.534
Tlr4toll-like receptor 40.506
Ifnginterferon gamma0.497
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.490
Tgfbr2transforming growth factor, beta receptor II0.487
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.473
Itgb1integrin beta 1 (fibronectin receptor beta)0.462
Ptk2PTK2 protein tyrosine kinase 20.457
Insrinsulin receptor0.430
Bmpr1abone morphogenetic protein receptor, type 1A0.422
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.418
Sox4SRY-box containing gene 40.410
Cd44CD44 antigen0.401
Pthlhparathyroid hormone-like peptide0.382
Ldb3LIM domain binding 30.379
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.377
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.374
Nos2nitric oxide synthase 2, inducible0.354
Clockcircadian locomotor output cycles kaput0.349
Gdnfglial cell line derived neurotrophic factor0.348
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.337
Vegfavascular endothelial growth factor A0.332
Rxraretinoid X receptor alpha0.327
Ezh2enhancer of zeste homolog 2 (Drosophila)0.318
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.312
Nf1neurofibromatosis 10.299
Ptprcprotein tyrosine phosphatase, receptor type, C0.296
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.296
Ccr2chemokine (C-C motif) receptor 20.281
Ghrgrowth hormone receptor0.272
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.267
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.262
Mef2amyocyte enhancer factor 2A0.254
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.252
Tgfbr1transforming growth factor, beta receptor I0.251
Smad4MAD homolog 4 (Drosophila)0.248
Rargretinoic acid receptor, gamma0.248
Keg1kidney expressed gene 10.244
Agtr2angiotensin II receptor, type 20.235
BlnkB-cell linker0.231
Thrbthyroid hormone receptor beta0.225
F2rcoagulation factor II (thrombin) receptor0.223
SrcRous sarcoma oncogene0.219
Gli2GLI-Kruppel family member GLI20.216
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.215
Rararetinoic acid receptor, alpha0.214
FasFas (TNF receptor superfamily member 6)0.214
Mas1MAS1 oncogene0.213
Foxa2forkhead box A20.213
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.211
Smyd1SET and MYND domain containing 10.198
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.196
Bmi1Bmi1 polycomb ring finger oncogene0.194
Isl1ISL1 transcription factor, LIM/homeodomain0.193
Pax8paired box gene 80.193
Cdk6cyclin-dependent kinase 60.192
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.191
Myod1myogenic differentiation 10.186
Stat5bsignal transducer and activator of transcription 5B0.177
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.173
Icam1intercellular adhesion molecule 10.172
Stat5asignal transducer and activator of transcription 5A0.171
Il1binterleukin 1 beta0.171
S100a8S100 calcium binding protein A8 (calgranulin A)0.163
Lyz2lysozyme 20.161
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism