The network for 'luteolysis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms


The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy.

NameDescriptionProbabilityFunc Analog Organism
CRADDCASP2 and RIPK1 domain containing adaptor with death domain1.000
CPEcarboxypeptidase E0.999
LRDDleucine-rich repeats and death domain containing0.985
RDH11retinol dehydrogenase 11 (all-trans/9-cis/11-cis)0.939
RAI1retinoic acid induced 10.898
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.812
NR4A1nuclear receptor subfamily 4, group A, member 10.724
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.568
HNRNPLheterogeneous nuclear ribonucleoprotein L0.553
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.407
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.339
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.242
VEGFCvascular endothelial growth factor C0.231
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.227
KCNRGpotassium channel regulator0.199
MMP10matrix metallopeptidase 10 (stromelysin 2)0.164
MFAP4microfibrillar-associated protein 40.145
HLA-DPB1major histocompatibility complex, class II, DP beta 10.123
RGS4regulator of G-protein signaling 40.122
MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)0.120
SLIT2slit homolog 2 (Drosophila)0.118
FAPfibroblast activation protein, alpha0.099
GIGYF1GRB10 interacting GYF protein 10.081
SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A0.078
FLRT2fibronectin leucine rich transmembrane protein 20.076
RXRAretinoid X receptor, alpha0.076
PCDH12protocadherin 120.074
LTBP1latent transforming growth factor beta binding protein 10.074
LAMA4laminin, alpha 40.073
PPP1R1Bprotein phosphatase 1, regulatory (inhibitor) subunit 1B0.069
LTBP4latent transforming growth factor beta binding protein 40.069
CASP10caspase 10, apoptosis-related cysteine peptidase0.069
CCL21chemokine (C-C motif) ligand 210.067
PCDH17protocadherin 170.063
OLFM2olfactomedin 20.061
ECM1extracellular matrix protein 10.060
NPR1natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)0.058
COL14A1collagen, type XIV, alpha 10.057
MMP13matrix metallopeptidase 13 (collagenase 3)0.054
SKP2S-phase kinase-associated protein 2 (p45)0.050
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.048
MMP14matrix metallopeptidase 14 (membrane-inserted)0.046
SFRP4secreted frizzled-related protein 40.044
RBMS3RNA binding motif, single stranded interacting protein 30.043
CACNB1calcium channel, voltage-dependent, beta 1 subunit0.042
SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 10.041
SLCO2A1solute carrier organic anion transporter family, member 2A10.041
PIP4K2Bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.040
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.040
INHBAinhibin, beta A0.039
NOVnephroblastoma overexpressed gene0.037
IGF1insulin-like growth factor 1 (somatomedin C)0.037
MYH11myosin, heavy chain 11, smooth muscle0.037
PTPRBprotein tyrosine phosphatase, receptor type, B0.037
ZNF331zinc finger protein 3310.037
SCG5secretogranin V (7B2 protein)0.035
CHRDL1chordin-like 10.034
SLIT3slit homolog 3 (Drosophila)0.033
LENG8leukocyte receptor cluster (LRC) member 80.032
PTHLHparathyroid hormone-like hormone0.032
JAM2junctional adhesion molecule 20.031
FMO1flavin containing monooxygenase 10.029
BNC2basonuclin 20.029
GNL3Lguanine nucleotide binding protein-like 3 (nucleolar)-like0.029
GLI3GLI family zinc finger 30.029
STEAP1six transmembrane epithelial antigen of the prostate 10.027
ROBO1roundabout, axon guidance receptor, homolog 1 (Drosophila)0.027
WNT2wingless-type MMTV integration site family member 20.027
EPHA3EPH receptor A30.027
STMN2stathmin-like 20.026
OLFML1olfactomedin-like 10.025
FRZBfrizzled-related protein0.025
ZG16Bzymogen granule protein 16 homolog B (rat)0.025
SLC7A11solute carrier family 7, (cationic amino acid transporter, y+ system) member 110.024
CDH5cadherin 5, type 2 (vascular endothelium)0.024
ESM1endothelial cell-specific molecule 10.024
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 20.023
NAV3neuron navigator 30.023
SNCAIPsynuclein, alpha interacting protein0.022
SEMA3Asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.022
F10coagulation factor X0.022
TCF21transcription factor 210.022
RAD54L2RAD54-like 2 (S. cerevisiae)0.022
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 50.022
SELEselectin E0.022
ZNF205zinc finger protein 2050.022
MEGF6multiple EGF-like-domains 60.021
THBS4thrombospondin 40.021
LDB2LIM domain binding 20.021
CNTNAP1contactin associated protein 10.021
COL13A1collagen, type XIII, alpha 10.020
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Casp1caspase 10.938
Mmp13matrix metallopeptidase 130.671
Mmp3matrix metallopeptidase 30.278
Bst1bone marrow stromal cell antigen 10.213
Accn3amiloride-sensitive cation channel 30.203
Tlr4toll-like receptor 40.193
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.176
Nat1N-acetyltransferase 10.143
Mmp7matrix metallopeptidase 70.113
Crotcarnitine O-octanoyltransferase0.102
Cd14CD14 molecule0.101
Casp2caspase 20.092
Tfpitissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)0.091
A3galt2alpha 1,3-galactosyltransferase 20.091
Cybbcytochrome b-245, beta polypeptide0.081
Casp8caspase 80.067
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.053
Casp12caspase 120.047
Folr2folate receptor 2 (fetal)0.047
Ccr1chemokine (C-C motif) receptor 10.046
Cd80Cd80 molecule0.046
Tacr1tachykinin receptor 10.039
Mmp12matrix metallopeptidase 120.033
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.031
Dhfrdihydrofolate reductase0.031
Ctsccathepsin C0.029
Mmp10matrix metallopeptidase 100.029
Hnmthistamine N-methyltransferase0.026
Casp3caspase 30.025
Olfml2bolfactomedin-like 2B0.022
Adam17ADAM metallopeptidase domain 170.020
Cacnb3calcium channel, voltage-dependent, beta 3 subunit0.020
Ms4a11membrane-spanning 4-domains, subfamily A, member 110.018
Dock8dedicator of cytokinesis 80.018
Glycam1glycosylation dependent cell adhesion molecule 10.016
Casp7caspase 70.016
Tnftumor necrosis factor (TNF superfamily, member 2)0.016
Col12a1collagen, type XII, alpha 10.016
Leprotleptin receptor overlapping transcript0.015
Apol3apolipoprotein L, 30.015
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.014
F2rl3coagulation factor II (thrombin) receptor-like 30.013
Smad2SMAD family member 20.013
Olfm1olfactomedin 10.013
Cpxm2carboxypeptidase X (M14 family), member 20.012
Pros1protein S (alpha)0.011
Cd48Cd48 molecule0.011
Tbxa2rthromboxane A2 receptor0.011
Pipprolactin induced protein0.011
Prrx1paired related homeobox 10.011
Cd44Cd44 molecule0.010
Srpxsushi-repeat-containing protein, X-linked0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism